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Öğe Effect of acute and chronic ellagic acid administration on penicillin-induced epileptiform activity in rats(Wiley, 2017) Beyazçiçek, Ersin; Ankaralı, Seyit; Beyazçiçek, Özge; Ankaralı, Handan; Çetinkaya, Ayhan[No Abstract Available]Öğe The effect of galanin and exercise on depression in rats(Wiley, 2017) Beyazçiçek, Ersin; Mermerci, Asuman; Özmerdivenli, Recep; Beyazçiçek, Özge; Orallar, Hayriye[No Abstract Available]Öğe Effect of initial Reactive Red 120 concentrations on the biomass production and dye uptake by Spirulina platensis(Parlar Scientific Publications (P S P), 2009) Çelekli, Abuzer; Yavuzatmaca, Mehmet; Beyazçiçek, Ersin; Bozkurt, HüseyinUptake of Reactive Red (RR) 120 and biomass production by Spirulina platensis in the Schlosser medium was followed at different initial dye concentrations (0, 15, 25, 50, 75 and 100 mg L(-1)) under 2.0 klux continuous illuminations. Initial dye concentrations and cultivation time significantly affected (p<0.01) biomass productions. It was observed that increment rate of biomass was especially achieved between 77 and 144 h at dye concentration range between 0.0-75 mg L(-1). However, remarkable increment rate was not observed at 100 mg L(-1) dye concentration. Change in initial dye concentrations from 15 to 100 mg L(-1) strongly affected (p<0.01) amount of the dye uptake (q(t)). Increasing initial dye concentrations from 15 to 1100 mg L(-1) increased (p<0.01) the equilibrium dye uptake (q(eq)) values from 8.08 to 18.31 mg g(-1). Tukey HSD test revealed that there was no significant difference (p>0.05) among q(eq) values at initial dye concentrations of 25, 50, and 75 mg L(-1). This cyanobacterium is able to withstand high concentrations of RR 120, which is to be important for waste-water treatment systems.Öğe The effect of rose oil on penicillin-induced epileptiform activity in rats: An electrophysiological study(2018) Ankaralı, Seyit; Beyazçiçek, Ersin; Kılınç, Erkan; Beyazçiçek, Özge; Özkan, Kayhan; Çetinkaya, AyhanObjective: Rose oil (from Rosa damascene) has several effects which are analgesic, antispasmodic, antioxidant and neuroprotective role. Its antiepileptic effect has not been yet studied enough. In the present study, it was aimed to investigate acute effects of rose oil on the epileptiform activity in penicillin-induced epilepsy model in rats. Methods: Forty-two male Wistar rats weighing 230 to 260 g were divided into six groups with seven rats in each group. Control (+Penicillin), RO alone, Diazepam, and different doses of Rose oil including 100, 500 and 1000 mg/kg. Rats were pretreated with different doses of RO 30 min prior to penicillin treatment. Electrocorticogram recordings were taken from each animal for 2 hours after penicillin treatment. Results: Only the dose of 100 mg/kg of rose oil reduced significantly epileptic spikewave frequency of epileptiform activity. However, comparing in terms of latency and spike-wave amplitude of epileptiform activity, there were no significant difference between the groups. Conclusions: In conclusion, acute administration of rose oil reduces spike-wave frequency of penicillin-induced epileptiform activity in rats. Therefore, these findings indicate that rose oil has antiepileptic effects.Öğe The effect of vortioxetine on penicillin-induced epileptiform activity in rats(Assoc Arquivos Neuro- Psiquiatria, 2019) Ögün, Muhammed Nur; Çetinkaya, Ayhan; Beyazçiçek, ErsinVortioxetine is a multimodal antidepressant agent that modulates 5-HT receptors and inhibits the serotonin transporter. It is indicated especially in cases of major depressive disorder related to cognitive dysfunction. There are many studies investigating the effects of antidepressants on the seizure threshold and short-term epileptic activity. However, the effect of vortioxetine on epileptic seizures is not exactly known. Our aim was to investigate the effects of vortioxetine on penicillin-induced epileptiform activity. Twenty-seven Wistar rats were divided into three groups: sham-control group, positive control group (diazepam), and vortioxetine group. After a penicillin-induced epilepsy model was formed in each of the three groups of animals, 0.1 ml of saline was administered to the control group, 0.1 ml (10 mg/kg) vortioxetine was administered in the vortioxetine group, and 0.1 mL (5 mg/kg) of diazepam was administered in the positive control group, intraperitoneally. The epileptic activity records were obtained for 120 minutes after the onset of seizure.There was no significant difference in spike wave activity between the vortioxetine and diazepam groups, whereas this was significantly reduced in the vortioxetine group compared with the controls. The administration of vortioxetine at a dose of 10 mg/kg immediately after the seizure induction significantly decreased the spike frequencies of epileptiform activity compared with the control group. No significant difference was found between the vortioxetine and positive controls.This study showed that vortioxetine reduces the number of acutely-induced epileptic discharges. Vortioxetine may be an important alternative for epileptic patients with major depressive disorder-related cognitive dysfunction.Öğe Effects of an extract of Salvia Miltiorrhiza on a penicillin-induced epilepsy model in rats(Springer, 2015) Bahadır, Anzel; Demir, Şerif; Orallar, Hayriye; Beyazçiçek, Ersin; Öner, FerideIn a penciling-induced epilepsy model, Wistar rats (16 males, 16 females) were i.p. administered with an extract of Salvia miltiorrhiza (SmE; total dose 50 mg/kg) once a day for 15 days. The rats were divided into four equal groups, control and SmE-treated for each sex. After the treatment period, an epilepsy model was produced by penicillin G injection (500 IU) into the motor cortex; the electrocorticogram (EcoG) was recorded for 120 min, and statistical analysis was performed. In the male control group with penicillin-induced epilepsy, the spike frequency was significantly (P < 0.05) higher than that in the female control group. The frequency values have been significantly (P < 0.01) increased within the observation period in the female SmE-treated group, while the respective values significantly (P < 0.05) decreased in the analogous male group. There were insignificant differences in the amplitude values and latency to onset of the spike/wave events between female/male SmE and female/male control groups (P > 0.05). Thus, the SmE exerts anticonvulsant effects in the male rat group, while its effect should be characterized as proconvulsant in the female group in the penicillin-induced epilepsy model. The difference (related to the presence of estrogen analogs in the SmE) is determined by dissimilar hormonal backgrounds in males and females. The SmE may be considered as the base for development of anticonvulsant drugs for clinical therapy of epilepsy in the future.