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Öğe Advantages of routine flexible nephroscope usage in percutaneous nephrolithotomy operations : Early results of prospective randomized study(Mary Ann Liebert Inc, 2012) Gücük, Adnan; Kemahlı, Eray; Üyetürk, Uğur; Tuygun, Can; Yıldız, Mevlüt; Metin, AhmetÖğe Alleviation of kidney damage induced by unilateral ureter obstruction in rats by rhodiola rosea(Mary Ann Liebert, Inc, 2013) Üyetürk, Uğur; Terzi, E. Hakan; Kemahlı, Eray; Gücük, Adnan; Tosun, Mehmet; Çetinkaya, AyhanPurpose: To evaluate the efficacy of Rhodiola rosea extract in terms of alleviating the renal damage induced by unilateral ureter obstruction (UUO) in rats. Material and Methods: Thirty Wistar albino male rats were divided into five groups: (I) Control, (II) UUO 7 days, (III) UUO 7 days+extract,(IV) UUO 14 days, and (V) UUO 14 days+extract. Seven or 14 days after the initiation of the experimental procedure, the left kidneys of rats in all five groups were removed for histological examination, and their blood was drawn for biochemical measurements. Result: Median malondialdehyde (MDA) and glutathione peroxidase (GPx) levels were, respectively, 39.4 (5.04) nmol/mL and 25.8 (8.01) nmol/minute/mL in group I, 77.9 (12.38) nmol/mL and 5.8 (1.95) nmol/minute/mL in group II, 48.7 (12.1) nmol/mL and 9.1 (2.3) nmol/minute/mL in group III, 58.5 (23.83) nmol/mL and 8.4 (2.1) nmol/minute/mL in group IV, and 44.8 (4.97) nmol/mL and 13.8 (3.73) nmol/minute/mL in group V. There was a statistically significant difference among the groups in terms of MDA and GPx levels (p<0.05 for both). The median numbers of apoptotic cells were 1 (1), 8 (2.25), 3 (1.25), 23.5 (9), and 7 (I) in groups I, II, III, IV, and V, respectively. There was a statistically siginificant difference among the groups in terms of apoptotic cell number (p<0.05). Conclusion:R. rosea extract was shown to alleviate the renal damage induced by UUO through its antioxidant effects. The mechanism by which R. rosea extract causes these effects merits further investigation.Öğe Are stone density and location useful parameters that can determine the endourological surgical technique for kidney stones that are smaller than 2 cm? A prospective randomized controlled trial(Urol & Nephrol Res Ctr-Unrc, 2019) Gücük, Adnan; Yılmaz, Burak; Gücük, Sebahat; Üyetürk, UğurPurpose: We aimed to evaluate whether these parameters could be guiding for us in selection between retrograde intrarenal surgery (RIRS) and mini-percutaneous nephrolithotomy (PNL) procedures in kidney stones that are smaller than 2 cm. Materials and Methods: The patients who had kidney stones smaller than two cm and were planned to undergo surgery were randomly distributed into 2 groups prospectively. RIRS was performed in the RIRS group using a 7.5-F fiberoptic flexible ureterorenoscope while mini-PNL group was dilated up to 16.5F and mini-PNL was performed with 12F nephroscopy. Preoperative characteristics, operative and postoperative results were compared in two groups. Thereafter, intra and intergroup comparisons were made to determine the effects of Hounsfield unit (HU) value indicating the stone density being higher or lower than 677 and stone location on stone-free rates. Results: The study involved 60 patients including 30 in each group. The groups' preoperative values were similar. The hospitalization time and the total duration of scopy were longer in mini-PNL when the postoperative values were compared (P <.0001). In terms of stone densities, HU values that were lower than 677 in the mini-PNL group affected the stone-free rate and reduced it from 100% (> 677HU) to 55.6% (< 677HU), whereas the change was significant (P =.005). Lower calyx stones affected the RIRS results negatively, whereas multiple calyceal stones affected the mini-PNL group negatively. Conclusion: Both methods had a similar success rate, but lower pole stones, multiple calyceal stones and stone density parameters affected the stone-free rates significantly, and these may be effective in treatment selection.