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Öğe Association between chronic obstructive pulmonary disease and blood types(Derman Medical Publ, 2017) Konuk, SuatAim: This research was performed on patients diagnosed with chronic obstructive pulmonary disease (COPD) in Sirnak province center to explore the relation between COPD and blood types. Material and Method: Pulmonary function tests were performed on 1000 patients over the age of 30 who were randomly selected from the patients residing in the city center of Sirnak. 570 (57%) of the participants were male and 430 (43%) were female. Results: When combined with the Global Obstructive Lung Disease (GOLD) criteria, the prevalence of COPD was 10.1% (101 patients). Disease stages were mild in 1.98%; moderate in 27.72%; severe in 43.36%; and very severe in 26.74% of COPD patients. COPD was diagnosed in 11.92% (68 patients) of men and 7.67% (33 patients) of women participating in the study. The blood types of 93 patients with COPD from the group of 101 were retrospectively reached from hospital records. Patients were classified according to ABO blood type data. As a result, it was found that COPD was more common in patients with blood type A. According to ABO blood types distribution of our cases with COPD were as follows: 39 patients (42%) were type A, 26 patients (28%) were type B, 17 patients (18%) were type AB and 11 patients (12%) were type O. Discussion: A conclusion is reached revealing the association of blood type with COPD risk factors, which was mentioned in much of the corpus of medical literature.Öğe Bolu il merkezinde kronik obstrüktif akciğer hastalığı prevalansının değerlendirilmesi(Bolu Abant İzzet Baysal Üniversitesi, 2009) Konuk, Suat; Tuğ, TuncerGünümüzde Kronik Obstrüktif Akciğer Hastalığı (KOAH), tüm dünya ülkelerinde önemli bir sağlık sorunu haline gelmiştir. Diğer hastalıkların mortalite oranlarının yıllar içinde düşmesine karşılık KOAH prevalansı ve mortalitesi giderek artış göstermektedir. Bu araştırma Bolu il merkezinde KOAH prevalansını belirlemek amacıyla yapıldı. Bolu il merkezinde oturan, ev tespit fişlerinden rastgele yöntemle seçilen 35 yaş ve üstü 500 kişiye solunum fonksiyon testi yapıldı. Çalışmaya katılan bireylerden 285'i (%57) erkek, 215'i (%43) kadın idi. Solunum fonksiyon testi ?The Global Initiative for Chronic Obstructive Lung Disease? (GOLD) kriterleri ile birlikte değerlendirildiğinde KOAH prevalansı %8.6 (43 kişi) bulundu. KOAH tespit edilen hastaların hiç biri hafif evrede değildi. %34.88'i orta, %41.86'sı ağır ve %23.25'i çok ağır evrede idi. KOAH tespit edilen hastaların %97.67'sinde sigara içme öyküsü vardı. Çalışmaya katılan erkeklerin %9.82'sinde (28 kişi), kadınların %6,97'sinde (15 kişi) KOAH saptandı. Sonuç olarak KOAH'ın, Bolu il merkezinde önemli bir halk sağlığı sorunu olduğu düşünüldü.Öğe Comparison of respiratory muscle activations in different dyspnea reduction positions in individuals with COPD(European Respiratory Soc Journals Ltd, 2023) Topcuoglu, Ceyhun; Yumin, Eylem Tutun; Saglam, Melda; Cankaya, Tamer; Konuk, Suat; Ozsari, Emine; Goksuluk, Merve BasolÖğe Evaluation of fatigue-related kinesiophobia and associated factors in individuals with lung cancer with and without respiratory comorbidity(2022) Özsari, Emine; Konuk, Suat; Özel, Alp; Yümin, Eylem TütünAim: To investigate fatigue-related kinesiophobia and associated factors in individuals with lung \rcancer.\rMethods: A total of 52 individuals were included in the study and the individuals were divided into \rtwo groups, each consisting of 26 individuals. Charlson comorbidity index, Brief Fatigue Inventory, \rmodified Medical Research Council dyspnea scale, Tampa Kinesiophobia Scale-Fatigue are applied \ras data collection tools.\rResults: The individuals in the study had similar demographic characteristics. There was no \rdifference between the groups in the study in terms of fatigue-related kinesiophobia. There was a \rdifference between the pain and performance status of the individuals in the study in activities of \rdaily living (p<0.05).\rConclusion: At the end of this study, it was observed that individuals with lung cancer with \rrespiratory comorbidity had worse pain, fatigue and performance values in activities of daily living, \rwhile kinesiophobia values related to fatigue were similar.