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Öğe Causes of hypouricemia among outpatients(American Society for Clinical Pathology, 2008) Buğdaycı, Güler; Balaban, Hatice Yasemin; Şahin, ÖzlemBackground: The aim of this study was no examine the ratio and underlying causes of hypouricemia in patients visiting our outpatient clinics. The assoication between hypouricemia and uricosuria and other renal tubular defects was also studied. Methods: Serum uric acid levels were determined by uricase methods in 18,330 serum samples. Hypouricemia was defined as a serum uric acid level less than 2.0 mg/dL. Fractional excretion of uric acid (FEUA) higher than 10% was considered as pathological uricousuria. Results: The frequency of hypouricemia in our patient population was 0.51% (94/18,330). Moreover, using univariate analysis, hypouricemia was associated with age, gender, diet, drugs, and tea and coffee consumption. Multivariate analysis revealed that FEUA, drugs and tea consumption were associated with hypouricemia. Conclusion: Hypouricemia is a relatively uncommon finding among our patients and when it occurs it is frequently caused by inappropriate uricosuria.Öğe The difference in cyclin D1, HSP 105, EGFR, RB, and MSH2 gene expressions in chronic gastritis with and without helicobacter pylori infection(Springer, 2007) Boran, Çetin; Balaban, Hatice Yasemin; Yılmaz, FahriÖğe Dipeptidyl peptidase IV (DDP IV) in NASH patients(Elsevier Espana, 2007) Balaban, Hatice Yasemin; Korkusuz, Petek; Şimşek, Halis; Gökcan, Hale; Gedikoğlu, GökhanObjective(s): Non-alcoholic steatohepatitis (NASH) is a chronic liver disease with unknown etiology. The insulin resistance, immune mechanisms and oxidative stress are the main factors in its pathogenesis. Dipeptidyl peptidase IV (DPPIV) or CD26 is a protein with endocrine and immune functions. This study aimed to elicudate the changes related to DPPIV in NASH patients. Methods: Serum and urinary DPPIV activities were measured in 31 NASH patients and 17 healthy controls. The liver biopsies of 29 patients were immunolabeled for CD26. Results: The mean age of patients were 46 +/- 11 years and 14 (45%) of them were female. The serum DPPIV activity was higher in patients (57.3 +/- 7.8 U/L) than controls (43.6 +/- 10.6 U/L) (p < 0.0001), and correlated with the histopathological grade (p = 0.038, r = 0.373) and hepatosteatosis (p = 0.018, r = 0.423) but not with stage (p = 0.286), class (p = 0.286) or CD26 staining (p = 0.743). The urinary DPPIV activity was similar in patients (1.52 +/- 0.94 U/mmol creatinine) and controls (1.37 +/- 0.68 U/mmol creatinine) (p = 0.861). Three acinar zones of liver had equal CD26 expression (p = 0.076). The intensity of CD26 immunostaining was correlated with histopathological grade (p = 0.001) and hepatosteatosis (p = 0.003) but no correlation with stage or class could be detected (p = 0.610 and 0.956, respectively). In Conclusions: The serum DPPIV activity and the staining intensity of CD26 in liver are correlated with histopathologic grade of NASH and hepatosteatosis. DPPIV can be proposed as a novel candidate with several potential functions in NASH pathogenesis.Öğe Do gene expressions differ between gastritis with and without helicobacter pylori?(Ortadogu Ad Pres & Publ Co, 2010) Boran, Çetin; Balaban, Hatice Yasemin; Yılmaz, FahriObjective: Helicobacter pylori infection is a well-defined risk factor for the development of gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. However, mechanisms of carcinogenesis in Helicobacter gastritis need to be elucidated. We aimed in this study to determine the immunohistochemical expressions of some cancer-associated genes, and to show differences between Helicobacter gastritis and Helicobacter-negative gastritis. Material and Methods: Sixty-three endoscopic biopsy samples were selected. The samples comprised of normal gastric mucosa (20 samples), Helicobacter gastritis (22 samples), and Helicobacter-negative gastritis (21 samples). Paraffin sections of samples were processed immunohistochemically with some suppressor genes (Rb, p53), protooncogenes (EGFR, cyclin D1), and a heat shock protein, HSP 105. The gene expressions in both crypt epithelia and lymphoid infiltrate were evaluated separately. Results: In epithelia; expressions of cyclin DI, p53, HSP 105, and EGFR were higher in Helicobacter-negative gastritis than in Helicobacter gastritis (p< 0.0001). Immune expression of HSP 105 in Helicobacter gastritis was lower than in control group (p= 0.008) as well as in Helicobacter-negative gastritis. However, expression of Rb was higher in Helicobacter gastritis than in Helicobacter-negative gastritis (p= 0.034). In lymphoid infiltrate; immune reactions for p53 and cyclin D1 were negative in all samples. Expressions of Rb, EGFR, and HSP 105 in lymphoid infiltrate were similar to expressions in epithelia for all groups. Conclusion: We can suggest that development of gastric cancer has a different pathway in Helicobacter gastritis when compared to the one Helicobacter-negative gastritis. In addition, decrease of heat shock proteins in Helicobacter gastritis may lead to sensitivity of crypt epithelia and lymphoid infiltrate for carcinogenic mutations.