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Öğe DETERMINATION OF HEMOGLOBIN A1c, LIPID PROFILES, HOMOCYSTEINE, OXIDATIVE STRESS AND PHYSICAL ACTIVITY LEVELS IN DIABETIC AND/OR NON-DIABETIC COVID-19 PATIENTS(2023) Özdemir, Kadirhan; Saruhan, Ercan; Kaya, Gözde; Benli, Tuba Kaya; Meral, Orhan; Bozoğlan, Hümeyra; Demir, HalitObjective: The coronavirus disease 2019 (Covid-19) pandemic results in higher morbidity and mortality rates. This study aims to compare hemoglobin A1c (HbA1c), lipid profiles, homocysteine, oxidative stress, and physical activity levels between diabetic Covid-19 patients (group I), non-diabetic Covid-19 patients (group II), and healthy controls (group III). Method: HbA1c, lipid profiles, homocysteine, oxidative stress, oxidant, and antioxidant status were analyzed from the venous blood samples and physical activity levels were measured with International Physical Activity Questionnaire. All the parameters were compared between the groups (n=16 for each group). Results: HbA1c and fasting blood glucose levels in group I were higher than group II and III (p<0.001). There were significant differences in serum levels of total cholesterol, triglyceride, high density lipoprotein cholesterol and low-density lipoprotein cholesterol between the groups (p<0.001). There was lower superoxide dismutase (p<0.001) and total antioxidant status (TAS) (p<0.001), and higher malondialdehyde (p<0.001), total oxidant status (TOS) (p<0.001), oxidative stress index (p<0.001), C-reactive protein level (p=0.001), and neutrophil/lymphocyte ratio (p<0.001) in group I and II compared with group III. Although the patients in group I and II had lower physical activity levels than group III, only the patients in group II had significantly lower physical activity levels than group III (p=0.006). Conclusion: Diabetic Covid-19 patients had higher blood glucose markers than non-diabetic Covid-19 patients and healthy controls in our study. Diabetic and non-diabetic patients had higher oxidant, lower antioxidant, and higher oxidative stress levels than healthy controls. In addition, the physical activity levels of non-diabetic Covid-19 patients were lower than diabetic Covid-19 patients and healthy controls.Öğe Küreselleşme ve Türkiye'ye yansımaları(Bolu Abant İzzet Baysal Üniversitesi, 1998) Meral, Orhan; Ülker, HalilÖZET KÜRESELLEŞME VE TÜRKİYE'YE YANSIMALARI MERAL, Orhan Yüksek Lisans Tezi Kamu Yönetimi Bölümü Tez Danışmanı: Prof. Dr. Halil ÜLKER Mayıs 1998.190 Sayfa. Bu tez çalışmasının amacı: küreselleşmenin, dünya üzerindeki: ekonomik, siyasi ve kültürel sonuçlarının incelenmesi ve bunların sebep olduğu etkilerin, Üçüncü Dünya ülkeleriyle birlikte, Türkiye'deki mevcut sisteme yansımalarının seviyesinin ve sonuçlarının değerlendirilmesidir. Küreselleşme ve Türkiye'ye yansımaları konusu ; altı bölümde incelenmiştir. Bunlar: 1. Giriş, 2. Dünyanın Eski Ekonomik Düzeni, 3. Dünyanın Yeni Ekonomik Düzeni, 4. Siyasal Yapıdaki Düzenlemeler, 5. Kültürel Etkileşimler, 6. Sonuç, Değerlendirme ve Öneriler, Küreselleşme adı ile dünya' ya empoze edilen yeni dünya düzeninin: 1980'lerin başından bu yana; ekonomik, siyasi ve kültürel yönlerden yarattığı sonuçları değerlendirilmiştir. Bu dönemde: azgelişmiş ve gelişmekte olan ülkelerden: çeşitli şekillerde ve özellikle borçlanma ve sermaye piyasalarının serbestleştirilmesiyle, rant yaratılması sonucu; Batı' lı gelişmiş ülkeler yönünde, büyük kaynak transferlerinin gerçekleştiği tespit edilmiştir. Ayrıca: azgelişmiş ve gelişmekte olan ülkelerde; siyasi yapılanma ve kültürel farklılıklar yaratılmış ve sosyo-ekonomik dengeler alt-üst edilmiştir. Bu sonuçların: gelecek yıllarda da artarak devam edeceği değerlendirilmiş olup; küreselleşmenin ve yeni dünya düzeninin ; Türkiye için yararlı olmadığı ve ileriye dönük olarak da yararlı sonuçların yaratılamayacağı sonucuna varılmıştır. Türkiye için; ulusal politikaların uygulanmasının faydalı olacağı sonucuna varılmıştır.Öğe Levels of oxidative stress, selenium and zinc, and health-related quality of life in healthy males before and after COVID-19 vaccination(Dustri-Verlag Dr Karl Feistle, 2024) Özdemir, Kadirhan; Saruhan, Ercan; Benli, Tuba Kaya; Kaya, Gözde; Çil, Zafer; Yavuz, Melike Yüksel; Meral, OrhanObjective: The aim of this study was to determine the changes in oxidative stress, selenium (Se) and zinc (Zn), and health-related quality of life (HRQoL) following COVID-19 vaccination. Materials and methods: 20 healthy male subjects received 2 doses of inactivated COVID-19 vaccines between January and August 2021. Peripheral blood samples were taken immediately before the 1 st dose and 3 days after the 2 nd dose of the vaccine. The oxidant status (malondialdehyde (MDA) and total oxidant status (TOS)), antioxidant status (superoxide dismutase (SOD) and total antioxidant status (TAS)), Se and Zn, and HRQoL levels of the subjects were evaluated. In addition, oxidative stress index (OSI) was calculated. Results: The mean age and body mass index of the subjects were 45.85 +/- 6.38 years and 28.53 +/- 4.50 kg/m(2), respectively. Following COVID-19 vaccinations, TAS levels decreased (p = 0.004); however, SOD levels increased (p = 0.012) significantly. In addition, there were no significant changes in TOS and MDA levels (p > 0.05). Moreover, OSI showed no significant differences (p > 0.05). After the vaccination process, Se and Zn increased; however, the differences were insignificant (p > 0.05). In addition, the HRQoL of the subjects did not change (p > 0.05). Conclusion: Although the antioxidant status decreased after 2 doses of COVID-19 vaccination, the oxidant status and the oxidative stress levels of the subjects remained stable. Thus, 2 doses of inactivated COVID-19 vaccination may have no effects on oxidative stress levels in healthy males. In addition, there were no changes in the serum concentrations of Se and Zn. Moreover, there was no difference in the HRQoL of the subjects. Therefore, COVID-19 vaccination process may not affect serum Se and Zn levels and HRQoL in healthy males.
