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    The effect of ethyl cyanoacrylate on experimental posterior lateral spinal fusion in a rat model
    (Via Medica, 2009) Gezici, Ali Riza; Ergun, Ruchan; Yilmaz, Fahri; Gurel, Kamil
    Background and purpose: Cyanoacrylates (CAs) are a type of tissue adhesives which are currently the most commonly used for cutaneous closings. The use of CAs was reported in other clinical procedures such as odontology, neurological surgery, maxillary surgery, orthopaedics, plastic surgery, etc. In this experimental study the authors carried out posterolateral spinal fusion in a rat model to test the usefulness of ethyl-cyanoacrylate (ECA) in fixation of allograft/autograft fusions. Material and methods: 25 Sprague-Dawley rats were randomized into two study groups. Bilateral posterolateral lumbar intertransverse process spinal fusion was performed with both autograft and allograft in both groups. ECA gel was dropped in the fusion area In a rat model in group II. Results: The fusion rates as determined by manual palpation were 75% in controls and 46% in the ECA group (p = 0.322). According to radiographic score, the spinal segment was considered to be fused radiographically in 66% of controls and in 46% of animals in the ECA group (p = 0.43). The mean histological scores were 5.58 +/- 0.14 and 4.53 +/- 0.18 for the control and treatment group, respectively (p = 0.001). The mean bone density of the fusion masses was 101.3 +/- 2.5 in the control group and 92.0 +/- 3.3 in the ECA treatment group (p = 0.044). Conclusion: Ethyl-cyanoacrylate appeared to retard the osteogenic fusion but was well tolerated and did not induce necrosis, allergic reaction, infection, necrosis or neurological deficit in a rat model of posterolateral spinal fusion.
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    Effects of oral L-arginine supplementation on vasodilation and VO2max in male soccer players
    (Walter De Gruyter Gmbh, 2010) Yaman, Hulya; Tiryaki-Sonmez, Gul; Gurel, Kamil
    Study aim: To determine the effects of oral L-arginine supplementation on vasodilation, blood flow and maximum oxygen uptake (VO(2)max) in soccer players. Material and methods: A group of 24 healthy male soccer players aged 20 - 26 years volunteered to participate in the study. The subjects were randomly assigned into 3 groups: experimental, placebo and control. Experimental group was given L-arginine (6 g orally) and the placebo group - starch (6 g orally) daily for a week; subjects from the control group remained untreated. Before the test and at the end of the week blood samples were collected, and systemic blood pressures, blood flows and maximal oxygen uptake (VO(2)max, by Queens College step test) were recorded. Blood samples were assayed for HDL, LDL, triglyceride and urea concentrations. The study was conducted in a randomised, single-blinded, placebo-controlled fashion consisting of 7-day treatment periods. Results: Oral supplementation of L-arginine significantly (p<0.01) decreased blood pressure indices and increased VO(2)max (p<0.01), blood flow (p<0.05), femoral artery diameter (p<0.05) and urea levels (p<0.05). There was no change in blood lipid levels (p<0.05). No significant changes were noted in the placebo and control groups. Conclusions: Oral supplementation of L-arginine may have beneficial effect on vasodilation and VO(2)max, therefore may increase the exercise capacity of soccer players.
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    Multiple Sclerosis and Hashimoto's Thyroiditis: A Case Report
    (Aves, 2011) Altunrende, Burcu; Yildiz, Serpil; Yildiz, Nebil; Gurel, Kamil
    It has been suggested that multiple sclerosis (MS) is an immune-mediated disease directed against central nervous system (CNS) myelin, although the exact pathogenesis is still unclear. There are a lot of reports regarding the coincidence of MS with other immune-mediated diseases. In recent years, there have been only few case reports of MS associated with Hashimoto's thyroiditis. This coincidence is especially important from both clinical and therapeutic standpoints. In this case report, we present a patient with MS and Hashimoto's thyroiditis and summarize the clinical features. (Archives of Neuropsychiatry 2011; 48: 224-6)