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Öğe Analysis of the factors related to the blood pressure control in hypertension(Coll Physicians & Surgeons Pakistan, 2018) Atik, Fatih; Aktaş, Gülali; Koçak, Mehmet Zahid; Erkuş, Edip; Şavlı, HalukObjective: To determine the factors associated with blood pressure control and comparing anthropometric and clinical parameters of subjects with well-controlled hypertension to those with poorly controlled blood pressure. Study Design: Observational cross-sectional study. Place and Duration of Study: Abant Izzet Baysal University Hospital, Bolu, Turkey, from January to June 2016. Methodology: Medical data obtained and recorded from computerised database and case files of our clinic. Subjects with mean blood pressure above target levels were defined as poorly controlled and others were as well-controlled hypertension group according to JNC VIII. Results: Out of 342 subjects, only 116 (33.9%) were aware of normal blood pressure range. The number of patients who had a blood pressure on goal in the group and knew the normal range of blood pressure was significantly higher than the patients in group who did not know the normal range of blood pressure. Body mass index and waist circumference were both significantly higher in poorly controlled compared to well-controlled hypertensive subjects. Treatment compliance was significantly associated with better control of hypertension. Conclusion: Striking results of present study indicate that lower body mass index and lesser waist circumference along with treatment compliance and awareness of normal blood pressure ranges are important factors that affect reaching treatment targets in hypertensive subjects.Öğe Analysis of the patients with nonvariceal upper gastrointestinal bleeding and comparison of Rockall and Glasgow-Blatchford scores(Springer India, 2022) Aktaş, Gülali; Ustaoğlu, Müge; Bakır, Tülay; Aslan, Rahmi; Gören, Fikret; Bektaş, AhmetBackground Nonvariceal upper gastrointestinal bleeding (UGB) has important morbidity and mortality. Predicting high-risk patients for mortality and rebleeding is necessary for a treatment plan. In the present study, we aimed to define the epidemiological and etiological characteristics of patients presenting with nonvariceal UGB and to observe mortality and morbidity rates. We also aimed to compare Rockall and Glasgow-Blatchford scoring systems in predicting rebleeding and mortality. Methods Subjects presenting with nonvariceal UGB over a 3-year period were included. Demographic characteristics, symptoms, and signs on physical examination, laboratory data, endoscopic signs and diagnosis, interventions during hospitalization and follow-up period were recorded. Glasgow-Blatchford and Rockall scores were calculated for every participant at the first day of the admission. Results A total of 709 patients were enrolled in the study. A total of 490 of them (69.1%) were men. The mean age of the women and men was 60.7 +/- 1.2 and 58.6 +/- 0.7 years, respectively. Melena was the most common presenting symptom. Duodenal ulcer (31%), gastric ulcer (20.7%), and erosive disease (17.6%) were the most common causes of bleeding. History of use of aspirin and/or nonsteroidal anti-inflammatory drug use were present in 63.7% of the subjects. All patients were followed up for 30th-day mortality. Overall, rebleeding and mortality rates were 11% and 7%, respectively. A Rockall score greater than 6 was the most important predictor of mortality (odds ratio:39.1) and rebleeding (odds ratio:4.7). Conclusion Nonvariceal UGB patients with a Rockall score greater than 6 should undergo aggressive endoscopic treatment and inpatient care.Öğe Analysis of the type 2 diabetic patients followed in a university clinic(2018) Koçak, Mehmet Zahid; Aktaş, Gülali; Erkuş, Edip; Duman, Tuba Taslamacıoğlu; Atak, Burcin Meryem; Şavlı, HalukObjective: The aim of present study was to determine the effects of factors to diabetic regulation; such as, awareness of the disease, compliance with treatment, awareness of HbA1c target, in T2DM patients whom followed up in our clinic. Methods: Patients with T2DM were enrolled to this retrospective study. Patient‘s data were obtained and recorded from institutional database. As well as blood pressure, anthropometric measurements, physical examination signs, and laboratory parameters were recorded. Study population grouped into two according to HbA1c level; well-regulated T2DM group with a HbA1c lower than 8% and poorly-controlled