Öğe Atrial electrical and mechanical dysfunction in non-diabetic, nonhypertensive hemodialysis patients(Carbone Editore, 2014) Tekçe, Hikmet; Öztürk, Serkan; Aktaş, Gülali; Tekçe, Buket Kın; Erdem, Alim; Üyetürk, Uğur; Özyaşar, Mehmet; Duman, Tuba Taslamacıoğlu; Yazıcı, MehmetBackground: Abnormalities in atrial conduction times and mechanical functions are considered as independent predictors of atrial fibrillation. However, there is no data in literature about functional parameters and electromechanical delay intervals in nondiabetic, non-hypertensive hemodialysis (HD) patients. We aimed to study atrial electromechanical conduction times and mechanical functions in this population. Methods: Forty-two non-diabetic, normotensive hemodialysis patients and age and sex matched control subjects have been enrolled in the study. Standard and Tissue Doppler Echocardiography have been performed before mid-week dialysis session for HD group and on admission for control group. Results: PA(lateral,), PA(septum) durations of the hemodialysis group were significantly longer than control group (70.6 +/- 9.1 vs 55.3 +/- 2.7, 50.8 +/- 5.2 vs 44.4 +/- 2.1; p<0.01). Interatrial and left-right intraatrial electromechanical delay intervals were significantly longer in hemodialysis group compared to controls (31.6 +/- 7.2 vs 18.0 +/- 2.6, 19.8 +/- 7.9 vs 10.9 +/- 2.7, 11.8 +/- 5.1 vs 7.1 +/- 1.2, respectively; all p<0.01). Measurements of left atrial diameter, maximum, minimum and before atrial systole, volumes and passive-active emptying volumes were both elevated in hemodialysis group compared to controls (all p<0.01). Conclusions: This is the first study enlightening deterioration in atrial mechanical and electromechanical functions in nondiabetic, non-hypertensive HD population. Results of the present study reflect not only negative effects of structural remodeling, which has been mentioned in previous studies in literature, but also negative effects of electrical remodeling. Prolonged inter- and intra-atrial electromechanical delay intervals should be the underlying pathophysiological factors increasing the rate of atrial fibrillation in hemodialysis population.Öğe Atrial electrical and mechanical dysfunction in non-diabetic, nonhypertensive hemodialysis patients(Oxford Univ Press, 2014) Tekçe, Hikmet; Öztürk, Serkan; Aktaş, Gülali; Tekçe, Buket Kın; Erdem, Alim; Üyetürk, Uğur; Özyaşar, MehmetÖğe Bolu ilindeki testis kanserli hastaların retrospektif analizi(2015) Üyetürk, Uğur; Üyetürk, Ümmügül; Metin, AhmetAmaç: Tests kanseri (Tca) erkeklerde görülen ürogenital malignitelerin yaklaşık %20’sini, tüm erkek maligni- telerinin yaklaşık %1-2’sini oluşturmasına rağmen, 15-35 yaş arası en sık görülen solid kanserlerdir. Kriptorşi- dizm, testküler mikrolitasis, Klinifelter ve Down Sendromu Tca için risk faktörleridir. Tca’lerinin %95’i germinal dokudan köken alır. Bu tümörler seminomatöz ve nonseminomatöz (embriyonel hücreli karsinom, teratom, koryokarsinom, yolk kesesi tümörü) olarak iki gruba ayrılmaktadır. Biz bu çalışmada, bölgemizde yaşayan Tca tanısı almış hastaların genel özelliklerini ve tedavi seçenekle rini retrospektf olarak değerlendirmeyi amaçladık. Gereç ve Yöntemler: 01.01.2012-30.07.2013 tarihleri arasında Bolu Abant İzzet Baysal Üniversitesi Tıp Fakülte - si, tbbi onkoloji polikliniğine başvuran Tca’li hastaların demografk özellikleri ve tedavi seçenekleri retrospektf olarak değerlendirildi. Bulgular: Bu süre içinde median yaşı 31(22-45) yıl olan 15 hastanın başvurduğu bulundu. İlk başvuru şikayet olarak 11’nunda (%74) testste kitle, 2’sinde (%13) ağrı, 2’sinde (%13) kitle ile birlikte ağrı vardı. Hastaların 14’ünde