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Öğe Assessment of the hemogram parameters in patients with paroxysmal supraventricular tachycardia: a retrospective study(Assoc Medica Brasileira, 2020) Coşgun, Mehmet; Güneş, Yılmaz; Sincer, İsa; Mansıroğlu, Aslı KurtarOBJECTIVE: Inflammation has been suggested as a potential mechanism in the pathogenesis of arrhythmia. Hemogram parameters such as monocyte count to high-density lipoprotein cholesterol ratio (MHR), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR) have been considered to be markers of inflammation and new cardiovascular risk predictors. This retrospective study aimed to investigate the relationship between MHR, NLR, and MLR in patients with paroxysmal supraventricular tachycardia (PSVT). METHODS: A retrospective study conducted at a university hospital in Bolu, Turkey, between 2017 and 2019. Our study included 196 patients who underwent electrophysiological study (EPS) due to palpitation or documented PSVT on electrocardiography (ECG). Patients having documented atrioventricular nodal re-entrant tachycardia (AVNRT) on ECG or inducible AVNRT on EPS were included in the PSVT group (n=130), and patients with palpitation but without inducible arrhythmia on EPS (n=66) were included in the control group. Routine biochemical and hemogram tests were performed before the EPS procedure. RESULTS: When hemogram parameters were compared, there was no statistically significant difference in MHR values [0.010 (0.001-0.030) vs 0.010 (0.001-0.020) p = 0.67]. Additionally, both NLR [2.21(0.74-11.36) vs 1.98(0.72-24.87) p=0.13] and MLR [0.25 (0.03-1.05) vs 0.24(0.07-1.39) p=0.41] were not statistically significant between the two groups. CONCLUSION: There is no significant difference in PSVT patients regarding hemogram parameters including white blood cell subtypes, MLR, NLR, and MHR. Therefore the evaluation of hemogram parameters may not be clinically relevant for PSVT patients.Öğe Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease(Termedia Publishing House Ltd, 2018) Sincer, İsa; Güneş, Yılmaz; Mansıroğlu, Aslı Kurtar; Coşgun, Mehmet; Aktaş, GülaliIntroduction: The prognostic value of hematological indices in cardiovascular diseases and the association between these parameters and cardiovascular conditions have been established in the literature. Aim: In this study, we aimed to investigate the relation of mean platelet volume (MPV), MPV to platelet ratio (MPR) and red cell distribution width (RDW) with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical coronary artery stenosis. Material and methods: A total of 306 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: a group with adequate CCD (n = 214) and a group with impaired CCD (n = 92). Routine complete blood count and biochemical parameters were measured before coronary arteriography. Results: The MPV and MPR levels were significantly higher in the inadequate CCD group (10.5 +/- 1.8 fl vs. 8.7 +/- 1.9 fl, p < 0.001 and 0.06 +/- 0.08 vs. 0.05 +/- 0.07, p = 0.036). Patients with inadequate CCD had significantly higher RDW levels compared to patients with adequate CCD (15.5 +/- 1.7% vs. 15.0 +/- 1.9%, p = 0.01). MPV and RDW were significantly associated with Rentrop collateral grading (r = -0.523, p < 0.001 and r = -0.239, p < 0.001, respectively), whereas the association with MPR was not significant. An MPV value greater than 9.95 fl, determined with ROC curve analysis, had 71% sensitivity and 70% specificity in predicting inadequate CCD. An RDW greater than 14.3% has 71% sensitivity and 53% specificity in selecting patients with adequate CCD. Conclusions: The present study suggests that MPV and MPR may be associated with the degree of collateral development in chronic stable CAD. However, the negative association of RDW with inadequate CCD, in combination with previous contradictory reports, raises a doubt about the possible value of RDW in stable CAD. Although these parameters may be affected by various conditions, a high MPV may lead clinicians to suspect possible inadequate collateral development in stable CAD patients.