Öğe Examination of diaphragm thickness, mobility and thickening fraction in individuals with COPD of different severity(Scientific and Technological Research Council Turkey, 2022) Topçuoğlu, Ceyhun; Yümin, Eylem Tütün; Hızal, Mustafa; Konuk, SuatBackground/aim: Diaphragm thickness and mobility assessed by ultrasound in individuals with Chronic Obstructive Pulmonary Disease (COPD) reflect the function of the diaphragm. The aim of this study is to compare the diaphragm thickness, mobility, and thickening fraction in individuals with COPD of different severity and healthy individuals and examine the relationship between these parameters and pulmonary function test parameters. Materials and methods: A cross-sectional observational study design was used. Thirty individuals (mild = 11; moderate = 13; severe = 6) with COPD and 29 healthy male individuals aged between 40-75 years were included in the study. The individuals included in the study were evaluated between October 2020/May 2021. Pulmonary functions were measured with a spirometer, while diaphragm thickness, mobility, and thickening fraction were measured by ultrasound. Results: The right and left diaphragm thickness, mobility, thickness variation, thickening fraction, and mobility were lower in individuals with COPD than in healthy individuals (p < 0.05). The left Functional Residual Capacity (FRC) diaphragm thickness, right Total Lung Capacity (TLC), and FRC diaphragm thickness were higher in mild COPD than moderate COPD and moderate COPD than severe COPD (p < 0.05). The right diaphragmatic thickening fraction and rate were higher in mild COPD than in moderate and severe COPD (p < 0.05). The left mobility was lower in severe COPD than in mild COPD (p < 0.05). Conclusion: Diaphragm ultrasound parameters decrease as disease severity increases in individuals with COPD. We think that adding diaphragm ultrasound parameters together with pulmonary function test to the evaluation of individuals with COPD will provide additional contributions to determining the course of the disease.Öğe Factors influencing influenza and pneumococcal immunization rates of COPD patients in Bolu, Turkey(2020) Ballar, Manolya; Tuğ, Tuncer; Mutlu, Mehmet Kayhan; Konuk, SuatThe aim of this study was finding out the rates of pneumococcal and influenza vaccination, the factors influencing vaccination, and non-vaccination in COPD patients.The study was conducted with 104 COPD patients diagnosed by a pulmonologist. The diagnosis was made according to the GOLD 2019 document via an FEV1/FVC ratio below 70%. The patients were inquired about getting vaccinated for influenza in the last year and pneumococci in the last five years. The patients were then grouped according to their vaccination status and inquired about their perception of the necessity of vaccination. The study revealed a significant association between COPD levels and the awareness of the necessity of annual influenza vaccination (p=0.019). However, there was no significant association between COPD levels and being vaccinated for influenza in the last year (p=0.434). There was no significant association between COPD levels and pneumococcal vaccination in the last five years or the awareness for the necessity of the vaccine (p=0.0559 and p=0.495). 22.2% of the patients who were vaccinated for pneumonia were also vaccinated for influenza and 98.7% of the patients who were not vaccinated for pneumonia were also not vaccinated for influenza in the last year. 85.7% of the patients who got an influenza vaccine in the last year also knew the necessity of getting annually vaccinated (p=<0.001). Every patient who has gotten the pneumonia vaccine in the last five years knew the necessity of getting a pneumonia vaccine as well (p<0.001).This study shows that most patients who got the influenza vaccine in the last year also knew the necessity of getting an influenza vaccine every year. Furthermore, all the patients who got the pneumococcal vaccine in the last five years knew the necessity of getting the pneumococcal vaccine. Most patients who were not vaccinated for pneumonia in the last 5 years were not vaccinated for influenza either.Öğe Have the number of pulmonary embolism cases increased during the COVID-19 pandemic?