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Öğe Alterations in placental pendrin expression in pre-eclampsia(Taylor & Francis Ltd, 2014) Karataş, Ahmet; Erdem, Havva; Albayrak, Mustafa; Oktay, Murat; Özlü, Tülay; Dönmez, Melahat EmineIntroduction: Pendrin is an integral membrane protein and plays a key role in extracellular fluid volume and blood pressure control. We aimed to investigate the relationship between pendrin immunostaining intensity in normal and pre-eclamptic placental tissue. Methods: Fifty-six placental tissues, of which 26 were in pre-eclamptic, and 30 were in control group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Results: There was more positive immunstaining in the pre-eclamptic placenta compared to the controls (p<0.001). A significant positive correlation was observed between immunostaining level and diastolic blood pressure (r = 0.533, p = 0.005) in the pre-eclamptic group. However, no significant correlation was observed between any condition and immunostaining level in the control group. Conclusions: Placentas in the pre-eclamptic group were significantly more immunostained with pendrin than were those in the control group. In addition, a positive correlation between immunostaining intensity with pendrin and both systolic and diastolic blood pressure were observed. Pendrin may play a role in the mechanism of severe hypertension in women with pre-eclampsia.Öğe A Case of Confluent and Reticulated Papillomatosis Mimicking Pitriasis versicolor(Duzce Univ, 2012) Gurlevikr, Zehra; Erdem, Havva; Yamk, M. Emin; Albayrale, Hiulya; Sahin, A. FahriConfluent and reticulated papillomatosis (CRP) which is also known as Gourgerot-Corteoud Syndrome is an unusual condition. The etio-pathogenesis is still unclear. This disease is mostly affecting female gender. The most common location for the CRP is on the intermammary and interscapular areas. We presented the case of a male patient with CRP resembling Pityriasis versicolor. The patient was treated with azitromycin and topical retinoid. We observed a good response to azitromycin.Öğe The effect of smoking on placental pendrin expression(Taylor & Francis Inc, 2017) Karataş, Ahmet; Erdem, Havva; Karataş, Zehra; Özlü, Tülay; Çakmak, BülentPendrin is important for transport of iodine across the placenta. Thiocyanate coming from cigarette is a competitive inhibitor of iodine transport. We aimed to evaluate the pendrin immunostaining intensity in placentas of smoker and non-smoker women. Placental tissues from 61 women, of which 28 were in smoking, and 33 were in non-smoking group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Birth weight was significantly lower in the smoker group (p=0.024). There was a negative correlation between birth weight and intensity of placental pendrin immunostaining in the smoker group (r=-0.44, p=0.02). Placentas of the smoking women showed significantly higher immunostaining with pendrin than the control group (p=0.006). Thiocyonate coming from cigarettes may competitively inhibit pendrin mediated iodine transport in the placenta and adversely affect foetal development by this mechanism.Öğe The effects of smoking on the placentas of smoker mothers in terms of MPO, MMP-9 and FGF(Bayrakol Medical Publisher, 2020) Aslan, Ali; Karataş, Ahmet; Erdem, Havva; Kadıoğlu, Nilüfer; Ankaralı, Handan; Admış ÖzlemAim: Smoking during pregnancy remains a common habit. Pregnant smokers harm both themselves and their fetus. Therefore, in this study, we aimed to investigate oxidative stress and angiogenic effects of smoking on pregnant smokers by analyzing FGF, MMP-9, and MPO levels. Material and Methods: The placentas of 68 pregnant women which referred to the pathology laboratory between the years 2010 and 2011 were included in the study. Of the total, 28 women were smokers (S) and 40 women were non-smokers (NS). The FGF, MMP-9, and MPO immunostaining of placental tissues were examined by manual microarray study. The number of cigarettes smoked, age, systemic disease rate, mean abortus number, blood pressure, hemoglobin and hematocrit, Apgar, and pathological parameters were also evaluated. Results: Statistically significant positive relationships were found between S and NS groups in terms of MMP-9 staining (grade 1) (p=0.039). There was no MMP-9 staining in S group. Systemic diseases were more frequent in S than NS group (p=0.049). There was no statistically significant relationship between other parameters. Discussion: The effects of smoking on the fetus have been demonstrated with MMP-9. More comprehensive studies are needed to reveal the relationship between fetus and smoking.