Öğe Association of SYNTAX Score withPATIMA Index, Carotid Intima- andExtra- Media Thicknesses(2021) Coşgun, Mehmet; Cosgun, Zeliha; Güneş, Yılmaz; Sincer, Isa; Erdal, Emrah; Mansiroğlu, Aslı; Inanir, MehmetObjectives: Several risk scoring systems have been validated for cardiovascular risk prediction and prognosis. Periarterial adipose tissue intima media adventitia (PATIMA) index combining carotid intima media thickness (CIMT), carotid extra media thickness (CEMT), cardiac epicardial fat thickness (EFT), and body mass index (BMI) are related to coronary artery disease (CAD).Materials and Methods: One-hundred-twenty-four patients were categorized as low synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) (<22) (n=84) or high SYNTAX (?22) (n=40) score groups. Association of PATIMA index and its components with SYNTAX score were analyzed.Results: CIMT, CEMT, BMI, EFT, and PATIMA index were not significantly different between groups. SYNTAX score was not significantly correlated with traditional CVS risk factors (diabetes, hypertension, hyperlipidemia, smoking, age). There was a significant correlation between the PATIMA index and age (r=0.308, p=0.001) but not with other risk factors. Age was significantly correlated with CIMT (r=0.289, p=0.001) and EFT (r=0.208, p=0.02) but not with CEMT (r=0.091, p=0.313). There was a significant correlation between CIMT and CEMT (r=0.414, p<0.001) and between CIMT and EFT (r=0.267, p=0.004).Conclusion: We have found that the recently described PATIMA index and its components, CIMT, CEMT, and EFT are not associated with the severity of CAD assessed by the SYNTAX score. Furthermore, they have not correlated with classical risk factors apart from age.Öğe Can inferior vena cava diameter and collapsibility index be a predictor in detecting preoperative intravascular volume change in pediatric patients?(Sciendo, 2021) Coşgun, Zeliha; Dağıstan, Emine; Coşgun, Mehmet; Öztürk, HayrettinBackground: Inferior vena cava (IVC) ultrasound measurement is a reliable indicator used in the assessment of intravascular volume status. The aim of this study was to evaluate intravascular volume changes in pediatric patients by measuring the IVC diameter and collapsibility index (CI) in children whose oral feeding was restricted preoperatively. Material and Methods: From May 2018 to October 2018, a total of 55 pediatric patients who were scheduled for surgery were included in this prospective, observational, cohort study. Fasting and satiety IVC diameters and CIs of patients were determined by ultrasonographic evaluation twice: in the preoperative preliminary evaluation, when the patients were satiated, and before surgery, during a fasting period of 6-8 hours. Ultrasonographic data were recorded and compared between fasting and satiety periods. Results: In the grey scale (B-mode), mean IVC diameter was significantly higher when the patients were satiated, compared to the measurements made just before surgery during the fasting period. In the M-mode, the mean IVC diameter was significantly higher only during the inspiratory phase when the patients were satiated, while during the expiratory phase it was detected to be statistically similar. Mean CI was significantly higher in the immediate preoperative period, compared to the assessment made when satiated. Conclusion: Preoperative ultrasound IVC diameter and CI measurement can be a practical and useful method for evaluating preoperative intravascular volume in children.Öğe The comparison of complete blood count parameters between acute and chronic peripheral arterial disease(2022) Coşgun, Mehmet; Güneş, Yılmaz; Mansiroğlu, Aslı; Sincer, Isa; Aktaş, Gülali; Erdoğdu, TayfurRecently published data demonstrated that peripheral arterial disease (PAD) is well associated with some hematological parameters. However, data in acute onset PAD\ris scarce. We aimed to search baseline hematological parameters in angiographically proven lower extremity PAD with chronic and acute thrombotic occlusions. In this\rretrospective study, angiographically proven 172 PAD patients (121 chronic and 51 acute thrombotic cases) and 80 control subjects (without documented coronary and\rperipheral arterial disease) were enrolled to this study and divided into three groups as chronic, acute PAD and control groups. Demographic characteristics, laboratory\rdata and angiography