Öğe The effects of nigella sativa extract and chronic exercise application on penicillin-induced epilepsy model in Mongolian gerbils(Wiley-Blackwell, 2016) Çetinkaya, Ayhan; Demir, Şerif; Orallar, Hayriye; Kayacan, Yıldırım; Beyazçiçek, ErsinAim: To evaluate the role of treadmill exercise on the oxidative stress in Mongolian gerbils with penicillin-induced epilepsy. Methods: This experimental study included 18 male Mongolian gerbils which were divided into three groups; sham-control group, penicillin group (500 units) and exercise + penicillin (500 units) group. Each animal group was composed of six Mongolian gerbils. The epileptiform activity was verified by electrocorticographic recordings. Results: The latency of the penicillin+exercise group was longer than the penicillin group, but this difference was not statistically significant. Following the penicillin administration, spike wave frequencies of epileptiform activity in the 10, 30, and 35 minutes were significantly lower in the penicillin+exercise group, compared with the penicillin group. There were generally significant decreases in the spike wave amplitude medians in the penicillin+exercise groups compared with the penicillin group in all time periods between 0 and 5 minutes. The serum superoxide dismutase, catalase and glutathione peroxidase levels increased in the penicillin+exercise group compared with those in the penicillin group. Conclusion: The results of present study indicate that regular exercise may contribute to the amelioration of epileptic activity by increasing the antioxidant effect. Keywords: Penicillin-induced epilepsy; treadmill exercise; oxidative stress; Mongolian gerbilsÖğe Evaluation of the effect of galanin and exercise on anxiety in rats by open field and elevated plus maze tests(Duzce University Medical School, 2018) Mermerci , Asuman; Özmerdivenli, Recep; Orallar, Hayriye; Beyazçiçek, Ersin; Sungur, Mehmet AliAim: Anxiety, known as worry, considered normal in everyday life, and also it is a type of behavior developed to protect the organism. The aim of this study is to investigate the effects of exogenous galanin given with exercise on anxiety. Material and Methods: In this study 96 adult male Wistar Albino rats were used. Rats were divided into 8 groups with twelve animals, and 4 of the groups were given regular exercise for 6 weeks. Galanin was administered intraperitoneally (IP) and intracerebroventricular (ICV) in half of the groups and saline was injected into the control group of each group with the same methods. At the end of the sixth week, open field and elevated plus maze tests were applied to the rats, and these tests recorded with the camera. The recordings of the both tests were analyzed, and total distance and speed values, the time spent in the open field test and the time spent in the closed arm of elevated plus maze were compared. Results: In the open field test were determined that in general, the total distance (p<0.001) and the speed increased (p<0.001) in rats injected with ICV compared to the rats injected with IP. There is no significant difference was detected in terms of exercise and galanin interaction. Also the total distance (p=0,032) and the speed increased (p=0,010) in rats injected with ICV compared to the rats injected with IP. In elevated plus maze test, exercise and galanin interaction were not found to be statistically significant, however the interaction between the injection pattern and the given substance was found to be significant in terms of time spent in the closed arm (p=0.020) and speed (p=0.032). Conclusion: Although it has been shown that central administration of galanin may have anxiolytic activity, this effect has not changed with exercise, and also it has been determined that exercise with galanin has no effect on this activity. © 2018, Duzce University Medical School. All rights reserved.Öğe Penicillin-induced epileptiform ECoG activity in gerbils: effects of physical exercise and a Diospyros kaki extract(Springer, 2016) Kayacan, Yıldırım; Bahadır, Anzel; Çetinkaya, Ayhan; Soytürk Orallar, Hayriye; Çakır, Serkan; Beyazçiçek, Ersin; Önal, Cansu; Yıldırım, ArzuMongolian gerbils (28 males) were divided into four groups, control (C), treadmill-exercised (Ex), treated with the extract of Diospyros kaki (Dk), and exercised plus treated with the Dk extract (Ex+Dk). Animals of the respective groups were running-exercised for 30 min per day during 8 weeks, and the Dk extract (dose 20 mg/kg) was given by gavage during five days per week within the same period. After the treatment and exercise period, an epilepsy model was produced by penicillin G injection (500 IU) into the left somatomotor cortex, and the electrocorticogram (ECoG) was recorded during 120 min. The mean frequency of spike/wave complexes was significantly smaller in the Ex and Ex+Dk groups from the 65th min of the observation period and, in the Dk group, from the 75th min than the respective value in the C group (P < 0.01, P < 0.05, and P < 0.01, respectively). The differences in the amplitude values and latency to onset of the spike/wave events among all groups did not reach the significance level (P > 0.05). Thus, both the running exercise and Dk extract applications inhibit penicillin-induced epileptiform activity by altering the spike/wave frequency or severity of seizures observed in ECoG recordings. Further studies are needed to determine the effects of physical activity of different intensities and forms and to analyze the active compounds in the Dk extract.
