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Öğe A childhood secondary headache case associated with Langerhans cell histiocytosis(2023) Kilinç, Yasemin Baranoğlu; Daniş, Ayşegül; Halicioglu, SiddikaNeurological involvement is very rare in patients with a diagnosis of Langerhans Cell Histiocytosis (LCH). During the course of the disease, headache can also be seen in addition to systemic effects. A 6 years old girl was admitted to the hospital with only a headache without any systemic symptoms and was diagnosed with LCH. Magnetic resonance imaging showed a solid mass extending from the sphenoid bone corpus to the left great wing of the sphenoid, left orbital apex, left posterior ethmoid cells, left cavernous sinus, and dural space. The correct decision for neuroimaging in patients with headaches is very important in terms of mortality and morbidity. We wanted to share our patient’s case who was diagnosed with LCH by presenting only with headache without any other systemic finding, to remind that LCH may be a secondary cause of headache.Öğe Effect of COVID-19 pandemic on children undergone percutaneous endoscopic gastrostomy due to neurologic diseases(2022) Bekdaş, Mervan; Daniş, Ayşegül; Kilinç, Yasemin Baranoğlu; Yoldaş, Meyri Arzu; Öztürk, HülyaAim: To investigate the effects of SAR-CoV-2 infection on nutritional status in patients who underwent \rpercutaneous endoscopic gastrostomy (PEG) for neurological disorders.\rMethods: The clinical and laboratory follow-up data of the patients who underwent PEG in our clinic between \r2002 and 2018 were evaluated before and during the pandemic. The results were analyzed statistically.\rResults: Twenty patients were included. They were 70.9±64.4 months old at the time of PEG, 97.9±67.8 \rmonths before the pandemic, and 105.5±60.8 months during the pandemic (p=0.048). Weight for age at the \rtime of PEG increased from 10.7±4.6 kg to 15.6±7.2 kg before the pandemic. Hemoglobin was 12.3±1.4 g/dl \rat the time of PEG, 13.5±1.6 g/dl before the pandemic (p=0.045). Vitamin D was 24.1±8.9 ng/ml at the time \rof PEG and increased to 45.7±9.7 ng/ml during the pandemic (p=0.018). The annual number of visits before \rthe pandemic was 9.8±5.7 and decreased to 2±1.7 during the pandemic (p=0.003). Twelve (%60) of the patients \rdeveloped PEG complications, 6(30%) had their PEG replaced. Those who had developed PEG complications \rhad low levels of albumin (3.3±0.4 vs 4±0.4 g/dl, p=0.022) and vitamin B12 (578±199 vs 1299±533 pg/ml, \rp=0.007). \rConclusions: Even if PEG is applied late, it provides a partial improvement in patients, but the COVID-19 \rpandemic reversed these benefits and caused an increase in PEG complications. In order for the patient to get \rthe maximum benefit from PEG, close follow-up is essential.Öğe The Predictors of Pneumonia in Children with COVID-19(2023) Yoldaş, Meyri Arzu; Tayfur, Aslı Çelebi; Daniş, Ayşegül; Hanci, Fatma; Atasoy, Halil Ibrahim; Bolu, Semih; Cosgun, ZelihaThe purpose of this study was to evaluate the relationship between the presence of pneumonia and blood parameters in cases of Coronavirus disease (COVID-19) and to examine their predictive characteristics in terms of pneumonia. We reviewed the file records of 151 pediatric patients with a diagnosis of COVID-19 confirmed by the real time-reverse transcription polymerase chain reaction test in nasopharyngeal swabs. The patients were divided into two groups based on direct chest X-ray and computed tomography results in [Group 1 (n:41), with pneumonia findings, and Group 2 (n:110), with no pneumonia findings]. The groups’ demographic data, clinical and laboratory findings were compared. Pulmonary involvement was determined in 41 (27.1%) of the 151 patients. The [body mass index (BMI) Z-score], red blood cell distribution width (RDW), mean platelet volume (MPV), neutrophil lymphocyte ratio, passive leg raise, and D-dimer levels were significantly higher in patients with pneumonia than those without pneumonia in our study. Based on multivariate logistic regression analysis, BMI Z-score, MPV, and RDW were found to be independent risk factors of pneumonia in patients. The current study showed higher levels of blood parameters in patients with coronavirus disease 2019 (COVID -19) presenting with pneumonia than those without pneumonia. We suggest that BMI-Z score and MPV value may assist in predicting pulmonary involvement in patients with COVID-19.Öğe Similarities and differences between familial Mediterranean fever (FMF) and multisystem inflammatory syndrome (MIS-C) in children(2023) Yoldaş, Meyri Arzu; Tayfur, Aslı Çelebi; Hanci, Fatma; Daniş, Ayşegül; Bolu, Semih; Atasoy, Halil IbrahimAim: We aimed to reveal the similarities and differences between the rare and severe multisystem inflammatory syndrome (MIS-C) and active familial Mediterranean fever (FMF) disease in children. Our study may help in the early recognition of MIS-C syndrome in children and distinguish it from other diseases with similar symptoms. Methods: We evaluated the demographic and clinical characteristics, laboratory findings, treatments and outcomes of patients with MIS-C syndrome and active FMF. Results: The clinical and laboratory findings of a total of 66 patients hospitalized in our pediatric clinic with the diagnosis of active FMF (n:42) and MIS-C syndrome (n:24) were reviewed retrospectively. The reason for pediatric emergency admission was determined as resistant fever in all patients. When the clinical findings of the patients were compared, it was determined that joint and abdominal pain in the FMF group and vomiting, rash, cough, Lenfadenopati (LAP) and myalgia findings in the MIS-C group were statistically significantly higher (p<0.05). When the laboratory findings were evaluated between the two groups, the lymphocyte count and vitamin D levels were statistically significantly lower, while the leukocyte count, glucose, C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), sedimentation, aspartate aminotransferase (AST), alanine aminotransferase (ALT) were found to be significantly higher in the group with MIS-C syndrome (p<0.05 ). Conclusion: We think that the results of our study may guide pediatricians and clinicians in the early differential diagnosis and management of MIS-C, by showing the similarities and differences among MIS-C patients from autoinflammatory diseases such as FMF.
