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Öğe Bactericidal permeability increasing protein gene polymorphism is associated with inflammatory bowel diseases in the Turkish population(Medknow Publications & Media Pvt Ltd, 2015) Can, Güray; Akın, Hakan; Özdemir, Filiz Türe; Can, Hatice; Yılmaz, BülentBackground/Aims: Inflammatory bowel disease, a chronic inflammatory disease with unknown etiology, affects the small and large bowel at different levels. It is increasingly considered that innate immune system may have a central position in the pathogenesis of the disease. As a part of the innate immune system, bactericidal permeability increasing protein has an important role in the recognition and neutralization of gram-negative bacteria. The aim of our study was to investigate the involvement of bactericidal permeability increasing protein gene polymorphism (bactericidal permeability increasing protein Lys216Glu) in inflammatory bowel disease in a large group of Turkish patients. Patients and Methods: The present study included 528 inflammatory bowel disease patients, 224 with Crohn's disease and 304 with ulcerative colitis, and 339 healthy controls. Results: Bactericidal permeability increasing protein Lys216Glu polymorphism was found to be associated with both Crohn's disease and ulcerative colitis (P = 0.0001). The frequency of the Glu/Glu genotype was significantly lower in patients using steroids and in those with steroid dependence (P = 0.012, OR, 0.80; 95% confidence interval [CI]: 0.68-0.94; P = 0.0286, OR, 0.75; 95% CI: 0.66-0.86, respectively). There was no other association between bactericidal permeability increasing protein gene polymorphism and phenotypes of inflammatory bowel disease. Conclusions: Bactericidal permeability increasing protein Lys216Glu polymorphism is associated with both Crohn's disease and ulcerative colitis. This is the first study reporting the association of bactericidal permeability increasing protein gene polymorphism with steroid use and dependence in Crohn's disease.Öğe Doksorubisin'e bağlı ortaya çıkan kemo-beyin üzerinde nigella sativa'nın ratlarda koruyucu etkisinin araştırılması(Bolu Abant İzzet Baysal Üniversitesi, 2019) Can, Hatice; Üyetürk, ÜmmügülGiriş: Meme kanseri, kadınlarda görülen en sık kanser olmakla birlikte kadınlarda kanser ilişkili ölümlerin de en sık nedenidir. Son dönemlerde erken tanı ve tedavi ile mortalitede azalma izlenmektedir. Kullanılan kemoterapi ilaçlarının kanser hücrelerine selektivitesi düşüktür, büyük bir kısmının ciddi sitotoksik yan etkileri mevcuttur. Meme kanserinde uzun süredir kullanılan doksorubisinin de bazı yan etkileri bulunmaktadır. Bu yan etkiler içinde, uzun dönemde kognitif fonksiyonların bozulmasıyla kendisini gösteren kemobeyine pratikte sıklıkla karşılaşılmaktadır. Deneysel çalışmalarda kemobeyin üzerine etkisi araştırılan birçok molekül bulunmaktadır. Antioksidan özelliğe sahip Nigella sativa (çörekotu)'nın birçok hastalıkta olumlu etkisinin olduğu çeşitli çalışmalarda ortaya konulmuştur. Nigella sativa'nın doksorubisine bağlı oluşan kemobeyin üzerine etkisinin araştırıldığı çalışma bulunmamaktadır. Amaç: Çalışmamızda deneysel hayvan modelinde doksorubisin ilişkili kemobeyin üzerine Nigella sativa'nın etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmada 24 adet dişi Wistar Albino cinsi rat kullanıldı. Ratlar, her grupta 8 hayvan olacak şekilde rastgele kontrol, doksorubisin ve doksorubisin+Nigella sativa gruplarına dağıtıldı. Kemobeyin indüksiyonu doksorubisin ile yapıldı. Doksorubisin, intraperitoneal olarak 5 miligram/kilogram/gün dozunda, 1. 8. ve 15. günler olmak üzere 28 gün boyunca toplamda 3 defa verildi. Nigella sativa ekstraksiyonu etanol metoduyla yapıldı. Nigella sativa özütü oral olarak gavaj ile 400 miligram/kilogram/gün dozunda 28 gün boyunca hergün verildi. Ratlar, 1. 2. 3. 