findings of the participants were obtained from computerized database and patient files. All groups were statistically similar with regards to baseline\rclinical and demographic features. WBC and the neutrophils count were found higher whereas the lymphocyte and eosinophil counts were found lower in acute PAD group\rthan chronic PAD and control group. In PAD group (acute and chronic), the median Fontaine stage was significantly positive correlated with N/L ratio and significantly\rnegative correlated with eosinophil count. In multivariable logistic regression analysis, in addition to sex presence of diabetes mellitus and smoking, eosinophil count was\rfound an independent predictor for the development of acute PAD. As well as N/L ratio, eosinophil count is associated with acute development of PAD rather than chronic\rprocess and may be used as a diagnostic marker for this purpose in patients undergoing percutaneous intervention.Öğe Comparison of eosinophil counts in patients with acute pulmonary embolism: Could itbe a predictor factor?(2021) Mansiroğlu, Aslı; Coşgun, Mehmet; Sincer, Isa; Güneş, YılmazAim: To investigate whether there is a relationship between both massive and sub-massive pulmonaryembolism (PE) and eosinophil counts in order to evaluate it as a predictor factor.Methods: This retrospective study included 108 patients (64 sub-massive and 44 massive) who received bothtomographic and clinical diagnoses of pulmonary embolism, and 75 subjects served as controls. Hemogramparameters were compared between patients with massive and sub-massive pulmonary embolism and those ofcontrol groups. Results: In terms of white blood cell and eosinophil counts, the lowest value was evident in the massive PEgroup whereas the control group had the highest value. The eosinophil counts increased significantly one weekafter the treatment when compared to those at the presentation with PE (0.112 (0.003-0.853) vs. (0.144 (0.011- 0.914), p=0.01). Spearman correlation test showed a significant positive correlation between right ventricular dysfunction or elevated cardiac troponin level and massive PE (r=0.54, p <0.001), whereas a negativecorrelation was detected between eosinophil count and the presence of massive PE (r=-0.36, p<0.001). Conclusion: The results of our study suggest that lower eosinophil counts may lead a physician to suggest ahigher probability of acute massive pulmonary embolism rather than sub-massive pulmonary embolism. However, further randomized studies are required to confirm these findings.Öğe Could platelet distribution width predict coronary collateral development in stable coronary artery disease?(2020) Sincer, İsa; Mansıroğlu, Aslı; Erdal, Emrah; Coşgun, Mehmet; Aktaş, Gülali; Güneş, YılmazOBJECTIVE: We hypothesized that hemogram parameters should be related to the development of coronary collateral vessels. For this purpose, we aimed to compare platelet distribution width (PDW) and PDW to platelet ratio (PPR) in subjects with stable coronary artery disease having adequate or inadequate coronary collateral development. METHODS: A total of 398 patients with stable angina pectoris undergoing coronary angiography were enrolled and divided on the basis of the development of coronary collateral (CCD) (inadequate CCD (n=267) and adequate CCD (n=131). Routine complete blood count and biochemical parameters were measured before coronary arteriography. RESULTS: Mean PDW and PPR values of inadequate and adequate CCD groups were 17.5% (10–23) and 12.4% (9.8–22) %, p<0.001, respectively. In multivariate analysis, age (p=0.012, 95% CI for OR: 0.958 (0.933–0.983) and PDW (p<0.001, 95% CI for OR: 1.432 (1.252–1.618) were found to be statistically significantly different inadequate CCD group compared to adequate CCD group. Receiver operating curve (ROC) analyses revealed that a PPR value greater than 0.057 had 76% sensitivity and 51% specificity and a PDW higher than 16.2% had 80% sensitivity and 66% specificity in predicting inadequate CCD. CONCLUSION: The present study suggests that PDW and PPR may be associated with the degree of collateral development in chronic stable coronary artery disease (CAD).