(Termedia Publishing House Ltd, 2022) Afşin, Emine; Özsarı, Emine; Konuk, Suat; Kocadağ, Derya; Bacaksız, EmreBackground. Coagulation disorders, endothelial dysfunction, immobility and dehydration contribute to deep vein throm-bosis (DVT) and pulmonary embolism (PE) in COVID-19 patients. While the prevalence of PE accompanying COVID-19 is high, the number of studies on its long-term effects is limited in literature. Objectives. We expanded this process and aimed to evaluate a one-year period before and during the pandemic. We sought an answer to the question: "Is there a change in the frequency and clinical course of PE?" Material and methods. Retrospectively, all patients admitted to our pulmonology clinic diagnosed with PE between October 2018-2019 (pre-pandemic) and April 2020-2021 (pandemic period) were included in the study. PE patients hospitalized due to COVID-19 infection were not included in the study. Results. The prevalence of PE cases increased by 43% in the first year of the pandemic, and there was no significant difference in terms of symptoms, localisation and extent of thrombus in the pulmonary artery, DVT frequency, systolic pulmonary artery pressure (PABs) values, right heart load, frequency of thrombolytic therapy and mortality rates. A significant decrease was observed in predisposing factors of pulmonary embolism only in the postoperative period (7 patients (77.8%) before the pandemic; 2 patients (22.2%) during the pandemic; p = 0.029). Conclusions. PE cases are encountered more frequently during the pandemic process, and no significant change was seen in patient's clinical findings and mortality.Öğe Investigation of sleep quality according to physical activity levels in individuals with lung cancer(2022) Özsari, Emine; Özel, Alp; Konuk, Suat; Yümin, Eylem TütünIntroduction: Lung cancer is a type of cancer that is usually diagnosed late and has a low life expectancy due to its incidence, high mortality, and initial asymptomatic course. Sleep disorders and related fatigue are common complaints for cancer patients. This study aims to examine sleep quality according to physical activity levels in individuals with lung cancer. Methods: This study was carried out between December 2021 and March 2022. Individuals diagnosed with lung cancer in Bolu Abant İzzet Baysal University Faculty of Medicine Chest Diseases Outpatient Clinic were retrospectively analyzed. 100 individuals were included in the study. Individuals diagnosed with lung cancer in the chest diseases department of a tertiary care center were retrospectively analyzed. Physical activity level with the International Physical Activity Questionnaire; sleep quality with the Pittsburg Sleep Quality Index; dyspnea with Modified Medical Research Council Scale; performance status with Eastern Cooperative Oncology Group; functional disability with Karnofsky Performance Status; Pain was evaluated with a numerical rating scale. Results: 52.0% of the individuals included in the study were sedentary. There was no difference between the two groups in terms of mean age (p=0.123), body mass index (p=0.157), disease duration (p=0.342), and length of hospital stay (p=0.273). There was a difference between the two groups in terms of Eastern Cooperative Oncology Group (p=0.001), Karnofsky Performance Status (p=0.001), and total score of Pittsburg Sleep Quality Index (p=0.001). Conclusion: In our study, it was found that the total sleep quality score of the physically active group was better than the sedentary group. Physical activity is a modifiable lifestyle behavior with positive physiological and psychological health consequences and a potential non-pharmacological intervention for poor sleep quality.Öğe Misuse of inhaler devices and associated factors in chronic obstructive pulmonary disease patients(Bayrakol Medical Publisher, 2021) Şeker, Serhat; Konuk, Suat; Özsarı, Emine; Tuğ, TuncerAim: Inhaler device misuse is a common problem in the management of Chronic Obstructive Pulmonary Disease (COPD). In this study, we aimed to evaluate the incorrect use of inhaler devices and associated factors in patients with COPD. Material and Methods: A total of 75 patients with the diagnosis of COPD were randomized. Demographic characteristics, type of device used, satisfaction with the drug, whether they received any training, and the inhalation technique were evaluated. Disease duration, pulmonologist follow-up, and device type were compared with