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Öğe The assessment of urinary function following extended lymph node dissection for colorectal cancer(Elsevier Sci Ltd, 2005) Çöl, Cavit; Hasdemir, Oğuz; Yalçın, Erol; Güzel, Hakan; Tunç, Gündüz; Bilgen, Köksal; Küçükpınar, TevfikAims. The aim of the current study is to demonstrate whether the effects of extended systematic lymph-node dissection (ESLND) on urinary dysfunctions differ from those of curative radical, surgery (CRS) only for rectal cancer. Methods. We present data about our patients who underwent rectal. resection for rectal. cancer over 5 years. One hundred and seventy patients with rectal, cancer were reviewed with respect to surgical. procedures and post-operative urinary problems. Results. We performed CRS on 146 patients and CRS + ESLND on 24 patients, and analysed the incidence of post-operative urinary dysfunction in both groups. Urinary incontinence rates were 39 and 58%, urinary retention rates were 4 and 16%, for the patients from CRS group and CRS+ESLND group, respectivety. Conclusions. We conclude that the addition of ESLND to CRS does not increase the frequency of post-operative urinary dysfunction, apart from an increased risk of urinary retention.Öğe Basal cell carcinoma in a bacillus Calmette - Guerin scar(Wiley-Blackwell Publishing, Inc, 2009) Polat, Mualla; Parlak, Ali Haydar; Hasdemir, Oğuz; Boran, ÇetinBasal cell carcinoma (BCC) is the most prevalent skin cancerand accounts for 97% of the total.1 Squamous cell carcinoma(SCC) is the most common malignancy originating from scartissue. It has been reported that only 0.5% of BCCs arederived from scar tissue.Öğe Carcinoma of the gastric stump following billroth ii operation(Oxford Univ Press, 2011) Çöl, Cavit; Hasdemir, Oğuz; Büyükaşık, OktayÖğe The clinical and histopathological characteristics of cutaneous Malignant Melanoma(2007) Çöl, Cavit; Tunç, Gündüz; Yandakçı, Kemal; Hasdemir, Oğuz; Yalçın, ErolThe most effective method of treatment of cutaneous malignant melanoma (CMM) is surgical excision performed in the early stages. Our aim was to evaluate the descriptive characteristics of CMM. Patients and Methods: Fifty-five patients with malignant melanoma (32 males, 23 females; mean age 50.9 ±12.9; years, range 26 to 76 years) were evaluated retrospectively. Surgical excision alone was performed on stage I and II patients. Regional lymph-node dissection was performed together with surgical excision on patients with palpabl lymph nodes (stages III and IV) detected during preoperative examination. Descriptive characteristics such as anatomical locations, histological subtypes and stages of the CMM were examined; the tumor size and thickness, adjuvant chemotherapy and immunotherapy rates, local recurrence rates were evaluated. Results: Palpabl lymph nodes were identified in 74% (n=41) of the patients. Lymph-node dissection was performed together with surgical excision on these patients. The average tumor thickness and tumor size were 2.1±1.3 mm and 21.7±11.6 mm respectively. Conclusion: Width of surgical margins and wide surgical resection with lymph-node dissection for CMM will have no effect on loco-regional recurrence, distant metastases and survival rates. The complications and benefits must be meticulously evaluated before application of lymph-node dissection.Öğe Evaluation of the effects of melatonin administration intraperitoneally on rats with acute pancreatitis induced by ductal ligation(2010) Çöl, Cavit; Dinler, Kahraman; Hasdemir, Oğuz; Büyükaşık, Oktay; Fırat, Tülin; Kükner, AyselBackground/aims: The aim of this study was to address the protective effects of exogenous melatonin injections intraperitoneally on the histopathological changes in a model of obstructive acute pancreatitis. Methods: In this study, ductal ligation technique was used in 20 adult male Wistar Albino rats to develop a model of obstructive acute pancreatitis and beginning pancreatic atrophy. Melatonin 20 mg/kg solution was injected in one group of rats intraperitoneally for one week and results were compared with the control group regarding histopathological findings in the pancreatic tissue. Results: The apoptosis rate in control group rats was 30.5%, while it was 12.7% in the melatonin group. Pancreatic edema, hemorrhage and polymorphonuclear leukocyte infiltration decreased remarkably in the melatonin group compared to the control group. Conclusions: Injection of exogenous melatonin in rats with obstructive acute pancreatitis for seven days prevents acinar cell degeneration, apoptosis and polymorphonuclear leukocyte infiltration.