Öğe COVID-19 and comorbidities: Predictors, clinical course, relationship with diseaseseverity, and outcome(2021) Afşin, Emine; Coşgun, MehmetAim: COVID-19 disease has a broad spectrum ranging from asymptomatic course to death. While data showthat the prognosis of the disease will be poor in the presence of comorbidity, we witness the death of patientswith no comorbidities in our clinical practice. This study aimed to investigate the effect of comorbidity on theclinical course and mortality of COVID-19 pneumonia. Methods: 155 Rt-PCR (+) adult patients hospitalized at İzzet Baysal State Hospital (Bolu, Turkey) diagnosedwith severe and critical pneumonia between August 2020 and February 2021 were included in this single center, retrospective study. The patients were divided into two groups with and without comorbidity, comparedthe severity of inflammation parameters, radiological involvement, and oxygen requirement, and evaluatedtheir effects on mortality and hospitalization duration. Results: There was no significant difference in the severity of the computed tomography (CT) involvement,the oxygen requirement, inflammation markers, and duration of hospitalization in patients with comorbiditiescompared to those without. When we evaluated the patients with comorbidities in general and their subgroups,the relationship with mortality was not significant. The severity of CT involvement, high oxygen requirement,and inflammation markers such as lymphocyte, lymphocyte ratio, LDH, CRP, troponin, ferritin levels werefound to be associated with mortality.Conclusions: In this study, we found that the presence of comorbidity did not affect mortality and durationof stay and that the severity of radiological involvement, the severity of hypoxemia, and the increase ininflammation markers were the determinants of mortality.Öğe Dating thrombus organization with eosinophil counts in deep venous thrombosis(Elsevier, 2021) Mansıroğlu, Aslı Kurtar; Sincer, İsa; Coşgun, Mehmet; Güneş, YılmazObjective: It is known that eosinophils (EOS) are essential for thrombus formation. Studies have demonstrated the association of EOS with coronary artery disease, stent thrombosis, coronary collateral development, and vasospastic angina. However, there is little data about the association of hemogram parameters, especially EOS counts, with deep venous thrombosis (DVT) subgroups. Methods: The present study comprised 243 patients diagnosed with DVT (of whom 86 were acute, 72 were indeterminate, and 85 were chronic) and 75 control patients. Medical records of all the patients were reviewed, and relevant data were collected retrospectively. The baseline characteristics, as well as hemogram and biochemistry parameters, were recorded. Results: The patients with DVT had significantly lower median EOS count yet higher median neutrophil to lymphocyte ratio (NLR) than those of control patients (P <.001). Similarly, acute DVT patients had lower EOS count yet higher NLR values compared with those of indeterminate and chronic DVT patients. However, EOS count was not significantly different between chronic DVT and control groups. While NLR ratio was significantly correlated with acute DVT (r = 0.34; P <.001), Spearman's correlation test revealed that EOS count was inversely correlated with the presence of acute DVT (r = –0.52; P <.001). Conclusions: Low EOS count may lead the physician to a higher probability of acute DVT rather than indeterminate and chronic DVT.Öğe Does mean platelet volume decrease in the presence of coronary artery fistula?(Arquivos Brasileiros Cardiologia, 2019) Sincer, İsa; Çekici, Yusuf; Coşgun, Mehmet; Aktaş, Gülali; Güneş, Yılmaz; Erdal, Emrah; Mansıroğlu, Aslı Kurtar; İnanır, MehmetBackground: Coronary artery fistula (CAF) is an abnormal connection that links a coronary artery to a cardiac chamber or another major blood vessel. Several studies have shown the association between mean platelet volume (MPV) and cardiovascular diseases. In the literature, there is no previous study about the association between hematologic parameters and congenital CAF. For this reason, we aimed to investigate the association of MPV with CAF. Methods: 70 patients with normal coronary arteries and 50 with coronary artery fistulas were included. Routine blood and biochemical parameters were measured