4. ve 5. haftalarda haftada bir defa tartıldı. Kemobeyin şiddeti 29. günde açık alan testi, 30. ve 31. günlerde pasif sakınma testi ile değerlendirildi. Açık alan testinde toplam aldıkları mesafe, hareketli ve hareketsiz süreler ile epizot sayıları, ortalama ve maksimum hızları, geçtikleri çizgi sayısı, merkez ve kenar alana giriş sayıları, bu alanlarda geçirdikleri toplam süre ile hareketli ve hareketsiz süreler, ortalama hızları ve aldıkları mesafeler kaydedildi. Pasif sakınma testinde birinci gün karanlık odada elektrik uyarısı verildi. İkinci gün karanlık odaya geçme süresi test edildi. Karanlık odaya geçmeyenler öğrenmiş kabul edildi. Ratlarda öğrenme oranları hesaplandı. Elde edilen sonuçlar istatistiksel olarak karşılaştırıldı. Anlamlı (p) değeri ?0,05 olarak kabul edildi. Bulgular: Doksorubisin grubunda hareketli ve hareketsiz epizot sayıları ile aktif ve inaktif epizot sayıları kontrol grubuna göre anlamlı derecede azalmış (herbiri için p?0,05), kenar ve merkez alanlara giriş sayıları ile merkez alanda alınan mesafe kontrol grubuna göre anlamlı derecede artmıştı (herbiri için p?0,05). Kenar alanda alınan süre kontrol grubuna göre doksorubisin grubunda daha az, merkez alanda geçirilen toplam süre ile hareketli süre daha fazla olmasına rağmen fark anlamlı değildi (herbiri için p?0,05). Doksorubisin+Nigella sativa grubunda kenar ve merkez alanlara giriş sayıları, merkez alanda alınan mesafe, merkez alanda geçirilen toplam süre ile hareketli süre doksorubisin grubuna göre anlamlı derecede azalmış (herbiri için p?0,05), aktif ve inaktif epizot sayıları ile kenar alanda geçirilen süre ise anlamlı derecede artmıştı (herbiri için p?0,05). Hareketli ve hareketsiz epizot sayıları doksorubisin grubuna göre doksorubisin+Nigella sativa grubunda daha fazla olmasına rağmen aradaki fark anlamlı değildi (p?0,05). Doksorubisin+Nigella sativa grubu ile kontrol grubu arasında hiçbir parametrede anlamlı fark yoktu (p?0,05). Bütün gruplarda, kenar alanda geçirilen süre ve alınan mesafe, merkez alandaki süre ve mesafeye göre anlamlı derecede daha fazlaydı (p?0,05). Bütün gruplarda merkez alandaki ortalama hız, kenar alandaki ortalama hızdan, merkez alandaki hareketli süre merkez alandaki hareketsiz süreden, toplam aktif epizot sayısı da inaktif epizot sayısından anlamlı derecede daha fazlaydı (p?0,05). Toplam hareketli ve hareketsiz süreler, alınan toplam mesafe ve baş mesafesi, ortalama ve maksimum hızlar, çizgiyi geçme sayıları, kenar alandaki hareketli ve hareketsiz süreler, merkez alandaki hareketsiz süre, kenar ve merkez alanlardaki ortalama hızlar ile kenar alanında alınan mesafe açısından gruplar arasında anlamlı fark yoktu (herbiri için p?0,05). Bütün gruplarda toplam hareketli süreler ile hareketsiz süreler, kenar alandaki hareketli süreler ile hareketsiz süreler, toplam hareketli epizot sayılar ile hareketsiz epizot sayıları ve kenar alana giriş sayıları ile merkez alana giriş sayıları benzerdi (herbiri için p?0,05). Tartışma: Doksorubisin uygulanan ratlarda anksiyete azaltmaktadır. Doksorubisinin, normal ratlarda korunma içgüdüsü gereği doğal olarak belli düzeyde olması gereken anksiyeteyi daha düşük seviyelere indirmesi, doksorubisinin anksiyeteyi düzenleyen santral mekanizmaları bozucu etki gösterdiğini düşündürmektedir. Nigella sativa, bu hasara engel olarak anksiyete seviyesini korunma için hayvanların ihtiyaç duyduğu seviyede tutmaktadır. Doksorubisin ile kısa süreli indüksiyon ile bilişsel fonksiyonlarda bozulma oluşmamıştır. Bunun olması için doksorubisin ile uzun süreli uygulanması veya daha uzun süre geçtikten sonra ratlarda bu testlerin tekrarlanması gerekiyor olabilir. Bu nedenle, Nigella sativa'nın bilişsel fonksiyonlar üzerine etkisinin değerlendirilmesi için daha uzun süreli çalışmaların yapılmasının gerekli olduğu sonucuna varıldı. Sonuç: Nigella sativa, doksorubisinin neden olduğu emosyonel davranış değişiklikleri üzerine koruyucu etkiye sahiptir. Fakat bilişsel fonksiyonlar üzerine etkisinin gösterilebilmesi için uzun dönem doksorubisin kullanıldığı