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Öğe Clinical and ultrasonographical findings in patients with multiseptate gallbladder(Tohoku Univ Medical Press, 2004) Erdoğmuş, Beşir; Yazıcı, Burhan; Özdere, Betül Ayça; Akçan, YusufMultiseptate gallbladder is one of the rare congenital malformations of the gallbladder. We present clinical and ultrasonographic findings in seven patients with multiseptate gallbladder. One of them had nausea and right upper quadrant pain, three had recurrent abdominal pain, while the remaining three patients had no symptoms, physical finding and laboratory abnormality which could be attributable to the biliary system. In patients with multiseptate gallbladder, disturbed motility of the gallbladder may be an etiopathogenetic factor for stasis of bile flow and in turn for development of cholelithiasis, cholecystitis and right upper quadrant pain.Öğe The importance of serial measurements of cytokine levels for the evaluation of their role in pathogenesis in familial Mediterraean fever(2003) Akçan, Yusuf; Bayraktar, Yusuf; Arslan, Serap; Van Thiel, David H.; Zerrin, B. C.; Yıldız, OğuzhanFamilial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent fever of unknown origin, renal amyloidosis, peritonitis, pleuritis and/or synovitis. There have been many studies to elucidate the etiopathogenesis of FMF. IL-6 is a cytokine that can induce the formation of serum amyloid A and C-reactive protein, both of which are important in development of amyloidosis. IL-6 was determined to be strongly associated in the etiopathogenesis of periodic fever in Chinese-pei dogs. The dogs with this syndrome experience periodic fever, arthritis, renal amyloidosis, a clinical picture very alike of human FMF. Here, we aimed to study mainly whether IL-6 had a similar etiopathogenetic role in human FMF as in Chinese-pei dogs syndrome. The median IL-6 blood levels were found to be higher in patients with acute (n=8) FMF attack (1.85 U/ml) compared to those (n=33) with asymptomatic ones (1.0 U/ml) (p=0.16). There are mainly two results: first; the study should be designed with a larger sample size of patients with acute attack in order to alleviate underestimation of significance, second; sampling time may give various results because of dynamic changes of cytokine levels during acute attack period.Öğe The low seropositivity of hepatitis B virus in vitiligo patients(Wiley, 2006) Akçan, Yusuf; Kavak, Ayşe; Sertbaş, Yaşar; Olut, Ali Ilgın; Korkut, Esin; Bicik, Zerrin; Kısacık, BünyaminDespite of its unknown aetiology, vitiligo may be triggeredby viral infection in a genetically predisposed host, likean autoimmune disease.Öğe Massive gastrointestinal tuberculosis in a young patient without immunosupression(WJG Press, 2003) Sertbaş, Yaşar; Alper, Murat; Akçan, Yusuf; Gürbüz, Yeşim Saliha; Öksüz, ŞükrüAlthough the lung is the major site for Mycobacterium tuberculosis infection, gastrointestinal involvement can be present as part of multiorgan disease process or, less commenly, can be seen as primary gastrointestinal tuberculosis. In the cases where the culture is negative, it can be difficult to differantiate tuberculosis from Crohn's disease based on both the clinical and histological features. When side effects of classic antimycobacteria are encountered, we can initially add ciprofloxacin to the treatment of tuberculosis. We reported a case of 19-yr-old patient, who was treated as Crohn's disease and worsen. We began to tuberculosis treatment, and the patient improved clinically and histologically. The main point in this case is that widespread involvement of gastrointestinal tract can be brought about by non resistant strains of Mycobacterium tuberculosis even in immunocompetent patients.Öğe Micropneumatosis coexistent with Helicobacter pylori and its improvement(2003) Belenli, Olcay Kandemir; Akçan, Yusuf; Alper, MuratMicropneumatosis intestinalis is the occurrence of gas-filled circular voids with diameter of 20-200 microns, not lined with epithelium. We report a 39-year-old man with superficial gastritis and Helicobacter pylori infection who also had gastric, duodenal and colonic micropneumatosis. Endoscopic biopsy after treatment for H. pylori gastritis showed no micropneumatosis in gastric, duodenal or colonic mucosal sections. We suggest that H. pylori may be one of the causative factors for micropneumatosis.Öğe The transmission of Helicobacter pylori via exposure to common sources outweighs the person-to-person contact among spouses in developing countries [9](Elsevier Inc., 2000) Akçan, Yusuf; Ersan, Sibel; Alper, Murat; Bjcjk, Zerrin; Aytuğ, Necip[No abstract available]
