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    Acute necrotizing encephalopathy of childhood: a single-center experience
    (Tubitak Scientific & Technological Research Council Turkey, 2021) Aksoy, Erhan; Oztoprak, Ulku; Celik, Halil; Ozdemir, Fatih Mehmet Akif; Ozkan, Mehpare; Kayalioglu, Hulya; Danis, Aysegul
    Background/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it. Materials and Methods: Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital between 2007 and 2020 were included in this study. Results: Nine patients (six females, three males) with a mean age of 4.05 +/- 1.94 years (age range 1-6.5) were included in this study. The interval range between fever and encephalopathy in patients was 1-4 days. Influenza A (3H1N1, one untyped) was detected in four patients, influenza B in three patients, and no cause was found in two patients. Major clinical findings other than febrile encephalopathy in all patients were a hemodynamic shock in seven patients, seizures in six patients, vomiting in five patients, dystonia in three patients, and flaccid paralysis in the upper extremity in one patient. Despite all our treatment approaches, including plasmapheresis, moderate to severe neurological sequelae was observed in all of our patients, who survived even with significant radiological improvement. Three patients for whom we could not perform plasmapheresis died. Conclusion: Our study revealed that thalamic involvement increased as the interval shortened, and brainstem involvement increased in patients over four years of age. The presence of persistent vomiting accompanying encephalopathy during the parainfectious period and plasmapheresis treatment being a treatment option that could prevent mortality were cautionary for our study.
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    Differential diagnosis and treatment of idiopathic occipital epilepsy and visual seizures in an adolescent case: is hallucination always hallucination?
    (Cukurova Univ, Fac Medicine, 2023) Ozdemir, Dilara; Tufan, Ali Evren; Ozturk, Yusuf; Danis, Aysegul; Sarioglu, Setenay
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    The relationship between blood biochemical parameters and oral health in children with obesity/overweight
    (Springernature, 2023) Yoldas, Meyri Arzu; Yilmazel, Simge Vural; Bolu, Semih; Danis, Aysegul
    Aim The purpose of this study was to evaluate the effects of obesity and overweight on the oral/dental health and blood biochemistry parameters in children.Methods A total of 87 children (29 boys, 58 girls) aged 1-18 presenting to our paediatric endocrinology outpatient clinic were included in the study. The patient group consisted of children with obesity/overweight and the control group consisted of children with normal weight. Paediatric patients were examined simultaneously by a paediatrician and a paediatric dentist. Oral/dental health examinations of all children included in the study were performed by a specialist paediatric dentist and dmft/DMFT (decayed, missing and filled teeth) values were calculated separately in the mixed dentition period. The Community Periodontal Index of Treatment Needs 23 index and the dental plaque 35 index were evaluated at oral/dental health examinations. Oral and dental health examination findings and blood biochemistry parameters were compared between the two groups.Results While DMFT, dental plaque index, blood c-reactive protein (CRP) and parathyroid hormone (PTH) levels were significantly increased in children with overweight/obesity compared to children with normal weight, there was no difference in terms of daily toothbrushing habits and last dental examination times. Overweight/obesity was found to be associated with the dental plaque and DMFT/dmft index, and elevation in the blood biochemistry parameters CRP and PTH among the children in this study.Conclusion The observation of significant elevation in DMFT and dental plaque indices and numbers of filled deciduous teeth showed that oral/dental health problems and dental decay may emerge more frequently in children with overweight/obesity. Children with overweight should be routinely provided with dental care as part of a multidisciplinary team that includes paediatricians and dentists. High c-reactive protein and parathyroid hormone values determined in children with obesity/overweight showed that excess weight causes an inflammatory process in the body.High, significant DMFT and dental plaque index scores detected in children with obesity/overweight may be evidence that overweight plays an effective role in dental caries in children.Excessive weight gain in children can cause oral and dental health problems, so necessary precautions should be taken.