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    Effects of isotretinoin on tooth movement, orthodontically induced and non-orthodontic root resorption: A micro-CT and study
    (Wiley, 2024) Gok, Gulay Dumanli; Halicioglu, Koray; Keles, Ali; Olgac, Nejat Vakur; Kayali, Damla; Cilingir, Ozlem Tugce
    ObjectivesThis study aims to investigate whether cumulative dose-dependent isotretinoin (Roaccutane (R)) could affect orthodontic tooth movement (OTM) and root resorption.Materials and MethodsNinety male Wistar Albino rats were divided into 4 groups. While, the control (SALINE), solvent (SOYBEAN) and orthodontic drug (ISOTM) groups underwent orthodontic force, the non-orthodontic drug group (ISO) did not. The rats were administrated saline, soybean oil (SBO) and isotretinoin diluted in SBO (ISOTM, ISO) for 30 days, respectively. Six rats were euthanized in each orthodontic group. Fifty grams of orthodontic force was applied to the remaining rats' first molars using the incisors as anchorage. Six more rats in each group were euthanized on the 7th, 14th and 21st days of the force application. In the ISO group, six rats were euthanized on the 37th, 44th and 51st days of administration. Six rats that were euthanized for ISOTM on the 30th day were also used for ISO to reduce the number of rats used. Micro-computed tomography (micro-CT) and histological analysis were performed.ResultsIndependent of orthodontic force, isotretinoin caused root resorption in the apical region. However, there was no statistically significant influence of isotretinoin on OTM and orthodontically induced root resorption (OIRR).ConclusionsDespite the lack of strong evidence supporting the orthodontically induced resorptive effect of isotretinoin, this study provided findings regarding the resorptive effects of isotretinoin on non-orthodontic root resorption. Therefore, the present results underscore the importance of close monitoring during orthodontic treatment to mitigate potential root resorption in patients who use isotretinoin because of acne complaints.
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    Forced eruption of palatally impacted maxillary canines with fixed and removable appliances: Case report
    (Cumhuriyet University Faculty of Dentistry, 2011) Halicioglu, Koray; Kiki, Ali; Yavuz, Ibrahim; Baydas, Bülent
    Eruption anomalies of maxillary anterior teeth are clinical problem which effects facial esthetics. Forced eruption and alignment of impacted teeth into the arch is the best treatment approach and supply a more esthetic smile for patient. For this purpose, clinician should be selecting the best ideal orthodontic mechanics. In this study presented that orthodontics and surgery treatment options was evaluated used for forced eruption of palatally impacted maxillary canines and on two cases that is forced eruption of palatally impacted maxillary canines used with fixed and removable orthodontics mechanics and explain that advantages and disadvantages of this mechanics. In the present two case explained new method that is an effective and simple removable appliance for the forced eruption of impacted teeth which included retention clasps and a helical spring.
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    Periodontally Accelerated Molar Distalization With Miniscrew Assisted Memory Screw: A Pilot Study
    (Aves Press Ltd, 2013) Corekci, Bayram; Irgin, Celal; Halicioglu, Koray; Hezenci, Yasin; Dursun, Saffet; Ozan, Fatih
    Objective: To examine the treatment effects of a miniscrew assisted memory screw system supported by piezoincision for the noncompliance molar distalization of maxillary first molars in patients with Class II malocclusion. Materials and Method: Nine subjects with skeletal Class I dental Class II malocclusion were treated. An anchorage unit was prepared using two miniscrew that were placed just behind a line connecting the first premolars at the mesial contact point. The memory expansion screw (500 g), and two miniscrews placed parallel to the occlusal plane provided stable, 4-point support for the appliance. Piezoincision was performed immediately after the appliance as cemented. Four midlevel incisions were made under local anesthesia between the roots of the teeth on the buccal side of the maxillary alveolar bone from the mesial first premolar to the second molar. A 3-mm piezoelectrical corticotomy was then performed by inserting the tip of Piezotome into each of these openings. Screw activation was started the following day. Skeletal and dental changes were measured on cephalograms, and dental casts were obtained before and after distalization. Results: Upper first molars were successfully distalized in approximately 4.6 months and the mean distalization at the end was 4.98 mm. The average distal tipping of the upper first molars was 7.75 degrees. No statistically significant changes were noted in the sagittal position of the maxilla or in the position of the upper incisors as a result of treatment. The maxillary first molars also moved palatinally (1.13 mm), but no significant distal rotation occurred. Conclusion: This system provided an efficient distalization method for posterior teeth and showed no anchorage loss. Molar tipping and palatal movement were observed as side effects in the patients.