ve ratların uzun süreli takip edildiği çalışmalara ihtiyaç vardır. Anahtar Kelimeler: Doksorubisin, Kemobeyin, Nigella sativa, RatÖğe The efficacy of tyrosine kinase inhibitor dasatinib on colonic mucosal damage in murine model of colitis(Elsevier Masson, Corporation Office, 2016) Can, Güray; Ayvaz, Süleyrnan; Can, Hatice; Karaboğa, İhsan; Demirtaş, Selim; Korkmaz, Uğur; Kurt, MevlütBackground and objective: Ulcerative colitis is an inflammatory condition of the colon in the gastrointestinal system. Currently, the most potent medications used for ulcerative colitis produce no response in 20-30% of cases. There is a need for more efficient and reliable medications. Tyrosine kinase inhibitors have shown efficacy in some inflammatory diseases. Although dasatinib, a tyrosine kinase inhibitor, suppresses proinflammatory cytokines in colonic tissue, there are a few cases of hemorrhagic colitis with dasatinib. There is no study investigating the effect of dasatinib on experimental colitis. We aimed to investigate the effect of dasatinib in a colitis model induced with acetic acid in our study. Methods: In the study, 24 male Sprague-Dawley rats randomly distributed into 4 groups of 6 rats each as control, dasatinib, colitis and dasatinib + colitis groups. For colitis induction, 4% acetic acid was used. Sacrificing of the rats was performed on the seventh day. Disease activity, morphologic and histological injury, superoxide dismutase, myeloperoxidase and malondialdehyde activity, TNF alpha and CD3 expression were assessed in colonic tissue. Results: Apart from malondialdehyde, significant difference in all parameters between the control and colitis groups was determined. Difference between the colitis and colitis + dasatinib groups was not significant in only weight loss and biochemical parameters. Though dasatinib does not fully resolve the changes in colitis, there was significant regression. Conclusions: Dasatinib decreased the inflammation in a rodent model of colitis. It may be provide this effect by the suppression of TNF alpha. Dasatinib may be one of the treatment options for ulcerative colitis. (C) 2016 Elsevier Masson SAS. All rights reserved.Öğe Epidemiologic features of inflammatory bowel disease in Western Blacksea region of Turkey for the last 10 years: Retrospective cohort study(Korean Assoc Internal Medicine, 2019) Can, Güray; Poşul, Emrah; Yılmaz, Bülent; Can, Hatice; Korkmaz, Uğur; Ermiş, FatihBackground/Aims: There are only a few epidemiological study about inflammatory bowel disease in the last 10 years in Turkey, especially in Western Blacksea region. In our study, we aimed to identify the changes in the incidence and the prevalence of inflammatory bowel disease in Western Blacksea region at the last 10 years. Methods: Totally 223 patients with inflammatory bowel disease (160 ulcerative colitis, 63 Crohn's disease) were enrolled in the study followed up between 2004 to 2013 years. The epidemiological characteristics of patients were recorded. Results: The prevalences were 12.53/10(5) and 31.83/10(5) for Crohn's disease and ulcerative colitis respectively. Mean annual incidences increased from 0.99/10(5) and 0.45/10(5) for ulcerative colitis and Crohn's disease (2004 to 2005 years) to 4.87/10(5) and 2.09/10(5) for ulcerative colitis and Crohn's disease respectively (2011 to 2013 years). While the prevalence was higher in urban areas in Crohn's disease (12.60/10(5)), it was higher in rural areas in ulcerative colitis (36.17/10(5)). In ulcerative colitis, mean annual incidences were 2.91/10(5) and 2.86/10(5) for urban and rural areas respectively. In Crohn's disease, they were 1.37/10(5) and 1.08/10(5) for urban and rural areas respectively. Conclusions: The incidence of inflammatory bowel disease seems to increase in Western Blacksea region at the last 10 years. This increment is more prevalent in rural areas.