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Öğe Açık kalp cerrahisinde malnütrisyon oranları ve ilişkili risk faktörlerinin araştırılması(Turkish Anaesthesiology and Intensive Care Society, 2014) Bayır, Hakan; Tekelioğlu, Ümit Yaşar; Koçoğlu, Hasan; Akkaya, Akcan; Demirhan, Abdullah; Bilgi, Murat; Erdem, Kemalettin; Dağlar, Bahadır; Yıldız, İsaObjective: Rates of malnutrition in hospitalized patients may vary depending on the type of the hospital and patient population. Malnourished patients have higher mortality and morbidity rates, longer length of hospital stay (LOS) and much more drug use than patients without malnutrition. We aimed to investigate rates of malnutrition in hospitalized patients undergoing open heart surgery and the associated risk factors. Material and Methods: We studied 50 ASA II-III patients aged between 40-85 years undergoing elective open heart surgery. Patients whose NRS-2002 score ? 3 and/or, Body Mass Index (BMI) <18.5 kg/m2, and/or serum albumin level <3 g/dl were evaluated as malnourished. Preoperatively patients' demographic data, preoperatwe left ventricular ejection fraction (LVEF), pulmonary function test results (FVC, FEV1, FEV1/FVC), hemoglobin, hematocrit, lymphocyte count, albumin, CRP, and cholesterol values were recorded. LOS in intensive care unit and service, type of complications that occurred during hospitalization were recorded. Pulmonary function test results were also obtained on the day patients discharged. Results: Malnutrition rate was 20 % in patients with open-heart surgery. Patients at risk of malnutrition had longer postoperative intubated time, LOS in ICU and in service, higher rates of postoperative complications and louer preoperative and postoperative FEV1, FVC, and FEV1/FVC values than those without risk of malnutrition. But these findings were not statistically significant. In addition, LOS in the ICU and service were found to be relatively longer in overweight and obese patients. Conclusion: In summary, a high rate of malnutrition can be observed in patients with open-heart surgery. Malnutrition has negative postoperative effects in these patients.Öğe Analgaesic Effect of Erector Spinae Plane Block in Coronary Surgery: A Randomised Controlled Trial(Coll Physicians & Surgeons Pakistan, 2024) Disikirik, Akin; Bilgi, Murat; Turkoglu, Mustafa; Ucaroglu, Erhan RenanObjective: To investigate the effect of preemptive erector spinae plane (ESP) block application on postoperative pain scores and opioid demand in off-pump coronary artery bypass graft (CABG) surgery. Study Design: Randomised-controlled trial. Place and Duration of the Study: Department of Anaesthesiology and Reanimation, Abant Izzet Baysal University (AIBU) Medical School, Bolu, Turkiye, from November 2020 to April 2021. Methodology: Fifty patients between the ages of 50 and 75 years, received CABG surgery. These participants who were at risk of the American Society of Anesthesiologists (ASA) III were randomly divided into two groups: ESP (Group E) and Control (Group C). Intervention in Group E was performed bilaterally at the T5 level before the operation. In the study, the primary outcome was postoperative opioid demand while the secondary outcomes consisted of intraoperative opioid demand, visual analogue scale scores, and the duration of hospital stay. Results: Tramadol demand was significantly decreased in Group E at 0-1, 1-12, 12-24, and 0-48 hours (p <0.05). Intraoperative fentanyl demand for Group E was also statistically significantly decreased (p= 0.001). In Group E, the visual analogue scale scores at 30 minutes, 1(st), 2(nd), 4(th), 8(th), 12(th) hour, and 16th hour after postoperative extubation were observed to be significantly lower than those of Group C (p <0.05). Conclusion: Preemptive ESP block application in CABG surgery patients reduced postoperative tramadol demand, intraoperative fentanyl demand, and postoperative pain scores.