T2DM group with a HbA1c 8% or greater. Results: A total of 150 patients with T2DM (72 men and 78 women) enrolled. Waist circumference, body mass index, duration of diabetes, LDL-cholesterol , total cholesterol, triglyceride and serum creatinine were significantly lower in well-controlled compared to poorly-controlled diabetic subjects (all p<0.05). Rate of well-regulated subjects was higher in patients living in urban compared to subjects living in rural area (p=0.01). Diabetic regulation rate was significantly higher in patients acknowledge the diabetic medications, in self-monitoring blood glucose, in subjects aware of HbA1c target, and free of diabetic complications; neuropathy, nephropathy, and diabetic foot (all p<0.05). Conclusions: Striking result of present study is that most important factors associated with better diabetic control were self monitoring of blood glucose, awareness of treatment target and acknowledgement of the diabetic medications; which all could be achieved by education and participation of the patient to the therapeutic process.Öğe Are red cell distribution width and mean platelet volume associated with rheumatoid arthritis?(Allied Acad, 2016) Çakır, Lütfullah; Aktaş, Gülali; Mercimek, Öznur Berke; Enginyurt, Özgür; Kaya, YaseminAim: The aim of this retrospective study was to investigate the correlation between Rheumatoid Arthritis (RA) and Mean Platelet Volume (MPV) and Red Cell Distribution Width (RDW), which are parameters of routine hemogram tests that are suggested to be related with inflammation. Methods: We included 81 patients with RA in this retrospective study. Control group was consisted of 80 healthy subjects admitted to our institution for a routine check-up. White Bood Cell count (WBC), haemoglobin (Hb), RDW, platelet count (PLT) and MPV values of the participants obtained and analyzed. Results: We found that, RDW and MPW values were significantly different in patients with RA compared to control subjects. Conclusion: We think that, MPV reduction and RDW elevation is associated with RA. However, prospective studies with larger population are needed to reveal the relationship between the disease activity and MPV and RDW.Öğe Assessment of general characteristics of patients with primary metastatic breast carcinoma: single center experience(Termedia Publishing House Ltd, 2013) Üyeturk, Ümmügül; Budakoğlu, Burçin; Türker, İbrahim; Helvacı, Kaan; Sönmez, Özlem Uysal; Aktaş, Gülali; Arslan, Ülkü Yalçıntaş; Öksüzoğlu, Ömür Berna ÇakmakIntroduction: Breast cancer (BC) is a heterogeneous disease. Several subgroups have been identified, according to the clinical presentation and radiographic, pathological, biological, and molecular characteristics of the tumor. Intrinsic genetic heterogeneity may be responsible for these differences. To date, little is known about the clinical features and outcome of patients with primary metastatic BC (PMBC) defined as those presenting with stage IV disease. Material and methods: Between September 2007 and May 2011, BC patients who were admitted to a clinic were assessed. Patients with PMBC were included in this retrospective analysis. The patients' demographic characteristics, treatment schedules, and survival data were recorded. Results: Of 2478 BC patients, 102 (4.1%) with PMBC were included in the analysis. The median age of the patients was 50 (26-90) years. Only four patients (3.9%) had previously undergone mammography. The median progression-free survival (PFS) and overall survival (OS) were 30 and 66 months, respectively. The PFS and OS were unaffected by age, menopausal status, ECOG, histology, or tumor grade. Both PFS and OS were affected by HR status (log rank p = 0.006, log rank p = 0.04), HER2 status (p = 0.001, p = 0.005), site of metastasis (p = 0.01, p = 0.04), radiotherapy (p = 0.04, OS p = 0.03), and bisphosphonate treatment (p = 0.02, p = 0.006). PFS was greater in the hormone therapy group (43 months, p = 0.03) while OS was greater in the patients that received chemotherapy (76 months, p = 0.01). Conclusions: Mammography should be given greater emphasis, considering its importance in the prevention of PMBC. As a treatment option for bone and soft tissue metastatic PMBC patients, hormone therapy should be effective as a first-line treatment.