before the arteriography. Differences between groups for continuous variables were analyzed with t- test or Mann-Whitney test. P values < 0.05 were considered significant. Regression analysis was used to find independent predictors of CAF. Results: Baseline patient demographics, including age and clinical risk factors, were similar between the groups. Compared to the control group, median (IQR) High-density lipoprotein cholesterol (HDL) levels were significantly higher (p=0.04) and MPV levels were significantly lower in the CAF group (8.84 +/- 1.71fL vs. 10.43 +/- 1.34, p < 0.001). In the multivariate analysis, only MPV was a significant predictor of CAF (p < 0.001, 95% CI for OR: 0.438 (0.306-0.629). A negative correlation was found between MPV and fistulae in Pearson's correlation test (r: -0.454, p < 0.001). An MPV level of < 9,6 fL showed sensitivity, specificity, positive predictive value and negative predictive value of 80%, 68%, 71% and 78% respectively (AUC = 0.766, 95% CI, 0.678-0.854) for the prediction of CAF. Conclusion: The present study suggests that MPV may decrease in patients with CAF.Öğe An easy and reliable way to prevent electrocardiographic deteriorations of patients undergoing off-pump coronary artery bypass surgery: Preoperative anxiolytic treatment(Soc Brasil Cirurgia Cardiovasc, 2019) Demirhan, Abdullah; Velioğlu, Yusuf; Yoldaş, Hamit; Karagöz, İbrahim; Coşgun, Mehmet; Çalışkan, Duygu; Yıldız, İsa; Erdem, Kemalettin; Bilgi, MuratObjective: To investigate the effects of preoperative anxiety relieving on electrophysiological changes in patients undergoing off-pump coronary artery bypass surgery. Methods: A total of 61 patients at ASA III risk group in the age range of 18-65 years were enrolled in the present study. Patients were randomly divided into two groups. Group S (Sedation group) was administered 0.04 mg/kg lorazepam per os (PO) twice before the operation. Group C (control group) was not administered with any anxiolytic premedication. State Trait Anxiety Inventory (STAI-I) and Beck Anxiety Inventory (BAI) were used to evaluate the level of anxiety. Electrocardiography (ECG), pulse oximeter and standard monitoring were performed for each patient. QT and P dispersions in each derivation of all ECGs were calculated. Results: Preoperative STAI-I scores were significantly lower in sedation group compared to the controls. Mean values of QT dispersion measured before induction, at the 1st minute of induction, 30th second of intubation and 4th minute of intubation in sedation group were significantly reduced compared to controls (P=0.024; P=0.027; P=0.001; P=0.033, respectively). The mean values of P dispersion measured before induction, at the 3rd minute of induction, 30th second of intubation and 4th minute of intubation in sedation group were significantly reduced compared to controls (P=0.001; P=0.020; P=0.023; P=0.005, respectively). Conclusion: Elevated anxiety levels in patients undergoing coronary bypass surgery have a negative effect through prolonged QT and P-wave dispersion times. Anxiolytic treatment before surgery may be useful to prevent ventricular and atrial arrhythmias and associated complications through decreasing the QT and P-wave dispersion duration.Öğe The effect of early surgery on electrocardiographic changes in patients with subarachnoid hemorrhage(Turkish Neurosurgical Society, 2021) Coşgun, Mehmet; Şenol, ÖzgürAIM: To investigate the effects of early surgery on electrocardiographic (ECG) parameters in patients with aneurysmal subarachnoid hemorrhage (SAH). We compared the parameters from ECGs performed preoperatively and on the 2nd and 8th days after surgery with those of normal individuals. MATERIAL and METHODS: Eighteen patients with aneurysmal SAH (as the study group) and 22 healthy subjects (as the control group) were enrolled in this study. The demographics and ECG data of the participants were collected, and the groups were compared. The analyzed data included HR, QRS duration, Pmax, Pmin, P wave dispersion (PWD), QT, QTc, Tp-e, JT, JTc, Tp-e/QT, Tp-e/QTc, Tp-e/JT, and Tp-e/JTc. The preoperative and postoperative 2 and 8'h day values were compared. RESULTS: The preoperative QT, QTc, JT, JTc, Pmax, and Pmin values of patients with aneurysmal subarachnoid hemorrhage were significantly higher than those of healthy subjects. There were no significant differences in the 2nd and 8th day ECG parameters of the groups. CONCLUSION: Early and successful surgery for SAH can alleviate ECG changes. This may decrease the requirement for cardiac interventions in these patients.