tümör unilateral, 1’inde bilateraldi. Tümör boyutu ortalama 4(0.8-10) cm’di. Hastaların tümörlerinin 7’si seminomatöz, 7’si nonseminomatöz ve bilateral tümörlü hastanın sağ testsi seminomatöz, diğeri nonse - minomatöz histolojiye sahipt. Orşiektomi sonrası seminomatöz evre IA olan 2 hastaya karboplatn, 1 hastaya izlem, evre IB olan 2 hastaya karboplatn, 1 hastaya izlem, evre IIB olan 1 hastaya bleomisin, etoposid, sisplatn (BEP) kemoterapisi verildiği, nonseminomatöz evre IA 2 hastaya izlem, evre II ve üzeri hastalara ise BEP kemoterapisi verildiği görüldü. Sonuç: Bolu ilindeki Tca’li hastaların değerlendirildiği bu retrospektf analiz sonuçları literatür ile uyumlu bulundu. Türkiye verilerini elde edebilmek için diğer illerinde dahil edileceği, daha fazla hasta katlımıyla yapılacak çalışmaların gerekli olduğunu düşünmekteyiz.Öğe Çinkodan zengin diyetin, sigara dumanı maruziyetindeki sıçan mesane dokusu sitokin profiline etkisi(2015) Hakan, Elçin Terzi; Kükner, Aysel; Aydın, Hatip; Özyalvaçlı, Mehmet Emin; Fırat, Tülin; Üyetürk, UğurAmaç: Sigara içimi akciğer, larinks, özefagus, mide, mes ane ve böbrek kanserleri ile kronik hastalıkların sebebidir. Sitokinler, inflamasyonun başlatılması ve sürdürülmesinde önemlidirler. Sigara, çinko eksikliği sebebidir. Çinko, antioksidan olup serbest radikallerin zararlarından hücreleri korur. Çalışmamızda sigara dumanına maruz bırakılarak çinkodan zengin diyet ile beslenen sıçanların mesane dokusundaki TLR 2, TLR 4, Nükleer faktör ka ppa B, İnterl ökin 1? ve İnterlökin 10 ekspresyonuna etkisi incelenmesi amaçlanmıştır. Yöntem : Çalışmada 24 adet erişkin erkek Wistar-Albino sıçanlar kullanıldı. Sıçanlar 4 gruba ayrıldı. Birinci grup normal, 2. grup ise çinkodan zengin diyetle beslendi. Üçüncü ve 4. gruplar sigara inhalasyonu yapılan gruplar olup sırasıyla normal ve çinkodan zengin diyetle beslenen gruplardı. Den ey sonunda alınan mesane dokuları histol ojik olarak değerlendirildi. Kalan doku örnekleri ise Real time polymerase chain reaction yöntemi ile sitokin ekspresyonları gösterilerek değerlendirildi. Bulgular: Çalışmadaki hiçbir grup mesane epitelinde değ işikli k izlenmemiştir. Sigara verilen grupta sadece düz kas yapılarında tabakalar arasında ödem ve bazı alanlarda yoğun inflamatuar hücreler ile bu alanlarda hemoraji ve konjesyona rastlanılmıştır. Çinkodan zengin diyetle besl enen denekler de ise inflamatuar hüc relere, konjesyona ve ödeme daha az rastlandı. Tüm sıçan gruplarının mesane dokularında sitokin ekspresyonları ikili olarak karşılaştı rmalarda sigaraya maruz kalmış sıçanlarda çinko almayan ve çinko alan sıçanlar için NF -?B2 geni için anlamlı farklılık bul undu. Sonuç : Sonuç olarak sigara maruz kalan sıçanlarda çinko kullanımının anlamı bir şekilde NF -?B2 ekpresyonunu artışına neden olması, çinkonun sigaraya bağlı gelişen mesane kanserlerinde kanserli hücre apopitozunu arttırarak tedaviye katkı yapabileceğin i düşündürmektedir.Öğe Clinical and prognostic importance of chromosomal abnormalities, Y chromosome microdeletions, and CFTR gene mutations in individuals with azoospermia or severe oligospermia(Tubitak Scientific & Technical Research Council Turkey, 2014) Ocak, Zeynep; Üyetürk, Uğur; Dinçer, Muhammet MuratAim: To illustrate the importance of genetic screening in the assessment of fertility and the correct diagnosis in patients with azoospermia or severe oligospermia. Materials and methods: This study examined 500 patients with reproductive failure, having fewer than 5 million sperm/mL detected in at least 2 consecutive spermiograms, who presented at a medical genetics polyclinic between 2008 and 2012. Metaphase preparations obtained from cell cultures were stained by trypsin-Giemsa banding. After DNA isolation, Y chromosome loci, including AZFa (SY84, SY86), AZFb (SY127, SY134), AZFc (SY254 SY255), and AZFd, were amplified by polymerase chain reaction