Öğe Association between hemogram parameters and coronary collateral development in subjects with non-ST-elevation myocardial infarction(Assoc Medica Brasileira, 2020) Sincer, İsa; Mansıroğlu, Aslı Kurtar; Aktaş, Gülali; Güneş, Yılmaz; Koçak, Mehmet ZahidOBJECTIVE: Coronary collateral development (CCD) predicts the severity of coronary heart disease. Hemogram parameters, such as mean platelet volume (MPV), eosinophil, red cell distribution width, and platelet distribution width (PDW), are supposed novel inflammatory markers. We aimed to compare hemogram parameter values in patients presenting with non-ST-elevation myocardial infarction (NSTEMI) with adequate or inadequate CCD. METHODS: A total of 177 patients with NSTEMI undergoing coronary arteriography were enrolled and divided into two groups based on the development of CCD: one group with adequate CCD (n=88) and the other with impaired CCD (n=89). RESULTS: Baseline demographics and clinical risk factors were similar between the groups. Hemogram parameters were not significantly different between the two groups. However, compared to the inadequate CCD group, the median PDW was significantly higher in the adequate CCD group, 17.6 (1.4) vs. 17.8 (1.6) p=0.004. In a multivariate analysis, PDW (p=0.001, 95% CI for OR: 0.489(0,319-0,750) was found to be significantly different in the adequate CCD group compared to the inadequate CCD group. Pearson's correlation analysis revealed that PDW was significantly correlated with the Rentrop score (r=0.26, p<0.001). CONCLUSIONS: We suggest that since PDW is an index that is inexpensive and easy to assess, it could serve as a marker of CCD in patients with NSTEMI.Öğe Association between hemogram parameters and survival of critically Ill patients(Sage Publications Inc, 2019) Karagöz, İbrahim; Aktaş, Gülali; Yoldaş, Hamit; Yıldız, İsa; Ögün, Muhammed Nur; Bilgi, Murat; Demirhan, AbdullahAim: Recently, hemogram parameters, such as mean platelet volume (MPV), had been proposed as novel inflammatory and prognostic factors. In present retrospective analysis, we aimed to determine and compare MPV of survived and dead patients whom admitted to intensive care unit (ICU) of our institution. Methods: We recorded hemogram parameters and other laboratory data and demographic characteristics of patients treated in ICU. Patients are divided into 2 groups-dead patients and survived patients. Laboratory data of survived patients compared to those of dead patients. Results: Age, gender, and other laboratory variables were not significantly different between dead and survived patients. On the other hand, MPV of survived patients was significantly higher than that of the dead patients (P = .001). Conclusion: We think that elevated MPV levels in an ICU patient should alert clinicians for worse outcome. Physicians should be more careful in the management of these patients.Öğe Association between nasal polyps and mean platelet volume(Univ West Indies Faculty Medical Sciences, 2017) Aktaş, Gülali; Alçelik, Aytekin; Şit, Mustafa; Şavlı, HalukThe Editor Sir, We have previously reported that mean platelet volume (MPV) is decreased in nasal polyp patients compared to control subjects (1). First of all, we agree with Erdur et al that MPV has not been fully elucidated as an inflammatory marker in certain circumstances. The biological and prognostic value of MPV is still controversial (2) and needs to be validated with prospective randomized controlled trials. However, this retrospective study could be the first step to larger studies aimed at observing the relationship between MPV and inflammation. We also accept that results of MPV studies represent the probability and not the absolute consequences. Methodologies of many studies in literature that observed association between MPV and inflammation are quite similarÖğe Association between nasal polyps and novel inflammatory parameters.(Allied Acad, 2017) Apuhan, Tayfun; Aktaş, GülaliNasal polyposis represents as a chronic hyperplastic sinusitis associated with chronic inflammation. In present retrospective study, we aimed to compare the Mean Platelet Volume (MPV), Red Cell Distribution Width (RDW) and Neutrophil to Lymphocyte Ratio (NLR) values of patients with nasal polyposis to those in healthy subjects. We included 35 nasal polyp patients and 45 healthy subjects into the study. White Blood Cell count (WBC), Neutrophil Count (NEU), Lymphocyte Count (LYM), Hemoglobin (Hb), Hematocrit (HTC), Mean Corpuscular Volume (MCV), RDW, Platelet Count (PLT) and MPV were recorded after obtaining from computerized database. There was statistically significant difference between study and control groups (p<0.001). Decreased MPV and elevated RDW and NLR are characteristics of nasal polyposis. These parameters may also be helpful in assessing the success of treatment. Further studies with a larger study population are needed to detect the possible correlation between MPV, RDW and NLR values in patients with nasal polyps.