Öğe Association between hemogram parameters and survival of critically Ill patients(Sage Publications Inc, 2019) Karagöz, İbrahim; Aktaş, Gülali; Yoldaş, Hamit; Yıldız, İsa; Ögün, Muhammed Nur; Bilgi, Murat; Demirhan, AbdullahAim: Recently, hemogram parameters, such as mean platelet volume (MPV), had been proposed as novel inflammatory and prognostic factors. In present retrospective analysis, we aimed to determine and compare MPV of survived and dead patients whom admitted to intensive care unit (ICU) of our institution. Methods: We recorded hemogram parameters and other laboratory data and demographic characteristics of patients treated in ICU. Patients are divided into 2 groups-dead patients and survived patients. Laboratory data of survived patients compared to those of dead patients. Results: Age, gender, and other laboratory variables were not significantly different between dead and survived patients. On the other hand, MPV of survived patients was significantly higher than that of the dead patients (P = .001). Conclusion: We think that elevated MPV levels in an ICU patient should alert clinicians for worse outcome. Physicians should be more careful in the management of these patients.Öğe Atropa Belladonna (Güzel Avrat Otu) meyvesi ile ilişkili antikolinerjik toksik sendrom: Bir olgu sunumu(2013) Demirhan, Abdullah; Tekelioğlu, Ümit Yaşar; Yıldız, İsa; Korkmaz, Tanzer; Bilgi, Murat; Akkaya, Akcan; Koçakoğlu, HasanAtropa Belladonna (güzel avrat otu) ile gelişen zehirlenmeler antikolinerjik sendroma yol açabilmektedir. Bitkinin yüksek miktarda alınması letarji, koma ve hatta ölümle sonuçlanabilen ciddi klinik tabloya neden olabiir. Bu olgu sunumunda ülkemizde güzel avrat otu olarak bilinen bitkinin meyvesinin bol miktarda yenmesi sonucu gelişen ciddi antikolinerjik sendromu literatür eşliğinde paylaşmayı amaçladık.Öğe Atropa belladonna and associated anticholinergic toxic syndrome: a case report(Univ Udayana, 2017) Karagöz, İbrahim; Bilgi, Murat; Boduç, Elif; Pehlivan, Murat; Solmaz, KübraAtropa belladonna causes poisoning by its anticholinergic effects. Excessive ingestion of this plant may cause peripheral anticholinergic effects, and moreover, a more severe clinical picture can be seen due to its central effects which can result in lethargy, coma or even death. In this article, we aimed to present a case with Atropa belladonna intoxication and to emphasize that Atropa belladonna poisoning should be kept in mind in cases with anticholinergic findings.Öğe Atropa bellodonna fruit (Deadly Nightshade) related anticholinergic toxic syndrome: A case report(2013) Demirhan, Abdullah; Tekelio?lu, Ümit Yaşar; Yildiz, Isa; Korkmaz, Tanzer; Bilgi, Murat; Akkaya, Akcan; Koço?lu, HasanAtropa Belladonna related poisoning may lead to anticholinergic syndrome. Ingestion of high amounts of the plant may cause lethargy, coma, and even a serious clinical picture that could lead to death. In this case report, we aim to share a case of anticholinergic syndrome that developed after ingestion of the fruit called "Deadly Nightshade" in our country. © 2013 by Turkish Anaesthesiology and Intensive Care Society.Öğe Bilateral orofasiyal yarıklı bir infantın anestezi yönetimi (Tessier Tip 3): Olgu sunumu(2014) Demirhan, Abdullah; Akkaya, Akcan; Tekelioğlu, Ümit Yaşar; Karabekmez, Furkan Erol; Bilgi, Murat; Yıldız, İsa; Koçoğlu, HasanTessier yüz yarıkları çok nadir görülmekte olup konjenital olarak birçok anomaliyi de içinde barındırmaktadır. Özelikle Tessier tip 3 de bulunan oblik yüz yarığı, yarık dudak ve damak bu hastaların havayolu yönetimini oldukça güçleştirmektedir. Uygulanacak olan anestezisi için multidisipliner bir yaklaşım gerekmektedir. Bu olguda Tessier tip 3 yüz yarıklı bir hastanın anestezi uygulaması ve anestezi yönetimi tartışılmıştır.Öğe Colostomy with transversus abdominis plane block(Aves, 2015) Tekelioğlu, Ümit Yaşar; Demirhan, Abdullah; Şit, Mustafa; Kurt, Adem Deniz; Bilgi, Murat; Koçoğlu, HasanTransversus abdominis plane (TAP) block is one of the abdominal field block. The TAP block is used for both anaesthetic management and post-operative pain therapy in lower abdominal surgery. TAP block is a procedure in which local anaesthetic agents are applied to the anatomic neurofacial space between the internal oblique and the transversus abdominis muscle. TAP block is a good method for post-operative pain control as well as allows for short operations involving the abdominal area. In this article, a case of colostomy under TAP block is presented.