using specific primers. Thirty-five patients with congenital unilateral absence of the vas deferens or congenital bilateral absence of the vas deferens (CBAVD) and a positive cystic fibrosis family history were evaluated for cystic fibrosis transmembrane conductance regulator gene mutations. Results: No chromosomal abnormalities were noted in 440 (88%) of the 500 patients, whereas structural or numerical chromosomal abnormalities were detected in 60 patients (12%). Individuals with Y deletions made up 5.6% (n = 28) of the study sample. Three patients with no AZF deletion or chromosomal abnormality, but with CBAVD, were heterozygous for I148T, G1130A, or IVS3 406-3T> C mutations. Conclusion: This study shows that genetic testing can make an important contribution to the treatment of patients planning in vitro fertilization due to azoospermia or severe oligospermia.Öğe Do renal cysts affect the success of extracorporeal shockwave lithotripsy? A retrospective comparative study(2013) Gücük, Adnan; Öztürk, Ufuk; Üyetürk, Uğur; Kemahlı, Eray; Akın, Güven; İmamoğlu, M.Abdurrahim; Metin, AhmetThe aim of this study was to assess the effect of simple renal cysts on extracorporeal shockwave lithotripsy (SWL) in patients with calyceal renal calculi. Patients with simple renal cysts >35 mm and ipsilateral renal calculi <20 mm that were treated with SWL constituted group 1 (cyst + calculi). The control group included patients aged >40 years that had renal calculi <20 mm and no cysts that were treated with SWL. The 2 groups were compared according to age, gender, body mass index, calculi size, localization, and density, the calculi fragmentation rate, and the percentage of stone-free patients. Mean cyst size in group 1 was 44.04 ± 9.08 mm. Mean age in group 1 was 61.4 ± 10.2 years versus 56.9 ± 8.2 years in the control group; the difference was significant (P = 0.045). There were not any other significant differences between the 2 groups, except for the stone-free rate (P > 0.05), which was 33.3% in group 1 and 68.2% in the control group (P = 0.017). The presence of renal cysts in a patient with calculi requires that an individualized treatment plan be devised, so as to provide the patient with the most effective treatment. © 2013 Adnan Gücük et al.Öğe Does the hounsfield ünit value determined by computed tomography predict the outcome of percutaneous nephrolithotomy?(Mary Ann Liebert Inc, 2012) Gücük, Adnan; Üyetürk, Uğur; Öztürk, Ufuk; Kemahlı, Eray; Yıldız, Mevlüt; Metin, AhmetPurpose: We aimed to evaluate whether the Hounsfield unit (HU) value predicts outcome in percutaneous nephrolithotomy (PCNL). Patients and Methods: One hundred and seventy-nine patients who had undergone PCNL in our clinics in the last 4 years were included. Demographic and clinical data of the patients and complications, if any, were recorded. The mean age of the patients was 45.3 +/- 14.3 years (range 5-82 y), and 111 of them were males (62%). The mean stone size and HU values were found to be 693.1 +/- 628.0 (95-4200) mm 2 and 706.3 +/- 245.0 (214-1325), respectively. Results: In logistic regression analysis, the size of the stone, the opacity of the stone, and the HU values were found to be independent predictors of the failure of the procedure (P < 0.05). A cutoff value of 677.5 was used for the HU in the receiver operating characteristics analysis. Having a HU value under the cutoff value increased the likelihood of procedure failure by 2.65 times, whereas stones residing in the staghorn localization increased failure by 5.68. It was also observed that if the stone's size was 485 mm(2) or more, the chance of failure increased by 1.9, whereas when the stone was nonopaque, failure increased by 6.04 times (P < 0.05). There was a positive correlation between hematocrit decrease and a decrease in HU values (P < 0.05), but no correlation was observed between the HU values and duration of surgery or fluoroscopy (P > 0.05). Conclusion: In addition to the size and location of the stones, the HU value determined in the unenhanced CT scan may be one of the parameters affecting PCNL outcomes. PCNL is a more efficient method in stones with higher HU values. Therefore, the HU values may be a useful tool for the selection of the treatment modality in patients with renal stones.