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    The comparison of dexmedetomidine and midazolam used for sedation of patients during upper endoscopy: A prospective, randomized study
    (Hindawi Ltd, 2007) Demiraran, Yavuz; Korkut, Esin; Tamer, Ali; Yorulmaz, İlknur; Kocaman, Buket; Sezen, Gülbin; Akcan, Yusuf
    The aim of the present prospective, randomized study was to investigate and compare the safety and efficacy of dexmedetomidine versus midazolam in providing sedation for gastroscopy. A total of 50 adult patients (25 patients receiving dexmedetomidine and 25 patients receiving midazolam), 18 to 60 years of age, and rated I and II on the American Society of Anesthesiologists physical status classification system were included. A brief questionnaire was used to collect demographic data; patients were asked to rate anxiety, satisfaction wit care to data and expected discomfort on a visual analogue scale. The following parameters were measured continuously and recorded every minute; heart rate, mean arterial pressure, hemoglobin oxygen saturation and respiratory rate. The two groups were similar with regard to age, body mass index, sex, education, duration of endoscopy, and ethanol or tobacco use. After the procedure, full recovery time, mean arterial pressure, heart rate, respiratory rate and hemoglobin oxygen saturation levels were similar in both groups. Both groups also had low levels of perceived procedural gagging, discomfort and anxiety scores (P > 0.05), and high satisfaction levels (90.1+/-3.0 for dexmedetomidine versus 84.9+/-4.5 for midazolam; P>0.05). Retching and endoscopist satisfaction were significantly different in patient receiving dexmedetomidine versus those receiving midazolam (88.8+/-6.5 versus 73.5+/-16.4, P<0.05; and 20.6+/-4.4 versus 45.2+/-6.0; P<0.001). In the midazolam group, the number of patients who had adverse effects was higher than the dexmedetomidine group (P<0.05). As a result, dexmedetomidine performed as effectively and safely as midazolam when used as a sedative in upper gastroscopy; it was superior to midazolam with regard to retching, rate of side effects and endoscopist satisfaction. It was concluded that dexmedetomidine may be a good alternative to midazolam to sedate patients for upper endoscopy.
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    The low seropositivity of hepatitis B virus in vitiligo patients
    (Wiley, 2006) Akçan, Yusuf; Kavak, Ayşe; Sertbaş, Yaşar; Olut, Ali Ilgın; Korkut, Esin; Bicik, Zerrin; Kısacık, Bünyamin
    Despite of its unknown aetiology, vitiligo may be triggeredby viral infection in a genetically predisposed host, likean autoimmune disease.
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    Safe lives biopsy in a patient with chronic hepatitis C under continuous ambulatory peritoneal dialysis treatment [9]
    (2005) Bicik, Zerrin; Akcan, Yusuf; Korkut, Esin; Korkmaz, Uğur; Sertbaş, Yaşar; Çalışkan, Şerife
    Shaanxi Province Diagnosis and Treatment Center of Kawasaki Disease/Children's Hospital of Shaanxi Provincial People's Hospital; Children's Hospital of Shanghai Jiao Tong University; Beijing Children's Hospital of Capital Medical University; Shengjing Hospital of China Medical University; Affiliated Hospital of Yan'an University; Expert Committee of Advanced Training for Pediatrician, China Maternal and Children's Health Association; General Pediatric Group of Pediatrician Branch of Chinese Medical Doctor Association; Shanghai Cooperation Organization Hospital Cooperation Alliance; Pediatric International Exchange and Cooperation Center; Editorial Board of Chinese Journal of Contemporary Pediatrics.
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    Two successive pregnancies after ursodeoxycholic acid therapy in a previously infertile woman with antimitochondrial antibody-negative primary biliary cirrhosis
    (Elsevier Inc., 2005) Korkut, Esin; Kısacık, Bünyamin; Akcan, Yusuf; Belenli, Olcay; Bicik, Zerrin; Yücel, Oǧuz
    Objective: To describe the benefit of ursodeoxycholic acid (UDCA) for the initiation and completion of a successful pregnancy in a previously infertile woman with primary biliary cirrhosis. Design: Case report. Setting: A university hospital with relevant departments. Patient(s): A 29-year-old woman with primary biliary cirrhosis and failure to conceive for 6 years. Intervention(s): Establishment of diagnosis with a liver biopsy, pretreatment of patient with UDCA before conception, and continuation of UDCA after first trimester until term. UDCA was used in the second pregnancy again after the first trimester. Main Outcome Measure(s): Achievement of a safe conception and full-term pregnancy. Result(s): Two consecutive successful pregnancies, a healthy 3,250-g male infant and a healthy 3,000-g female infant. The second conception occurred in a period without the use of UDCA, implicating a latent beneficial effect of either UDCA orthe previous pregnancy via some possible immune mechanism. Conclusion(s): Ursodeoxycholic acid could help achieve conception in infertile women with primary biliary cirrhosis. The use of UDCA after the first trimester is shown to be safe in two consecutive pregnancies. Although it cannot be conclusive, the unintentional use of UDCA in the first 20 days after conception did not result in any teratogenicity in the first child. © 2005 by American Society for Reproductive Medicine.