Yazar "Erdem, Fatma Hizal" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • Küçük Resim
    Öğe
    The effects of ivabradine on left atrial electromechanical function in patients with systolic heart failure
    (Springer, 2016) Öztürk, Serkan; Öztürk, Selçuk; Erdem, Fatma Hizal; Erdem, Alim; Ayhan, Selim; Dönmez, İbrahim; Yazıcı, Mehmet
    Aim Heart rate (HR) reduction with ivabradine improves left ventricle filling by the prolongation of the diastolic time and increases stroke volume. But, it remains unclear what ivabradine's effect is on atrial conduction time and atrial mechanical functions. The aim of our study was to evaluate in stable outpatients with systolic heart failure (HF) the 3 months effect of ivabradine on atrial conduction time and mechanical functions. Method We evaluated prospectively 43 (31 males, 12 females) patients with HF. Before and after treatment, all patients were evaluated by transthoracic M mode, two dimensional (2D), pulsed-wave (PW), continuous wave (CW), color flow and tissue Doppler imaging (TDI), and LA volumes were obtained apical four-chamber views by a disc's method. LA maximum volume (Vmax) at the end-systolic phase, LAminimum volume (Vmin) at the end-diastolic phase, and LA volume before atrial systole (Vp) were evaluated. The LA function parameters were calculated as follows: LA passive emptying volume=Vmax -Vp; LA passive emptying fraction = [(Vmax -Vp)/Vmax] x100%, LA active emptying volume= Vp-Vmin; LA active emptying fraction=[(Vp-Vmin)/Vp] x100%. Results Thirty men and 13 women with mean +/- SD age of 63.9 +/- 10.1 years were included in this study. Resting heart rate was significantly reduced after ivabradine treatment. There were no significantly difference in LVEF, and E/A before and after ivabradine treatment. LA diameter and Vmin were similar before and after ivabradine treatment (p= 0.793 and p = 0.284). However, Vmax and Vp were significantly decreased after ivabradine treatment (p = 0.040 and p = 0.012). Moreover, LA active emptying volume and LA active emptying fraction were significantly decreased after ivabradine treatment (p= 0.030 and p= 0.008). The PA lateral, septal, and tricuspid durations were significantly reduced after ivabradine treatment (p< 0.001, p< 0.001, and p= 0.002, respectively). Interatrial electromechanical delay and right intraatrial electromechanical delay were significantly decreased after ivabradine treatment (33.7 +/- 12.7 vs 26.2 +/- 10.1, p = 0.001; and 14.1 +/- 6.1 vs 9.2 +/- 6.8, p< 0.001). Conclusions The present study demonstrated that adding ivabradine to the standard therapy reduced HR and improves significantly LA electrical and mechanical functions in systolic HF patients.
  • Küçük Resim
    Öğe
    The effects of ivabradine on left ventricular synchronization and Tei index in patients with systolic heart failure
    (Taiwan Soc Cardiology, 2017) Erdem, Fatma Hizal; Öztürk, Serkan; Öztürk, Selçuk; Erdem, Alim; Ayhan, Selim
    Background: The aim of our study was to evaluate in stable outpatients with systolic heart failure (HF) the 3 months effect of ivabradine on LV synchronization and Tei index in stable outpatients with systolic HF. Methods: We evaluated prospectively 40 (30 males, 10 females) patients with HF. All patients were evaluated before and after treatment by transthoracic M mode, two dimensional (2D), pulsed-wave (PW), continuous wave (CW), color flow and tissue Doppler imaging (TDI) and tissue synchronization imaging (TSI). Standard deviation of Ts of the 12 LV segments (Ts-SD-12) is the most widely used parameter of intra-LV asynchrony. Results: Thirty men and 10 women with mean +/- SD age of 64.7 +/- 9.9 years were included in this study. Most of the patients benefitted from some degree of clinical improvement, 12/16 (75.0%) from NYHA III to II and 18/24 (75.0%) from II to I, respectively. Resting heart rate was significantly reduced after ivabradine treatment (84.3 +/- 11.4 vs. 66.5 +/- 11.5 bpm, p <0.001). E/E' and Tei index were significantly changed after ivabradine treatment (17.3 +/- 9.0 vs. 14.8 +/- 7.1, p = 0.02 and 0.86 +/- 0.74 vs. 0.81 +/- 0.69, p = 0.02). Intra-LV synchrony parameters Ts-SD-12 and Ts-12 were significantly reduced after ivabradine (46.8 +/- 13.6 vs. 42.7 +/- 13.1, p = 0.01 and 142.5 +/- 44.0 vs. 128.5 +/- 45.2, p = 0.009). Conclusions: The present study demonstrated that adding ivabradine to the standard therapy reduced HR and significantly improved LV ventricular asynchrony and Tei index in systolic HF patients.