Öğe Does the kidney injury molecule-1 predict cisplatin-induced kidney injury in early stage?(Sage Publications Inc, 2015) Tekçe, Buket Kin; Üyetürk, Ümmügül; Tekçe, Hikmet; Üyetürk, Uğur; Aktaş, Gülali; Akkaya, AkcanBackground It is not possible to diagnose acute kidney injury (AKI) in early stages with traditional biomarkers. Kidney injury molecule-1 (KIM-1) is a novel biomarker promising the diagnosis of AKI in early stages. We studied whether urinary and serum KIM-1 (KIM-1(U) and KIM-1(S)) concentrations were useful in predicting cisplatin-induced AKI in early stages. Methods We prospectively analysed 22 patients on cisplatin treatment. KIM-1(S) and KIM-1(U) concentrations were assessed in the samples of the patients on four different time periods (before treatment [BT], first [AT(1)], third [AT(3)] and fifth [AT(5)] day after treatment). Results KIM-1(U) concentrations on the first day after cisplatin treatment in patients with AKI were significantly increased compared to both KIM-1(U) concentrations of the same patients BT (P=0.009) and to AT(1)-KIM-1(U) concentrations of the patients without AKI (P=0.008). A receiver operating characteristic analysis revealed that AT(1)-KIM-1(U) concentrations may predict AKI with an 87.5% sensitivity and 93.3% specificity (area under the curve=0.94). KIM-1(S) concentrations were not significantly changed between BT and AT periods. Conclusions KIM-1(U) concentrations may predict cisplatin-induced AKI in early stages with high sensitivity and specificity.Öğe Does ureteral access sheat usage lead to permanent damage in the ureter? a placebo controlled trial in a rabbit model(Acta Cirurgica Brasileira, 2018) Gücük, Adnan; Söyler, Gizem; Üyetürk, Uğur; Yılmaz, Burak; Nalbant, İsmailPurpose: To evaluate the clinical stenosis or precursor histological changes that ureteral access sheaths commonly used in ureteroscopic surgeries may cause in the long term in ureter. Methods: In this study, the animals were divided into 9 groups and according to their groups, ureters of the rabbits were endoscopically fitted with 2F and 3F ureter catheters. The catheters were left in place and withdrawn after a specified period of time. All the ureters were excised and evaluated macroscopically, microscopically and histologically. Ureter diameters were measured and FGF-2 (+) labeled fibroblasts were counted in connective tissue as stenosis precursors. Results: Macroscopically or microscopically, no stenosis was found in any group. The ureter diameter of the group that were catheterized for the longest time with the catheter that had the widest diameter was significantly lower than the group with the shorter duration and the catheter with the narrower diameter and the control group. When the groups were compared in terms of their FGF values, there was a significant difference in FGF-2 counts at all three ureter levels (p < 0.05). Conclusion: The use of ureteral access sheath may lead to histological changes, as its diameter and duration increase.