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Öğe Anterior burun tamponunun orta kulak basıncı üzerine etkisi(2003) Harputluoğlu, Uğur; Koçak, Salih; Öztürk, Özcan; Demirci, Levent; Egeli, ErolAmaç: Septoplasti ameliyatı yapılan hastalarda anterior burun tamponunun orta kulak basıncına etkisi araştırıldı. Hastalar ve Yöntemler: Çalışmaya burun tıkanıklığı nedeniyle septoplasti ameliyatı uygulanan 43 erişkin hasta (26 erkek, 17 kadın; ort. yaş 30; dağılım 18-56) alındı. Tüm hastalarda işitme kaybı olmamasına, otoskopik muayenenin normal olmasına ve ameliyat öncesi timpanogramın tip A olmasına dikkat edildi. Septoplasti ameliyatı sonrası klasik anterior burun tamponu uygulandı ve 36 saat kadar burunda tutuldu. Timpanometrik ölçümler ameliyat öncesinde, tamponun çıkarılmasından hemen önce ve ameliyat sonrasında beşinci günde yapıldı. Ameliyat öncesi ve sonrasında orta kulak basınçları arasında 50 daPa veya daha fazla farklılık olması anlamlı kabul edildi. Bulgular: Hiçbir hastada orta kulak efüzyonu gelişmedi. Ameliyat öncesi ve ameliyat sonrası birinci günkü orta kulak basınçları arasında anlamlı farklılık bulundu. (p<0.05) Ameliyat sonrası beşinci günkü kontrol timpanogramlarmda östaki disfonksiyonunun düzeldiği görüldü (p<0.05). Sonuç: Septoplasti ameliyatlarından sonra, cerrahi travma ve burun tamponunun etkisine bağlı olarak orta kulak basıncı düşmekte, bu durum tampon çıkarıldıktan sonra'normal sınırlara dönmektedir.Öğe Bone induction capacity of the periosteum and neonatal dura in the setting of the rat zygomatic arch fracture model(American Medical Association, 2003) Özçelik, Derya; Turan, Tuğrul; Kabukcuoǧlu, Fevziye; Uğurlu, Kemal; Öztürk, ÖzcanObjectives: Osteogenic properties of the dura and periosteum are thought to contribute to the regenerative capacity of membranous bone tissue. The purpose of this investigation was to elucidate (1) whether dura without underlying neural tissues can induce osteogenesis, (2)to what extent the periosteum participates in membranous bone healing, and (3) the difference between durainduced and periosteum-induced osteogenesis. Methods: A standardized 2-mm defect was created within the middle portion of each zygomatic arch in 30 Wistar albino rats. The rats were divided into 3 groups, 10 animals in each group. In group 1, the periosteum was removed and neonatal dura grafts were transplanted onto the zygomatic arch bone defect circumferentially. In group 2, the overlying periosteum was preserved. In group 3, the periosteum was removed. At 3 and 10 weeks, animals from each group were killed, and specimens were obtained. Data were collected from the 3-dimensional computed tomographic scans and histologic studies to compare the extent of bony repair. Results: Fracture sites demonstrated osteogenesis associated with chondrogenesis in groups 1 and 2 and only limited osteogenesis with no chondrogenesis in group 3. In some animals in group 3, cortical bone ends underwent resorption. In groups 1 and 2, bone defects were obliterated by the formation of the mature compact bone at 10 weeks postoperatively. The difference between bone regeneration in these groups was not significant (P=.16). In group 3, the defects failed to heal by bony union, and in most of the samples the fibrous union was observed instead. The difference between groups 1 and 3 was significant (P=.03). The difference between groups 2 and 3 was not significant (P=.09). Conclusions: The trend toward significance is in agreement with the current clinical practice of preserving periosteum in the manipulations of the membranous bone defects. Newborn dura can exert a potentiating effect on osteogenesis. © 2003 American Medical Association. All rights reserved.Öğe Can post-adenotonsillectomy morbidity be reduced by intravenous 24 h hydration in pediatric patients following adenotonsillectomy?