Öğe Evaluation of epicardial adipose tissue and carotid intima-media thickness as a marker of atherosclerosis in patients with inflammatory bowel disease(ARÁN EDICIONES, S.L., 2021) Ekmen, Nergiz; Can, Güray; Yozgat, Ahmet; Can, Hatice; Bayraktar, Muhammed Fatih; Demirkol, Muhammed Emin; Kayhan, Meral Akdoğan; Sasani, HadiBackground and aim: this study aimed to compare carotid intima media (CIMT) and epicardial adipose tissue (EAT) measurements, which are considered as markers for the detection of early atherosclerosis in healthy controls and inflammatory bowel disease (IBD) cases. Methods: a total of 60 IBD patients (25 Crohn’s disease and 35 ulcerative colitis) and 60 healthy patients (as a control group) were included in the study. The measurements of CIMT and EAT were performed using echocardiography and ultrasonography, respectively. Statistical analysis was used to determine the relationship between the parameters. Results: the thickness of bilateral (right and left) CIMT and EAT were significantly higher in IBD than in the control group (p < 0.05). There was a positive correlation between EAT and bilateral (right and left) CIMT in IBD patients (p < 0.05). Conclusion: IBD is associated with an increased thickness of EAT and CIMT. Chronic inflammation in IBD may increase the risk of atherosclerotic heart disease. Thus, only measur ing the thickness of EAT and CIMT can be used as an objec tive, easy, simple, affordable, non-invasive and accessible assessment method in order to screen for this riskÖğe Is there any link between atrial arrhythmias and inflammatory bowel disease?(Wolters Kluwer Medknow Publications, 2021) Can, Güray; Can, Hatice; Bayraktar, Muhammet Fatih; Demirkol, Muhammed Emin; Kayhan, Meral Akdoğan; Sasani, Hadi; Ekmen, NergizBackground: Inflammation plays an important role in the development of cardiovascular disease, including atherosclerosis and arrhythmia. The aim of this study was to evaluate atrial conduction times (ACTs) in patients with inflammatory bowel disease (IBD) in which systemic chronic inflammation is evident. Methods: In this cross-sectional, prospective, single-center study, 79 IBD patients (51 ulcerative colitis; 28 Crohn's disease) and 70 healthy controls were included. Atrial electromechanical properties were measured by recording simultaneous surface electrocardiography (ECG) with transthoracic echocardiography (ECHO) and tissue Doppler imaging methods. The relationship between age, disease duration, and ACT was evaluated. Results: There were significantly increased conduction durations of lateral-PA (time interval from the onset of the P-wave on surface ECG to the beginning of the late diastolic wave), septal-PA, tricuspid-PA, and interatrial-electromechanical delay (IA-EMD), right intraatrial EMD, and left intraatrial (LI-EMD) durations in IBD patients (P < 0.001). In IBD patients, there was a positive correlation with age, lateral PA, septal PA, tricuspid PA, IA-EMD, and LI-EMD (P < 0.05). A positive correlation was found between disease duration and only lateral PA and tricuspid PA (P < 0.05). Conclusion: In IBD patients, prolonged ACT consists a potential risk for severe atrial arrhythmias. ECG and ECHO screening can be useful in identifying risk groups in IBD patients and taking precautions for future cardiac complications.Öğe Preliminary examination of the relations between disease stage, illness perceptions, coping strategies, and psychological morbidity in chronic hepatitis B and C guided by the Common-Sense Model of Illness(Lippincott Williams & Wilkins, 2021) Ekmen, Nergiz; Can, Güray; Can, HaticeBackground and aims Chronic viral hepatitis (CVH) has a spectrum from asymptomatic disease to cirrhosis and hepatocellular carcinoma. In our study, we aimed to establish the relations between disease stage, illness perception, coping strategies and psychological morbidity in CVH. Methods A total of 182 patients with chronic hepatitis B (CHB) (n = 136) and chronic hepatitis C (CHC) (n = 46) were