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Öğe Akut miyokard enfarktüsü sonrası gelişen geniş ventriküler septal rüptürün başarılı tedavisi(Aves, 2007) Kaya, Ahmet; Kaya, Yasemin; Ordu, Serkan; Özkökeli, Mehmet; Özhan, Hakan; Dağlar, Bahadır; Yazıcı, MehmetPostinfarct ventricular septal rupture (VSR) is a rare but mortal complication of acute myocardial infarction (MI). VSR must be diagnosed earlier and the correct treatment must be applied immediately. Abrupt surgical repair is the choice of treatment, which decreases early mortality and improves long term survival. Septal rupture occurs more frequently with anterior than with other types of acute myocardial infarction. VSR occurs usually within 2 weeks after infraction. We describe here a 76-year-old woman with a giant VSR with little hemodynamic disturbance that developed twenty days after anterior myocardial infarction. She was successfully treated with abrupt surgical closure.Öğe Are red cell distribution width and mean platelet volume associated with rheumatoid arthritis?(Allied Acad, 2016) Çakır, Lütfullah; Aktaş, Gülali; Mercimek, Öznur Berke; Enginyurt, Özgür; Kaya, YaseminAim: The aim of this retrospective study was to investigate the correlation between Rheumatoid Arthritis (RA) and Mean Platelet Volume (MPV) and Red Cell Distribution Width (RDW), which are parameters of routine hemogram tests that are suggested to be related with inflammation. Methods: We included 81 patients with RA in this retrospective study. Control group was consisted of 80 healthy subjects admitted to our institution for a routine check-up. White Bood Cell count (WBC), haemoglobin (Hb), RDW, platelet count (PLT) and MPV values of the participants obtained and analyzed. Results: We found that, RDW and MPW values were significantly different in patients with RA compared to control subjects. Conclusion: We think that, MPV reduction and RDW elevation is associated with RA. However, prospective studies with larger population are needed to reveal the relationship between the disease activity and MPV and RDW.Öğe Association between BNP and in Stent Restenosis in Patients who had Undergone Coronary Angioplasty(Aves, 2007) Kaya, Ahmet; Kaya, Yasemin; Ordu, Serkan; Albayrak, Enver Sinan; Satilmisoglu, M. Hulusi; Erkan, Melih Engin; Ozhan, HakanIntroduction: Brain natriuretic peptide (BNP) is a highly sensitive and specific diagnostic tool used in prediction of cardiovascular events in patients with ischemic and non-ischemic cardiovascular heart disease. In this study, we sought to test the efficacy of BNP in predicting restenosis rate in patients who had undergone PCI. Materials and Methods: Seventy-three consecutive stable angina and acute coronary syndrome patients who were admitted to cardiology department and performed percutaneous coronary intervention (PCI) were included in this study. The study was performed in Duzce University School of Medicine, Dept of Cardiology between 2006 and 2008. Pre and post PCI BNP levels were measured in all the patients. The patients were followed up for stent restenosis. Results: Sixteen out of 23 patients who were screened for restenosis with coronary angiography were found to have restenosis. The differences between the mean BNP levels measured before and after PCI were not statistically significant. Conclusion: BNP measured before and after PCI could not predict restenosis.Öğe A case successfully treated giant ventricular septal rupture after acute myocardial infarction(Springer, 2007) Kaya, Ahmet; Kaya, Yasemin; Ordu, Serkan; Özkökeli, Mehmet; Özhan, Hakan; Dağlar, Bahadır; Yazıcı, MehmetVSR occurs in 1-3 % of all MI cases, usually within 2 weeks after infraction. 50-80% of partients die within the first week after the rupture unless they are surgically treated.Öğe Isolation and characterization of yogurt starter cultures from traditional yogurts and growth kinetics of selected cultures under lab-scale fermentation(Taylor & Francis Inc, 2023) Çakmakoğlu, Selma Kayacan; Vurmaz, Melike; Bezirci, Emine; Kaya, Yasemin; Dikmen, Hilal; Encu, Betül; Soykut, Esra Acar; Çakır, İbrahimThe development of new starter cultures is a crucial task for the food industry to meet technological requirements and traditional products are important reservoirs for new starter cultures. In this respect, this study aimed to isolate, identify, and determine the technological characteristics of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus strains originated from traditional yogurt samples. Genotypic discrimination of 200 isolates revealed the presence of distinct 19 S. thermophilus and 11 Lb. delbrueckii subsp. bulgaricus strains as potential starter cultures. Strain-specific properties determined the acidification capacity of the yogurt starter cultures and a higher acidification capacity was observed for S. thermophilus strains compared to Lb. delbrueckii subsp. bulgaricus strains. Proteolytic activity was found between 0.012-0.172 and 0.078-0.406 for S. thermophilus and Lb. delbrueckii subsp. bulgaricus strains, respectively. 