Öğe Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men(Taylor & Francis Ltd, 2019) Bilgin, Satılmış; Aktaş, Gülali; Koçak, M. Zahid; Atak, Burçin M.; Kurtkulağı, Özge; Duman, Tuba T.; Şavlı, HalukAim: Hemogram indices were proposed as novel inflammatory markers in chronic conditions and inflammation has substantial role in the pathogenesis of type 2 diabetes mellitus (T2DM). We aimed to observe hemogram parameters of type 2 diabetic male subjects with various age groups in well and poorly controlled subsets. Methods: Data of type 2 diabetic men enrolled to the study were recorded from patient files of the institution. Study population were grouped into three according to the age. Group A was consisted of patients younger than 55 years, Group B was consisted of patients aged between 55 and 64 years, and Group C was consisted of patients aged 65 years or older. Data of the study groups were compared. Results: Study population was consisted of 130 subjects; 44 in Group A and 43 in each of Groups B and C. Median red cell distribution width (RDW) (p = .04), mean RDW to platelet ratio (RPR) (p = .006), median mean platelet volume to platelet ratio (MPR) (p = .02) levels of the study groups were statistically different. HbA1c level was significantly and positively correlated with RDW (r = 0.45, p < .001), neutrophil to lymphocyte ratio (NLR) (r = 0.47, p < .001), mean platelet volume to lymphocyte ratio (MLR) (r = 0.35, p < .001), MPR (r = 0.26, p = .003), and RPR (r = 0.37, p < .001) levels. Conclusion: Elevated RDW, NLR, MLR, MPR, and RPR levels in diabetic men should trigger the measurement of HbA1c since each were strongly correlated with HbA1c level. Moreover, elevated RDW, NLR, MLR, and RPR could be marker of worse diabetic control in men with T2DM.Öğe Association between omentin levels and insulin resistance in pregnancy(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2014) Aktaş, Gülali; Alçelik, Aytekin; Özlü, Tülay; Tosun, Mehmet; Tekçe, Buket Kın; Savlı, Haluk; Tekçe, HikmetAims: Omentin is a new adipokine secreted mainly from visceral adipose tissue. Serum omentin is found to be reduced in patients with impaired glucose tolerance, type 2 diabetes mellitus, obesity and insulin resistant states. Despite the fact that pregnancy is also characterized with hyperinsulinemia, literature is lacking about data of omentin levels and its association with insulin resistance in pregnant women. We aimed to evaluate the association of omentin levels and insulin resistance in pregnant women and to compare these levels with those of non-pregnant, nondiabetic women. Methods: Uncomplicated pregnant women who admit to our outpatient clinics for routine follow-up were included in the study group. Non-pregnant women without diabetes mellitus were served as control group. Fasting glucose, insulin, omentin levels and HOMA IR were recorded. SPSS 15.0 for Windows was used for statistical analysis. Results: There were 36 pregnant women in the study group and 37 healthy, non-pregnant women in the control group. Serum omentin and fasting glucose levels were significantly decreased and fasting insulin was significantly increased in the study group compared to control group. Conclusion: Omentin might be an indicator of insulin resistance in pregnant women. Larger prospective studies are needed to claim whether omentin can have a clinical use for diagnosis of gestational diabetes mellitus.Öğe The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: The abund study(Associação Médica Brasileira, 2021) Kösekli, Mehmet Ali; Kurtkulağı, Özge; Kahveci, Gizem; Duman, Tuba Taslamacıoğlu; Tel, Burçin Meryem Atak; Bilgin, Satılmış; Demirkol, Muhammed Emin; Aktaş, GülaliOBJECTIVE: Non- alcoholic fatty liver disease, which is characterized by lipid being deposited into hepatocytes, affects nearly one in three adults globally. Inflammatory markers were suggested to be related with hepatic steatosis. Uric acid to HDL cholesterol ratio is proposed as a novel inflammatory and metabolic marker. We aimed to compare Uric acid to HDL cholesterol ratio levels of patients with Non-alcoholic fatty liver disease to those of healthy controls and find out potential correlations between Uric acid to HDL cholesterol ratio and other