Öğe Comparison of analgesic effects of pure bupivacaine and morphine added as bupivacaine adjuvant in USG guided adductor canal block following total knee arthroplasty(2020) Türkoğlu, Kübra; Yıldız, İsa; Özturan, Kutay Engin; Işık, Cengiz; Karagoz, İbrahim; Yoldaş, Hamit; Bilgi, MuratObjectives: Total knee arthroplasty (TKA) is an operation that causes severe postoperative pain. Adductor canal block (ACB) is separated from the other peripheral blocks as a method that can provide analgesia by sensory blockade only. The aim of this study was to compare the analgesic effect of morphine-bupivacaine with pure bupivacaine in USGguided ACB after TKA. Methods: Sixty patients aged between 40-80 years with ASA I-III physical status who were scheduled for TKA surgery in our hospital were included in this prospective randomized study. Patients were randomly divided into two groups as Group BM (bupivacaine+morphine) and Group B (bupivacaine) by closed envelope method, and then the groups were compared with each other. Results: In Group BM, compared to Group B, there was a significant decrease in visual analogue scale (VAS) values during rest and movement at 8th hour, 12-24 hours time zone analgesic consumption and additional analgesia usage. Conclusion: We conclude that the morphine added to bupivacaine in the adductor canal block reduces the VAS value at 8th hour and analgesic consumption.Öğe Comparison of cerebral effects of thiopental and propofol infusion in traumatic brain injured rats(2022) Kiliccioğlu, Yıldıray; Yildiz, Isa; Yoldaş, Hamit; Karagoz, Ibrahim; Tekçe, Buket Kin; Çetinkaya, Ayhan; Bilgi, MuratObjective: Head trauma is a lethal, disabling, and pathological condition requiring long-term treatment and care. Thiopental and propofol infusions are frequently used for sedation in the intensive care unit (ICU). However, we do not have clear data on whether they are neuroprotective or neurotoxic. We aimed to compare the early cerebral effects of propofol and thiopental, which are used for sedation in acute head trauma. Methods: A total of 30 rats were included in this experimental study, and the animals were randomly divided into three groups; 5 ml/kg/h 0.9% dose NaCl infusion was given in the control group, 30 mg/kg/h dose propofol infusion was given in the propofol group, and 140 mcg/kg/h dose of thiopental infusion was given in the thiopental group. Blood samples were taken 4 hours after infusion. A craniotomy was performed, the brain was removed, and it was placed in 10% neutral formalin for histological examination. The materials were examined biochemically and histologically and then compared between the groups. Results: The S100B value between the groups was significantly lower in the thiopental group than in the control group (p=0.018). Tau protein levels were significantly lower in the propofol group than in the control group (p=0.07). In histological examinations, the number of apoptotic cells in the propofol and thiopental groups were significantly lower than in the control group (p=0.02). There was no significant difference between the propofol and thiopental groups in apoptotic cell numbers (p=0.3). Conclusion: Our study demonstrated that thiopental and propofol infusions following a head trauma reduced apoptotic cell death and caused a decrease in trauma markers.Öğe Comparison of effects of low and high flow desflurane anaesthesia on hemogram parameters(2019) Yoldaş, Hamit; Karagoz, İbrahim; Ekici, Mustafa Ayhan; Eş, Abdulhamit; Yıldız, İsa; Demirhan, Abdullah; Bilgi, MuratObjectives: To compare the effects of low and high flow desflurane anaesthesia on hemogram parameters in lower abdominal surgeries. Methods: Sixty female patients who underwent lower abdominal surgery under general anaesthetic were included in this prospective study. Patients were randomly divided into two groups, as Group I (low flow) and Group II (high flow), and then compared with each other according to their demographic features and hemogram parameters. Results: Groups were statistically similar, and there were no significant differences in terms of demographic data between the groups (p>0.05). The comparisons of hemogram parameters within the groups showed that there were significant differences in plateletcrit, platelet-lymphocyte ratio and neutrophil-lymphocyte ratio values in Group I (p<0.05). The comparisons of hemogram parameters within Group II showed a statistically significance in plateletcrit and platelet-lymphocyte ratio values. A statistically significant difference was found for red cell distribution width, neutrophil- lymphocyte ratio, platelet-lymphocyte ratio and plateletcrit values between groups for the pre-operative and post-operative values of hemogram parameters (p<0.05). Conclusion: Our study showed that the administration of low flow anaesthesia led to a positive effect on the inflammatory response by lowering neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and red cell distribution width values, in comparison to high flow anaesthesia.