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    Effect of methylphenidate at different doses on new bone formation with rapid maxillary expansion: A micro-CT and histomorphometric study in rats
    (Wiley, 2022) Dursun, Saffet; Erhamza, T. Sezen; Önder, Mustafa Ercüment; Düzcü, Selma Erdoğan
    Objectives This study aimed to evaluate the effect of systemically administered methylphenidate hydrochloride (MPH) on new bone formation in premaxillary suture after rapid maxillary expansion (RME). Setting and Sample Population Thirty-three Wistar rats were divided into four groups: Group 1 (high dose, 30/60 mg/kg MPH), Group 2 (low dose, 4/10 mg/kg MPH), Group 3 (positive control) and Group 4 (negative control). Methods RME was applied on the 70th day of the study. A 5-day RME period was followed by a 12-day retention period. The experiment was terminated on the 87th day. Micro-CT for radiological evaluation, haematoxylin-eosin and Masson's trichrome staining methods were used for histomorphometric evaluation. Results Among experimental groups with RME, the lowest number of osteoblasts and capillaries in Group 1 (P < .05). New bone formation, fibrous callus formation, distal osteotomy line, proximal osteotomy union and cortex remodelling were observed to be lower in Group 1 and Group 2 than Group 3 (P < .05). There was a statistically significant difference between Group 4 and each of the other groups (P = .000) in the evaluation of the results for bone mineral density, bone volume, bone volume percentage, trabecular thickness and trabecular number. Conclusions MPH reduces cellular activity for new bone formation in suture in RME groups. Before performing rapid maxillary expansion in patients using MPH, the use of the drug should be postponed after a multidisciplinary decision process or clinical doses should be lowered.
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    Effects of plasma-emulating light-emitting diode (LED) versus conventional LED on cytotoxic effects and polymerization capacity of orthodontic composites
    (Sage Publications Ltd, 2014) Çörekçi, Bayram; Irgın, Celal; Halıcıoğlu, Koray; Dursun, Saffet; Yavuz, Muhsine Zeynep
    Objectives: The aim of this study was to evaluate, the cytotoxicity of orthodontic composites in vitro as a function of degree of conversion (DC) and the light curing units (LCU) employed on mouse fibroblast (L929). Materials and Methods: Cured samples of the composites Light bond (Reliance Orthodontic Products, Itasca, Illinois, USA), Ortho bracket paste (Bisco, Schaumburg, Illinois, USA), Opal bond MV (OPAL, South Jordan, Utah, USA), and Transbond XT (3M, Monrovia, California, USA) were prepared. Polymerization was performed with two LCUs: VALO Ortho (Ultradent, South Jordan, Utah, USA) is a third-generation LCU and Elipar S I 0 (3M, USA) is a second-generation LCU. Four samples were immersed in cell culture medium to obtain composite extracts. After incubation of L929 cell cultures with the extracts obtained, cytotoxicity was determined using the methyl tetrazolium test. Fourier transform infrared spectroscopy (FTIR) was used to evaluate DC for five samples. A multivariate analysis of variance (ANOVA), two-way ANOVA, and Tukey's honestly significant difference test were utilized for statistical analyses. Results: Cytotoxicity and DC of all tested composites (p < 0.001) and the interaction between composites and LCUs < 0.01) were significantly different. LCUs had no significant influence on the cytotoxicity and DC of composite materials (p > 0.05). The correlations between cell viability and DC were positive for three composites but statistically insignificant. Conclusion: Composites and LCUs must be matched with one another to result in satisfactory maximal biocompatibility and DC. Opal Bond plasma light-emitting diode combination was a better choice for cell viability. Three composites showed a positive correlation between cytotoxicity and DC. Therefore high-intensity LCUs can be said to efficiently affect polymerization, and so, higher DC rates may achieve higher cell viability rates.
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    Periodontally Accelerated Molar Distalization With Miniscrew Assisted Memory Screw: A Pilot Study
    (Aves Press Ltd, 2013) Corekci, Bayram; Irgin, Celal; Halicioglu, Koray; Hezenci, Yasin; Dursun, Saffet; Ozan, Fatih
    Objective: To examine the treatment effects of a miniscrew assisted memory screw system supported by piezoincision for the noncompliance molar distalization of maxillary first molars in patients with Class II malocclusion. Materials and Method: Nine subjects with skeletal Class I dental Class II malocclusion were treated. An anchorage unit was prepared using two miniscrew that were placed just behind a line connecting the first premolars at the mesial contact point. The memory expansion screw (500 g), and two miniscrews placed parallel to the occlusal plane provided stable, 4-point support for the appliance. Piezoincision was performed immediately after the appliance as cemented. Four midlevel incisions were made under local anesthesia between the roots of the teeth on the buccal side of the maxillary alveolar bone from the mesial first premolar to the second molar. A 3-mm piezoelectrical corticotomy was then performed by inserting the tip of Piezotome into each of these openings. Screw activation was started the following day. Skeletal and dental changes were measured on cephalograms, and dental casts were obtained before and after distalization. Results: Upper first molars were successfully distalized in approximately 4.6 months and the mean distalization at the end was 4.98 mm. The average distal tipping of the upper first molars was 7.75 degrees. No statistically significant changes were noted in the sagittal position of the maxilla or in the position of the upper incisors as a result of treatment. The maxillary first molars also moved palatinally (1.13 mm), but no significant distal rotation occurred. Conclusion: This system provided an efficient distalization method for posterior teeth and showed no anchorage loss. Molar tipping and palatal movement were observed as side effects in the patients.