Öğe Effect of mitomycin, bevacizumab, and 5-Fluorouracil to inhibit urethral fibrosis in a rabbit model(Mary Ann Liebert, Inc, 2014) Üyetürk, Uğur; Gücük, Adnan; Fırat, Tülin; Kemahlı, Eray; Kükner, Aysel; Özyalvaçlı, Mehmet EminBackground and Purpose: Mitomycin C (MMC), bevacizumab, and 5-fluorouracil (5-FU) are frequently used in cancer treatment. Each of these agents also exhibits antiproliferative properties in different tissues. We compared the efficacy of MMC, bevacizumab, and 5-FU may inhibit urethral fibrosis (UF) without statistically significant differences among them. Materials and Methods: Forty male rabbits with traumatized urethras were divided into four groups: Group 1 (control), no medical treatment; group 2, MMC applied to the traumatized area; group 3, bevacizumab applied to the traumatized area; and group 4, 5-FU applied to the traumatized area. All animals were euthanized after 28 days to evaluate the presence of chronic inflammation and fibrosis. Tissue samples were subjected to hematoxylin and eosin and Masson trichrome staining to assess the presence of fibrosis, the state of the epithelium, and collagen density. Results: The MMC and control groups showed the most significant difference in outcomes (P<0.001), followed by the bevacizumab (P=0.002) and 5-FU groups (P=0.005). No statistically significant difference was noted when all three treatment groups were compared with one another. Histopathologic examination revealed inflammatory cell infiltration in the connective tissue, irregular collagen bundles, increased fibroblasts, and a moderate degree of fibrosis in the control group. Compared with controls, all treatment groups exhibited mild fibrosis, less collagen bundle irregularity, and lower numbers of fibroblasts. Conclusion: MMC, bevacizumab, and 5-FU may inhibit UF. There were no statistically significant differences in the effectiveness among the three agents.Öğe Evaluation of different p16 immunostaining methods and the prognostic role of p16/Ki-67 combined expression in non-muscle invasive bladder cancers(Vesalius Univ Medical Publ, 2015) Özyalvaçlı, Gülzade; Özyalvaçlı, Mehmet Emin; Astarcı, Hesna Müzeyyen; Boran, Çetin; Yeşil, Cemile; Üyetürk, Uğur; Aktaş, GülanThere are many scoring methods evaluating the expression of p16 in the bladder immunohistochemically. In this study our aim was to determine an optimal p16 scoring method by discussing different staining methods related with p16 expression in bladder cancers and to establish the association of p16 and Ki-67 expressions, alone or in combination, with recurrence and progression. Ninety patients undergoing their first transurethral resection for bladder cancer and newly diagnosed papillary urothelial carcinoma (pTa and pT1) were included in the study. Four different scoring methods were used for p16 (p16a, p16b, p16c, p16d). The patients were divided into two groups based on recurrence and progression. There was a statistically significant difference between recurrence and abnormal p16d staining (p = 0.005). In other staining patterns of p16, there was no statistically significant difference in terms of recurrence or progression.In the multivariate logistic regression analysis, combined Ki-67 >= 10 and abnormal p16d staining was found to be the only independent predictive factor for recurrence (OR = 2.26, 95% CI: 0.13-46.41, p = 0.035) and no independent predictive factor for progression was found. Determining an adequate expression scoring by taking normal transitional epithelial staining pattern as a reference would be an objective approach in p16 evaluation. Moreover, it was found that evaluating p16d and Ki-67 in combination would be significant in predicting recurrence in pTa and pT1 urothelial carcinomas.