Öğe Comparison of the effects of bispectral index-controlled use of remifentanil on propofol consumption and patient comfort in patients undergoing colonoscopy(Univ Catholique Louvain-Ucl, 2015) Bilgi, Murat; Tekelioğlu, Ümit Yaşar; Şit, Mustafa; Demirhan, Abdullah; Akkaya, Akcan; Yıldız, İsa; Koçoğlu, HasanBackground and study aims : In endoscopic procedures, propofol can be safely administered either alone or in conjunction with remifentanil. The aim of the study is to compare the effects of the administration of propofol alone and the administration of remifentanil in addition to propofol on patient and endoscopist satisfaction, preoperative hemodynamic response, and propofol consumption. Materials and methods : A totally 60 patients were enrolled in the study. Propofol group (Group 1) : A 0.4-mg/kg propofol bolus and 1 mg/kg/h maintenance infusion of propofol until a bispectral Index-value of 70-75 was achieved. Propofol + remifentanil group (Group 2) received a 0.4 mg/kg propofol bolus dose and maintained with a 0.5 mg/kg/h infusion of propofol + 0.2 mcg/kg/min infusion of remifentanil. The infusion dose of remifentanil was maintained, and the propofol infusion dose was titrated until a BIS value of 7075 was achieved. Results : In Group 1 (colonoscopic intervention 1 and 5 min) and Group 2 (colonoscopic intervention 10 min.), main blood pressure (MBP) value has a significant decrease. Hypotension occurred in 6 patients in group 1, while 12 patients in group 2. No significant difference was found between the Patient's endoscopist' satisfaction, MBP and heart rate. Propofol consumption was greater in group 1 than in group 2. When the Ramsay sedation levels of Group 1 and Group 2 were compared, a statistically significant difference was observed. Conclusion : The addition of remifentanil to propofol may be an alternative to the use of alone propofol for sedation in colonoscopic interventions.Öğe A comparison of the effects of lidocaine or magnesium sulfate on hemodynamic response and QT dispersion related with intubation in patients with hypertension(ARSMB-KVBMG, 2014) Kıracı, Gökhan; Demirhan, Abdullah; Tekelioğlu, Ümit Yaşar; Akkaya, Akcan; Bilgi, Murat; Erdem, Alim; Bayır, Hakan; Koçoğlu, Hasan; Yıldız, İsaBackground: The aim of this study was to investigate the effect of magnesium administered before induction on the hemodynamic response and QT dispersion (QTd) related with intubation in hypertensive patients and to compare it with lidocaine.Methods: Patients with essential hypertension who were under ? 65 years old, scheduled for elective surgery with a Mallampati score of I-II were included in the study. Patients were randomly divided into three groups; group M (n=20) received magnesium sulfate, group L was prescribed lidocaine, and group C (control group) received saline. Standard 12-lead ECG readings were taken before the induction of anesthesia and at the first and fifth minutes following intubation.Results: There were no statistically significant differences between the groups in terms of age, sex and demographic characteristics. There was no significant difference in the QT interval values before induction and 5 minutes after intubation in all groups. In group M, QTd values were significantly lower at the first and fifth minutes than before induction. There were no statistically significant differences in QTd values at different times in group L and group C.Conclusion: QTd is not increased during tracheal intubation in hypertensive patients so there is no need for magnesium sulfate for these patients. But as QTd has been shown to increase during tracheal intubation for coronary artery disease patients, magnesium sulfate might be useful for those patients although future studies are required to confirm this statement.Öğe Comparison of the effects of magnesium sulphate and dexmedetomidine on surgical vision quality in endoscopic sinus surgery : randomized clinical study(Elsevier Science Inc, 2014) Akkaya, Akcan; Tekelioğlu, Ümit Yaşar; Demirhan, Abdullah; Bilgi, Murat; Yıldız, İsa; Apuhan, Tayfun; Koçoğlu, HasanBackground and objectives: Even a small amount of bleeding during endoscopic sinus surgery can corrupt the endoscopic field and complicate the procedure. Various techniques, including induced hypotension, can minimize bleeding during endoscopic sinus surgery. The aim of this study was to compare the surgical vision quality, haemodynamic parameters, postoperative pain, and other effects of magnesium, a hypotensive agent, with that of dexmedetomidine, which was initially developed for