enrolled. Illness perceptions were measured with the Brief Illness Perceptions Questionnaire. Coping strategies were measured with the Carver Brief Coping Questionnaire. Anxiety and depression were measured with the Hospital Anxiety and Depression Scale. Relations were evaluated by structural equation modeling (SEM). Results In CHB, combining the questionnaire data using SEM resulted in a final model with an excellent fit [chi(2) (2) = 0.00, P = 1.000, chi(2)/N = 0.00, root mean square error of approximation (RMSEA) < 0.001, comparative fit index (CFI) = 1.000, goodness-of-fit index (GFI) = 1.000]. Disease stage had a significant direct influence on illness perceptions (beta = 0.23, P = 0.006). Illness perceptions had a significant direct influence on emotional coping strategy, depression and anxiety (beta = 0.20, P = 0.019; beta = 0.33, P < 0.001; beta = 0.59, P < 0.001, respectively). While the use of emotional coping strategies was associated significantly (P = 0.01) with the presence of anxiety, problem-focused coping strategy was associated with depression (P = 0.004). In CHC, SEM resulted in a final model with an excellent fit [chi(2) (2) = 0.078, P = 0.962, chi(2)/N = 0.039, RMSEA<0.001, CFI = 1.000, GFI = 0.999]. Disease stage did not have a significant direct influence on illness perceptions (P > 0.05). Illness perceptions had a significant direct influence on depression and anxiety (beta = 0.27, P = 0.023; beta = 0.44, P < 0.001, respectively). Conclusion The psychological consequences of the disease vary depending on the person's perception of illness and coping strategies.Öğe Social stigmatization in Turkish patients with chronic hepatitis B and C(Ediciones Doyma, S.L., 2021) Yozgat, Ahmet; Can, Güray; Can, Hatice; Ekmen, Nergiz; Akyol, Taner; Kasapoğlu, Benan; Kekilli, MuratBackground and aim: Viral hepatitis is the most important cause of chronic hepatitis worldwide. Stigmatization is defined as a feeling of rejection and isolation of patients by society due to illness. There are no studies on chronic viral hepatitis in the literature in English, which has its own religious and socio-cultural structure. In our study, we aimed to investigate the presence of social stigmatism and psychosocial effects on patients with different stages of chronic viral hepatitis B and C. Methods: Forty-five patients with chronic hepatitis C and 114 patients with chronic hepatitis B were enrolled in the study. Berger's scale was used for stigmatization, composed of 40 four-point Likert items that have four subscales: personalized stigma, disclosure, negative self-image, and public attitude. Stigma score ranges between one and four. Stigma is accepted as present if the overall score is above two. Results: Overall the mean stigma scores were 1.97 ± 0.58 and 2.14 ± 0.57 for chronic hepatitis B and C, respectively. There was stigma in 47.4% of the patients with chronic hepatitis B, and 60% of the patients with chronic hepatitis C. Being male was the risk factor on overall stigma, disclosure and public attitude in chronic hepatitis C. Living in an urban setting was the risk factor on negative self-image in chronic hepatitis C and on personalized stigma and disclosure in chronic hepatitis B. Conclusions: To the best of our knowledge, this is the first study that provides qualitative information about chronic hepatitis-related stigma. Stigmatization is a major problem in Turkey and worldwide. We believe that increasing the knowledge of the patients and society by teaching about the transmission routes of the disease and focusing on vaccination studies will prevent stigmatization.