the frequency and type of errors. Results: Among the patients, 85.3% received information from the pulmonologist, 9.3% from another healthcare professional, and 5.3% did not receive any information about drug use; 20% of the patients were on Diskus, 4% on Turbohaler, 33.3% on capsuled devices, 37.3% pMDI, and 5.3% were on Ellipta. In total, 49.3% of patients were using their devices correctly. In patients who had 3 or more pulmonology follow-ups per year, correct installation of the device, mouth washing, and total correct use scores were significantly higher (p<0.05). Capsuled device users had significantly higher rates of performing adequate inhalation and the total score of correct use compared to pMDI users (p<0.05). Discussion: In COPD patients, frequent follow-up and the type of device used were found to be related to correct inhaler use. Applied inhaler device training should be given by a pulmonologist both initially and during follow-up, with particular attention to the technique of using the pMDI.Öğe Neural Respiratory Drive During Different Dyspnea Relief Positions and Breathing Exercises in Individuals With COPD(Daedalus Enterprises Inc, 2024) Topcuoglu, Ceyhun; Yumin, Eylem Tutun; Saglam, Melda; Cankaya, Tamer; Konuk, Suat; Ozsari, Emine; Goksuluk, Merve BasolBackground: When the work load of the respiratory muscles increases and/or their capacity decreases in individuals with COPD, respiratory muscle activation increases to maintain gas exchange and respiratory mechanics, and perception of dyspnea occurs. The present study aimed to compare diaphragm and accessory respiratory muscle activation during normal breathing, pursed-lip breathing, and breathing control in different dyspnea relief positions, supine and side lying. Methods: A cross-sectional study design was used. Sixteen individuals with COPD age between 40-75 y were included. Pulmonary function was evaluated by spirometry, muscle activation by surface electromyography, and dyspnea by the modified Borg scale. Muscle activation was measured in the diaphragm, scalene, sternocleidomastoid, and parasternal muscles. The evaluation was made in the dyspnea relief positions (sitting leaning forward, sitting leaning forward at a table, leaning forward with back against a wall, standing leaning forward, and high lying), seated erect, supine, and side lying. Results: There were significant differences between the 8 positions (P < .001). There was no significant difference in muscle activation between sitting leaning forward and sitting leaning forward at a table position with analyzing post hoc test results (P > .99 for each muscle). However, muscle activation was lower in these 2 positions than in the other positions (P < .001 for each muscle). Muscle activation was greater in the supine position than in the other positions (P < .001 for each muscle). No difference was observed in muscle activation between the seated erect, leaning forward with back against a wall, standing leaning forward, high-lying, or side-lying positions (P > .05 for each muscle with a minimum P value of .09). Conclusions: The use of sitting leaning forward and sitting leaning forward at a table positions together with breathing control may help people with COPD to achieve more effective dyspnea relief and greater energy efficiency.Öğe Oxidant and antioxidant balance in stable COPD patients and during acute COPD exacerbations(2020) Cansız, Kübra; Tuğ, Tuncer; Konuk, SuatThe oxidant-antioxidant imbalance is an important factor in the pathogenesis of COPD and yet there is a lack of evidence about total antioxidant levels of COPD patients, which may provide valuable information about the prognosis of the disease. In this study, we aimed to evaluate and compare the oxidant-antioxidant systems in healthy controls and in COPD patients with a stable disease and during an acute exacerbation. The study was conducted with 42 COPD patients diagnosed by a pulmonologist and 21 healthy volunteers. Pulmonary function tests were performed, arterial blood gas; white blood cell, hemoglobin, hematocrit, platelet, neutrophil%, MCV, CRP, and sedimentation rate results were compared with total antioxidant status, total oxidant status levels, and oxidative stress index. There was a statistically significant difference between the three groups in $FEV_1/FVC$ , $FEV_1$ , FVC, $pCO_2$ , $pO_2$ , $\%SpO_24 , white blood cell count, neutrophil %, CRP, and ESR values. In regard to oxidant-antioxidant system measurements there was no statistically significant difference in TAS levels, but there was a significant difference in TOS and oxidative stress index levels. Positive correlation between WBC and TOS was detected in the analysis performed and no correlation was found in other parameters. Our study showed that the measurement of TAS, TOS and OSI were meaningful parameters in the evaluation of oxidative imbalance. Oxidant stress was found to be significantly increased in all COPD patients, especially in patients with COPD exacerbations. Despite the increase in oxidative stress, no increase in antioxidant levels was observed in COPD patients.Öğe The prevalence of chronic obstructive pulmonary disease in Bolu province of Turkey(Derman Medical Publ, 2017) Konuk, Suat; Tuğ, TuncerAim: Chronic Obstructive Pulmonary Disease (COPD) is increasingly recognized as a leading cause of global morbidity and mortality throughout the world. The prevalence and mortality of COPD have increased through years. This study was conducted to explore the prevalence of COPD in the central Bolu province of Turkey. Material and Method: Pulmonary function testing (PFT) was performed on 500 subjects above the age of 35 years who were selected randomly using 'Family Identification Cards' in each governor office in central Bolu. Of the 500 subjects, 285 (57.0%) were male. The diagnostic criteria of Global Initiative for Chronic Obstructive Lung Disease (GOLD) with spirometry was used to diagnose COPD. Results: The prevalence of COPD was found to be 8.6% (43 of 500 subjects). None of the diagnosed subjects had stage 1 disease in terms of GOLD stage definition. Stage 2, stage 3, and stage 4 diseases were found in 34.9%, 41.8%, and 23.3% of COPD-diagnosed subjects, respectively Smoking history was positive in 42 of 43 subjects with COPD (97.7%). In terms of all subjects, COPD was diagnosed in 9.8% of males (28 of 285) and 6.9% of females (15 of 215). Discussion: COPD was defined as a significant public health problem in Bolu province of Turkey.Öğe The relation between pregnancy-associated plasma protein a and obstructive sleep apnea syndrome(Hindawi Ltd, 2018) Cengiz, Ali; Konuk, Suat; Tuğ, TuncerAim. We aimed to investigate the relationship between serum pregnancy-associated plasma protein A (PAPP-A) levels and obstructive sleep apnea syndrome (OSAS). Materials and Method. 44 patients with OSAS and 44 healthy adults were included in this study. The participants having rheumatic or systemic inflammatory disease, advanced liver or kidney failure, diabetes, heart failure, hypertension, pregnancy, prerenal azotemia, known history of coronary artery disease, any pulmonary disease, rhinitis, or atopy, history of major trauma or surgery within the last six 6 months, and inhaled nasal or systemic corticosteroid use or other anti-inflammatory medications and those with < 18 years of age were excluded. Serum PAPP-A levels were determined by the Elisa method with the immune sandwich measuring method. Statistical analysis of the study was performed with SPSS 17.0 statistical analysis package program, and p < 0.05 was considered as significant. Results. Serum PAPP-A levels of patients with OSAS (2.350 ng/ml (0.641-4.796)) were significantly higher (p < 0.001) when compared with healthy controls (0.971 ng/ml (0.109-2.679)). There was a statistically significant difference in serum PAPP-A levels between groups of OSAS patients according to the classification of OSAS severity. Between the groups of patients with OSAS, serum levels of PAPP-A in moderate group was significantly higher when compared with severe OSAS group (p < 0.001). There was positive correlations between PAPP-A levels and night minimum (p=0.042, r=0.309), and average oxygen levels (p=0.006, r=0.407). There was a negative correlation between PAPP-A levels and AHI (p=0.002, r=0.460). Conclusion. Higher PAPP-A levels in OSAS patients that were found in this study show inflammatory component in OSAS.Öğe Relationship of obesity with exercise capacity, quality of life and fatigue level in chronic obstructive pulmonary disease(2021) Özel, Alp; Yümin, Eylem Tütün; Konuk, Suat; Tuğ, TuncerThis study was planned to investigate the relationship of obesity with exercise capacity, quality of life, and fatigue level in Chronic Obstructive Pulmonary Disease (COPD). 