Öğe LIFE-THREATENING ANGIOMYXOMA OF THE LARYNX(Jimma Univ, Ethiopia, 2015) Yaman, Huseyin; Erdem, Havva; Belada, Abdullah; Besir, Fahri Halit; Oktay, Murat; Uzunlar, Ali KemalBACKGROUND: Angiomyxoma is a benign proliferative mesenchymal tumor and a very rare mass in the larynx. There is not enough information about the etiology, clinical finding, treatment and prognosis of laryngeal angiomyxoma. CASE DETAILS: A 52 years old man presented with respiratory distress. Also, he had suffered from dysphagia, dysphonia, cough, and obstructive sleep apnea in the supine position for 6 months. He was operated on via transoral approach under general anesthesia with orotracheal intubation. The mass was encapsulated and completely removed. The histopathologic diagnosis was reported as angiomyxoma. CONCLUSION: Angiomyxoma should be considered in the differential diagnosis of the larynx masses. The treatment of angiomyxomas of the larynx is surgical. The mass can be usually excised intraorally or endoscopically.Öğe A Rare Posterior Mediastinal Mass: Esophageal Leiomyoma(Derman Medical Publ, 2014) Ozturk, Omur; Karapolat, Sami; Ates, Hakan; Iskender, Abdulkadir; Erdem, HavvaLess than 0.5% of esophagus masses in the posterior mediastinum consist of smooth muscle tumors. In this group; esophageal leiomyomas are often settled in the middle or the lower 1 / 3 parts of the esophagus, and appears as singlewell demarcated submucosal masses. A 25-year-old female followed for 4 years with diagnosis of gastroesophageal reflux and symptoms do not respond to the medical treatment. We performed esophagoduodenoscopy, and observed external pressure to lower 1 / 3 part of esophagus. In thorax tomography and magnetic resonance imaging, we determined a properly defined, approximately 4 x 4 cm sized a solid mass, located in the esophagus wall on the right posterior mediastinum. The mass was separated from muscle and mucosa tissues of the esophagus, and resected totally via right posterolateral thoracotomy. The diagnosis of leiomyoma was based on the histopathological examination. She was asymptomatic both clinically and radiologically after 6 months follow-up. Esophageal leiomyomas should be kept in mind in patients with posterior mediastinal masses with dyspeptic complaints that do not respond to medical treatment.Öğe Rectal Pseudolipomatosis(Medical Univ Press, 2014) Titiz, Hafize; Ermis, Fatih; Erdem, HavvaÖğe Tinea Corporis and Concomitance of Rosacea Triggered By Systemic Steroid Treatment(Duzce Univ, 2011) Erdem, Havva; Guvenc, Serdar Cenk; Albayrak, Hulya; Yanik, M. Emin; Gurlevik, ZehraTinea corporis is a superficial dermatophyte infection characterized by either inflammatory or noninflammatory lesions on the glabrous skin (ie, skin regions except the scalp, groin, palms, and soles). Rosacea is a common inflammatory disease in which numerous etiologic and triggering factors play a role, and characterized with flushing episodes, telangiectasias, and recurrent inflammatory papules and pustules. Herein, we report a case of concomitance of rosacea triggered by systemic steroid treatment and tinea corporis with atypic clinic presentation.Öğe What is your diagnosis(Deri Zuhrevi Hastaliklar Dernegi, 2013) Turan, Hakan; Erdem, HavvaÖğe What is your diagnosis 1?(Deri Zuhrevi Hastaliklar Dernegi, 2015) Turan, Hakan; Uslu, Esma; Erdem, Havva; Basar, FeyzaÖğe What is your diagnosis 1?(Deri Zuhrevi Hastaliklar Dernegi, 2015) Turan, Hakan; Uslu, Esma; Yavuzcan, Gizem; Basar, Feyza; Erdem, Havva
