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    Efficacy of daptomycin on experimental methicillin-resistant staphylococcus aureus keratitis in rabbits
    (Mary Ann Liebert, Inc, 2013) Mengeloğlu, Fırat Zafer; Küçükbayrak, Abdulkadir; Bucak, Yasin Yucel; Erdurmuş, Mesut; Taş, Tekin; Özyalvaçlı, Gülzade; Bayram, Recep; Bucak , Özlem; Akdeniz, Hayrettin
    Purpose: We aimed to compare the efficacy of topical daptomycin (DAP) with that of vancomycin (VA) in the treatment of keratitis caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: One hundred colony-forming unit MRSA bacteria were injected intrastromally into both corneas of 28 rabbits. Sixteen hours after injection, the rabbits' eyes were treated with 1 drop of topical DAP (10 or 50mg/mL), VA (50mg/mL), or isotonic saline for 19 doses. Their eyes were examined for clinical severity before and after treatment. Results: The minimum inhibitory concentration values of VA and DAP against the bacterial strain were found to be 2 and 0.5g/mL, respectively. The mean pre- and post-treatment clinical scores of the eyes did not differ significantly among the groups. However, the mean difference between the post- and pretreatment clinical scores was significantly lower in the 50mg/mL DAP group than in the other groups (P=0.042). A marked decrease in bacterial load was detected in all treatment groups compared to the control group (P=0.002). Although there were no significant differences in bacterial load among the treatment groups, the 50mg/mL DAP group showed the greatest decrease. The mean % epithelial erosion rate tended to be higher in the 50mg/mL VA group than in the other groups (P=0.31). Conclusions: Topical DAP significantly reduced the bacterial load and showed activity against MRSA comparable to that of fortified VA in this experimental model.
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    Relationship Between Ocular Surface Disease Index, Dry Eye Tests, and Demographic Properties in Computer Users
    (Turkish Ophthalmological Soc, 2014) Simavli, Huseyin; Onder, Halil Ibrahim; Bucak, Yasin Yucel; Erdurmus, Mesut; Guler, Emre; Hepsen, Ibrahim Feyzi
    Objectives: The aim of the present study is to evaluate the ocular surface disease index (OSDI) in computer users and to investigate the correlations of this index with dry eye tests and demographic properties. Materials and Methods: In this prospective study, 178 subjects with an age range of 20-40 years and who spent most of their daily life in front of the computers were included. All participants underwent a complete ophthalmologic examination including basal secretion test, tear break-up time test, and ocular surface staining. In addition, all patients completed the OSDI questionnaire. Results: A total of 178 volunteers (101 female, 77 male) with a mean age of 28.8 +/- 4.5 years were included in the study. Mean time of computer use was 7.7 +/- 1.9 (5-14) hours/day, and mean computer use period was 71.1 +/- 39.7 (4-204) months. Mean OSDI score was 44.1 +/- 24.7 (0-100). There was a significant negative correlation between the OSDI score and tear break-up time test in the right (p=0.005 r=-0.21) and the left eyes (p=0.003 r=-0.22). There was a significant positive correlation between the OSDI score and gender (p=0.014 r=0.18) and daily computer usage time (p=0.008 r=0.2). In addition to this, there was a significant positive correlation between the OSDI score and ocular surface staining pattern in the right (p=0.03 r=0.16) and the left eyes (p=0.03 r=0.17). Age, smoking, type of computer, use of glasses, presence of symptoms, and basal secretion test were not found to be correlated with OSDI score. Conclusions: Long-term computer use causes ocular surface problems. The OSDI were found to be correlated with tear break-up time test, gender, daily computer usage time, and ocular surface staining pattern in computer users.