Öğe Evaluation of general characteristics of renal cell carcinoma patients: A single center experience(2018) Üyetürk, Ümmügül; Duman, Tuba Taslamacıoğlu; Yılmaz, Burak; Küçüköztaş, Nadire; Üyetürk, UğurObjective: Renal cancer (RC) accounts for 3.2% of all newly diagnosed cancers and approximately 90% of RC cases are renal cell carcinoma (RCC). Smoking and hypertension are the most important risk factors. The aim of our study was to evaluate the general characteristics of RCC patients in Bolu, Turkey. Materials and Methods: Patients who visited our medical oncology clinic and were diagnosed with RCC between January 1st, 2012 and May 31st, 2017 were evaluated retrospectively. Results: Eighty-one patients were diagnosed with RCC during the study period. The median age of the patients was 62 years (range: 38-87 years). Fifty-seven (70.4%) of the patients were male and 24 (29.6%) were female. Thirty patients (37.1%) were diagnosed incidentally. Forty-eight (59.3%) of the patients were smokers. The most common comorbidity was hypertension (58%). Radical nephrectomy was performed in 59 (72.8%) of the patients. The most common histological subtype was clear cell carcinoma (72.8%) and 39 (48.1%) were stage 1 when evaluated according to the stage of RCC. Of the 16 patients with metastatic disease, 11 (13.6%) received interferon therapy, and 5 patients (6.2%) refused treatment. After interferon treatment, 7 patients received targeted therapy with sunitinib/pazopanib as second-line treatment, 5 received everolimus as third-line treatment, and 3 received axitinib treatment as fourth-line treatment. Ten patients with bone metastasis underwent palliative radiotherapy. The median follow-up time of the patients was 21 months (0-123 months). Sixty-five patients (80.2%) survived this period. Conclusion: Smoking cessation and effective treatment of hypertension, preventable etiological factors of RCC, and incidental diagnosis of early RCC are very important. With early diagnosis, the partial nephrectomy rate might be increased.Öğe An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis(Canadian Urological Association, 2016) Kemahlı, Eray; Yıldız, Mevlüt; Fırat, Tülin; Özyalvaçlı, Mehmet Emin; Üyetürk, Uğur; Yılmaz, Burak; Gücük, AdnanIntroduction: The aim of this experimental study was to investigate the histopathological and biochemical effects of pyrrolidine dithiocarbamate, an antioxidant and inhibitor of NF-k beta, on ischemia-reperfusion injury in rats. Methods: A total of 21 male Wistar-Albino rats were randomly distributed into three groups as sham group (Group 1), ischemia-reperfusion (I/R) group (Group 2) and I/R with pyrrolidine dithiocarbamate (PDTC) group (Group 3). Left testicles of rats in Groups 2 and 3 underwent testicular torsion of 720 degrees for four hours and 100 mg/kg of PDTC was administered intraperitoneally prior to detorsion in Group 3. An hour after detorsion process, left orchiectomies were performed and 5 ml of intracardiac blood samples were drawn from rats in all three groups. Histopathological examination of testis tissues performed and measurement of superoxide dismutase (SOD) and malondialdehyde (MDA) levels in blood samples were taken. Results: Elevated levels of MDA and decreased SOD activity, together with decreased Johnson tubular biopsy scores consistent with I/R injury were observed in Group 2 (p<0.05). Group 1 and Group 3 were similar in terms of MDA levels, SOD activity, and Johnson scores (p>0.05). Conclusions: Our results indicated that PDTC may have beneficial effects for alleviation of I/R injury in testicular tissue in rats. Understanding the underlying mechanisms and exploration of its diagnostic and therapeutic potential requires further randomized, controlled trials on a larger scale.Öğe Is cystoscopy needed in spontaneous ürethral prolapses(Mary Ann Liebert Inc, 2012) Kemahlı, Eray; Üyetürk, Uğur; Gücük, Adnan; Yılmaz, Burak; Yağlı, Ömer Faruk; Metin, AhmetÖğe Kas İnvaziv Olmayan Mesane Karsinomlu Hastalarda Klinikopatolojik Parametrelerin Rekürrens ve Progresyonla İlişkisi(2015) Özyalvaçlı, Gülzade; Özyalvaçlı, Mehmet Emin; Gücük, Adnan; Astarcı, Hesna Müzeyyen; Üyetürk, Uğur; Kemahlı, ErayAmaç: Bu çalışmada Abant İzzet Baysal Üniversitesi (AİBÜ) Tıp Fakültesi'nde ilk tanısı pTa ve pT1 transisyonel hücreli mesane karsinomlu hastalarda evre ve grade gibi histopatolojik parametrelerin yanısıra yaş, tümör