4 of S. thermophilus and 3 of Lb. delbrueckii subsp. bulgaricus strains were found resistant to all tested bacteriophages. The antibiotic susceptibility tests of the isolates revealed that a very low antibiotic resistance was observed for the yogurt starter cultures. Finally, the growth kinetics of selected strains were determined and the maximum specific growth rate of selected S. thermophilus and Lb. delbrueckii subsp. bulgaricus was calculated as 0.527 h(-1) and 0.589 h(-1), respectively.Öğe Polikistik over sendromlu hastalarda artmış ürik asit düzeyleri ve klinik ile ilişkisi(2016) Keskin, Havva; Timur, Özge; Kaya, Yasemin; Utlu, Mustafa; Yıldız, Faruk; Ademoğlu, EsraAmaç: Polikistikover sendromu (PKOS) üreme çağındaki kadınları etkileyen en sık endokrin bozukluktur. Klinik ve biyokimyasal özellikleri metabolik sendrom ile benzerlik göstermektedir. Metabolik sendromlu hastalarda insülin direnci, serum ürik asit düzeyi ile ilişkilidir. Çalışmamızda PKOS hastalarında serum ürik asit düzeylerinin laboratuar ve klinik ile ilişkisini incelemeyi amaçladık. Gereç ve Yöntemler: Hastanemiz Endokrin Kliniğin'de takip edilen 172 PKOS hastası, 34 yaş ve vücut kitle indeksi (VKİ) uyumlu kontrol grubu toplam 206 olgu katılmıştır. Erken folliküler fazda, 12 saat açlık sonrası kan örnekleri alınmıştır. Bazal serum hormon düzeyleri immunoassay ile değerlendirildi. Bulgular: Ürik asid düzeylerinin PKOS grubunda kontrol grubuna göre istatistiksel olarak anlamlı bir şekilde daha yüksek saptanmıştır (4,25 ± 1,07 PKOS, 3,7 ± 0,79 kontrol, P = 0,048). Ürik asit ile VKİ, total kolesterol, insülin, siklus süresi, Ferriman Gallwey skoru arasında pozitif anlamlı korelasyon, HDL kolesterol ile anlamlı negatif korelasyon bulunmuştur. Çok değişkenli logistik regresyon yapıldığında ürik asit düzeylerinin PKOS grubunda yaş ve VKİ'den bağımsız olarak iki kat daha yüksek olduğu saptanmıştır. Sonuçlar: Çalışmamızda PKOS grubunda ürik asit düzeyleri anlamlı bir şekilde yüksek bulunmuş ve bu yüksekliğin yaş ve VKİ'den bağımsız olduğu görülmüştür. Ürik asit ile kardiyovasküler risk faktörü olan kolesterol, Trigliserit, VKİ, insülin arasında pozitif korelasyon görülmüştür. Klinik gösterge olan Ferriman Gallwey, siklus süresi açısından da pozitif korelasyon saptanmıştır. Artmış ürik asit düzeyleri PKOS hastalarında kardiyovasküler hastalık oluşumu için bağımsız bir risk faktörü olabilir, klinikte olumsuz sonuçları gösterebilirÖğe The Relationship between Helicobacter Pylori and Intestinal Parasites in Patients with Peptic Ulcer(2023) Kaya, Yasemin; Karaman, Ülkü; Çolak, Cemil; Çinar, Hamza; Karataş, Ahmet; Arserim, Neval Berrin; Yolalan, GamzeAim: This study aimed to evaluate the frequency of Helicobacter pylori (H. pylori), risk factors, and co-infection with intestinal parasites in adult patients presenting gastrointestinal complaints. Materials and Methods: The working group of the study consisted of 385 patients with gastrointestinal complaints. A questionnaire including questions aiming to canvass the socio-demographic features, lifestyles, and complaints of the patients was administered to the study population. Cellophane slide method, native-lugol, sedimentation and Modified kinyoun acid-fast methods were used for the diagnosis of parasites in stool, under microscope. The H. pylori antigen was studied in the stool sample taken for the diagnosis of H. pylori.Results: H. pylori positivity was found to be 27.79% in the patients included in the study. 76.6% of those who are positive for H. pylori are women, and the positivity rate was found to be higher at the age of 40 and over (75.7%). The majority of patients with H. pylori positivity expressed being married (73.8%), having middle / low-income (89.7%), having a low educational background (82.2%), living in a village (55.1%), and in a nuclear family (72.2%) (p<0.001). H. pylori positivity was higher in those who used tap water (40.2%) and those who had a vegetable-based diet (75.7%) (p<0.001). The study found a statistically significant correlation between Entamoeba histoloytica and Enterobius vermicularis positivity and H. pylori positivity (p<0.05 p<0.001, respectively). The calculated odds ratio showed that H. pylori positivity was 1.19 times higher in Entamoeba histoloytica positivity and 11.27 times higher in Enterobius vermicularis positivity. Conclusion: Larger and more comprehensive studies should be performed to understand better the epidemiology, clinical effects, treatment, and control of H. pylori co-infection.
