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    The Association of Omentin Levels in Non-Diabetic Postmenopausal Women with Bone Mineral Density and Total Body Composition
    (2015) Özlü, Tülay; Sarman, Hakan; Alçelik, Aytekin; Işık, Cengiz; Yazıcı, Selma; Tosun, Mehmet; Caglar, Hilal
    Objectives: Positive relation between body mass and bone mineral density (BMD) is thought to be due to weight bearing effect. However, adipose tissue derived adipokines may have important effects on bone. Obese women have decreased levels of omentin in circulation which is related with adverse metabolic events. The hypothesis was that performed in this study, we aimed to study the association of omentin levels with body composition and BMD in non-diabetic postmenopausal women. Methods: Postmenopausal women aged 40 to 70 years, scheduled for BMD testing were prospectively evaluated. Patients with known diabetes, chronic renal failure, chronic liver disease, malabsorption, inflammatory bowel disease, <40 and >70 years of age were excluded. BMD and body composition were measured by DXA (GE-Lunar DPX pro). Fasting blood samples were obtained for analysis of complete blood count, glucose, creatinine, lipid profile and omentin. Statistical analyses were performed by using SPSS version 18 for windows. P<0.05 was considered statistically significant. Results: Mean age of the patients in the osteoporosis group was higher than that of the control group (59.1±7.6 vs 53.3±5.7, p<0.05). Mean omentin level was higher in osteoporosis group than in osteopenia and control groups (479.7±141.6 vs 342.3±173.6 and 346.8±127.2, p<0.05). Total body fat mass, muscle mass and the T score of lumbar spine had a negative correlation with omentin levels (r=-0.252, -0.276, -0.344, p<0.05). Conclusions: Body composition does not seem to effect omentin levels. Women with a lower BMI have increased omentin levels. Higher omentin levels are associated with lower T scores at the lumbar spine.
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    Evaluation of Atrial Conduction Times, Epicardial Fat Thickness and Carotid Intima-Media Thickness in Patients With Ankylosing Spondylitis
    (2016) Çağlar, Sabri Onur; Boyraz, Ismail; Erdem, Fatma; Yazici, Selma; Caglar, Hilal; Koç, Bünyamin; Çağlar, Emrah
    Objectives: This study aims to determine the relationship between atrial electromechanical delay (EMD), carotid intima-media thickness (CIMT), and epicardial fat thickness (EFT) in ankylosing spondylitis (AS), which has a complicated inflammatory nature.Patients and methods: The study population included 42 consecutive patients with AS (28 males, 14 females; mean age 39.3±8.5 years; range 22 to 60 years) and 40 healthy subjects as controls (24 males, 16 females; mean age 37.2±8.7 years; range 22 to 60 years) (p>0.05). All patients underwent a standard tissue Doppler echocardiography to assess the left ventricular diastolic dysfunction, atrial EMD, CIMT, and EFT. All values were compared between the groups.Results: Interatrial (29.5±5.8 ms vs. 17.9±5.3 ms) left and right intraatrial EMD (18.2±4.6 ms and 11.7±3.5 ms vs. 11.9±3.2 ms and 7.1±3.2 ms, respectively) intervals were longer in AS patients than in healthy controls (all p<0.001). Left and right CIMT (0.50±0.11 mm and 0.44±0.06 mm vs. 0.51±0.11 mm and 0.43±0.04 mm, respectively) and EFT (0.73±0.15 cm and 0.63±0.07 cm) values were higher in AS patients than in healthy controls (all p<0.01).Conclusion: To our best knowledge, this is the first report evaluating the atrial EMD, CIMT, and EFT values together in AS patients. As indicators of cardiovascular involvement, all parameters were higher in AS patients.