Yazar "Kilinc, Yasemin Baranoglu" seçeneğine göre listele

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    The Effects of Luteolin on Basal And Nitroglycerin-Induced CGRP Release from Ex-Vivo Rat Meningeal Preparations
    (Wiley, 2023) Jameel, Bassem Saleh; Torum, Ibrahim Ethem; Kilinc, Yasemin Baranoglu; Kilinc, Erkan
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    Esculetin Exerts Anti-nociceptive Effects by Suppressing CGRP and c-fos Expression and Mast Cell Activation in an Experimental Migraine Model
    (Wiley, 2023) Gonul, Ayca Nur; Torun, Ibrahim Ethem; Kilinc, Yasemin Baranoglu; Kilinc, Erkan
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    The MT2 Receptor-Mediated Therapeutic Effects of Melatonin in In-Vivo and Ex-Vivo Rat Models of Migraine
    (Wiley, 2023) Kilinc, Erkan; Torun, Ibrahim Ethem; Kilinc, Yasemin Baranoglu; Tore, Fatma
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    Plasma levels of neurogenic inflammation related neuropeptides in pediatric patients with community-acquired pneumonia and their potential diagnostic value in distinguishing viral and bacterial pneumonia
    (Springer, 2024) Bekdas, Mervan; Saygi, Bilgi; Kilinc, Yasemin Baranoglu; Kilinc, Erkan
    Neurogenic inflammation is involved in the development and progression of respiratory inflammatory diseases. However, its role in community-acquired pneumonia (CAP) remains unclear. We therefore aimed to investigate plasma levels of neurogenic inflammation-related neuropeptides, calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY), and procalcitonin (PCT) in pediatric patients with CAP and to assess their diagnostic value in viral and bacterial/mixed pneumonia. A total of 124 pediatric patients with CAP (1 month-18 years old) and 56 healthy children of similar ages were prospectively enrolled. The patients were classified as viral (n = 99) and bacterial/mixed (n = 25) pneumonia. Plasma levels of the peptides were quantified by ELISA. ROC analysis was performed to evaluate possible diagnostic value of the peptides. While plasma levels of CGRP, VIP and PCT were significantly higher in patients with CAP than in the control group, respectively, NPY levels were significantly lower. Moreover, plasma levels of all neuropeptides and PCT were significantly higher in bacterial pneumonia patients compared to viral pneumonia patients. ROC analysis revealed that CGRP, SP and NPY had a diagnostic value in distinguishing viral and bacterial/mixed pneumonia.Conclusions: Our findings suggest that these neuropeptides may be implicated in pediatric CAP. CGRP, SP and NPY together may be a promising candidate in distinguishing viral and bacterial/mixed pneumonia, however, for this, further studies are needed.What is Known:center dot Neurogenic inflammation contributes to the development and progression of respiratory inflammatory diseases such as chronic obstructive pulmonary disease and bronchial asthma.What is New:center dot Plasma levels of neurogenic inflammation related neuropeptides calcitonin gene-related peptide, substance P, vasoactive intestinal peptide and neuropeptide Y are changed in pediatric community-acquired pneumonia. Calcitonin gene-related peptide, substance P and neuropeptide Y are promising candidates in distinguishing viral and bacterial/mixed pneumonia.