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    Comparison of GnRH agonist and antagonist protocols among patients with mild-moderate endometriosis and endometrioma: a novel clinical approach.
    (Elsevier Science Inc, 2005) Pabuçcu, Recai; Önalan, Göğşen; Selam, Belgin; Ceyhan, Temel; Akar, Münire; Önalan, Reşide
    Different IVF protocols individualized according to various stages of endometriosis and according to management of endometrioma may be essential for the improvement of clinical outcomes in IVF programs.
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    Serum and follicular fluid levels of soluble Fas and soluble Fas ligand in IVF cycles
    (Elsevier, 2006) Önalan, Göğşen; Selam, Belgin; Önalan, Reşide; Ceyhan, Temel; Cıncık, Mehmet; Pabuçcu, Recai
    Objective: To determine follicular fluid (FF) and serum levels of soluble Fas (sFas) and soluble Fas ligand (sFasL) in patients undergoing IVF cycles. S Study Design: A prospective comparative study among patients with endometriosis (n = 12), infertility due to male factor (11 = 12) and poor responders (n = 32) undergoing IVF cycles in Centrum IVF Clinic. Individual FF and serum samples were collected from patients during transvaginal ultrasonography-guided follicle aspiration. Patients were classified as poor responder patients undergoing IVF cycles with GnRHa, triptorelin and GnRH antagonist, cetrotide, patients with endometriosis and patients with infertility due to male factor. sFas, sFasL levels in both FF and serum samples and their correlations with clinical outcomes of IVF were measured in each study group. Results: Serum and FF levels of sFas, sFasL were similar in the poor responder and male factor groups. There were no differences between the serum and FF levels of both sFas and sFasL among poor responder patients receiving either GnRH agonist or antagonist therapies. Serum levels of sFas were significantly lower in the endometriosis group compared to the male factor group. Serum and FF levels of sFas, sFasL were similar among patients with or without clinical pregnancy. Conclusion: sFas and sFasL are detected in both serum and follicular fluid samples from IVF cycles, their levels are similar between poor responder and male factor groups as well as between GnRH agonist and antagonist treatment groups. These soluble apoptotic factors may not be predictive for the outcomes of IVF. Decreased serum levels of sFas, suggests increased apoptosis in endometriosis.