boyutu, tümör sayısı ve reTUR gibi klinik verilerin rekürrens ve progresyonla ilişkisinin ortaya konması amaçlanmıştır. Yöntem: 2008-2013 yılları arasındaki Abant İzzet Baysal Üniversitesi'nde ilk transüretral rezeksiyon (TUR) sonrası patolojik tanısı transizyonel hücreli mesane kanseri olarak rapor edilen (pTa, pT1) ardışık 119 hasta retrospektif olarak değerlendirildi. Bu hastalara ait klinik veriler ve histopatolojik preparatlar AİBÜ Üroloji ve Patoloji A.D. arşivinden elde edildi. Bulgular: Çalışmamıza dahil edilen hastaların 109'u erkek, 10'u bayandı. Ortalama takip süresi 30.14ay (2.86-80.74) idi. Univariate analizinde rekürrens ile tümör boyutu, grade'i, evresi, sayısı, Re-TUR ve sigara kullanımı arasında istatistiki fark varken progresyon ile tümör grade'i, boyutu, sayısı ve sigara kullanımı arasında istatistiki fark vardı. Multivariate analizde rekürrensi belirlemede bağımsız prediktif faktörler tümör boyutu (OR: 5.26,%95CI: 1.42-19.55) ve sigara kullanımı(OR: 4.65,%95CI: 1.2317.53) iken progresyonu belirlemede sadece tümör grade'i saptandı(OR: 5.32,%95CI 1.37-20.59). Kaplan Meier analizinde tümör boyutu <3 olan hastalar ile >=3 cm'nin üzerindeki hastalarda tahmini rekürrens zamanı sırasıyla 14.8ay (11.41-18.31) ve 7.6 ay (5.76-9.49) iken tümör sayısı tekli grup ile çoklu grupta sırasıyla 14.43ay (6.51-22.35) ve 7.17ay (5.63-8.70) idi. Gruplar arasında istatistiki anlamlı fark vardı (p=0.009). Sonuç: pTa ve pT1 mesane tümörlü hastaların progresyonunu öngörmede grade'in tek başına çok önemli olduğu ve WHO 2004'te güncellenen ikili derecelendirme sisteminin bu tümörleri derecelendirmede daha kolay ve uygun olabileceği düşünülmüştür. Evrelendirmede bu tümörlerin rekürrens açısından farklılık gösterdiği ve aslında klinik olarak yüzeyel başlığı altında aynı kategoride yer almasının çok da doğru bir yaklaşım olmadığı sonucuna varılmıştır.Öğe Management of the scrotal trauma caused by an air-compressed gun in a child: A case report(2019) Üyetürk, UğurChildren exposed to air gun pellets may also have a different clinical picture, from mild tissue damage to life-threatening injury. Although these weapons are known as toys, there has been a significant increase in the muzzle velocity of these weapons with advances in gas technology, recently. Air gun injuries are frequently presented in head, neck and thorax region, but injuries in genitourinary tract are rare in children. Here, we report a 12-year-old boy who was injured by a random shot with an air gun, due to the features of his diagnosis and treatment.Öğe Mean platelet volume : a simple indicator of chronic prostatitis(Carbone Editore, 2013) Aktaş, Gülali; Çakıroğlu, Basri; Şit, Mustafa; Üyetürk, Uğur; Alçelik, Aytekin; Savlı, Haluk; Kemahlı, ErayBackground: Chronic prostatitis is a widespread urological disease, however, underlying pathophysiology is poorly understood and it is usually characterized with recurrences. Platelets take in charge in hemostasis, tissue repairment and inflammation. Mean platelet volume (MPV), is considered as a marker of platelet activation. The aim of present study is to find out the possible association between MPV and chronic prostatitis. Methods: A total of 40 patients with chronic prostatitis and 45 healthy controls enrolled to the study. Laboratory data of chronic prostatitis patients and healthy controls obtained from the computerized databases of the hospitals and platelet count (PLT) and mean platelet volume (MPV) values of the participants recorded. Results: There was no statistically significant difference between groups in terms of mean age and PLT count. However, patients with chronic prostatitis had significantly increased MPV compared to controls (p=0.004). Conclusion: Increased MPV should help the diagnosis of chronic prostatitis but, more studies with larger study population are needed to confirm our results.
