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    The frequency of plasminogen activator inhibitor (pai) polymorphism and its effects on recurrent ivf failure.
    (Elsevier Science Inc, 2016) Ersoy, Ebru; Yılmaz, Nafiye; Ersoy, Ali; Karataş, Ahmet; Engin Üstün, Yaprak
    OBJECTIVE: Recurrent IVF failure is still a challenging clinical situation. Plasminogen Activator Inhibitor (PAI) enzyme polymorphisms have been recently cited to be associated with endometrial receptivity which is about the differential effect of PAI-1 enzyme activity on extracellular matrix degradation (1). Here we aimed to investigate the frequency of different PAI polymorphism groups and their effects on IVF outcomes. DESIGN: Retrospective cross-sectional study. MATERIALS AND METHODS: One hundred seventy-nine nulliparous patients who had a history of two IVF failure at least and attended to the Assisted Reproduction Clinics of our tertiary care institution between January 2013 and January 2015 were included in this study. PAI-1 gene polymorphisms were detected using PCR prior to any controlled ovarian hyperstimulation protocols. The patients were merged into three groups as followings: 5G/5G (Normal), 4G/5G (Heterozygote), 4G/4G (Homozygote). Individual characteristics and IVF outcomes were compared among groups. RESULTS: The ages, FSH levels (Day 3), mean number of oocytes retrieved, fertilisation rate and the number of transferred good quality embryos were comparable among groups. Clinical pregnancy rates were 25%, 34.1%, 34.9%, respectively, and there was no significant difference among them. Also, live birth rates were comparable among groups. CONCLUSIONS: The present study indicated that different PAI polymorphism states had no effect on IVF outcomes of patients who had recurrent VF failure.Footnote of the table: CI: Confidence interval, PAI: Plasminogen Activator Inhibitor. Values were given as meanstandard deviation, median (range), or number (percentage).