short-term sedation in the intensive care unit but also is an alpha 2 agonist sedative. Method: 60 patients between the ages of 18 and 45 years were divided into either the magnesium group (Group M) or the dexmedetomidine group (Group D). In Group M, magnesium sulphate was given at a pre-induction loading dose of 50 mg kg(-1) over 10 min and maintained at 15 mg kg(-1) h(-1); in Group D, dexmedetomidine was given at 1 mcg kg(-1) 10 min before induction and maintained at 0.6 mcg kg(-1) h(-1). Intraoperatively, the haemodynamic and respiratory parameters and 6-point intraoperative surgical field evaluation scale were recorded. During the postoperative period, an 11-point numerical pain scale, the Ramsay sedation scale, the nausea/vomiting scale, the adverse effects profile, and itching parameters were noted. Results: Group D showed a significant decrease in intraoperative surgical field evaluation scale scale score and heart rate. The average operation time was 50 min, and Group M had a higher number of prolonged surgeries. No significant difference was found in the other parameters. Conclusions: Due to its reduction of bleeding and heart rate in endoscopic sinus surgery and its positive impacts on the duration of surgery, we consider dexmedetomidine to be a good alternative to magnesium. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.Öğe Dexamethasone added to levobupivacaine in ultrasound-guided tranversus abdominis plain block increased the duration of postoperative analgesia after caesarean section : a randomized, double blind, controlled trial(Verduci Publisher, 2014) Akkaya, Akcan; Yıldız, İsa; Tekelioğlu, Ümit Yaşar; Demirhan, Abdullah; Bayır, Hakan; Özlü, Tülay; Bilgi, MuratOBJECTIVES: When added to local anaesthetics, dexamethasone can prolong the duration of peripheral blocks. Dexamethasone has a long and efficient glucocorticoid structure and presents anti-inflammatory properties. The aim of this study was to determine the effect of dexamethasone on the block duration added to levobupivacaine used for transversus abdominis block (TAP) applied to patients who underwent caesarean section. PATIENTS AND METHODS: Forty-two patients with spinal anaesthesia in an American Society of Anesthesiologists (ASA) I-II risk group were included in the study and divided into two groups. Bilateral 30 ml 0.25% levobupivacaine and 2 ml 0.9% NaCl for the levobupivacaine group and bilateral 30 ml 0.25% levobupivacaine and 2 ml dexamethasone (8 mg) for the dexamethasone group were administered in a TAP block performed with ultrasonography. The time need for the first analgesic in the postoperative period was recorded. The numeric evaluation scale, and the total additional analgesic amounts were recorded. RESULTS: The time before the administration of the first additional analgesic dose was prolonged significantly in the dexamethasone group compared to the levobupivacaine group (p = 0.004). The pain scores were lower in the dexamethasone group for superficial pain. A significant difference for the dexamethasone group was observed in the evaluation of deep pain. The total consumption of tramadol was significantly lower in the dexamethasone group (p = 0.001). CONCLUSIONS: The utilization of dexamethasone, which has a prolonging effect on the transversus abdominis plane block, may be an alternative to epidural opioid analgesia in caesarean section. We observed that dexamethasone added to levobupivacaine in a TAP block applied for analgesia following a caesarean section procedure prolonged the time required for analgesia.Öğe Dexmedetomidine or midazolam in combination with propofol for sedation in endoscopic retrograde cholangiopancreatography: a randomized double blind prospective study(Termedia Publishing House Ltd, 2020) Koruk, Senem; Koruk, İrfan; Arslan, Ayse Mızrak; Bilgi, Murat; Gül, Rauf; Bozgeyik, ŞemsettinIntroduction: Interventional endoscopic procedures, such as endoscopic retrograde cholangiopancreatography (ERCP), often require sedation during the procedure. The most commonly used drugs for this purpose are midazolam and propofol, which are used as sedative and hypnotic agents with minimal analgesic potential. Aim: To compare the analgesic sedative effects of midazolam-propofol and dexmedetomidine-propofol combinations and their influence on hemodynamic and respiratory variables in patients undergoing ERCP. Material and methods: Forty adult patients aged 20-78 and undergoing ERCP were randomized to two groups. Patients were premedicated with