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    Comparisons of clinical and inflammatory parameters of metabolically healthy and unhealthy obese with healthy lean body individuals in Turkish adults
    (Carbone Editore, 2015) Türker, Yasemin; Baltacı, Davut; Türker, Yasin; Öztürk, Serkan; Iliev, Darko
    Aims: Aimed to determine the frequency, demographic, clinical and inflammatory parameters of metabolically healthy obese (MHO), metabolically unhealthy obese (MuHO) and metabolically healthy lean body individuals (MHLB). Materials and methods: The cross-sectional study was carried out between February 2013 and January 2014. The consecutive patients who admitted to outpatient clinic of obesity and check-up of family medicine, Duzce University, school of medicine, were enrolled. The socio-demographic features and medical history, anthropometric measurements, blood pressure records, blood samples and body fat analysis of total of 1958 patients were obtained. The patients were assigned into three groups as: MHO. MuHO and MHLB. Results: A total of 1958 patients were included. Mean homeostatic model assessment of insulin resistance (HOMAIR) value was significantly higher in subjects with MuHO than with MHO and MHLB (p<0.001 and p<0.001, respectively). Mean high density lipoprotein cholesterol (HDL-chol) was significantly lower in subjects with MuHO than in both MHO and MHLB (p<0.001). Mean low density lipoprotein cholesterol (LDL-chol) and total cholesterol was significantly higher in MuHO subjects than in MHO and MHLB (p=0.001 and p<0.001; p=0.002 and p<0.001), and lower in MHLB subjects than MHO and MuHO subjects (p<0.001 and p<0.001). Mean high-sensitivity C-reactive protein level was significantly different between groups (p<0.001), and lowest mean level was observed in subjects with MHLB (1.49 +/- 2.27 mg/dL) and highest mean level was observed in subjects with MuHO (5.32 +/- 5.71 mg/dL). Similarly, mean uric acid level was significantly higher in subjects with MuHO than in those with MHO and MHLB (p<0.001 and p<0.001. respectively). Mean uric acid level in MHLB group was lower than MHO and MuHO (p<0.001 and p<0.001, respectively). Conclusion: Obese individuals with metabolically healthy carried high risk for cardiovascular diseases and subclinical inflammation as well as metabolically unhealthy obese individuals, but carried greater risk than individuals with metabolically healthy lean body.