Öğe Effects of lidocaine oropharyngeal spray applied before endotracheal intubation on qt dispersion in patients undergoing coronary artery bypass grafting: A prospective randomized controlled study(Soc Brasil Cirurgia Cardiovasc, 2020) Bilgi, Murat; Velioğlu, Yusuf; Yoldaş, Hamit; Coşgun, Mehmet; Yüksel, Ahmet; Karagöz, İbrahim; Yıldız, İsa; Eş, Abdülhamit; Erdem, Kemalettin; Demirhan, AbdullahObjective: To investigate the effects of lidocaine oropharyngeal spray applied before endotracheal intubation on hemodynamic responses and electrocardiographic parameters in patients undergoing coronary artery bypass grafting. Methods: A total of 60 patients who underwent coronary artery bypass grafting surgery were included in this prospective randomized controlled study. Patients were randomly divided into two groups, the topical lidocaine group (administration of 10% lidocaine oropharyngeal spray, five minutes before laryngoscopy and endotracheal intubation) and the control group. Both groups were compared with each other in terms of main hemodynamic parameters including mean arterial pressure and heart rate, as well as P and QT wave dispersion durations, before and after endotracheal intubation. Results: The groups were similar in terms of age, gender, and other demographics and basic clinical characteristics. There was a statistically significant difference between the groups in terms of QT dispersion durations after laryngoscopy and endotracheal intubation. The increase in QT dispersion duration was not statistically significant in the topical lidocaine group, whereas the increase in QT dispersion duration was statistically significant in the control group. When the groups were compared in terms of P wave dispersion durations, there were significant decreases in both groups, but there was no significant difference between the groups. Conclusion: Our study revealed that the topical lidocaine administration before endotracheal intubation prevented increase of QT dispersion duration in patients undergoing coronary artery bypass grafting.Öğe Evaluation of electrocardiographic ventricular repolarization parameters in extreme obesity(Churchill Livingstone Inc Medical Publishers, 2019) İnanır, Mehmet; Sincer, İsa; Erdal, Emrah; Güneş, Yılmaz; Coşgun, Mehmet; Mansıroğlu, Aslı KurtarBackground and objectives: The risk of sudden death and cardiac arrhythmia increases in morbidly obese patients. We aimed to evaluate the marker of arrhythmias such as Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc ratios in extreme obesity. Methods: The study included 41 extremely obese patients and 41 control subjects. QTmax, QTmin, US, JT and Tp-e intervals were measured od 12-lead electrocardiographies. In addition, Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc rates and QTc, cQTd and JTc intervals were calculated. Results: Tp-e interval (79.2 +/- 9.7 ms (milisecond) vs. 68.6 +/- 8.1, p < 0.001), QTc interval (395.9 +/- 18.8 vs. 377.9 +/- 19.3 ms, p < 0.001), JTc interval (317.1 +/- 27.0 vs. 297.4 +/- 23.2 ms, p = 0.001), Tp-e/QT ratio (0.22 +/- 0.03vs. 0.19 +/- 0.02, p < 0.001),Tp-e/QTc ratio (0.20 +/- 0.26vs. 0.18 +/- 0.02, p = 0.001), Tp-e/JT ratio (0.29 +/- 0.04 vs. 0.25 +/- 0.03, p < 0.001), TPe/JTc ratio (025 +/- 0.04 vs. 0.23 +/- 0.03, p = 0.018), QTd (32.8 +/- 10 vs.15 +/- 6.4 ms, p < 0.001) and cQTd (70.0 +/- 30.1 vs. 313 +/- 22.4 ms, p < 0.001) were significantly higher in obese patients. Conclusion: Compared to healthy subjects potential ECG repolarization predictors were significantly increased in extremely obese patients. (C) 2018 Elsevier Inc. All rights reserved.