(Elsevier Ireland Ltd, 2004) Egeli, Erol; Harputluoğlu, Uğur; Öztürk, Özcan; Oğhan, Fatih; Koçak, SuzanObjective: To determine the benefit of 24h intravenous hydration for pediatric postoperative adenotonsillectomy patients. Study design: A prospective, randomized controlled clinical study. Methods: The study is consisting of two groups of pediatric patients following adenotonsillectomy performed in a university hospital. One group received 24 h IV hydration at hospital white the other did not have IV hydration. Chi-square and two-tailed unpaired Student's ttests were used to compare the two independent groups. P < 0.05 was accepted as statistically significant. Results: Although the postoperative parameters such as nausea, fever, vomiting, odor, bleeding, otalgia and trismus were not statistically different between the two groups based on chi-square analysis (P > 0.05), a significant pain-relieving effect was seen in hydration group after the second day (P < 0.05). There were no complications associated with intravenous hydration. Conclusion: Results of the current study suggest that 24 h IV hydration can reduce postoperative pain in late postoperative period following adenotonsillectomy in children but does not offer much advantage over without IV hydration therapy based on a number of other parameters. Furthermore, it seems to be cost effective, safe and easy and even these are encouraging for further studies in the future.Öğe Does the prevalence of otolaryngological diseases in deaf children differ from children without hearing impairment?(Springer-Verlag, 2008) Oğhan, Fatih; Harputluoğlu, Uğur; Öztürk, Özcan; Güçlü, Ender; Mayda, AtillaThere is no enough data about the prevalence of otorhinolaryngological (ORL) diseases in deaf children. In this study, we aimed to determine the prevalence of ORL diseases among deaf children and compare children from a school for the deaf with those attending regular primary schools for the presence of ear, nose and throat (ENT) problems. The subjects were 1,282 children attending three primary schools in the province of Duzce and 572 hearing-impaired children from eight schools for the deaf. Following ENT examinations, ORL findings were statistically compared between two groups using a Chi-square test and P values less than 0.05 were considered significant. Upper airway pathologies including chronic tonsillitis, rhinitis, septal deviation and tubal dysfunction, and chronic otitis media (COM) were found to be statistically higher in deaf children than in children without hearing impairment. Although the incidence of middle ear effusion was found to be higher in deaf children, it was not statistically significant. On the other hand, the incidence of impacted wax was lower in deaf children than others. In conclusion, we should have enough data on the prevalence of ORL diseases in deaf children to give a clue to help prevent ORL diseases and if we can detect them early, we can solve the problems before they become more complicated and we can rehabilitate these children better.Öğe Does topical lidocaine with adrenaline have an effect on morbidity in pediatric tonsillectomy?(Elsevier Ireland Ltd, 2005) Egeli, Erol; Harputluoğlu, Uğur; Oğhan, Fatih; Demiraran, Yavuz; Güçlü, Ender; Öztürk, ÖzcanObjective: To evaluate the efficacy of lidocaine with adrenaline on post-operative morbidity in pediatric patients after tonsillectomy. Study Design: A double blind prospective randomized controlled clinical study. Methods: The study is consisting of two groups of pediatric patients following tonsillectomy performed in a university hospital. One group received lidocaine with adrenaline soaked swabs packed in their tonsillar fossae white the control group received saline-soaked swabs. Chi-square and two-tailed unpaired Student's t-tests were used to compare the two independent groups. p < 0.05 was accepted as statistically significant. Results: No significant pain-relieving effect was seen in the lidocaine with adrenaline group (p > 0.05) and also the other post-operative parameters such as nausea, fever, vomiting, odor, bleeding, otalgia and trismus were not statistically different between the two groups based on chi-square analysis (p > 0.05). There were no complications associated with lidocaine and adrenaline. Conclusion: We suggest that application of topical lidocaine with adrenaline seems to be a safe and easy medication for local anesthetic use. However, in our study, lidocaine with adrenaline offered no advantage over placebo in the control of post-operative pain and other morbidity related factors following pediatric tonsillectomy. We therefore do not recommend topical application of lidocaine with adrenaline for reducing morbidity in pediatric tonsil surgery.