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    Could triglyceride to high density lipoprotein-cholesterol ratio predict hepatosteatosis?
    (2021) Kurtkulaği, Özge; Bilgin, Satilmis; Kahveci, Gizem; Tel, Burçin Meryem Atak; Kösekli, Mehmet Ali
    Aim: The triglyceride / HDL cholesterol (TG/HDL-c) ratio is increased in a variety of diseases including, coronary heart disease and type 2 diabetes mellitus. However, its role in non-alcoholic hepatosteatosis is not well understood. In present study, we aimed to compare the TG/HDL-c levels of the patients with non-alcoholic hepatosteatosis to those of the healthy subjects. Methods: Medical data of the patients with non-alcoholic hepatosteatosis whom presented to the outpatient internal medicine clinics of our institution were retrospectively analyzed. Healthy subjects whom admissions to our clinics were due to check up were enrolled to the study as control group. TG/HDL-c of the groups compared. Results: TG/HDL-c level of the liver steatosis group (5 (2-22) %) was higher than the control group (2.7 (1-8) %), (p<0.001). TG/HDL-c was significantly and positively correlated with fasting blood glucose (r=0.31, p<0.001), C - reactive protein (r=0.25, p<0.001) and LDL-cholesterol (r=0.3, p<0.001) levels. A TG/HDL-c value greater than 3.1% has 91% sensitivity and 77% specificity in detecting hepatosteatosis. Conclusions: We suggest that TG/HDL-c ratio could be a useful marker of non-alcoholic hepatosteatosis due to its inexpensive and easy to assess nature.
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    A Novel Laboratory Marker for Hepatosteatosis:Mean Platelet Volume to Lymphocyte Count Ratio
    (2021) Bilgen, Satılmış; Kurtkulaği, Özge
    Amaç: Hepatosteatosis (HS) is defined as accumulation of fat in liver reaching to an amount of at least 5% of liverweight. Not just mean platelet volume (MPV), but also MPV to lymphocyte ratio (MPVLR) has been introduced asa marker in inflammatory and metabolic conditions. We aimed to compare MPVLR values of patients with hepa tosteatosis with those of healthy controls. We also investigated the correlation between CRP and MPVLRMethods: The data of the patients with HS who were admitted to internal medicine outpatient clinics of our insti tution between 2018 December and 2019 December were enrolled into the study. The MPVLR were calculatedusing MPV/lymphocyte formula. Results: The median MPVLRs of the HS and control groups were 4.3% (2.1) and 3.6% (1.7), respectively (p<0.001).The median CRP levels of the HS and control groups were 3.6 (4.9) mg/L and 0.4 (0.2) mg/L, respectively (p<0.001).The MPVLR was positively and strongly correlated with CRP (r=0.64, p<0.001). However, MPVLR and the biochemi cal parameters; LDL-cholesterol, ALT and triglyceride were not correlated at all.. Conclusion: We suggest that elevated MPVLR should alert physicians for possible hepatosteatosis in a populationwithout comorbidities. Positive and strong correlation between CRP and MPVLR should also prompt use of MPVLRas a reliable inflammatory predictor.
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    Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules
    (2021) Bilgin, Satilmis; Kahveci, Gizem; Tel, Burçin Meryem Atak; Kurtkulaği, Özge; Kösekli, Mehmet Ali
    Aim: Differentiation of thyroid nodules, either as benign or malignant, is a real diagnostic challenge.Inflammation has an important role in development of the malignancy. Therefore, inflammatory markers areassociated with malignant thyroid nodules. Platelet /lymphocyte ratio (PLR) is also one of the novelinflammatory indices derived from hemogram tests. We hypothesized whether PLR was associated withmalignant thyroid nodules. For this purpose, we compared PLR levels of the patients with benign thyroidnodules to the PLR of the subjects with malignant nodules.Methods: The subjects who visited outpatient internal medicine clinics of our institution with a diagnosis ofthyroid nodule were enrolled to the present retrospective study. According to the examination of the fine needleaspiration cytology (FNAC) specimen of the nodules, patients grouped into benign or malignant nodule groups.PLR of groups were compared.Results: Median PLR values of the benign and malignant thyroid nodule groups were 106 (48-432) % and 119(48-365) %, respectively (p=0.001). PLR value higher than 106% has 69% sensitivity and 51% specificity indetecting malignant nodules (AUC: 0.59, p=0.001, 95% CI: 0.54-0.65). PLR was positively correlated withTSH level (r=0.10, p=0.34).Conclusion: We suggest that elevated PLR could be an additional tool to differentiate malignant thyroidnodules from benign ones in supportive of sonography, scintigraphy and cytology.