Öğe Evaluation of electrocardiographic ventricular repolarization parameters in stable coronary artery disease(2021) Coşgun, Mehmet; Erdal, Emrah; Güneş, Yılmaz; Sincer, Isa; Mansiroğlu, AslıAim: To examine the relationship between the SYNTAX score (SS) and cardiac repolarization parameterssuch as cQTd and Tp-e values, and Tp-e/QT, Tp-e/JT, Tp-e/QTc, and Tp-e/JTc ratios in patients who havestable angina pectoris.Methods: 12-lead resting electrocardiograms (ECGs) and SS of 160 patients (51 female and 109 male)undergoing coronary angiography with the pre-diagnosis of stable angina pectoris were evaluated. Patientswith a SS below 22 were classified as Group 1 (low-SYNTAX), and those above 22 (high-SYNTAX) as Group2. Forty-four patients with normal coronary angiography were included in Group 3.Results: Mean age of the patients was 62.4±9.1 years. The heart rate, QRS, QT, cQT and JT durations betweenthe groups were similar. In addition, relatively recent ventricular repolarization indices such as Tp-e intervaland Tp-e/QT, Tp-e/JT, Tp-e/QTc, and Tp-e/JTc ratios were also not substantially different between groups.Conclusion: Several surface ECG predictors of ventricular arrhythmias, including QTd, JT and Tp-e intervalsand their ratios to QT and JT, are not significantly correlated with SYNTAX score-assessed CAD severity inpatients with stable angina pectorisÖğe Evaluation of epicardial fat tissue thickness in patients with multiple sclerosis(2021) Coşgun, Mehmet; Sincer, Isa; Yilmaz, Güneş Nurdan; Kök, Zafer; Türkoğlu, Şule AydinAim: Multiple sclerosis (MS), which is inflammatory in its pathogenesis, damages the myelin sheath in the central nervous system (CNS) and causes axonal loss. Epicardial fat tissue (EFT), located between the myocardium and the visceral layer of the pericardium, surrounds the heart and several inflammatory cytokines is secreted from this tissue. In this study, we aimed to investigate EFT thickness in MS patients and compared with that of volunteer non-MS subjects. Methods: A total of 154 subjects comprising 61 MS patients and 93 volunteers matched for gender and age were included in our study. Epicardial fat tissue thickness was measured by echocardiography. All values were compared between groups.Results: Echocardiographic parameters were similar in both groups. However, the mean EFT thickness was significantly higher in the MS group than in the control group (p<0.001). Epicardial fat tissue thickness was also significantly correlated with the presence of MS (r=0.33, p<0.001). Conclusion: The results of our study suggest that the increase in epicardial adipose tissue thickness in MS patients may be a predictive factor for cardiovascular disease. However, the clinical significance of this finding and its relevance to MS pathogenesis should be investigated in further studies.Öğe Holter analyses in children with adenotonsillar hypertrophy(Elsevier Ireland Ltd, 2006) Yılmaz, Fahrettin; Gündüz, Hüseyin; Karaaslan, Kazım; Arınç, Hüseyin; Coşgun, Mehmet; Sessiz, Nihat; Uyan, CihangirObjective: The cardiac complications of adenotonsillar hypertrophy (ATH) have been investigated by many scientists by using supplemental diagnostic modalities such as echocardiography. But, arrhythmia analysis has not been studied adequately in patients with ATH. This study aimed at evaluating the prevalence of arrhythmias, heart rate variability (HRV) and heart rate turbulence (HRT) analyses by means of 24 h Hotter ECG monitoring in pre- and post-operative periods in children with ATH. Methods: Twenty-five children with ATH consisting of 12 female and 13 mate patients (mean age 66 15 months, range 24-108 months) included in this study. All children were assessed pre-operatively and at 1 month post-operatively with 24-h Hotter monitoring and ECG analysis. The prevalence analysis of arrhythmias, heart rate variability and heart rate turbulence analysis was assessed. These data were compared. Results: Although some ECG and hotter findings such as sinusal tachycardia, Mobitz type 1 second-degree AV block improved after the operation, the prevalence of arrhythmias, HRV and HRT values were not changed significantly in post-operative period (p > 0.05). Conclusion: Measurement of HRT and HRV are attractive and easily applicable ways of non-invasive risk prediction of cardiac complications. But, these parameters have not changed significantly in post-operative period. However, ECG and 24-h Hotter monitoring of electrocardiography may be useful at evaluating the prevalence of arrhythmias and determining cardiac complications in pre-operative period.