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Öğe Albendazole versus metronidazole treatment of adult giardiasis: An open randomized clinical study(WJG Press, 2004) Karabay, Oguz; Tamer, Ali; Gündüz, Hüseyin; Kayaş, Derya; Arınç, Hüseyin; Çelebi, HarikaAim: To investigate the efficacy and tolerability of albendazole and metranidazole treatment in giardiasis. Methods: The open comparative randomized trial was carried out prospectively from December 1999 to July 2001 in Duzce City of Turkey. The diagnosis was based on the presence of signs and symptoms compatible with giardiasis including a positive stool examination of giardia cysts or trophozoite. Metranidazole group consisted of 29 patients and was given metranidazole 500 mg, three times a day for 5 d and albendazole group was consisted of 28 patients and was given albendazole 400 mg/d for 5 d. Results: There were no significant differences in demographical and therapeutical effects and patient's compliance between both groups. But side effects were seen more in metranidazole group than in albendazole group. Conclusion: Albendazole is as effective as metranidazole in adults' giardiasis. Albendazole has less side effect potentials than metranidazole in the treatment of giardiasis. Copyright © 2004 by The WJG Press.Öğe ANTIMICROBIAL SUSCEPTIBILITY OF ENTEROBAKTERIACEA SPECIES CAUSING COMMUNITY ACQUIRED URINARY TRACT INFECTION: A RETROSPECTIVE STUDY(Aves, 2007) Eroglu, Muzaffer; Kocoglu, Esra; Karabay, Oguz; Semercioz, AtillaIntroduction: The rates of antibiotic resistance in common pathogenic bacteria have been increasing due to high and unnecessary antibiotic use. It can vary according to geographical and regional location. But little is known about the epidemiology of community-acquired antibiotic resistant enterobacteriacea spices in our region. The aim of this study is to assess the antimicrobial susceptibility of enterobacteriacea spices causing community-acquired urinary tract infection in our region. Materials and Methods: Medical records of AIBU microbiology laboratory from August 2004 to August 2006 were retrospectively reviewed to identify all adult patients with community acquired urinary tract infection (UTI). Patients, who had more than three episodes of UTI in the last year, hospitalization in the last month, pregnancy and those with upper UTI were excluded. Susceptibility testing for urinary tract isolates was performed if there were >= 100,000 colonies per milliliter. The resistance rates of ampicilline, ciprofloxacine, gentamisin, amikacin, nitrofurantoin and SXT were investigated by Kirby-Bauer disk diffusion technique. Antibacterial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute criteria's (CLSI). Results: During the study period, 3575 urine samples were analyzed and the mean age was 47.2 years (range: 17-74). The overall female to male ratio was 4.8. A total of 305 patients were excluded due to contamination and 697 (21.3%) bacterial isolates were examined in the study. E. coli was the most causative agent (87.1%) and it was followed by Klebsiella pneumonia with a percentage of 9.6%. Highest and lowest antibiotic resistance to Escherichia coli was ampicillin (41%) and nitrofurantoin (0.05%), respectively. Conclusion: Resistance rates of SXT and kinolons are increasing in every day due to high and widespread antibiotic usage. In our region nitrofurantoin and amikacin may be better empiric choices in patients with community-acquired UTI, because their resistance rates are only 0.05% and 3.5%, respectively. Although nitrofurantoin has maintained excellent activity against almost all E. coli strains causing UTI, it is not active against some strains of Enterobacter, Klebsiella and most strains of Proteus species. Urine culture and antimicrobial susceptibility should be essential in the treatment of UTI. Antibiotic resistance rates are changing in every region. Physicians must be educated continuously about the antibiotic resistance and they should know the local antibiotic resistance rates in order to prescribe appropriate antibiotics. Local infection control guidelines must be prepared in every year.