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    Brucellosis. An evaluation of 140 cases
    (Aves, 2008) Gursoy, Bensu; Tekin-Koruk, Suda; Sirmatel, Fatma; Karaagac, Leman
    Brucellosis is an important preventable disease for our country. In this study the epidemiological, clinical and laboratory findings of 140 patient with brucellosis followed in our department between January 2004-December 2007 were evaluated. Seventy of the patients were male, 70 were female. Mean age was 37.09 +/- 18.2 (ranges of 5-80) years. Rates of acute, subacute and chronic infection forms were 80.0, 14.3, 5.7%, respectively. The most common mode of transmission was consumption of unpasteurized milk products (62.1%). The main symptoms were fever, arthralgia, sweating and malaise. The frequent signs were fever (61.2%), lymphadenomegaly (11.4%), splenomegaly (10.7%), hepatomegaly (8.6%) and arthritis (5.7%). In 82 (59%) patients elevated C-reactive protein, in 39 (27.9%) patients elevated transaminase levels, in 36 (25.7%) patients anemia and in 22 (15.7%) patients leukocytosis were determined.
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    Evaluation of Cases with Acute Viral Hepatitis
    (Galenos Yayincilik, 2006) Koruk, Suda Tekin; Gursoy, Bensu; Koruk, Ibrahim; Zeyrek, Fadile Yildiz; Unutmaz, Gokhan; Karaagac, Leman; Sirmatel, Fatma
    Acute viral hepatitis is a worldwide health problem. Sixty-eight patients with acute viral hepatitis admitted to Harran University Hospital between March 2004 and March 2007 were included in this study. These patients were evaluated according to their age, gender, complaints, clinical findings, laboratory results and prognosis. Thirty-three (48.5%) of the cases were diagnosed as acute hepatitis A virus (HAV) infection, 22 (32.3%) as hepatitis B virus (HBV) infection, 9 (13.2%) as hepatitis C virus (HCV) infection, 2 (2.9%) as HBV and hepatitis D virus (HDV) co infection and 2 (2.9%) as HBV and HAV co infection. Mean age was 28.24 +/- 16.48 years and 34 (50%) of them were male. Two patients with acute HBV infection were pregnant at their 20 and 22nd weeks. The symptoms and signs of the patients at the hospital course were weakness (95.6%), jaundice (90.9%), dark urine (86.2%), anorexia (79.4%), nausea (64.7%), icterus (92.6%), hepatomegaly (38.2%), fever (35.3%) and splenomegaly (14.6%). The mean ALT level was 1418.4 +/- 999.7 U/L, AST level was 993.7 +/- 927.4 U/L and total bilirubin was 7.51 +/- 6.94 mg/dL. atypical clinical course was seen in three of the hepatitis a cases (9%); in one of them fulminan hepatic failure was developed and she has died. In 3 (13.6%) of the acute B cases HBsAg carrier stage was observed, all of the other cases showed seroconversion during follow up. In conclusion acute viral hepatitis infection is a global health problem associated with morbidity and mortality. Prevention of viral hepatitis relies on improvements in sanitation and vaccination for HAV and HBV infection.
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    Seroprevalance of Hepatitis B Virus, Hepatitis C Virus and Hepatitis D Virus in Healthy Blood Donors
    (Galenos Publ House, 2012) Sirmatel, Fatma; Yetkin, Gulay; Eris, Fatma Nur; Koruk, Suda Tekin; Duygu, Fazilet; Karaagac, Leman; Dincer, Sevim
    Objective: Training and research Hospital in the two different region, healthy volunteer blood donors were admitted to Blood Bank which serological markers to chronic viral hepatitis HBV, HCV and HDV seroprevalance was investigated by EIA. The aim of this study is to determine seropositivity indicating chronic hepatitis through west and southeast regions and to debate the difference between two regions according to literature. Materials and Methods: This study was performed in two groups. First group was enrolled in Sanliurfa between 2004-2006 years, whereas second group was programmed in Bolu between 2007-2009 years. Both of them were taken University Hospital Blood Bank. Healthy blood donors were chosen on a voluntary basis. The serological markers of donors HBV and HCV were studied by macro EIA (Abbott Axsym UK), whereas HDV markers in the sera of patients with HBsAg positive by micro EIA (Abbott UK). All the patients' ages, professions, birth places and history of transmission were questioned in detail. Results: In the first group; 565 (2.9%) HBsAg and 104 (0.5%) anti-HCV positive cases were found in a total of 19.250 healthy blood donors. Only 194 HBsAg positive cases were followed and monitories in which 5 (2.5%) ones of all were found to be anti-HDV positive. In the second group including 2012 blood donors, HBsAg and anti-HCV positivity were found respectively 24 (1.19%) and 5 (0.24%) besides no anti-HDV positivity. All subjects' mean age was 33.9(between 18-71 years). Conclusion: When comparing population of both Southeast and West cities in aspect of chronic viral hepatitis markers, it is found to be significantly less in West. Previously chronic viral hepatitis seroprevalance is higher in the Southeast region to show decline in recent years and especially in the western region has a remarkable absence of and anti-HDV positivity. We assume that the decrease in the rate seropositivity of chronic viral hepatitis is due to routine immunization and education programs.