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Öğe Anaphylaxis: Turkish national guideline 2018(Bilimsel Tıp Yayinevi, 2018) Orhan, Fazıl; Civelek, Ersoy; Şahiner, Ümit Murat; Arga, Mustafa; Can, Demet; Çalışkaner, Ahmet Zafer; Çetinkaya, Feyzullah; Erkoçoğlu, MustafaAnaphylaxis is an acute and potentially fatal systemic reaction that sould be recognized and managed by all helthcare professionals. This is the first national guideline of Turkish National Society of Allergy and Clinical Immunology on diagnosis and management of anaphylaxis. The guideline is prepared by Anaphylaxis Interest Group with the incorporation of 20 allergy/immunology specialists and the epidemiology, etiology, pathophysiology, symptoms and signs, diagnosis/differentials, and acute and long-term management of anaphylaxis are reviewed in detail.Öğe Clinical and etiologic evaluation of the children with chronic urticaria(Ocean Side Publications Inc, 2016) Azkur, Dilek; Civelek, Ersoy; Toyran, Müge; Mısırlıoğlu, Emine Dibek; Erkoçoğlu, MustafaBackground: Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for >6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). Objectives: To evaluate the clinical features, possible causes, associated findings, and laboratory results of different subtypes of CU in children according to a new classification. Methods: In this study, we evaluated the clinical features, laboratory investigations, and provocation tests of children with different subtypes of CU according to a new classification. Results: Two hundred and twenty-two children (59.9% girls) were enrolled in the study. Of the study patients, 59.9% and 40.1% were diagnosed as having CSU and CIndU, respectively. Antithyroid antibody levels were positive in 7.1% of the patients with CSU, 32.8% of the children had positive 14C-urea breath test results, and 6.5% of the patients had positive stool examination results for parasites. Autologous serum skin test results were positive in 53.5% of the patients with CSU. Of the patients with CIndU, 77.5% had symptomatic dermographism, 16.8% had cold urticaria, 2.2% had cholinergic urticaria, 2.2% had solar urticaria, and 1.1% had aquagenic urticaria. Conclusion: Children with CSU represent the majority of patients with CU, and more than a half of these patients might have autoimmune urticaria. Symptomatic dermographism was the most common type of CIndU.Öğe Clinical and Etiological evaluation of the children with chronic urticaria(Wiley-Blackwell, 2016) Azkur, Dilek; Civelek, Ersoy; Toyran, Müge; Erkoçoğlu, Mustafa; Mısırlıoğlu, Dibek Emine[No Abstract Available]Öğe The etiology and clinical features of anaphylaxis in a developing country: a nationwide survey in Turkey(Allergy Immunol Soc Thailand,, 2017) Civelek, Ersoy; Erkoçoğlu, Mustafa; Akan, Ayşegül; Özcan, Celal; Kaya, Ayşenur; Tokaç, MahmutBackground: Despite the increasing frequency of anaphylaxis, there is inadequate information on the etiology and clinical features in various countries, regions and age groups, especially in developing countries. Objective: Our aim is to assess the etiology and clinical findings of anaphylaxis in Turkey. Gathering reliable data about the etiology and clinical findings of anaphylaxis in the general population will decrease the related morbidity and mortality. Method: We obtained the names and phone numbers of individuals who had been prescribed an epinephrine auto-injector with a diagnosis of anaphylaxis from ministry of health. Demographic data, clinical history of the first episode of anaphylaxis including the triggering agent, clinical findings, course of hospitalization, and the management of anaphylaxis were obtained by phone survey. Results: A total of 843 patients with a mean age of 21.4 +/- 17.3 years were evaluated. There was a significant male predominance among children younger than 10 years of age but a female predominance in older subjects. The most common causes of anaphylaxis were foods(40.1%) in children and bee venom(60.8%) in adults. The biphasic reaction rate was 4.3% and the median