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Öğe The Association of Binge Eating Disorder with Glycemic Control in Patients with Type 2 Diabetes(Galenos Yayincilik, 2011) Canan, Fatih; Gungor, Adem; Onder, Elif; Celbek, Gokhan; Aydin, Yusuf; Alcelik, AytekinObjective: Our aim was to assess the prevalence of binge eating disorder (BED) in individuals with type 2 diabetes and to investigate whether a comorbidity with BED would affect glycemic control in these patients. Materials and Methods: Eighty-two type 2 diabetic patients were enrolled. The participants were assessed for eating disorders by a psychiatrist. Blood samples were drawn and HbA1c and other biochemical parameters were measured. Results: Of the 82 subjects, 27 (34.1%) met the criteria for BED. No other types of eating disorders were detected. HbA1c was significantly higher in individuals with BED (p< 0.05). Conclusion: Our findings reveal that BED is highly prevalent among type 2 diabetic patients and it impairs glycemic control. Thus, patients with type 2 diabetes should be assessed carefully for eating disorders.Öğe The effect of breast-feeding duration on bone mineral density in postmenopausal Turkish women: a population-based study(Termedia Publishing House Ltd, 2011) Yazici, Selma; Korkmaz, Ugur; Erkan, Melih; Korkmaz, Nurdan; Baki, Ali Erdem; Alcelik, Aytekin; Onder, ElifIntroduction: In the present study, we investigated the effects of breast-feeding time on bone mineral density (BMD) later in life. Material and methods: The current study was based on a retrospective analysis of 586 postmenopausal women with a mean age of 60.8 years, who were screened for osteoporosis by dual energy X-ray absorptiometry (DXA). They were classified into 4 groups with respect to the duration of their breast-feeding as never (group 1), 1-24 months (group 2), 25-60 months (group 3), or > 60 months (group 4). Bone mineral density results for the femur neck and lumbar spine were classified into 3 groups according to WHO criteria as normal (T score > -1.0 SD), osteopenia (T score -1.0 to -2.5 SD), and osteoporosis (T score < -2.5 SD). Patients with osteopenia or osteoporosis (T score < -1.0 SD) were considered as having low bone mass (LBM). Results: We found a correlation between duration of lactation and femur BMD or spine BMD in the study population (r = 0.116, p < 0.005; r = -0.151, p = 0.001, respectively). Significant differences were found between femur BMD and spine BMD of groups in one-way ANOVA analysis (p = 0.025, p = 0.005, respectively). Additionally, when compared with the other three groups, group 4 was older and had longer duration of menopause (p < 0.01). In logistic regression analysis, age and body mass index were found as independent risk factors of LBM [odds ratio: 1.084 (95% CI 1.031-1.141); odds ratio: 0.896 (95% CI 0.859-0.935)], while duration of lactation was not found as an independent predictor of LBM. Conclusions: In this study, we have found that changes of bone metabolism during lactation had no effect on postmenopausal BMD measured by DXA. Consequently, it can be suggested that long breast-feeding duration is not a risk factor for low bone mass later in life.Öğe EVALUATION OF ANTI-BODY RESPONSE OF HEMODIALYSIS AND PERITONEAL DIALYSIS PATIENTS TO HEPATITIS-B VACCINE(Istanbul Univ, Faculty Medicine, Publishing Office, 2007) Alcelik, Aytekin; Bicik, Zerrin; Bahcebasi, Talat; Acikgoz, Elif; Yildirim, Mustafa; Onder, ElifObjective: Hemodialysis patients are at higher risk for Hepatitis B virus (HBV) infection when compared with the rest of the population. Adequate antibody response (approximately 90%) is achieved when healthy individuals are immunized with HBV vaccine; however, the response is about 50% and 70% in chronic renal failure (CRF) patients. In this study, it is aimed to assess the influence of different factors and the type of renal replacement, for antibody response to double dose of recombinant HBV-vaccine in dialysis patients. Materials and methods: In this retrospective study, we included 37 patients (19 males, 18 females) who were in the schedule of hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) at