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Öğe Acute Hepatitis C Infection Developing in the Offspring Born to an Anti-HCV- Positive Mother: A Case Report(Aves, 2009) Sirmatel, Fatma; Midikli, Durdane; Sirmatel, Ocal; Gursoy, Bensu; Duygu, FaziletAcute hepatitis C developed one month after delivery in a child whose mother was an inactive carrier of HCV and had given birth by normal vaginal delivery. Acute hepatitis C was diagnosed after one month in the child by serological, biochemical and ultrasonographic tests. Although the patient had high liver enzyme levels (ALT 245 IU/L, AST 123 IU/L), and positivity for both anti HCV (by ELISA) and HCV-RNA viral load (by PCR), the mother was an inactive HCV carrier. The patient was breasfed by the mother and showed spontaneous clearence without antiviral treatment after two years. Women should be examined for HCV before pregnancy in regions with medium HCV risk levels, and need to be enlightened regarding this issue. Also, considering that 20-25% of acute hepatitis C cases show spontanous clearance within 6-12 months on follow up, unnecessary treatment can be prevented.Öğe Brucellosis. An evaluation of 140 cases(Aves, 2008) Gursoy, Bensu; Tekin-Koruk, Suda; Sirmatel, Fatma; Karaagac, LemanBrucellosis is an important preventable disease for our country. In this study the epidemiological, clinical and laboratory findings of 140 patient with brucellosis followed in our department between January 2004-December 2007 were evaluated. Seventy of the patients were male, 70 were female. Mean age was 37.09 +/- 18.2 (ranges of 5-80) years. Rates of acute, subacute and chronic infection forms were 80.0, 14.3, 5.7%, respectively. The most common mode of transmission was consumption of unpasteurized milk products (62.1%). The main symptoms were fever, arthralgia, sweating and malaise. The frequent signs were fever (61.2%), lymphadenomegaly (11.4%), splenomegaly (10.7%), hepatomegaly (8.6%) and arthritis (5.7%). In 82 (59%) patients elevated C-reactive protein, in 39 (27.9%) patients elevated transaminase levels, in 36 (25.7%) patients anemia and in 22 (15.7%) patients leukocytosis were determined.Öğe Evaluation of Cases with Acute Viral Hepatitis(Galenos Yayincilik, 2006) Koruk, Suda Tekin; Gursoy, Bensu; Koruk, Ibrahim; Zeyrek, Fadile Yildiz; Unutmaz, Gokhan; Karaagac, Leman; Sirmatel, FatmaAcute viral hepatitis is a worldwide health problem. Sixty-eight patients with acute viral hepatitis admitted to Harran University Hospital between March 2004 and March 2007 were included in this study. These patients were evaluated according to their age, gender, complaints, clinical findings, laboratory results and prognosis. Thirty-three (48.5%) of the cases were diagnosed as acute hepatitis A virus (HAV) infection, 22 (32.3%) as hepatitis B virus (HBV) infection, 9 (13.2%) as hepatitis C virus (HCV) infection, 2 (2.9%) as HBV and hepatitis D virus (HDV) co infection and 2 (2.9%) as HBV and HAV co infection. Mean age was 28.24 +/- 16.48 years and 34 (50%) of them were male. Two patients with acute HBV infection were pregnant at their 20 and 22nd weeks. The symptoms and signs of the patients at the hospital course were weakness (95.6%), jaundice (90.9%), dark urine (86.2%), anorexia (79.4%), nausea (64.7%), icterus (92.6%), hepatomegaly (38.2%), fever (35.3%) and splenomegaly (14.6%). The mean ALT level was 1418.4 +/- 999.7 U/L, AST level was 993.7 +/- 927.4 U/L and total bilirubin was 7.51 +/- 6.94 mg/dL. atypical clinical course was seen in three of the hepatitis a cases (9%); in one of them fulminan hepatic failure was developed and she has died. In 3 (13.6%) of the acute B cases HBsAg carrier stage was observed, all of the other cases showed seroconversion during follow up. In conclusion acute viral hepatitis infection is a global health problem associated with morbidity and mortality. Prevention of viral hepatitis relies on improvements in sanitation and vaccination for HAV and HBV infection.Öğe Evaluation of Total Oxidative Level and Total Antioxidant Capacity in Cases with Chronic Viral Hepatitis(Aves, 2009) Sirmatel, Fatma; Duygu, Fazilet; Celik, Hakim; Selek, Sahabettin; Sirmatel, Ocal; Gursoy, Bensu; Eris, Fatma NurObjective: Oxidative stress is described as an instability between production of free radicals from cells and antioxidant defence of the body. The aim of the study was to investigate the correlation of total antioxidant capacity (TAC) and total oxidative level (TOL) with the severity of the disease and reliability of these parameters in the follow up of response to treatment in cases with chronic viral hepatitis (CVH). Methods: Between January 2004-March 2006, 73 cases with CVH were included in the study. The ages of the patients ranged from 15 to 70 years. Diagnosis of CVH was confirmed by clinical serological, and biochemical markers. The cases were divided into two groups: Group 1 as HBsAg-positive or anti-HCV-positive but HBV DNA or HCV RNA-negative and Group 2 as proven CVH. TAC, lipid hydroperoxide (LOOH), and TOL of the sera were studied according to Erel method, and statistically evaluated by 2 test in all the cases. Results: TAC, LOOH and TOL were found statistically significantly different between two groups. Average values of TAC were 1.8 +/- 0.5 mmol Trolox-Eqv./L and 1.0 +/- 0.15 mmol Trolox-Eqv./L in Group 1 and Group 2 (p=0.0001) respectively. Average values of LOOH were 5.3 +/- 2.8 mu mol H2O2 in Group 1 and 10.6 +/- 10.1 mu mol H2O2 in Group 2 (p=0.002). Average values of TOL were 10.2 +/- 5.9 mu mol H2O2 Eqv./L in Group 1 and 18.5 +/- 16.6 mu mol H2O2 Eqv./L in Group 2 (p=0.004). Conclusions: TAC was found higher, and TOL and LOOH were found lower in Group 1 than Group 2. The evaluation of plasma TAC, TOS ve LOOH levels may be important activation markers for the follow up of CVH.
