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    THE EFFECTS OF INTRAPERITONEAL MELATONIN INJECTION AND PINEALECTOMY IN EXPERIMENTAL ACUTE PANCREATITIS
    (Istanbul Univ, Faculty Medicine, Publishing Office, 2009) Dinler, Kahraman; Hasdemir, Ahmet Oguz; Col, Cavit; Gunduz, Blent; Bugdayci, Gler; Kukner, Aysel
    Objectives: In this study the aim was to evaluate the effects of on biochemical markers and histopathological findings of pancreas tissue of decreeasing and increasing serum melatonin levels in rats with had experimental acute pancreatitis. Materials and methods: This study was conducted three groups of Winstar Albino rats (ten animals in every group) that have experimental acute pancreatitis. First group was evaluated as control group. Surgical pinealectomy was applied in the second group and the source of endogen melatonin was (low melatonin levels group). Third group of rats injected with 0.1 ml daily intraperitoneal injection of 20 mg/ml melatonin solution for one week was high melatonin levels group. The effects of melatonin levels on acute pancreatitis were evaluated by comparing these group according to histopathologial results of polimorphonuclear leukocytes. infiltration, oedema, haemorrhagie, apoptosis, aciner cellular degeneration in pancreatic tissue and the levels of malonyledialdeyde (MDA), glutathione reductase (GSH), superoxyde dismutase (SOD), aspartate transaminase (AST), alanine transpherase (ALT), amylase, lactate dehydrogenase (LDH) and bilirubine. Results: We investigated that high melatonin levels has an decreasing effect on of polimorphonuclear leukocyte infiltration, oedema, haemorrhage, aciner cellular degeneration, apoptosis in pancreatic tissue, AST, LDH, bilirubine and MDA levels. Conclusion: As a conclusion exogenous melatonin may have a preventive effect on inflammatory process by reducing oxidative damage in pancreatic tissue.