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    Effectiveness of osteopathic manipulative applications on hypothalamic-pituitary-adrenal (HPA) axis in youth with major depressive disorder: a randomized double-blind, placebo-controlled trial
    (Walter De Gruyter Gmbh, 2024) Pala, Omer O.; Citaker, Seyit; Guney, Esra; Sepici, Aylin; Guveli, Guner M.; Arslan, Burak; Guru, Meltem
    Context: Osteopathic treatments regulate the neurovegetative system through joint mobilizations and manipulations, and myofascial and craniosacral techniques. Despite the growing body of research, the precise impact of osteopathic medicine on the autonomic nervous system (ANS) is not yet fully elucidated. As to Kuchera's techniques, the stimulation of the sympathetic trunk and prevertebral ganglia contributed to harmonization of the sympathetic activity. However, potential relationships between the harmonization of the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis largely remain uncertain and warrant further exploration. Objectives: This study was designed to evaluate the effectiveness of the osteopathic sympathetic harmonization (OSH) on the SNS and the HPA axis in youth with major depressive disorder (MDD). Methods: The study included 39 youths aged 15-21 years and diagnosed with MDD. The participants were randomly assigned into either the OSH or the placebo group. Stimulation was performed on the sympathetic truncus and prevertebral ganglia in the OSH group. The stimulation of the placebo group was performed with a lighter touch and a shorter duration in similar areas. Each participant completed the Beck Depression Inventory (BDI) and the State and Trait Anxiety Inventory (SAI and TAI) before the application. Blood pressure (BP) and pulse measurements were made, and saliva samples were taken before, immediately after, and 20 min after application. Results: The baseline BDI (p=0.617) and TAI (p=0.322) scores were similar in both groups. Although the SAI scores decreased in both groups postintervention, no statistically significant difference was found between the two groups. Subjects who received OSH had a decrease in alpha-amylase level (p=0.028) and an increase in cortisol level (p=0.009) 20 min after the procedure. Conclusions: Following OSH application in depressed youth, SNS activity may decrease, whereas HPA axis activity may increase. Future studies may examine the therapeutic efficacy of repeated OSH applications in depressed individuals.
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    The immediate effects of kinesio taping on scapular muscle endurance and strength in asymptomatic subjects: a single-blind, randomized, placebo-controlled trial
    (Edizioni Minerva Medica, 2024) Pala, Omer O.; Hazar, Zeynep; Gunaydin, Gurkan; Sozlu, Ugur; Alkan, Zeynep B.; Basar, Selda; Citaker, Seyit
    BACKGROUND: The purpose of this study was to investigate the immediate effects of Kinesio-taping (KT) on scapular muscle endurance and strength and compared to placebo Kinesio-taping in asymptomatic subjects. METHODS: Thirty-nine asymptomatic subjects were included in this study. Subjects were randomly allocated to KT (with the muscle facilitation technique) and placebo-KT (without any technique and tension). Scapular isometric muscle endurance was measured with a scapular muscle endurance test. The strength of the upper, middle, and lower trapezius, and serratus anterior was assessed using a hand-held digital dynamometer. Data were analyzed with 2x2 (groups [KT and Placebo-KT] x time [pre- and post-intervention]) mixed-model ANOVA. RESULTS: There were no significant main effect of time and time x group interaction was found for scapular muscle endurance, middle and lower trapezius strength. For the upper trapezius muscle strength main effect of time (F1,37 = 11,629, P=0.002, partial 1 2 =0.239) and time x group interaction (F1,37 = 7.502, P=0.009, partial 1 2 =0.169) were found, indicating an increase in KT group. However, this increase did not make a difference between groups. There was an interaction effect (time x group) for the serratus anterior muscle strength (F1,37 = 7.770, P=0.008, partial 1 2 =0.174), demonstrating a decrease in the placebo-KT group. Similarly, this situation did not create a difference between groups. CONCLUSIONS: These results suggest that the use of KT in asymptomatic subjects has no immediate effects on scapular muscle endurance, trapezius, and serratus anterior muscle strength compared to the use of placebo-KT.
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    Reliability and validation of the Turkish version of the Low Back Outcome Score
    (Turkish Assoc Orthopaedics Traumatology, 2020) Alhomedah, Ghofran; Citaker, Seyit; Gunaydin, Gurkan; Sezer, Refia; Khan, Furqan
    Objective: This study aimed to validate the Turkish version of the Low Back Outcome Score and check its reliability in patients with chronic low back pain (LBP). Methods: Overall, 105 patients [81 women and 24 men; mean age: 49.5 years (18-65 years)] with a complaint of LBP for at least 3 months were included in this study. Test-retest reliability was assessed after 7 days. Overall score of LBOS was compared with the overall scores of Rolland-Morris Disability Questionnaire: Oswestry Disability Index:' Quebec Back Pain Disability Scale: SF-36: and Bournemouth Questionnaire for Back Pain to calculate the convergent validity by using Pearson correlation coefficient. Results: The questionnaire was noted to have high internal consistency. The test-retest analysis revealed an excellent correlation (ICC=0.80). Pearson correlation coefficient of the LBOS was assessed using VAS and had an excellent correlation with all the questionnaires included in this study. Conclusion: The Turkish version of the LBOS questionnaire appeared to be a valid and reliable outcome measure.
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    Reliability and validation of Turkish version of the Dallas Pain Questionnaire
    (Kare Publ, 2022) Alhomedha, Ghofran; Citaker, Seyit; Gunaydin, Gurkan; Khan, Furqan; Sezer, Refia
    Objectives: Evaluation of low back pain (LBP) requires a condition specific disability questionnaire along with pain and satisfaction measure such as self-assessment pain scales. Dallas Pain Questionnaire (DPQ) is a 16-item visual analog scale, developed for evaluating patient's cognitions about the percentage that chronic pain affects four aspects of the subject's lives. It's easy to understand; can be answered in 3-5 min and can be scored in <1 min. This reliability and validation study offers health-care providers an opportunity to utilize this distinct questionnaire in Turkish population with back pain.The objectives are translation of Dallas questionnaire from English to Turkish language and to perform validation and reliability study. Methods: A total of 102 patients (79 women and 23 men) with mean age of 50.2 years and LBP for at least 3 months answered DPQ along with five other previously translated and validated questionnaires in Turkish language. Fifty-nine of these patients participated retest reliability after 7 days. Internal consistency and test-retest analyzes were conducted to determine the reliability and convergent validity was evaluated for the validation study. Results:The questionnaire was noted to have high internal consistency. The test-retest analysis revealed an excellent correlation (ICC=0.969). Pearson correlation coefficient shows that all subscales (sections) of DPQ are significant and comparable with each of the other questionnaires included in this study proving that it has sufficient convergent validity (p<0.001). Conclusion:The Turkish version of DPQ is content, valid, and reliable. DPQ is sensitive to use in patients with LBP.