Öğe Ear examination findings at the Yeditepe School for the deaf(Elsevier Sci Ireland Ltd, 2003) Egeli, Erol; Çiçekçi, Günferi; Öztürk, ÖzcanObjective: To find out the prevalence and etiologies of middle ear disease among deaf children in a school for the deaf. Methods: A total of 162 students with hearing impairment attending a school for the deaf during the school year of 2001 2002 were admitted to this study. The range of age was from 6 to 20 years. The examination consisted of inspection of the auricle and external auditory canal, and otoscopic, audiometric and tympanometric evaluation. School performance was assessed using the results of end-of-year school examination and continuous assessments obtained from the school administration. Results: The demographic properties of the study group revealed that 81 (60.9%) of children were mate and 52 (39.09%) were female. Most of the children (45%) were in the group of 9-13 years of age. On pure tone audiometric evaluation, sensorineural hearing loss (HL) was found in 99 (85.3%) and mixed type HL in 17 (14.6%) of 116 cases. Impacted wax was the most common pathology and was seen in 15 (39.4%) of children. Middle ear diseases were detected in 38 (28.5%) of children with otoscopic examination. Conclusion: This study shows that hearing impairment and preventable ear diseases are important health problems among the school children for the deaf. It is essential to start the school education early in time and to start using hearing aid before 2.5 year of age.Öğe Effect of ketamine anaesthesia on middle ear pressure in rabbits: A pilot study(2006) Kocaman, Buket; Öztürk, Özcan; Demiraran, Yavuz; Ağartan, Canan Aldırmaz; Egeli, ErolObjectives: Although most studies about effect of anaesthetics on middle ear pressure were explained with gas effect there are no studies about effect of ketamine on middle ear pressure. The aim of this study was to evaluate the effect of ketamine anaesthesia on middle ear pressure. Methods: Male New Zealand rabbits (n=15), weighing between 2.5-3.2 kg were randomly divided into two groups. Those in Group I (n=9) were anaesthetized by intravenous ketamine 50 mg.kg-1 whilst Group II (n=6) were injected with the same volume of saline. Baseline tympanometry readings were performed on the left and right ears after otoscopy examination and again at 5 and 20 minutes. Results: The change of tympanometric measurements before ketamine, at 5th and 20th minutes of the administration was no statistically significant in both of Group I and II (p>0.05). There was a slightly significant difference at 20th min of administration when ketamine group compared with control group (-55.6±29.5 in Group I; -29.0±33.5 in Group II) (p=0.03). Conclusion: In this study it is concluded that ketamine anaesthesia has no effect on the pressure in middle ear.Öğe Effects of otorhinolaryngological diseases and socioeconomic status on school performance: a survey study(Elsevier Ireland Ltd, 2004) Egeli, Erol; Oğhan, Fatih; Öztürk, Özcan; Harputluoğlu, UğurObjective: The aim of the present study was to investigate the effects of otorhinolaryngological (ORL) diseases and socioeconomic status (SES) on school performance. Methods: This study was conducted in three primary schools located in Duzce. Of three schools, two schools (group A) are located in the suburb area of the city and students had a low SES. The other one (group B) is in the center of the city and students had a high SES. A total of 1282 (urban 609 and rural 673) students attending to these three schools were examined considering the ORL diseases. SES of the students were evaluated according to the mean monthly income within the family, educational level of parents and occupation, presence of conflict within the family, and smoking habits. School performance of the children is ranged between 1 and 5. School success of students were evaluated by asking their educators. Results: The mean (S.D.) age was 9.15 (1.48) years (range, 7-12). The students in group B were observed as more successful than that of group A. A major finding in this study is that the incidence of ORL diseases in the rural school is high and it was found that when ORL diseases increased, the mean school success grade of the students decreased in group B. The otological diseases were found to have an effect on school performance more than the other ORL diseases independently of SES. When we analyzed the effect of SES on school performance, we found that the students' school grade level in group A was low. Conclusions: ORL diseases are more commonly detected in the primary schools with tower socioeconomic level than the other and we found that the effects of ORL diseases and SES on school performance in group B was low.