  • Küçük Resim
    Öğe
    Electrophysiological validation of total atrial conduction time measurement by tissue doppler echocardiography according to age and sex in healthy adults
    (Elsevier Science Bv, 2016) Erdem, Fatma Hizal; Erdem, Alim; Özlü, Fatih; Öztürk, Serkan; Ayhan, Suzi Selim; Çağlar, Sabri Onur; Yazıcı, Mehmet
    Background: We sought to validate total atrial conduction time (TACT) measurement via tissue Doppler imaging (TDI) by comparing the electrophysiological study (EPS) measurements of healthy subjects, according to age and sex. Methods: Eighty patients with normal EPS results were included. TACT was measured by EPS and TDI. For validation, the results of TDI were compared with those of EPS. TACT was assessed by measuring the time interval between the beginning of the P-wave on the surface ECG, and the peak A-wave on TDI from the left atrial lateral wall, just over the mitral annulus. Electrophysiological TACT was defined as the time from the high right atrial electrogram to the distal coronary sinus atrial electrogram around the left lateral portion of the mitral ring. Results: EPS and TDI measurements of the TACT were significantly and positively correlated among men and women in 20-30 years (p=0.008, r=0.412; p > 0.001, r=0.706, respectively), and those in the 30-40 years group (p=0.001, r=0.649; p=0.001, r=0.696). In contrast, EPS and TDI measurements of TACT were not significantly different among men and women in the 20-30 years and those in the 30-40 years group (p > 0.05, for both). On univariate regression analyses, TACT was independently associated with age (beta=0.342, =0.001). Conclusions: When assessed according to the age and sex of healthy participants, TDI and EPS measurements during TACT assessments were similar and correlated with each other. The measurement of TACT via TDI may be used accurately and confidently than the measurement via EPS in healthy individuals. (C) 2015 Japanese Heart Rhythm Society. Published by Elsevier B.V.
  • Küçük Resim
    Öğe
    A relationship between mitral valve prolapse and subtypes of supraventricular tachycardia
    (Springer, 2012) Erdem, Alim; Yontar, Osman Can; Öztürk, Serkan; Ayhan, Suzi Selim; Özlü, Mehmet Fatih; Erdem, Fatma Hizal; Yazıcı, Mehmet
    The aim of this study was to investigate the frequency of mitral valve prolapse (MVP) in patients with supraventricular tachycardia (SVT) who were diagnosed by intracardiac electrophysiological study (EPS). The study was a retrospective cohort of 378 adult patients (128 males and 250 females, 17 to 63 years) admitted with EPS. We included 267 SVT patients (58.4 % (n = 156) atria-ventricular nodal reentrant tachycardia (AVNRT), 30 % (n = 80) atria-ventricular reentrant tachycardia (AVRT), 6.4 % (n = 17) atrial tachycardia (AT), and 5.2 % (n = 14) other). MVP prevalence was compared in individuals with SVT. MVP prevalence was found 27.7 % (n = 74) in patients with SVT. In subgroup analyses, there was a significant difference between AVRT and others about MVP prevalence (AVRT 52.7 % n = 39, AVNRT 33.8 % n = 25, AT 9.5 % n = 7, and others 4.1 % n = 3; p < 0.005). Also, there was a significant difference between females and males (75.7 % (n = 56); 24.3 % (n = 18); p < 0.05). There was a significant negative correlation between age and MVP just in female group (r = -0.116, p = 0.024). It was demonstrated in our study that AVRT and female sex may be related to MVP in SVT patients. It was dedicated from these results that the existence of arrhythmia should be focused on young female subjects with MVP more than the others.
  • Küçük Resim
    Öğe
    Serum prolidase activity and left ventricular diastolic dysfunction: the contribution of the autonomic nervous system function
    (Taylor & Francis Ltd, 2016) Erdem, Fatma Hizal; Yazıcı, Mehmet
    To the Editor With great interest, we read the recent article by Erkus et al.1 regarding the association between the serum prolidase activity and left ventricular diastolic dysfunction (LVDD). The authors very clearly discussed the relation of the serum prolidase level – which is an important factor in collagen metabolism, matrix remodelling and cell growth – and LVDD. In addition to their discussion, we aimed to emphasize the possible other relative mechanism between the prolidase and left ventricular diastolic dysfunction: the effect of the autonomic nervous system function. In the literature a lot of studies showed the associations between alterations in the autonomic nervous system and the development of left ventricular diastolic dysfunction2-4. Poireir et al. showed a relation between left ventricular diastolic dysfunction and cardiac autonomic dysfunction. Habek et al. also found a close correlation between left ventricular diastolic function with heart rate and its variability in diabetes mellitus type 2 patients4 . Prolidase is an enzyme that catalyzes the final step of collagen breakdown, a step-limiting factor in the regulation of collagen biosynthesis5. Also, prolidase plays a role in collagen metabolism, matrix remodelling and cell growth. Previously, impaired autonomic functions have been clearly shown to have an important relationship with collagen metabolism and remodelling6-8.As a consequence, we believe that the impairment on cardiac autonomic nervous system function may play a role in the result of the article by Erkus et al.1. We hope that the above-mentioned items would add to the value of the well-written article of Erkus et al. regarding the relation between serum prolidase activity and left ventricular diastolic dysfunction.