midazolam (0.05 mg/kg 10 min before the procedure) in group M and with dexmedetomidine (1 mu g/kg for 10 min) in group D. Propofol was used for maintenance. The sedation level was monitored using the bispectral index (BIS) to maintain a score between 70 and 80. Hemodynamic and respiratory variables, recovery time and adverse events were recorded. Results: The hemodynamic and respiratory variables were similar in both groups. Total propofol consumption was significantly lower in the dexmedetomidine group (208.5 +/- 80.0 vs. 154.5 +/- 66.7 mg; p = 0.011). The recovery period was shorter in group D (time to achieve the Aldrete score 9 was 9.4 +/- 2.1 vs. 6.6 +/- 1.1 min; p < 0.001). Changes in hemodynamic and respiratory variables and adverse events were not different between the two groups. Conclusions: We found a shorter recovery time and comparable sedative and adverse effects with the dexmedetomidine-propofol combination compared with the midazolam-propofol combination. Dexmedetomidine in combination with propofol may be a safe and useful alternative for sedation for ERCP patients.Öğe An easy and reliable way to prevent electrocardiographic deteriorations of patients undergoing off-pump coronary artery bypass surgery: Preoperative anxiolytic treatment(Soc Brasil Cirurgia Cardiovasc, 2019) Demirhan, Abdullah; Velioğlu, Yusuf; Yoldaş, Hamit; Karagöz, İbrahim; Coşgun, Mehmet; Çalışkan, Duygu; Yıldız, İsa; Erdem, Kemalettin; Bilgi, MuratObjective: To investigate the effects of preoperative anxiety relieving on electrophysiological changes in patients undergoing off-pump coronary artery bypass surgery. Methods: A total of 61 patients at ASA III risk group in the age range of 18-65 years were enrolled in the present study. Patients were randomly divided into two groups. Group S (Sedation group) was administered 0.04 mg/kg lorazepam per os (PO) twice before the operation. Group C (control group) was not administered with any anxiolytic premedication. State Trait Anxiety Inventory (STAI-I) and Beck Anxiety Inventory (BAI) were used to evaluate the level of anxiety. Electrocardiography (ECG), pulse oximeter and standard monitoring were performed for each patient. QT and P dispersions in each derivation of all ECGs were calculated. Results: Preoperative STAI-I scores were significantly lower in sedation group compared to the controls. Mean values of QT dispersion measured before induction, at the 1st minute of induction, 30th second of intubation and 4th minute of intubation in sedation group were significantly reduced compared to controls (P=0.024; P=0.027; P=0.001; P=0.033, respectively). The mean values of P dispersion measured before induction, at the 3rd minute of induction, 30th second of intubation and 4th minute of intubation in sedation group were significantly reduced compared to controls (P=0.001; P=0.020; P=0.023; P=0.005, respectively). Conclusion: Elevated anxiety levels in patients undergoing coronary bypass surgery have a negative effect through prolonged QT and P-wave dispersion times. Anxiolytic treatment before surgery may be useful to prevent ventricular and atrial arrhythmias and associated complications through decreasing the QT and P-wave dispersion duration.Öğe The effect of desflurane on postoperative olfactory memory(Verduci Publisher, 2016) Yıldız, İsa; Bayır, Hakan; Sağlam, İbrahim; Şereflican, Murat; Bilgi, Murat; Yurttaş, Veysel; Demirhan, Abdullah; Koçoğlu, HasanOBJECTIVE: In this study, we investigated the effects of desflurane 6%, on olfactory memory. PATIENTS AND METHODS: This is a prospective clinical study performed with 40 patients aged 18-60 who had elective surgery and American Society of Anesthesiologists (ASA) physical status I-III. The Brief Smell Identification Test (BSIT) was used for evaluating patients' olfactory memories before and after the surgery. Patients received standard general anesthesia protocol and routine monitoring. For induction, 1.5 mg/kg of fentanyl, 2 mg/kg of propofol, and 0.5 mg/kg of rocuronium bromide were administered. Anesthesia was maintained with the inhalational of anesthetic desflurane (6%). The scores are recorded 30 minutes before the surgery and when the Aldrete Recovery Score reached 10 in the postoperative period. Preoperative and postoperative results were compared and p-values <0.05 were considered statistically significant. RESULTS: The patients' mean age was 41.1 +/- 12.0. Preoperative total correct answer rate to odorous substances was 92.7%, and postoperative rate was 92.1%. Percentage of the odor substance identification by the patients revealed no statistically significant difference when pre and post-operative rates have been compared (p-value > 0.05). CONCLUSIONS: We have observed for the first time in the literature that general anesthesia using desflurane (6%) did not affect short-term olfactory memory. Further studies will be necessary to confirm our findings with larger sample size.