Öğe The syk inhibitor fostamatinib decreases the severity of colonic mucosal damage in a rodent model of colitis(Oxford Univ Press, 2015) Can, Güray; Ayvaz, Süleyman; Can, Hatice; Demirtaş, Selim; Akşit, Hasan; Kurt, MevlütBackground and aims: Inflammatory bowel disease is a chronic inflammatory disease of the gastrointestinal system. In some cases, current medications used for inflammatory bowel disease may not be enough for remission, creating a need for more potent and reliable medications. There is no study showing the efficacy of fostamatinib, with proven effects on some inflammatory diseases, on ulcerative colitis. In our study we planned to research the efficacy of fostamatinib, a spleen tyrosine kinase inhibitor, on acetic acid-induced colitis. Methods: The study included 28 male Sprague-Dawley rats, randomly divided into control group, fostamatinib group, colitis group and fostamatinib + colitis group, each containing seven rats. Colitis induction was performed with 4% acetic acid. Colonic inflammation was assessed with disease activity index, macroscopic and histological damage scores, colonic myeloperoxidase, malondialdehyde and superoxide dismutase activity, and tumour necrosis factor alpha [TNF alpha], CD3, Syk, and phospho-Syk expression. Results: There was a significant difference between the colitis and control groups in terms of all parameters. The disease activity index, macroscopic and microscopic damage scores, immunohistochemical TNF alpha, CD3, Syk, and phospho-Syk expression, and tissue myeloperoxidase activity were found to be significantly lower in the colitis + fostamatinib group compared with the colitis group. There was no significant difference between the two groups in terms of myeloperoxidase and malondialdehyde activity. Conclusions: Fostamatinib reduced the inflammatory damage in the experimental colitis. This effect may be due to suppression of TNF alpha, T-lymphocytes, and neutrophils in colonic mucosa via suppression of Syk. Fostamatinib may be an appropriate treatment alternative for ulcerative colitis. Further clinical studies are required to support this.Öğe Tyrosine kinase-2 gene polymorphisms are associated with ulcerative colitis and Crohn's disease in Turkish Population(Elsevier Masson, Corp Off, 2015) Can, Güray; Tezel, Ahmet; Gürkan, Hakan; Can, Hatice; Yılmaz, BülentBackground and objective: Inflammatory bowel disease is a group of chronic inflammatory conditions affecting gastrointestinal tract. Lots of genes have been identified resulting in susceptibility to inflammatory bowel disease. Any polymorphism leading to functional modifications in tyrosine kinase-2 may precipitate excessive immune response in the intestinal mucosa. The aim of our study is to investigate the involvement of tyrosine kinase-2 polymorphisms in the patients with inflammatory bowel disease in Turkish population. Methods: Four single nucleotide polymorphisms in tyrosine kinase-2 (rs280523, rs2304256, rs280519 and rs280496) were genotyped in 60 Crohn's disease, 151 ulcerative colitis patients and 89 unrelated healthy controls. These polymorphisms were detected by real-time polymerase chain reaction. Results: The presence of genotype (CC) in rs2304256 and (AA) in rs280519 were found to increase the susceptibility to ulcerative colitis (P = 0.024, 0.025, respectively). rs2304256 (CA) and rs280519 (AG) have provided protection against ulcerative colitis (P = 0.021, 0.012, respectively). rs280519 (AG) was protective against Crohn's disease (P = 0.045). rs2304256 (CC) increased the susceptibility to inflammatory Crohn's disease (P = 0.014). The presence of rs2304256 (A) increased the susceptibility to perianal Crohn's disease (P = 0.03). Both rs280519 and rs2304256 polymorphisms were associated with the requirement of corticosteroid and immunosuppressive therapy in ulcerative colitis. Conclusion: This study is the first demonstration of the single marker association of tyrosine kinase-2 polymorphisms with ulcerative colitis and Crohn's disease in Turkish population. They may be effective in the etiology of inflammatory bowel disease in our population. Disparity between our study and others may be related to ethnic differences. (C) 2015 Elsevier Masson SAS. All rights reserved.