Öğe Hepatocellular carcinoma and cholangiocarcinoma are associated with high serum levels of hepatocyte growth factor [7](2006) Balaban, Hatice Yasemin; Us, Durdal; Hasçelik, Gülşen; Bayraktar, Yusuf[No abstract available]Öğe HFE mutations analysis of Turkish patients with nonalcoholic steatohepatitis(Springer, 2006) Şimşek, Halis; Balaban, Hatice Yasemin; Sümer, Hale; Yılmaz, Engin; Tatar, GoncaChronic liver disease is a well-known cause of secondary iron overloading. Iron overloading of liver is associated with severity of fibrosis and increased risk for hepatocellular carcinoma as well as resistance to antiviral treatment. Iron content of liver in nonalcoholic steatohepatitis (NASH) patients is important because NASH causes chronic hepatitis, and there is also a debate on the role of iron for the pathogenesis of NASH.Öğe Mapping of microsatellite instability in endoscopic normal colon(Mary Ann Liebert, Inc, 2012) Tuğ, Esra; Balaban, Hatice Yasemin; Şahin, Ebru KaplanGenomic instability in colorectal cancer (CRC) occurs as either microsatellite instability (MSI) or chromosomal instability. The present study was aimed at examining the MSI for the MLH1 and MSH2 genes in normal colon and polyps, if detected. Four segments of the colon were sampled in 102 subjects during colonoscopy. DNA samples were analyzed for the MSI status according to the Bethesda consensus panel. Family history of any type of cancer or for colon cancer was present in 44.8% and 9.4% of the individuals, respectively. Forty-eight percent of individuals were microsatellite stable for all five markers at all locations, 20% had low MSI status (MSI-L), and 32% had high MSI status (MSI-H). The frequencies of MSI markers differed significantly from each other (p = 0.003). The most frequent positive marker was D17S250. This is the first study which revealed that MSI is present in endoscopically normal-looking colon of normal individuals and, more frequently, in individuals with family histories of CRC. The detection of very early-stage CRC is possible by MSI analysis of DNA mismatch repair genes in colon tissues. This study has revealed crucial information for the use of molecular tests in CRC screening, such as high frequencies of MSI in endoscopically normal colon, which might cause false positivity.Öğe Metabolic syndrome, non-alcoholic steatohepatitis (NASH), and hepatocyte growth factor (HGF)(Fundacion Clinica Medica Sur, 2006) Balaban, Hatice Yasemin; Sumer, Hale; Şimsek, Halis; Us, Durdal; Tatar, GoncaBackground: Hepatocyte growth factor (HGF) is not only an antiapoptotic and antifibrotic factor of liver, but it is also an adipokine. Serum HGF levels are strongly associated with liver diseases, obesity, insulin resistance (IR), and metabolic syndrome (MS). Non-alcoholic steatohepatitis (NASH) is the hepatic component of MS. To the best of our knowledge, serum HGF levels in patients with NASH have not been previously studied. Our aim was to elucidate the correlation of HGF with the clinical and histopathological parameters of NASH. Methods: The study group consisted of 26 patients (13 men) who had clinical diagnoses of NASH and underwent liver biopsies. Controls were 13 volunteers (3 men) with negative viral autoimmune markers, and with normal levels of serum lipids and liver enzymes. Results: Among the NASH patients, 14 (54%) were overweight and 10 (39%) had grade I-II obesity. All the patients had class 3-4 non-alcoholic fatty liver disease (NAFLD) except for 2 who had class 2 disease. All of the patients had Child's class A liver disease, and MS was present in 5 (19%) patients and 8 (31%) patients had Homeostasis Model Assessment of Insulin Resistance (HOMA) > 3. Serum HGF levels were similar in NASH patients (1.24 ± 1.09 pg/mL) and controls (0.86 ± 0.22 pg/mL) (p = 0.21). The levels of serum HGF did not differ between the patients with or without MS (1.65 ± 1.48 pg/mL and 1.04 ± 0.80 pg/mL, respectively, p=0.65). HGF was not correlated with the laboratory or histopathological parameters. Conclusions: Serum HGF levels were higher in NASH patients than in the controls, although it was statistically insignificant and a correlation with MS could not be detected in this study.