inflammatory and metabolic markers of Non-alcoholic fatty liver disease. METHODS: Patients with a diagnosis of Non-alcoholic fatty liver disease who were on clinical follow-up in our institution were enrolled in the study as the Non- alcoholic fatty liver disease group, while healthy volunteers were enrolled as the control group. The Uric acid to HDL cholesterol ratio of the groups was compared and potential correlations were studied between Uric acid to HDL cholesterol ratio and fasting blood glucose, transaminases, serum lipids (triglyceride, LDL- cholesterol), weight, and body mass index. RESULTS: The Uric acid to HDL cholesterol ratio of the Non-alcoholic fatty liver disease (13 +/- 5%) group was significantly higher compared to the Uric acid to HDL cholesterol ratio of the control (10 +/- 4%) group (p<0.001). Uric acid to HDL cholesterol ratio was significantly and positively correlated with fasting blood glucose, transaminases, triglyceride, body weight, waist circumference, hip circumference, and body mass index. A ROC analysis revealed that a Uric acid to HDL cholesterol ratio level greater than 9.6% has 73% sensitivity and 51% specificity in determining Non-alcoholic fatty liver disease. CONCLUSION: Due to the inexpensive and easy-to-assess nature of Uric acid to HDL cholesterol ratio, we suggest that elevated Uric acid to HDL cholesterol ratio levels be considered a useful tool in diagnosing hepatic steatosis.Öğe Association between the prognostic nutritional index and chronic microvascular complications in patients with type 2 diabetes mellitus(MDPI, 2023) Aktaş, GülaliThe prognostic nutritional index (PNI) is associated with inflammatory conditions. Since type 2 diabetes mellitus (T2DM) and its microvascular complications produce a significant inflammatory burden, we aimed to compare the PNI levels of the subjects with T2DM to those of healthy individuals. Furthermore, we aimed to compare the PNI levels of the diabetic subjects, with and without microvascular complications. The study cohort consisted of T2DM patients and healthy volunteers. The general characteristics, laboratory data, and PNI of the T2DM and control groups were compared. We further compared the PNI levels of the diabetic patients, with and without diabetic microvascular complications. The PNI levels of the T2DM patients and the control group were 51.6 (30.1-73.8)% and 64.8 (49.4-76)%, respectively (p < 0.001). Subgroup analyses revealed that the PNI was lower in the diabetic subjects with diabetic microvascular complications than in the diabetic patients without microvascular complications (p < 0.001), in patients with diabetic nephropathy compared to those without nephropathy (p < 0.001), in patients with diabetic retinopathy compared to those without retinopathy (p < 0.001), and in patients with diabetic neuropathy compared to those without neuropathy (p < 0.001). In conclusion, we assert that assessing the PNI may yield additional diagnostic value in regards to the timely determination of diabetic microvascular complications.Öğe Association between thyroid hormone status and complete blood count parameters in anemic patients(Universiti Putra Malaysia Press, 2021) Atak Tel, Burçin M.; Aktaş, Gülali; Duman Taslamacıoğlu, Tuba; Kurtkulağı, Özge; Bilgin, Satılmış; Kahveci, Gizem; Sağdıç, TuğrulIntroduction: Anemia and thyroid conditions effect each other in clinical practice. Anemia may induce alteration in thyroid hormone status and various thyroid conditions induce various types of anemia. In present study, we aimed to study the thyroid function tests of the anemic subjects and to compare characteristics and laboratory features of the three groups; hypothyroid, hyperthyroid, and euthyroid subjects. Methods: Anemic subjects divided into three groups according to the thyroid hormone status, either as hyperthyroid, hypothyroid and euthyroid groups. Hemogram indices and laboratory parameters compared between three groups. Results: Mean red cell distribution width (RDW) of hypothyroid anemic subjects was significantly lower than the RDW of euthyroid anemic subjects (p=0.003). White blood cell (WBC) count of hypothyroid anemic subjects was significantly reduced compared to the euthyroid (p<0.001) and hyperthyroid (p=0.047) anemic subjects. Significant inverse correlation between RDW and TSH (r=-0.25, p=0.001), between RDW and hemoglobin (r=-0.44, p<0.001), between RDW and hematocrit (r=-0.35, p<0.001) and between RDW and mean corpuscular volume (r=-0.53, p<0.001) were noted. Conclusions: Since anemia is common in thyroid conditions, besides its role in differential diagnosis of the anemia, RDW could also serve as an adjunct diagnostic tool in estimation of the thyroid hormone status in anemic subjects.