Öğe Exogenous melatonin treatment reduces hepatocyte damage in rats with experimental acute pancreatitis(Wiley, 2010) Çöl, Cavit; Dinler, Kahraman; Hasdemir, Oğuz; Büyükaşık, Oktay; Buğdaycı, Güler; Terzi, HakanBackground/purpose The hormone melatonin affects cellular immunity in particular and the immune system in general both directly and indirectly. We report our evaluation of the effects of decreasing and increasing serum melatonin levels on hepatocyte damage in rats with experimental acute pancreatitis. Methods Winstar Albino rats with experimentally induced acute pancreatitis were divided into three groups of ten rats each: (1) control (induced acute pancreatitis only); (2) rats with induced acute pancreatitis plus surgical pinealectomy (no melatonin injections); (3) rats with induced acute pancreatitis plus injections of exogenous melatonin. The effects of melatonin levels were evaluated using biochemical and histopathological parameters. Results Rats undergoing the pinealectomy had increased amylase and lactate dehydrogenase (LDH) levels, while those receiving injections of exogenous melatonin had decreased amylase, aspartate transaminase, LDH, and bilirubin levels but increased levels of alanine transferase levels. Conclusion Melatonin may have a therapeutic or protective effect on acute pancreatitis and obstructive jaundice.Öğe Hİ-TEX®PARP NT yama ile Proceed Yama’nın adezyon yapıcı özelliklerinin karşılaştırılması(2008) Yalçın, Ercan; Hasdemir, Oğuz; Büyükaşık, Oktay; Dinler, Kahraman; Çöl, CavitAmaç: Bu deneysel çalışmanın amacı, iki farklı prostetik materyalin ( Hi-TEX®Parp NT yama ve Proceed yama) herni onarımında adezyon yapıcı özelliklerinin karşılaştırılmasıdır. Gereç ve Yöntem: Çalışma 20 adet Wistar- Albino sıçan ile yapıldı. Her denekte karın ön duvarının sağında ve solunda 2x1 cm defekt oluşturuldu. Sıçanla¬rın yarısında Proceed yama sağ tarafa, HI-Tex yama sol tarafa (Grup A) ve diğer yarısında Proceed yama sol tarafa, HI-Tex yama sağ tarafa (Grup B) implante edilmek suretiyle defekt onarıldı. Posto¬peratif 7., 14., 21., 28. ve 35. günlerde her gruptan iki sıçan sakrifiye edilerek adezyon yaygınlığı ve şiddeti değerlendirildi. Bulgular: Çalışma sonunda; her iki grup arasında adezyon yaygınlığı ve şiddeti yönünden fark olmadığı, 7. ve 14. günlerde sakrifiye edilen sıçanlar¬da adezyonların yoğun olduğu, Proceed yama ile adezyon yaygınlı¬ğının (U=376, p<0.05), ve şiddetinin (U=352, p<0.05) HI-Tex yama’ya göre anlamlı olarak az olduğu ve implantlara doku reaksiyonunun HI-Tex yama’da daha fazla olduğu ama istatistiksel olarak fark ol¬madığı (x2=0.41, p>0.05) saptandı. Sonuç: Herni onarımında Proceed yama’nın HI-Tex yama’ya göre daha az adezyon yapıcı etkisinin olması nedeniyle daha uygun bir materyal olduğu görüşüne varıldı.Öğe Local recurrence and survival rates after extended systematic lymph-node dissection for surgical treatment of rectal cancer(H G E Update Medical Publishing S A, 2005) Hasdemir, Oğuz; Çöl, Cavit; Yalçın, Erol; Tunç, Gündüz; Bilgen, Köksal; Küçükpınar, TevfikBackground/Aims: Extended systematic lymphnode dissection (ESLND) is a surgical procedure aimed at decreasing the local recurrence rate of rectal cancer and increasing the survival rate. However, it is criticized because it has not shown the expected effects on survival, and it has been shown to increase the proportion of complications in rectal cancer surgery. This study was designed to determine incidence and patterns of recurrence after curative resection with or without ESLND for rectal cancer. Methodology: A total of 184 patients with rectal cancer were reviewed with respect to surgical procedures, local recurrence