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Yazar "Alişik, Murat" seçeneğine göre listele

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  • Küçük Resim Yok
    Öğe
    Can dynamic thiol-disulfide homeostasis be an effective marker in the diagnosis of nodular goiter and thyroid cancer?
    (2023) Aydin, Altan; Bulus, Hakan; Alişik, Murat; Erel, Özcan
    Aim: The oxidative stress has an important role in thyroid pathologies by nature of thyroid gland. Dynamic thiol-disulfide homeostasis is one of the markers of oxidative stress and its counterpart antioxidants in the body. In our study, the dynamic thiol-disulfide homeostasis was investigated in cases underwent surgery due to thyroid cancer or nodular goiter. Material and Methods: The study included patients who underwent thyroidectomy in General Surgery Department of Keçiören Teaching and Research Hospital between 01.03.2017 and 01.06.2017. The patients were assigned into groups according to postoperative histopathological examination: group 1 included patients with benign lesion in histopathology report and group 2 included patients with malignant lesions in histopathology report. The patients who had no pathology in sonography and did not undergo surgery were assigned into group 3 as controls. In all patients, venous blood samples were drawn to evaluate dynamic thiol-disulfide homeostasis before surgery. Results: In the study, 98 cases underwent bilateral total thyroidectomy; 77 of which had benign disease and 21 of which had malignant disease. Native thiol values (µmol/L) were 317.4±4.2, 349.9±7.9 and 299.9±7.9 (p=0) while total thiol values (µmol/L) were 353.5±4.8, 386.5±9.5 and 332.6±8.3 (p=0) and disulfide values (µmol/L) were 18.4±0.5, 20.5±0.7 and 16.7±0.6 (p=0) in group 1 (benign disease), group 2 (malignant disease) and group 3 (controls), respectively. In addition disulfide: native thiol was 5.8±0.1, 5.9±0.2 and 5.7±0.2 (p=0.8) while disulfide: total thiol was 5.2±0.1, 5.4±0.2 and 5.1±0.2 and native thiol: total thiol was 89.9±0.5, 90.7±0.5 and 90.5±1.5 (p=0.4) in group 1, 2 and 3, respectively. Conclusion: The dynamic thiol-disulfide homeostasis can be used as a marked in the thyroid diseases; however, further studies with larger sample are needed.
  • Küçük Resim Yok
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    The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early-Stage Non-Small Cell Lung Cancer
    (2023) Kavaş, Murat; Gürer, Deniz; Alişik, Murat; Öztürk, Akın; Bekir, Sümeyye Alparslan; Eroğlu, Selma Aydoğan; Ersöz, Elçin
    Objective: Lung cancer has a poor prognosis. Thiol groups with high antioxidant capacity are converted to disulfide bonds through biochemical reactions that neutralize different oxidant compounds. The thiol-disulfide (SH-SS) homeostasis has significant effects on cell mechanisms, transcription, and apoptosis. Here we present the prognostic role of dynamic SH-SS homeostasis in patients operated for NSCLC. Materials and Methods: Patients operating for early-stage NSCLC were prospectively analyzed. SH-SS homeostasis tests were measured using the automated spectrophotometric method. Results: This study enrolled 138 subjects, including 77 patients and 61 healthy controls. Native thiol and total thiol levels were significantly lower in the patient group. The disulfide-to-native thiol ratio, which is an indicator of oxidative stress in SH-SS homeostasis, also reached a level of statistical significance in the patient group (p<0.001). According to the cut-off values (305 and 326.3), the median overall survival rate was significantly shorter in patients with low native thiol and total thiol levels (p<0.001). Conclusions: This study demonstrated decreased native thiol and total thiol levels as well as decreased disulfide levels and SS/SH ratio in early-stage NSCLC. Impaired SH-SS homeostasis may contribute to lung cancer pathogenesis and poor prognosis because of enhanced oxidative stress.
  • Küçük Resim Yok
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    The Effect of Wet Cupping Therapy on Anxiety and Thiol/Disulfide Homeostasis in Premature Ovarian Failure: An Experimental Study
    (2022) Çelik, Humeyra; Çetinkaya, Ayhan; Bozat, Bihter Gökçe; Düzcü, Selma Erdoğan; Alişik, Murat; Yis, Özgür Mehmet
    Objective: The effect of wet cupping therapy on anxiety\rand thiol/disulfide homeostasis was evaluated in rats with premature\rovarian failure (POF) induced by cyclophosphamide (CYC). Material\rand Methods: Twenty four Wistar Albino female rats were divided\rinto control (n=6), POF (n=6), wet cupping (n=6), POF+wet cupping\r(n=6) groups. CYC at a dose of 200 mg/kg was injected intraperitoneally\rto POF and POF+wet cupping groups. One week later, wet cupping\rtherapy was applied to wet cupping and POF+wet cupping groups for\r5 minutes. The next day, Open Field Test and Elevated Plus Maze Test\rwere applied to all experimental groups to evaluate anxiety. After sacrification,\rto assess pattern formation, endometrial thickness and ovarian\rreserve were measured with hematoxylin-eosin staining.\rThiol/disulfide homeostasis and erythrocyte oxidized-reduced glutathione\rlevels were measured in serum to measure oxidative stress. Results:\rAlthough there was no statistical significance, it was observed\rthat anxiety decreased in POF+wet cupping compared to POF group.\rThere was no change in thiol-disulfide values in POF+wet cupping\rcompared to POF group (p>0.05). Conclusion: Wet cupping therapy\rdid not reduce anxiety in the experimental POF model and did not shift\rthe balance to positive in thiol/disulfide homeostasis in favor of thiols.\rHowever, the obtained graphics, numerical data and high standard deviation\rsuggest that meaningful data could be obtained with more subjects.
  • Küçük Resim Yok
    Öğe
    A NOVEL AND SEMIAUTOMATED ASSAY FOR THIOL OXIDATIVE STRESS INDEX: TOSI
    (2020) Neselioglu, Salim; Şenat, Almila; Oğuz, Esra Firat; Alişik, Murat; Erel, Özcan
    Objective: The aim of the study is to develop a new andautomated method determining irreversible and reversible thioloxidation products which are formed by the exposure of theplasma to oxidation and to measure the resistance of thiolgroups to oxidation.Material and Methods: The method is based on thioldisulphidehomeostasis measurement of plasma thiol groupsbefore and after exposure to oxidative stress. According to themeasurements, the levels of reversible thiol oxidation products(RTOP), irreversible thiol oxidation products (ITOP), and thioloxidative stress index (TOSI=ITOP/RTOP) were determined.Results: Plasma levels of ITOP were 24.02±12.1 ?mol/L, levelsof RTOP were 26.68±14.96 ?mol/L and TOSI was 0.67±0.60 inthe healthy control group. The level of ITOP of patients withlung and colon cancer were found to be significantly higher thanthe control group, while the level of RTOP was found to besignificantly lower. When the parameter of TOSI which wasused to determine the direction of the balance was examined, itwas observed that the formation of ITOP was more dominant inboth colon and lung cancer patients when compared to thecontrol group.Conclusion: Practical, inexpensive and semi-automaticspectrophotometric RTOP, ITOP and TOSI tests, developed byus for the first time, can be used to investigate many diseasesassociated with oxidative stress.

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