length of stay at an emergency department was 4.0 hours. Almost 60% of the patients had recurrent anaphylaxis episodes. Only 10.7% of the cases were prescribed an epinephrine auto-injector at their first anaphylaxis episode and only 59.2% of the patients were referred to an allergist during discharge from the emergency department. Conclusions: In Turkey, bee venom was the most common cause of anaphylaxis, followed by food and drug. While more than a half of patients reported recurrent attacks; only 10% had been prescribed epinephrine auto-injector kit after their first episode. Strategies to improve the anaphyalxis management are therefore urgently required.Öğe The knowledge and attitudes of patients about epinephrine autoinjector use in Turkey(Wiley-Blackwell, 2016) Kaya, Ayşenur; Erkoçoğlu, Mustafa; Civelek, Ersoy; Toyran, Müge; Akan, Ayşegül[No Abstract Available]Öğe Obezitesi Olan ve Olmayan Astımlı Çocuklarda Vitamin D Düzeyleri(2016) Erkoçoğlu, Mustafa; Çapanoğlu, Murat; Civelek, Ersoy; Kaya, Ayşenur; Giniş, Zeynep; Toyran, Müge; Misirlioğlu, Emine DibekGiriş: Astım ve obesite dünya genelinde milyonlarca insanı etkileyen önemli toplumsal sağlık sorunlarındandır. Son yıllarda vitamin D'nin allerjik hastalıkların ve obezitenin prevelansında etkisi olabileceği ileri sürülmüştür. Bu çalışmada vitamin D düzeyleri ile astım, obezite varlığı ve astım şiddeti arasındaki ilişki araştırılmıştır.Gereç ve Yöntem: Çalışmaya 119 olgu dahil edildi. Yaş ve cinsiyete göre eşleştirilmiş dört çalışma grubu oluşturuldu: Obezite ve astımı olanlar Grup I (n:34), normal kilolu astımlılar Grup II (n:28), astımı olmayan obez hastalar Grup III (n:30), normal kilolu ve astımı olmayan kontrol grubu Grup IV (n:27) olarak kabul edildi. Bulgular: Serum 25 hidroksi vitamin D düzeyleri açısından dört grup karşılaştırıldığında aralarında fark saptanmadı. Hastalar astım şiddetlerine göre serum vitamin D düzeyleri açısından karşılaştırıldığında gruplar arasında fark saptanmadı.Sonuç: Sonuç olarak, çalışmamızda serum 25 hidroksi vitamin D düzeyleri ile astım, obezite ve atopi varlığı arasında ilişki saptanmamıştır.Öğe Unusual presentation: Concurrent IgA deficiency and idiopathic pulmonary hemosiderosis(Wiley-Blackwell, 2016) Erkoçoğlu, Mustafa; Civelek, Ersoy; Kocabaş, Can NaciIdiopathic pulmonary hemosiderosis (IPH) is a rare disorder that should be considered in the differential diagnosis of patients with hemoptysis, recurrent alveolar hemorrhage, dyspnea and iron deficiency anemia (IDA). The frequent association of autoimmune disorders with IPH and a favorable response to steroids suggest the presence of an underlying immune disorder. Here we present a case of a patient with cough, fever, and cyanosis who was also diagnosed with IPH and concurrent selective immunoglobulin A deficiency. This presentation is a unique presentation because of the co-occurrence of these two disorders.Öğe Vitamin D levels of asthmatic children with and without obesity(Bilimsel Tip Yayinevi, 2016) Erkoçoğlu, Mustafa; Çapanoğlu, Murat; Civelek, Ersoy; Kaya, Ayşenur; Giniş, ZeynepObjective: Asthma and obesity are important public health problems that affect millions of people in the world. Recently it has been shown that vitamin D may affect the prevalence of allergic disease and obesity. In this study, we evaluated the correlations between vitamin D, asthma, obesity and severity of asthma. Materials and Methods: One hundred and nineteen subjects were included in the study. The study population consisted of four ageand sex-matched groups: Obese asthmatic children as group 1 (n:34), non-obese asthmatic children as group 2 (n: 28), obese non-asthmatic children as group 3 (n: 30) and non-obese non-asthmatic children as group 4 (n: 27). Results: There was no significant difference in serum vitamin D levels between groups. Also there was no difference between groups when we compared the serum vitamin D levels according to the severity of asthma. Conclusion: There was no correlation between levels of serum vitamin D and presence of asthma and obesity.