Öğe Effect of Inhaler Budesonide on Nasal and Oropharyngeal Carriage of Staphylococcus aureus in Asthma Patients(Bilimsel Tip Publishing House, 2007) Talay, Fahrettin; Karabay, Oguz; Yilmaz, Fahrettin; Kocoglu, EsraWe aimed to investigate the effect of inhaler budesonide spray that was used for one month to treat asthma on nasal and oropharyngeal carriage of Staphylococcus aureus. Fourty two asthma patients (32 female, 10 male) and 42 healthy control groups (33 female, 9 male) were accepted for this study. Oropharyngeal cultures were obtained from asthmatics admitted to the outpatient clinic of chest disease, before and after one- month 800 g/day inhaler budesonide therapy, evaluated for nasal and oropharyngeal carriage for S. aureus and compared with one single culture that was obtained from healthy controls. Three nasal and four oropharyngeal cultures were found to be positive for S. aureus in pretreatment cultures, and 4 nasal and 4 oropharyngeal cultures were positive after treatment. Five nasal and two oropharyngeal cultures were positive for S. aureus in control group. There was no difference in nasal and oropharyngeal S. aureus colonization in asthmatics before treatment compared to controls, and after treatment compared to pretreatment values (p > 0.05). There was no relationship between nasal and oropharyngeal colonization of S. aureus and gender, age, smoking, presence of atopy, and the degree of the illness in three groups (p > 0.05). We thought that the orally used inhaler steroid, budesonide which was administered to treat asthmatic do not affect the colonization of S. aureus in the nose and oropharynx.Öğe ESCHERICHIA COLI SEPSIS THAT DEVELOPED AFTER PROSTATE NEEDLE BIOPSY IN A PATIENT UNDER CIPROFLOXACIN PROPHYLAXIS(Aves, 2006) Karabay, Oguz; Kocoglu, Esra; Uysal, Blent; Metin, AhmetIntroduction: Transrectal prostate biopsy (TPB) is frequently used for diagnosis in urological practice and complications such as hematuri, pain, voiding difficulty, asymptomatic bacteriurea, urinary infection are reported to occur. Quinolons have been used safely for TPB prophylaxis for many years. However, increasing resistance to quinolons, similar to many other antibiotics, may cause many problems in these patients too. In this paper, we present a patient with septic shock that developed after TPB despite to adequate and reliable oral siprofloxacin prophylaxis.Öğe Impact of antimicrobial drug restrictions on doctors' behaviors(Tubitak Scientific & Technological Research Council Turkey, 2016) Karabay, Oguz; Hosoglu, Salih; Guclu, Ertugrul; Akalin, Serife; Altay, Fatma Aybala; Aydin, Emsal; Ceylan, BahadirBackground/aim: Broad-spectrum antibiotics have become available for use only with the approval of infectious disease specialists (IDSs) since 2003 in Turkey. This study aimed to analyze the tendencies of doctors who are not disease specialists (non-IDSs) towards the restriction of antibiotics. Materials and methods: A questionnaire form was prepared, which included a total of 22 questions about the impact of antibiotic restriction (AR) policy, the role of IDSs in the restriction, and the perception of this change in antibiotic consumption. The questionnaire was completed by each participating physician. Results: A total of 1906 specialists from 20 cities in Turkey participated in the study. Of those who participated, 1271 (67.5%) had <= 5 years of occupational experience (junior specialists = JSs) and 942 (49.4%) of them were physicians. Specialists having >5 years of occupational experience in their branch expressed that they followed the antibiotic guidelines more strictly than the JSs (P < 0.05) and 755 of physicians (88%) and 720 of surgeons (84.6%) thought that the AR policy was necessary and useful (P < 0.05). Conclusion: This study indicated that the AR policy was supported by most of the specialists. Physicians supported this restriction policy more so than surgeons did.Öğe Tularaemic cervical lymphadenopathy(New Zealand Medical Assoc, 2007) Karabay, Oguz; Yilmaz, Fahrettin; Gurcan, Saban; Goksugur, Nadir