the Dialysis Center of Duzce University Hospital between 2004 and 2005. The patients were administered double doses of recombinant DNA derived HBV vaccine IM for four times at 0, 1, 2, and 6 months. The patients' antibody responses were determined ated by ELISA test. Results: Six of the 37 patients (16.2%) had no response to the vaccine, while 15 patients (40.5%) had low response and 16 patients (43.2%) had complete response. There was no difference between hemodialysis patients and peritoneal dialysis patients in terms of the antibody response (p>0.05). Levels of hemoglobin, total cholesterol, triglyceride and albumin, type and duration of dialysis, and gender were not correlated with the antibody response (p>0.05). Conclusion: As a result, for dialysis patients, antibody response to the HBV-vaccine is lower than that in the healthy population and this decline in response seems to be multifactorial.Öğe Evaluation of psychiatric morbidity and quality of life in inactive HbsAg carriers(Academic Journals, 2011) Kucukbayrak, Abdulkadir; Canan, Fatih; Alcelik, Aytekin; Aktas, Gulali; Kocoglu, Esra; Tas, TekinHepatitis B virus (HBV) infection develops in forms from asymptomatic carrier to cirrhosis. There are several studies examining the quality of life of patients with HBV in literature. However, only two studies have investigated the psychiatric morbidity in hepatitis B patients. In this study, we evaluated psychiatric morbidity and quality of life in inactive HbsAg carriers. This case-controlled study was performed among 26 healthy volunteers as control group and 31 inactive HbsAg carriers. Seven (22.5%) of our Hepatitis B patients were found to have an Axis I psychiatric diagnosis. For the carriers, the diagnoses made were major depression (3 patients), major depression with conversion disorder (1 patient), moderate depressive disorder (1 patient), cyclothymic disorder (1 patient), and obsessive-compulsive disorder (1 patient). No significant difference was found between carriers and controls in terms of quality of life scores and anxiety and depression scores. According to these findings, the patients with hepatitis should undergo psychiatric evaluation by a specialist. Also, physicians should be aware that emotional and psychiatric support is not necessary for all of the patients with hepatitis B.Öğe A Preliminary Psychometric Evaluation of the Type D Personality Construct in Turkish Hemodialysis Patients(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Alcelik, Aytekin; Yildirim, Osman; Canan, Fatih; Eroglu, Mustafa; Aktas, Glali; Savli, HalukObjective: Type D personality, which is defined by both negative affectivity (NA) and social inhibition (SI), is associated with adverse outcomes in cardiac patients. The validity and reliability of the Type D Scale (DS_14) have been confirmed in various countries, particularly among cardiac patients. The purpose of the present study was to cross-validate the DS_14 in Turkish hemodialysis patients. Method: One hundred one patients, who had received maintenance hemodialysis for more than 3 months at a center in north-west region of Turkey, completed the Turkish version of the DS_14. Hospital Anxiety and Depression Scale (HAD) was administered to establish discriminant validity. The DS_14 was re-administered 1 month after first administration in order to examine the stability of the DS_14 in 100 patients. Results: The two-factor structure of the DS_14 and the internal consistency of the NA (alpha = 0.82) and SI (alpha = 0.81) subscales were confirmed. Both NA and SI were found to correlate positively with anxiety and depression scores. The DS_14 was stable over a 1-month period (r = 0.84/0.78; p< 0.01). The prevalence of Type D personality was 27.7%. Type D individuals had significantly higher mean scores on anxiety (p<0.01) and depression (p<0.01) subscales of the HAD when compared with non-Type D individuals. Conclusion: Preliminary evidence suggests that the Turkish DS_14 is a valid and reliable tool for identifying Type D personality. Future studies are warranted to evaluate the utility of the scale in different groups of patients.
