Yazar "Mohammad, Abubaker" seçeneğine göre listele

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    Extraction, isolation and characterisation of oil bodies from pumpkin seeds for therapeutic use
    (Elsevier Sci Ltd, 2012) Adams, Gary G.; Imran, Shahwar; Wang, Sheng; Mohammad, Abubaker; Kök, Mehmet Şamil
    Pumpkin, a member of the Cucurbitaceae family has been used frequently as functional medicines for therapeutic use. Several phytochemicals such as polysaccharides, phenolic glycosides, 13-hydroxy-9Z, 11E-octadecatrienoic acid from the leaves of pumpkin, proteins from germinated seeds, have been isolated. Here the influence of pH, ionic strength, and temperature on the properties and stability of oil bodies from pumpkin (Cucurbita) were determined with a view to patterning oil body size and structure for future therapeutic intervention. Oil bodies from pumpkin seeds were extracted, isolated, characterised using optical microscopy, zeta potential and particle size distribution obtained. During microscopic analysis, the oil bodies were more intact and in an integrated form at the time of extraction but were ruptured with time. Water extracted oil bodies were spherical for all four layers where cream had larger oil bodies then upper curd. Lower curd and supernatant had considerably smaller size with lower curd densely packed and seemed to be rich in oil bodies than any of the four layers. At pH 3, in the absence of salt, the zeta potential is approximately +30 mV, but as the salt concentration increases, the C potential rises at 10 mM but then decreases over the salt range. This trend continues for the upper curd, lower curd and the supernatant and the degree of the reduction (mV) in zeta potential is of the order cream < upper curd < lower curd < supernatant. At pH 7.4, physiological pH, the changes in salt concentration from 10 to 100 mM reduce the zeta potential significantly across all layers such that increased salt concentrations induce negative potentials. Increasing the salt concentrations still further, however, does not make the C potential more negative. However, at pH 9 the zeta potential falls from 0 to 50 mV as the salt concentration increases with the largest reduction shown with 100 mM salt. Particle size distribution at increasing pH salt concentration shows the average size distribution of pumpkin seed oil bodies at an increasing pH (3, 7.4 and 9) and salt concentration (0, 10,50 and 100 mM) across all four layers. The lowest average size distributions are seen at pH 7.4 across all four layers especially within the cream and upper curd layers. At pH 3 and 9, the highest average size distributions are seen in the lower curd and cream layers. Oil bodies can be extracted, isolated and from pumpkins using an aqueous extraction method and may prove to be a useful new source of lipids for application in patterning therapeutics for clinical use. (C) 2012 Elsevier Ltd. All rights reserved.
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    The hypoglycaemic effect of pumpkins as anti-diabetic and functional medicines
    (Elsevier, 2011) Adams, Gary G.; Imran, Shahwar; Wang, Sheng; Mohammad, Abubaker; Kök, Mehmet Şamil
    Diabetes mellitus is considered as a common, growing, serious, costly, and potentially preventable public health problem. In 2030, the number of people with diabetes is estimated to increase from 117 million in 2000 to 366 million. The prevalence of diabetes has and will continue to have burden on the health and finances of economic climates, which in turn, will impact on individuals, families and nations. There are many different types of insulins available to treat diabetes, but there are still physiological consequences for such use. Alternatives are, therefore, required and this includes herbal preparations as well as dietary plants in the form of curcubitaceae (pumpkin). Pumpkin is widely considered to have active hypoglycaemic properties. Pumpkin is a plant, which has been used frequently as functional food or medicine and belongs to the family Cucubitaceae, and consists of succulent stem with numerous seeds. Based on previous evidence of its fruit pulp, it is reported to have anti-diabetic effects. This review has focused on the main medicinal properties of pumpkin and how this has been used in animal models, and point out areas for future research to further elucidate mechanisms whereby this compound may reduce disease risk. (C) 2011 Elsevier Ltd. All rights reserved.
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    The Hypoglycemic effect of pumpkin seeds, trigonelline (TRG), nicotinic acid (NA), and D-Chiro-inositol (DCI) in controlling glycemic levels in diabetes mellitus
    (Taylor & Francis Inc, 2014) Adams, Gary G.; Imran, Shahwar; Wang, Sheng; Mohammad, Abubaker; Kök, Muhammet Şamil
    In the contemporary society, diabetes mellitus is considered as a common, growing, serious, costly, and potentially preventable public health problem. It is forecasted that in 2030, the number of people with diabetes will go up from 117 million in 2000 to 366 million in 2030. The prevalence of diabetes will place a huge burden on health and financial structures of countries, and these will impact on individuals, as well as families and nations. Polysaccharides, para-aminobenzoic acid, fixed oils, sterol, proteins, and peptides are biologically active ingredients, which are found in pumpkins. The chemicals within pumpkins such as the fruit pulp, oil from ungerminated seeds, and protein from germinated seeds have hypoglycemic properties. Preliminary investigation showed that pumpkin seeds, and the macromolecules, therein, such as Trigonelline (TRG), Nicotinic acid (NA), and dchiro-inositol (DCI), possess hypoglycemic properties and could assist in maintaining glycemic control.