Öğe Is ionizing radiation a risk factor for anxiety in employees?(Assoc Medica Brasileira, 2020) Mansıroğlu, Aslı Kurtar; Erer, Murat; Coşgun, Mehmet; Sincer, İsa; Güneş, YılmazOBJECTIVE: Workers describe many physical and mental symptoms when working in radiation areas. This study aimed to assess these symptoms in radiation workers using the Beck Anxiety Inventory (BAI). METHODS: A total of 42 radiation workers (22 males and 20 females, mean age 34 +/- 7 years) and 47 control subjects (22 males and 27 females, mean age 31 +/- 8 years) who work in non-radiation areas in the hospital were included in the study. All participants anonymously filled out the Beck Anxiety Inventory (BAI) questionnaire. RESULTS: The demographic data of workers were not significantly different between groups. In the BAI, the dizzy or lightheaded (p =0.01), terrified (p= 0.01), unsteady (p=0.02), heart-pounding and racing (p=0.02) items were significantly higher in the radiation-exposed group compared to the control group. vertical bar The BAI score was also significantly higher in the radiation-exposed group (11.1 +/- 6.8 vs. 8.7 +/- 3.8, p =0.04) CONCLUSION: These results suggest the possibility that radiation may play a role in the psychometric properties of workers. The effects of radiation on the health of employees need to be further investigated and understood.Öğe A promising marker in patients with coronary artery ectasia: Uric acid / HDL ratio(2021) Mansiroğlu, Aslı; Coşgun, Mehmet; Sincer, Isa; Güneş, YılmazAim: Elevated levels of uric acid and low levels of high-density lipoprotein (HDL) cholesterol are associated with cardiovascular events and mortality. We investigated a novel marker, uric acid/HDLratio (UHR), in coronary artery ectasia patients (CAE). Materials and Methods: The present study included 104 patients (58 male, 46 female; mean age, 61±12 years) diagnosed as having isolated CAE and 110 controls (44 male, 66 female; mean age, 60±12 years) whose coronary artery findings were normal as revealed by coronary angiography. Medical records of all the patients were reviewed and the data were collected retrospectively. Baseline characteristics, hematologic and biochemistry parameters were recorded, and we calculated the value of UHRResults: The CAE group had significantly higher values of uric acid (6.48±1.62 vs. 5.37±1.12; p<0.001) and UHR (0.15±0.05 vs. 0.11±0.05; p<0.001). Spearman’s correlation test showed a significant association of uric acid and UHR with CAE (r=0.40, p<0.001 and r=0.51, p<0.001, respectively). On the other hand, HDL had a negative correlation with the presence of CAE (r=0.44, p<0.001). A receiver operating curve (ROC) analysis revealed that a cut-off>0.120 UHR (%) values had a sensitivity of 72% and specificity of 68% for the determination of CEA.Conclusion: We observed in our study the finding in which the uric acid and UHR values were higher in individuals with CAE compared to non-CAE subjects. There was an association between UHR and CAE.Öğe The role of baseline and post-treatment frontal QRS-T angle for detecting arterial blood pressure control(Taylor & Francis Inc, 2021) Mansıroğlu, Aslı Kurtar; Coşgun, Mehmet; Sincer, İsa; Güneş, YılmazObjectives: In this study, we aimed to investigate the value of the frontal QRS-T angle (f(QRS-T)) in determining blood pressure control among newly diagnosed hypertensive patients with no left ventricular hypertrophy. Methods: Fifty patients with newly diagnosed hypertension were included in this single-center study. The patients were examined with 12-lead ECGs and 24-hour ambulatory blood pressure monitoring (24 h-ABPM) before and 1 month after antihypertensive treatment. Results: Baseline and post-treatment f(QRS-T) angle values were observed to be similar (38.0 [0.0-174.0] and 37.0 [1.0-139.0], respectively; p = .827). The values of QT minimum (p = .006), QTc mean (p = .030), Tp-e (p = .027), and JTc (p = .010) significantly decreased after control of blood pressure. Conclusions: The f(QRS-T) angle, which can be easily calculated on the ECG, is not a useful tool to determine hypertension control at early stage in newly diagnosed hypertensive patients.