and survival rates. Results: 170 of 184 patients with rectal cancer were administered curative surgical resection. ESLND was added to the surgical procedure of 24 of these 170 patients. The local recurrence rate of the patients who did not receive lymph-node dissection was 15%, and the survival rate over 5 years was 58.9%. The local recurrence rate of the patients receiving ESLND was 12.5%, and the survival rate over 5 years was found to be 55.7% (p > 0.05). Conclusions: Because ESLND is a procedure added on to curative resection in the surgical treatment of rectal cancer, it increases the general anesthesia and length of surgery, and it is possible that some complications due to the operation itself may arise. In the current study and in a large amount of research in the literature, a statistically significant effect on the survival rate has not been found. In conclusion, the opinion has been reached that ESLND does hot have an important benefit in the curative surgical treatment of rectal cancer.Öğe Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis(Zhejiang Univ Sch Medicine, 2010) Çöl, Cavit; Dinler, Kahraman; Hasdemir, Oğuz; Büyükaşık, Oktay; Buğdaycı, GülerBACKGROUND: Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant, secreted by the pineal gland. In this study, we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute pancreatitis. METHODS: Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal ligation. The first group had only acute pancreatitis and served as the control. Surgical pinealectomy was added to acute pancreatitis in the second group, removing the source of endogenous melatonin (low melatonin levels group). The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group). The effects of melatonin levels were evaluated by comparison of the levels of MDA, SOD, and GS in pancreatic tissue. RESULT: We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic tissue. CONCLUSION: Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis.Öğe Sexual dysfunction after curative radical resection of rectal cancer in men: the role of extended systematic lymph-node dissection(Int Scientific Information, Inc, 2006) Çöl, Cavit; Hasdemir, Oğuz; Yalçın, Erol; Yandakçı, Kemal; Tunç, Gündüz; Küçükpınar, TevfikBackground: This study was designed to determine the incidence and patterns of sexual dysfunction after curative radical resections (CRR) with or without extended systematic lymph-node dissection (ESLND) for rectal cancer. Material/Methods: A total of 91 patients with rectal cancer were reviewed with respect to surgical procedures and postoperative sexual functions using the International Index of Erectile Function (IIEF), a 15-item self-administered questionnaire. CCR (abdomino-perineal resections or sphincter-saving anterior resections) was performed in 78 patients (Group 1) and ESLND plus CRR in 13 patients (Group 11), and sexual functions were also evaluated in the colostomy and non-colostomy subgroups. Results: In the postoperative period, the five domains of IIEF scoring decreased significantly from the pre-operative scores in both groups (p < 0.05), but the postoperative decreases were not significant between groups I and II (p > 0.05). Having a permanent colostomy decreases IIEF scores in all colostomized patients. Conclusions: CRR and CRR+ESLND both decrease sexual function and lymph-node dissection is not considered to have any additive effect on this decrease. In addition to standard surgery, anxiety about having a malignant disease and permanent colostomy may play an important role in male sexual dysfunction.Öğe Splenik arter invazyonu yapan gastrik karsinoid tümör: İki olgu sunumu(2007) Hasdemir, Oğuz; Dinler, Kahraman; Köybaşıoğlu, Fatma Fulya; Çetinkünar, Süleyman; Çöl, CavitKarsinoid tümörler nadiren makroskopik üst gastrointestinal sistem kanamasına neden olurlar. Bununla birlikte, gastrik karsinoid tümörlere bağlı masif gastrointestinal sistem kanamaları daha da nadir görülen bir durumdur. Bu makalede splenik artere invazyon yaparak masif üst gastrointestinal sistem kanamasına neden olan iki olgu sunulmuş ve gastrik karsinoid tümörler tartışılmıştır
