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    Abelmoschus esculentus Seed Ethanol Extract Protects Against Lipopolysaccharide-Induced Lung Injury in Rats through Anti-Inflammatory Properties
    (Shaheed Beheshti University of Medical Sciences and Health Services, 2023) Tirink, Omer Faruk; Bekdas, Mervan; Cetinkaya, Ayhan; Duzcu, Selma Erdogan; Alısık, Murat; Yoldas, Meyri Arzu
    Background: Acute lung injury is respiratory failure due to various causes. Increased inflammatory and oxidative processes are recognized to play an essential role in the etiology of ARDS. Abelmoschus esculentus is an herbal product used to treat various diseases due to its anti-inflammatory and antioxidant effects. We aimed to investigate whether Abelmoschus esculentus has an effect on acute lung injury. Materials and Methods: In this experimental study, we used the ethanol extract of Abelmoschus esculentus seed. It divided forty male Wistar rats into five equal groups: 1) control, 2) Abelmoschus esculentus, 3) lipopolysaccharide, 4) lipopolysaccharide+Abelmoschus esculentus, and 5) lipopolysaccharide+ Abelmoschus esculentus +dexamethasone groups. Results: In the lipopolysaccharide group, native thiol, total thiol, IL-10, and IFN-? levels significantly changed. Abelmoschus esculentus was effective when used with dexamethasone in increasing native thiol and total thiol values (p=0.008 and p=0.004, respectively). On the other hand, when Abelmoschus esculentus was used alone, it significantly increased IL-10 levels and decreased IFN-? levels in the lipopolysaccharide group (p=0.025 and p<0.001, respectively). Additionally, improvements were noted in histological findings of alveolar congestion (p=0.006), intra-alveolar hemorrhage (p=0.006), and intra-alveolar macrophages (p=0.001). Conclusion: Abelmoschus esculentus, with its anti-inflammatory effect, may represent a new potential for treating acute lung injury. © 2023 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran.
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    Colchicine poisoning related rhabdomyolysis in a child
    (Aves, 2013) Demircioglu, Fatih; Kazanci, Elif; Edogan, Hakan; Bekdas, Mervan; Goksugur, Sevil
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    Plasma levels of neurogenic inflammation related neuropeptides in pediatric patients with community-acquired pneumonia and their potential diagnostic value in distinguishing viral and bacterial pneumonia
    (Springer, 2024) Bekdas, Mervan; Saygi, Bilgi; Kilinc, Yasemin Baranoglu; Kilinc, Erkan
    Neurogenic inflammation is involved in the development and progression of respiratory inflammatory diseases. However, its role in community-acquired pneumonia (CAP) remains unclear. We therefore aimed to investigate plasma levels of neurogenic inflammation-related neuropeptides, calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY), and procalcitonin (PCT) in pediatric patients with CAP and to assess their diagnostic value in viral and bacterial/mixed pneumonia. A total of 124 pediatric patients with CAP (1 month-18 years old) and 56 healthy children of similar ages were prospectively enrolled. The patients were classified as viral (n = 99) and bacterial/mixed (n = 25) pneumonia. Plasma levels of the peptides were quantified by ELISA. ROC analysis was performed to evaluate possible diagnostic value of the peptides. While plasma levels of CGRP, VIP and PCT were significantly higher in patients with CAP than in the control group, respectively, NPY levels were significantly lower. Moreover, plasma levels of all neuropeptides and PCT were significantly higher in bacterial pneumonia patients compared to viral pneumonia patients. ROC analysis revealed that CGRP, SP and NPY had a diagnostic value in distinguishing viral and bacterial/mixed pneumonia.Conclusions: Our findings suggest that these neuropeptides may be implicated in pediatric CAP. CGRP, SP and NPY together may be a promising candidate in distinguishing viral and bacterial/mixed pneumonia, however, for this, further studies are needed.What is Known:center dot Neurogenic inflammation contributes to the development and progression of respiratory inflammatory diseases such as chronic obstructive pulmonary disease and bronchial asthma.What is New:center dot Plasma levels of neurogenic inflammation related neuropeptides calcitonin gene-related peptide, substance P, vasoactive intestinal peptide and neuropeptide Y are changed in pediatric community-acquired pneumonia. Calcitonin gene-related peptide, substance P and neuropeptide Y are promising candidates in distinguishing viral and bacterial/mixed pneumonia.