109 individuals with COPD were included in the study. Individuals were stratified into three groups as normal (18.5?, ?24.9 kg/m2, n=34), overweight (25?, ?29.9 kg/m2, n=43) and obese (>30 kg/m2, n=32). After taking socio-demographic information of the individuals, The Shuttle Walking Test was used to measure exercise capacity, St. George Respiratory Questionnaire to measure quality of life, and the Fatigue Severity Scale to measure fatigue levels. The average age and BMI of normal, overweight and obese individuals participating in the study were 60.58±13.21 years, 21.48±1.83 kg/m2; 61.83±11.33 years, 26.98±1.50 kg/m2 and 57.55±12.85 years, 33.46±3.93 kg/m2 respectively with age being similar between the groups (p>0.05). In the correlation analysis, there was a significant relationship between exercise capacity and fatigue severity (r= -0.532, p= 0.007), SGRQ activity parameter (r= -0.508, p= 0.011) in individuals with obesity (p<0.05). No relation was observed in these parameters in the normal and overweight COPD group (p> 0.05). There was a relationship between fatigue severity and all sub-parameters of SGRQ in all 3 groups (p<0.05). In obese individuals with COPD, BMI was found to be related to the individual's exercise capacity. It was found that exercise capacity in individuals with obesity is related to fatigue severity and quality of life. For this reason, it was thought that rehabilitation approaches to control weight and increase exercise capacity may positively affect individuals' fatigue status and quality of life.Öğe A short survey study in asthma patients related to misperception of the disease(Derman Medical Publ, 2017) Konuk, SuatAim: To evaluate the extensity of two basic misperceptions in asthma patients. Material and Method: The patients over 18 years of age who had been diagnosed with asthma and using asthma drugs were enrolled in the study. The patients were consecutively selected who examined in the private office of the author. Participants have been asked whether 'asthma is a contagious disease' and whether 'asthma drugs cause addiction. Results: A total of 1,003 patients were included in the study. The ratios of patients who declared that 'asthma is a contagious disease' or 'asthma is not a contagious disease' were 15.3% and 58.0%, respectively. The ratio of patients who declared that 'asthma drugs cause addiction' and 'asthma drugs do not cause addiction were 17.9% and 27.0%. Discussion: Although most patients answers were in accordance with scientific facts, the ratios of misperception are thought to be high.Öğe Sıradışı semptomları nedeniyle KOAH tanısı ile izlenen nadir bir sendrom: Chiliaditi sendromu; bir olgu nedeniyle(2007) Konuk, Suat; Tuğ, Tuncer; Talay, Fahrettin; Kurt, Bahar; Bölük, Murat; Gökay, ÇiğdemChiliaditi sendromu nadir görülen ve transvers kolonun yalnız başına veya ince bağırsakla birlikte hepatodiyafragmatik aralığa sıkışması sonucu gelişen bir sendromdur. Asemptomatik olabileceği gibi bazen karın ağrısı, bulantı, kusma ve kabızlık gibi tipik semptomların yanı sıra; nefes darlığı ve göğüs ağrısı gibi atipik şikayetlere de neden olabilir. Fizik muayene incelemelerimiz KOAH tanısını doğrulamamasına rağmen, klinik ve laboratuvar bulgularının KOAH'la uyumlu olması nedeniyle KOAH gibi tedavi edilen, 63 yaşındaki erkek hasta Chiliaditi sendromunun nadir rastlanılır klinik özellikleri nedeniyle sunulduÖğe Sıradışı semptomları nedeniyle KOAH tanısı ile izlenen nadir bir sendrom:Chiliaditi sendromu;bir olgu nedeniyle(2007) Konuk, Suat; Tuğ, Tuncer; Talay, Fahrettin; Kurt, Bahar; Bölük, Murat; Gökay, ÇiğdemChiliaditi sendromu nadir görülen ve transvers kolonun yalnız başına veya ince bağırsakla birlikte hepatodiyafragmatik aralığa sıkışması sonucu gelişen bir sendromdur. Asemptomatik olabileceği gibi bazen karın ağrısı, bulantı, kusma ve kabızlık gibi tipik semptomların yanı sıra; nefes darlığı ve göğüs ağrısı gibi atipik şikayetlere de neden olabilir. Fizik muayene incelemelerimiz KOAH tanısını doğrulamamasına rağmen, klinik ve laboratuvar bulgularının KOAH'la uyumlu olması nedeniyle KOAH gibi tedavi edilen, 63 yaşındaki erkek hasta Chiliaditi sendromunun nadir rastlanılır klinik özellikleri nedeniyle sunuldu.(Akciğer Arşivi 2007;8:140-2)