Öğe Multinodular leiomyoma of the esophagus with internodular hydropic degeneration and bulbous serosal protrusions similar to cotyledonoid uterine leiomyoma(Oxford Univ Press Inc, 2007) Boran, Çetin; Şengül, Neriman; Balaban, Hatice Yasemin; Gürel, SafiyeLeiomyoma is the most common benign tumor of the esophagus, and usually occurs as a solitary mass. We report a case of esophageal leiomyoma which shows multinodular growth pattern with bulbous serosal protrusions. The patient was a 26-year-old woman who had an esophageal ulcerated mass near the gastroesophageal junction. Clinical findings were consistent with carcinoma of the gastric cardia. Based on the clinical diagnosis, total gastrectomy with distal esophagectomy was performed. Histologic appearance of the resected specimen was consistent with leiomyoma which had a multinodular growth pattern.Öğe The preventive effect of low molecular weight heparin on CCL4-induced necrosis and apoptosis in rat liver(Elsevier Espana, 2010) Kükner, Aysel; Töre, Fatma; Fırat, Tülin; Terzi, E. Hakan; Öner, Hakan; Balaban, Hatice YaseminIntroduction Heparin having anti inflammatory and anti fibrotic properties may have therapeutic effect on liver injury The present study investigated the effect of low molecular weight heparin (Enoxaparin) on carbon tetrachloride (CCl4) induced hepatic necrosis and apoptosis in rats Material and methods Thirty male rats were divided into 5 groups Group I Control, Group II Olive oil dissolved CCl4 at dose of 1 mL/kg, ip, twice per week, Group III CCl4 and Enoxaparin at dose of 180 IU/kg, sc, daily, Group IV Enoxaparin, Group V Olive oil at dose of 1 mL, ip, twice per week The liver histology at the forth week was examined by haematoxylin eosin, Masson's trichrome, Toluidine blue and Periodic acid schiff stains Proliferative and apoptotic activities were assessed semi quantitatively by proliferating cell nuclear antigen (PCNA) and cas pase 3 immune staining and TUNEL method Semi quantitative values formulated by the equation HSCORE = Sigma P-i (1+1) including both distribution and intensity of staining Additionally, mdogen and a smooth muscle actin were labeled by immunohistochemistry Results CCl4 group had marked hepatocelluar necrosis around the vena centralis and increased inflammatory cells and mast cells Hepatocytes showed deposition of lipid droplets, decrease in glycogen, apoptosis, and picnotic or enlarged nuclei Enoxaparin reduced necrosis, apoptosis, and number of mast cells but had no effect on lipid droplets in hepatocytes HSCORE's of caspase 3 and PCNA were also significantly decreased by administration Conclusion Enoxaparin have beneficial effects against necrosis as well as apoptosis at the early stage of CCL4 induced liver injuryÖğe Serum hepatocyte growth factor in autoimmune and hepatitis B-associated liver diseases [2](2007) Balaban, Hatice Yasemin; Batman, Figen; Us, Durdal; Hasçelik, Gülsen; Bayraktar, Yusuf[No abstract available]Öğe Solitary lipomatous polyp or lipoma of gastrointestinal tract : 3 case reports(Springer, 2007) Yılmaz, Fahri; Balaban, Hatice Yasemin; Şengül, Neriman; Boran, ÇetinBackgrounds: Lipomas are most common, benign, mesenchymal neoplasm consisting of mature adipous tissue in their stroma. Most of the lipomas are located superficially or deeply in the skin, although, they also can be seen in gastrointestinal tract and are usally insidental findings in the submucosa or serosa of the small and large intestine. The solitary lipomas of colon have been reported to have a tendency to occur in the vicinity of ileocaecal valve or the ascending colon. Lipomatous poliposis is a rare “non-inherited gastrointestinal polyposis syndrome” associated with diffuse lipomatous polips of colon. Here we reported 2 cases of solitary colonic lipomatous polips at distal colon and a case of duodenal lipoma in order to emphasize the confusion in the terminology of lipoma and lipomatous polip.Öğe Wilson hastalığı: Olgu sunumu(2007) Tuğ, Esra; Balaban, Hatice YaseminWilson Hastalığı (WH), değişik derecelerde hepatik ve nöropsikiyatrik hastalığa yol açan, insan bakır metabolizmasının otozomal resesif geçişli kalıtsal bir hastalığıdır. Tahmin edilen prevalansı 1/30.000’dir. WH’da hepatik bakır transport proteinini kodlayan ve bakır metabolizmasında önemli rolü olan 13. kromozom üzerindeki (13q14.3-q21.1) ATP7B geni etkilenmiştir. Klinik bulguları komplekstir; tremor, disartri, psikiyatrik bozukluklar gibi nörolojik semptomlar yanı sıra akut karaciğer yetmezliği, kronik hepatit ya da karaciğer sirozu gelişir. Son 1 yıldır benign pozisyonel vertigo tanısı ile dış merkezde izlenen 27 yaşında bayan hasta devam eden baş dönmesi ve ellerde titreme şikayeti ile kliniğimize başvurdu. Hastanın kız ve erkek kardeşinin WH tanısı almış olduğu öğrenildi. Hastamızın yapılan muayenesinde karaciğer hastalığının periferik bulguları veya hepatosplenomegali mevcut değildi. Nörolojik muayenesi ise pozisyonal tremor dışında normaldi. Olgumuz nadir görülen ancak kötü prognozla seyreden WH için az rastlanır klinik özellikleri nedeniyle ve Türkiye’de sık görülen mutasyonların araştırılması gerekliliğinin vurgulanması amacıyla sunulmuştur.
