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    DETERMINATION OF HEMOGLOBIN A1c, LIPID PROFILES, HOMOCYSTEINE, OXIDATIVE STRESS AND PHYSICAL ACTIVITY LEVELS IN DIABETIC AND/OR NON-DIABETIC COVID-19 PATIENTS
    (2023) Özdemir, Kadirhan; Saruhan, Ercan; Kaya, Gözde; Benli, Tuba Kaya; Meral, Orhan; Bozoğlan, Hümeyra; Demir, Halit
    Objective: The coronavirus disease 2019 (Covid-19) pandemic results in higher morbidity and mortality rates. This study aims to compare hemoglobin A1c (HbA1c), lipid profiles, homocysteine, oxidative stress, and physical activity levels between diabetic Covid-19 patients (group I), non-diabetic Covid-19 patients (group II), and healthy controls (group III). Method: HbA1c, lipid profiles, homocysteine, oxidative stress, oxidant, and antioxidant status were analyzed from the venous blood samples and physical activity levels were measured with International Physical Activity Questionnaire. All the parameters were compared between the groups (n=16 for each group). Results: HbA1c and fasting blood glucose levels in group I were higher than group II and III (p<0.001). There were significant differences in serum levels of total cholesterol, triglyceride, high density lipoprotein cholesterol and low-density lipoprotein cholesterol between the groups (p<0.001). There was lower superoxide dismutase (p<0.001) and total antioxidant status (TAS) (p<0.001), and higher malondialdehyde (p<0.001), total oxidant status (TOS) (p<0.001), oxidative stress index (p<0.001), C-reactive protein level (p=0.001), and neutrophil/lymphocyte ratio (p<0.001) in group I and II compared with group III. Although the patients in group I and II had lower physical activity levels than group III, only the patients in group II had significantly lower physical activity levels than group III (p=0.006). Conclusion: Diabetic Covid-19 patients had higher blood glucose markers than non-diabetic Covid-19 patients and healthy controls in our study. Diabetic and non-diabetic patients had higher oxidant, lower antioxidant, and higher oxidative stress levels than healthy controls. In addition, the physical activity levels of non-diabetic Covid-19 patients were lower than diabetic Covid-19 patients and healthy controls.
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    Relationship between erythrocyte catalase and serum adenosine deaminase activities in eclampsia
    (Taylor & Francis Ltd, 2009) Kolusarı, Ali; Kurdoğlu, Mertihan; Buğdaycı, Güler; Adalı, Ertan; Yıldızhan, Recep; Çebi, Ayşegül; Demir, Halit
    Objective. To examine the relationship between antioxidant status and T-cell activation in the pathogenesis of eclampsia by measuring the activities of erythrocyte catalase, an enzyme of antioxidant mechanism, and serum adenosine deaminase (ADA), regarded as a marker of T-cell activation. Methods. A total of 60 patients [20 eclamptic (E) pregnant women, 20 healthy pregnant (HP) women and 20 non-pregnant (NP) women] were included in the study. Maternal venous blood samples were obtained from each patient during weeks 28-37 of gestation, and biochemical analyses of catalase activity in erythrocytes and ADA activity in serum were carried out. Results. Erythrocyte catalase activity was significantly lower and serum ADA activity was significantly higher in the E pregnant women when compared with the HP women and NP women (P 0.001). No significant correlation was observed between erythrocyte catalase activity and serum ADA activity. Conclusions. Erythrocyte catalase and serum ADA activities may at least in part contribute to the pathogenesis of eclampsia. However, more studies are needed to verify and clarify the relationship between antioxidant status and T-cell activation in eclampsia.