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    ANGIOPOIETIN-2 GENE POLYMORPHISM IN SPORADIC PROSTATE CANCER
    (Gazi Univ, Fac Med, 2007) Onen, H. Ilke; Konac, Ece; Eroglu, Muzaffer; Ekmekci, Abdullah
    Purpose: Angiogenesis is a critical requirement for local proliferation and metastasis of prostate cancer. Single nucleotide polymorphisms in angiogenesis-dependent genes affect the degree of cancer development and progression. Angiopoietin-2 (ANGPT-2) is one of the principal regulators of vascular growth and regression; however, its role in normal prostate and prostate tumors is largely unknown. DNA sequence variations in ANGPT-2 may alter the production outcomes or activities of the genes. In this study, we aimed to determine how the changes in the ANGPT-2 exon 4 G/A affect sporadic prostate cancer patients in the Turkish population. Materials and Methods: A case-control study on 52 sporadic prostate cancer patients and 52 healthy control subjects was conducted. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses were performed to identify different ANGPT-2 alleles. Results: The distribution of genotype and allele frequencies of the polymorphism did not yield a statistically significant difference between patients and controls (P>0.05). Furthermore, classification of patients by tumor, lymph nodes, metastasis (TNM), Gleason scores (GS), and serum prostatespecific antigen (PSA) levels showed no significant differences among the ANGPT-2 exon 4 G/A genotypes (P>0.05). Conclusion: This is the first report on the ANGPT-2 exon 4 G/A polymorphism in patients with sporadic prostate cancer demonstrating that the investigated polymorphism is not associated with prostate cancer in the Turkish population.
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    ANTIMICROBIAL SUSCEPTIBILITY OF ENTEROBAKTERIACEA SPECIES CAUSING COMMUNITY ACQUIRED URINARY TRACT INFECTION: A RETROSPECTIVE STUDY
    (Aves, 2007) Eroglu, Muzaffer; Kocoglu, Esra; Karabay, Oguz; Semercioz, Atilla
    Introduction: The rates of antibiotic resistance in common pathogenic bacteria have been increasing due to high and unnecessary antibiotic use. It can vary according to geographical and regional location. But little is known about the epidemiology of community-acquired antibiotic resistant enterobacteriacea spices in our region. The aim of this study is to assess the antimicrobial susceptibility of enterobacteriacea spices causing community-acquired urinary tract infection in our region. Materials and Methods: Medical records of AIBU microbiology laboratory from August 2004 to August 2006 were retrospectively reviewed to identify all adult patients with community acquired urinary tract infection (UTI). Patients, who had more than three episodes of UTI in the last year, hospitalization in the last month, pregnancy and those with upper UTI were excluded. Susceptibility testing for urinary tract isolates was performed if there were >= 100,000 colonies per milliliter. The resistance rates of ampicilline, ciprofloxacine, gentamisin, amikacin, nitrofurantoin and SXT were investigated by Kirby-Bauer disk diffusion technique. Antibacterial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute criteria's (CLSI). Results: During the study period, 3575 urine samples were analyzed and the mean age was 47.2 years (range: 17-74). The overall female to male ratio was 4.8. A total of 305 patients were excluded due to contamination and 697 (21.3%) bacterial isolates were examined in the study. E. coli was the most causative agent (87.1%) and it was followed by Klebsiella pneumonia with a percentage of 9.6%. Highest and lowest antibiotic resistance to Escherichia coli was ampicillin (41%) and nitrofurantoin (0.05%), respectively. Conclusion: Resistance rates of SXT and kinolons are increasing in every day due to high and widespread antibiotic usage. In our region nitrofurantoin and amikacin may be better empiric choices in patients with community-acquired UTI, because their resistance rates are only 0.05% and 3.5%, respectively. Although nitrofurantoin has maintained excellent activity against almost all E. coli strains causing UTI, it is not active against some strains of Enterobacter, Klebsiella and most strains of Proteus species. Urine culture and antimicrobial susceptibility should be essential in the treatment of UTI. Antibiotic resistance rates are changing in every region. Physicians must be educated continuously about the antibiotic resistance and they should know the local antibiotic resistance rates in order to prescribe appropriate antibiotics. Local infection control guidelines must be prepared in every year.
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    Penile lymphangioma circumscriptum in advanced age: a rare case
    (Aves, 2011) Akkoc, Ali; Metin, Ahmet; Yanik, Serdar; Yildiz, Mevlut; Kandirali, Engin; Eroglu, Muzaffer
    Lymphangioma circumscriptum is a lymphatic malformation that is observed at early ages. It affects mostly the skin and subcutaneous tissues, but may affect all of the body organs and extend to the muscles. A 67-year-old male was referred to our department complaining of vesicular and erythematous lesions on the glans penis and an edematous skin lesion on the penile shaft that had recurred over the last 6 months. The patient had no history of allergy, trauma, drug use, or insect bites. An excisional biopsy taken from the penile skin was diagnosed as lymphangioma circumscriptum. The patient refused surgical excision or other treatment options for the penile lesion. Lymphangioma circumscriptum is predominantly observed at early ages, but it may arise at advanced ages and be confused with other penile lesions. Here, we report a case of penile lymphangioma circumscriptum that was observed at an advanced age to alert physicians to this rare condition and to prevent unnecessary therapy.