Öğe The association between vitamin d levels and handgrip strength in elderly men(Editura Acad Romane, 2020) Koçak, Mehmet Zahid; Aktaş, Gülali; Atak, Burçin Meryem; Bilgin, Satılmış; Kurtkulağı, Özge; Duman, Tuba Taslamacıoğlu; Özçil, İrem EmirContext. Vitamin D is a steroid hormone that acts by binding to the vitamin D receptor (VDR) found in many tissues. According to the long-term mechanism, vitamin D causes the proliferation and differentiation of muscle cells by gene transcription. Objective. We aimed to evaluate the relationship between muscle strength and serum vitamin D levels in elderly men. Design. Cross-sectional study. Subjects and Methods. Male patients over age 50 were included in the study. Study population was divided into 2 groups with handgrip strength according to body mass index, either as subjects with weak or with normal handgrip strength test (HGST). Vitamin D levels and other variables compared between weak and normal groups. Results. Vitamin D level of weak and normal groups were 75 (3-19.9) mu g/L, and 11.6 (11.6-34.9) mu g/L, which means significant reduced vitamin D levels in weakness group (p=0.01). Vitamin D levels were significantly correlated with HGST levels (r:0.362, p=0.001). Vitamin D levels were found to be an independent predictor of weakness according to HGST in logistic regression analysis (OR: 0.453, 95% CI:0.138-0.769, p=0.05). Conclusions. Low vitamin D level is an independent risk factor for muscle weakness in men aged more than 50 years. Therefore, vitamin D levels should be screened and early replacement should be initiated for the sake of improvement of muscle strength in elderly subjects that vulnerable for frailty.Öğe Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease(Termedia Publishing House Ltd, 2018) Sincer, İsa; Güneş, Yılmaz; Mansıroğlu, Aslı Kurtar; Coşgun, Mehmet; Aktaş, GülaliIntroduction: The prognostic value of hematological indices in cardiovascular diseases and the association between these parameters and cardiovascular conditions have been established in the literature. Aim: In this study, we aimed to investigate the relation of mean platelet volume (MPV), MPV to platelet ratio (MPR) and red cell distribution width (RDW) with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical coronary artery stenosis. Material and methods: A total of 306 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: a group with adequate CCD (n = 214) and a group with impaired CCD (n = 92). Routine complete blood count and biochemical parameters were measured before coronary arteriography. Results: The MPV and MPR levels were significantly higher in the inadequate CCD group (10.5 +/- 1.8 fl vs. 8.7 +/- 1.9 fl, p < 0.001 and 0.06 +/- 0.08 vs. 0.05 +/- 0.07, p = 0.036). Patients with inadequate CCD had significantly higher RDW levels compared to patients with adequate CCD (15.5 +/- 1.7% vs. 15.0 +/- 1.9%, p = 0.01). MPV and RDW were significantly associated with Rentrop collateral grading (r = -0.523, p < 0.001 and r = -0.239, p < 0.001, respectively), whereas the association with MPR was not significant. An MPV value greater than 9.95 fl, determined with ROC curve analysis, had 71% sensitivity and 70% specificity in predicting inadequate CCD. An RDW greater than 14.3% has 71% sensitivity and 53% specificity in selecting patients with adequate CCD. Conclusions: The present study suggests that MPV and MPR may be associated with the degree of collateral development in chronic stable CAD. However, the negative association of RDW with inadequate CCD, in combination with previous contradictory reports, raises a doubt about the possible value of RDW in stable CAD. Although these parameters may be affected by various conditions, a high MPV may lead clinicians to suspect possible inadequate collateral development in stable CAD patients.