Yazar "Alpar, Sibel" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • Küçük Resim
    Öğe
    Breast metastasis in a male patient with nonsmall cell lung carcinoma
    (Lippincott Williams & Wilkins, 2007) Uçar, Nazire; Kurt, Özlem Kar; Alpar, Sibel; Örsel, Osman; Demirağ, Funda; Kurt, Bahar
  • Küçük Resim
    Öğe
    A case of squamous cell lung carcinoma with gastric metastasis
    (Lippincott Williams & Wilkins, 2006) Alpar, Sibel; Kurt, Özlem Kar; Uçar, Nazire; Örsel, Osman; Aydoğ, Gülden; Kurt, Bahar
    Lung cancer usually meta.stasizes the bone, adrenal glands, and brain. It is uncommon in the digestive system, particularly in the stomach. The most common sites of primary malignancy in patients who presented with gastric metastasis is malignant melanoma, breast cancer, and lung cancer.
  • Küçük Resim Yok
    Öğe
    CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients
    (SAP - Slovak Academic Press, spol. s.r.o., 2010) Ada, Ahmet Oğuz; Kunak, Celalettin Semih; Bilgen, Serdar; Alpar, Sibel; Gülhan, Meral
    Several polymorphisms in cytochrome P-450s (CYP)s and Glutathione S-transferases (GST)s have been reported to be associated with survival rates of patients with non-small cell lung cancer (NSCLC) but the studies in this regard are scarce and the results are contradictory. In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Ala114Val) and GSTT1 polymorphisms were determined in 138 patients with advanced NSCLC to evaluate their role in survival. Of the studied CYP and GST polymorphisms only GSTP1 exon 6 variant significantly altered (improved) the survival compared to wild type (p=0.036) with median survival of 22.2 months and 16.1 months, respectively. Multivariate analysis also revealed a significant reduction of adjusted hazard ratio of death associated only with the GSTP1 exon 6 variant genotype of 0.45 (95% confidence interval (95% CI), 0.23-0.89, p=0.022). These results show that the GSTP1 exon 6 variant genotype is associated with improved survival in the patients with advanced NSCLC.
  • Küçük Resim
    Öğe
    The diagnostic role of capnography in pulmonary embolism
    (W B Saunders Co-Elsevier Inc, 2010) Kurt, Özlem Kar; Alpar, Sibel; Sipit, Tuğrul; Güven, Selma Fırat; Ertürk, Hakan; Kurt, Emine Bahar
    The aim of this study was to evaluate the diagnostic contribution of alveolar dead space fraction (AVDSf) measured using capnography in patients admitted with suspected pulmonary embolism (PE). A total of 58 patients who were admitted to our hospital with suspected PE between October 2006 and January 2008 were included in this study. All patients were assessed using the Wells clinical score, capnography, computed tomographic pulmonary angiography, D-dimer measurement, lower-extremity venous Doppler ultrasonography, and V/Q scintigraphy. Forty patients (69%) had PE based on computed tomographic pulmonary angiography findings. The AVDSf value with the highest sensitivity and specificity, which was at the same time statistically significant, was 0.09. This value was consistent with the AVDSf value obtained using receiver operating characteristic analysis. In our study, the sensitivity of capnography was 70%, with a specificity of 61.1%, positive predictive value of 80%, and negative predictive value of 47.8%. The use of AVDSf in combination with any of the several scoring systems that evaluate clinical likelihood of PE and D-dimer levels resulted in higher sensitivity and specificity rates for the diagnosis of PE. (C) 2010 Elsevier Inc. All rights reserved.
  • Küçük Resim
    Öğe
    The diagnostic role of neopterin in lung cancer
    (2010) Alpar, Sibel; Ersoy, Güzin G.; Kurt, Özlem K.; Uçar, Nazire; Aydın, Ahmet; Kurt, Bahar
    The aim of this study was to investigate the relationship between bronchoalveolar lavage (BAL) neopterin levels and lung cancer subtypes. Serum and BAL fluid samples were collected from lung cancer patients and control cases. BAL and serum neopterin levels were measured spectrofotometrically using the Neopterin ELISA kit. A total of 43 patients, 36 male and 7 female, who applied to our hospital were included in this cross sectional study. Thirty-two of the patients had confirmed primary lung cancer, while the 11 patients who formed the control group had benign lung diseases. The mean age in the lung cancer group was 59.8 ± 7.9, while for the control group it was 47.6 ± 8.2 years. The standardized BAL neopterin levels were 2.63 ± 1.53 nmol/L in NSCLC patients, 2.09 ± 1.02 nmol/L in SCLC patients, 2.36 ± 0.83 nmol/L in control groups. No significant difference was found. For patients with NSCLC, no correlation could be established between serum and BAL neopterin levels and stage of disease. In conclusion the standardized BAL and serum neopterin levels were inadequate to distinguish the lung cancer from the control group.