Öğe Effect of perioperative inadvertent hypothermia on the ECG parameters in patients undergoing transurethral resection(Verduci Publisher, 2016) Bayır, Hakan; Yıldız, İsa; Erdem, Fatma; Tekelioğlu, Ümit Yaşar; Özyalvaçlı, Mehmet Emin; Bilgi, MuratOBJECTIVE: Perioperative inadvertent hypothermia (PIH) (core body temperature to < 36 degrees C) is a common event during surgery. PIH may result from multiple factors. Elderly urology patients are at greater risk than other patients for hypothermia. PIH may cause adverse postoperative cardiac clinical manifestations. Our study aimed to determine the effects of postoperative alteration of core body temperature on the ECG parameters in patients undergoing transurethral resection. PATIENTS AND METHODS: Fifty-nine patients, 40-83 years of age, who were scheduled for elective Transurethral Resection Prostate and/or Bladder (TUR-P and/or TUR-B) were enrolled in the study. Patients with operation times more than 30 minutes were included. Core temperatures were measured and standard 12-lead ECG readings were taken before surgery and immediately upon arrival in the postanesthesia care unit. RESULTS: 59 patients were included this study. Prevalence of PIH (< 36 degrees C) was (57.6%). The postoperative temperature was found to be significantly lower than the preoperative of all patients (preop 36.46 +/- 0.39; postop 35.68 +/- 0.59, paired sample t-test, p<0.001). Also in all patients, postoperative QTc dispersions were found to be significantly longer than the preoperative QTc dispersions (preop 59.66 +/- 32.69; postop 74.57 +/- 37.47 ms, p<0.05). When we divided the patients; hypothermic and normothermic, postoperative QTc dispersions were significantly different between two groups (68.23 +/- 33.43 ms, and 83.20 +/- 41.50 ms; p=0.009). CONCLUSIONS: The prevalence of inadvertent intraoperative hypothermia in patients undergoing transurethral resection is relatively high. QTc dispersion of mild hypothermic patients was significantly longer than normothermic patients'.Öğe Effect of pregabalin and dexamethasone addition to multimodal analgesia on postoperative analgesia following rhinoplasty surgery(Springer, 2013) Demirhan, Abdullah; Tekelioğlu, Ümit Yaşar; Akkaya, Akcan; Bilgi, Murat; Apuhan, Tayfun; Karabekmez, Furkan Erol; Bayır, Hakan; Kurt, Adem Deniz; Koçoğlu, HasanWe investigated the effect of a combination of pregabalin and dexamethasone, when used as part of a multimodal analgesic regimen, on pain control after rhinoplasty operations. Sixty patients were enrolled in this study. They were randomly assigned into three groups: Group C (placebo + placebo), Group P (pregabalin + placebo), and Group PD (pregabalin + dexamethasone). Patients received either pregabalin 300 mg orally 1 h before surgery, dexamethasone 8 mg intravenously during induction, or placebo according to their allocation. Postoperative pain was treated with intravenous patient-controlled analgesia (tramadol, 20-mg bolus dose, 45-min lockout time). The numeric rating scale (NRS), side effects, and consumption of tramadol, pethidine, and ondansetron were assessed. The median NRS scores at 0, 1, and 6 h after surgery were significantly higher in Group C than in Group PD (p < 0.001 for all). The 24-h consumption of tramadol and pethidine was significantly reduced in Groups P and PD compared to Group C (p < 0.01 and p < 0.01). The total tramadol consumption was decreased by 54.5 % in Group P and 81.9 % in Group PD compared to Group C (p < 0.001 for both). The incidence of nausea was higher in Group C than in Groups P and PD between the postoperative 0-2 and 0-24-h periods (p < 0.05 for both). The frequency of blurred vision was significantly higher in Groups P and PD than in Group C within the 0-24-h period (p < 0.05 for both). We found that the addition of a single dose of pregabalin and dexamethasone to multimodal analgesia in rhinoplasty surgeries provided efficient analgesia and thus decreased opioid consumption. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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