Öğe Associations of non-HDL-C and triglyceride/HDL-C ratio with coronary plaque burden and plaque characteristics in young adults(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2023) Aktaş, GülaliDear Editor:I read with great interest the article by Akin et al., reportingan association between coronary plaque and serum lipidparameters [1]. The authors examined serum lipid levels inpatients undergoing computed tomography of the coronaryarteries and reported that LDL cholesterol, total cholesterol,non-HDL cholesterol, triglycerides, and the ratio of triglyc-erides to HDL cholesterol were significantly higher in patientswith coronary artery disease, and HDL cholesterol was signifi-cantly lower than in patients without coronary atherosclerosis.The results presented in the above study are consistent withdata from the literature. Increased total and LDL cholesterollevels were found in patients with adequate coronary collateraldevelopment compared with patients with inadequate coronarycollateral development [2].Öğe Atrial electrical and mechanical dysfunction in non-diabetic, nonhypertensive hemodialysis patients(Carbone Editore, 2014) Tekçe, Hikmet; Öztürk, Serkan; Aktaş, Gülali; Tekçe, Buket Kın; Erdem, Alim; Üyetürk, Uğur; Özyaşar, Mehmet; Duman, Tuba Taslamacıoğlu; Yazıcı, MehmetBackground: Abnormalities in atrial conduction times and mechanical functions are considered as independent predictors of atrial fibrillation. However, there is no data in literature about functional parameters and electromechanical delay intervals in nondiabetic, non-hypertensive hemodialysis (HD) patients. We aimed to study atrial electromechanical conduction times and mechanical functions in this population. Methods: Forty-two non-diabetic, normotensive hemodialysis patients and age and sex matched control subjects have been enrolled in the study. Standard and Tissue Doppler Echocardiography have been performed before mid-week dialysis session for HD group and on admission for control group. Results: PA(lateral,), PA(septum) durations of the hemodialysis group were significantly longer than control group (70.6 +/- 9.1 vs 55.3 +/- 2.7, 50.8 +/- 5.2 vs 44.4 +/- 2.1; p<0.01). Interatrial and left-right intraatrial electromechanical delay intervals were significantly longer in hemodialysis group compared to controls (31.6 +/- 7.2 vs 18.0 +/- 2.6, 19.8 +/- 7.9 vs 10.9 +/- 2.7, 11.8 +/- 5.1 vs 7.1 +/- 1.2, respectively; all p<0.01). Measurements of left atrial diameter, maximum, minimum and before atrial systole, volumes and passive-active emptying volumes were both elevated in hemodialysis group compared to controls (all p<0.01). Conclusions: This is the first study enlightening deterioration in atrial mechanical and electromechanical functions in nondiabetic, non-hypertensive HD population. Results of the present study reflect not only negative effects of structural remodeling, which has been mentioned in previous studies in literature, but also negative effects of electrical remodeling. Prolonged inter- and intra-atrial electromechanical delay intervals should be the underlying pathophysiological factors increasing the rate of atrial fibrillation in hemodialysis population.Öğe Atrial electrical and mechanical dysfunction in non-diabetic, nonhypertensive hemodialysis patients(Oxford Univ Press, 2014) Tekçe, Hikmet; Öztürk, Serkan; Aktaş, Gülali; Tekçe, Buket Kın; Erdem, Alim; Üyetürk, Uğur; Özyaşar, MehmetÖğe C-reactive protein to LymphocytE count ratio could be a reliable marker of thyroiditis; the CLEAR-T study(Wiley, 2022) Demirkol, Muhammed Emin; Aktaş, GülaliInflammation of the thyroid gland is referred to as thyroiditis and is associated with inflammation. Recent studies found significant association between thyroiditis and novel inflammatory and metabolic markers, as well as C-reactive protein (CRP). CRP/lymphocyte count ratio (CLR) is a novel inflammatory marker that associated with various conditions and has not been studied in thyroiditis, yet. We aimed to investigate CRP to lymphocyte count ratio in patients with thyroiditis and to compare to those in healthy subjects. Patients with thyroiditis that presented to internal medicine outpatient clinics of our institution between January 2019 and August 2021 were enrolled to the retrospective study. Healthy volunteers were enrolled as control group. CLR of the thyroiditis and control groups were compared. Median CLR of the thyroiditis and control groups were 3.14 (0.14%-38)% and 0.4 (0.03-8.86)%, respectively (p < .001). The sensitivity and specificity of CLR > 0.43% in detecting thyroiditis were 92% and 58%, respectively (AUC: 0.88, p < .001, 95% CI: 0.85-0.92).CLR was significantly and positively correlated with free T4 (FT4) (r = .18, p < .001) and inversely correlated with thyroid stimulating hormone (TSH) (r = -.52, p = .003) levels. In conclusion, we suggest that high CLR levels may yield additional diagnostic value in patients with thyroiditis.
