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    Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain
    (2018) Kılınç, Erkan; Dagistan, Yaşar; Töre, Fatma
    Objective: The cranial dura mater contains plenty of mast cells and is principallysupplied by the middle meningeal artery which has a key role in the generation ofheadaches. Neurogenic inflammation caused by perivascular nerve activation anddural vasodilation is held responsible for migraine pain. Dural mast cells contributeneurogenic inflammation and migraine via vasoactive and proinflammatory mediatorsin their secretory granules. In the present study, it was aimed to investigate vasoactiveeffect of mast cell degranulating agent compound 48/80 induced dural mast celldegranulation on the middle meningeal artery and its anterior and posterior branches.Methods: Isolated skulls obtained from male Wistar rats were divided into 2 halves.The skull cavities with intact the dura mater were applied synthetic interstitial fluidfor control group or mast cell degranulating agent compound 48/80 (10 µg/ml) insynthetic interstitial fluid for treated group at 37 oC for 15 min. Diameters of middlemeningeal artery and its anterior and posterior branches were measured and mastcells were counted from whole-mount preparations of meningeal dura mater.Results: While compound 48/80 induced massive degranulation of dural mast cells(P<0.01), it did not change the number of mast cells in the dura mater. Moreover,compound 48/80 increased diameter of middle meningeal artery (P<0.01) andits anterior (P<0.05) and posterior (P<0.01) branches, respectively compared tosynthetic interstitial fluid treatment.Conclusion: Dural mast cell degranulation causes dilatation of middle meningealartery which is involved in the pathophysiology of migraine, therefore testing of mastcell stabilizing agents in vivo models of migraine pain may promise hope for the nextbig things in the treatment of migraine headaches.