Öğe Effects of sevoflurane and TIVA with propofol on middle ear pressure(Elsevier Ireland Ltd, 2006) Öztürk, Özcan; Demiraran, Yavuz; İlçe, Zekeriya; Kocaman, Buket; Güçlü, Ender; Karaman, EminObjective: To evaluate the effects of sevoflurane and TIVA with propofol on middle ear pressure and to show the importance of anesthesia without using any inhalational agents during middle ear surgery. Study design: A prospective, randomized controlled clinical study. Methods: In this study, 25 male children that were scheduled for circumcision were randomised into two groups. Group I (n = 13) received TIVA with propofol and group II (n = 12) received sevoflurane. Baseline tympanometry reading was performed on each ear just before anesthesia. The next tympanometry reading was taken 10 min after applying the laryngeal mask. Data were analysed by Mann-Whitney U (between groups) and Wilcoxon tests (within groups). Results: Mean MEP values in 26 ears of 13 boys in group I did not show any significant difference before and after the anesthesia with propofol (p > 0.05). In group II mean MEP values in 24 ears of 12 boys showed a significant increase after the anesthesia with sevoflurane (p < 0.001). No significant difference was found between the MEP values of the two groups before the anesthesia (p > 0.05), and MEP values measured during the anesthesia were significantly higher in group II (p = 0.007). Conclusion: Sevoflurane may increase the middle ear pressure and TIVA with propofol may be used in middle ear operations more safely than sevoflurane.Öğe Etiology of deafness at the Yeditepe School for the deaf in Istanbul(Elsevier Sci Ireland Ltd, 2003) Egeli, Erol; Çiçekci, Günferi; Sılan, Fatma; Öztürk, Özcan; Harputluoğlu, Uğur; Onur, Aşkın; Egeli, AytenObjective: The etiology of deafness can be classified as genetic, acquired and unknown. An unknown etiology was a high incidence in previous reports. The aim of this study is to explore the etiology of deafness and to reduce the cases in the unknown group. Methods: This study was conducted on 162 students at the Yeditepe School for the deaf. Otologic, physical and psychological. examinations were performed by a team of doctors including four otologists, a geneticist, a dentist, an ophthalmologist and an audiologist. Results: A genetic cause was identified in 41.35%, acquired 37.65% and unknown 20.98%. Genetic etiologies were stratified as familial and syndromic subgroups. A familial cause was found in 60 of 162 children and in 22 of those 60 cases, the parents had a consanguineous marriage. There was 11 cases associated with a syndrome. Ninety four minor abnormalities have been established in some deaf children. Febrile convulsion (36%) was identified as the most common etiology in acquired cases. Conclusion: In contrast with other studies the consanguineous marriage was present in 36.6% of the familial cases and 38.8% in total of the school. An unknown etiology was reported in high rates in previous reports. These unknown cases could be described as a part of a syndrome by a crowded team of consultants. Evaluation of early diagnostic criterias and minor abnormalities can help us to provide early rehabilitation of deafness in childhood.Öğe Evaluation of deaf children in a large series in Turkey(Elsevier Ireland Ltd, 2005) Öztürk, Özcan; Sılan, Fatma; Oğhan, Fatih; Egeli, Erol; Belli, Şeyda; Tokmak, Abdurrahman; Harputluoğlu, Uğur; Önder, Halil İbrahim; Zafer, CansuObjective: Evaluation of the deafness etiology, ear examination findings and hearing levels of deaf children in a large series. Patients and methods: We studied 840 deaf primary school children (486 mate, 354 female, mean age 12.69 +/- 3.52, range 5-22). A questionaire investigating the prenatal, perinatal and postnatal etiological causes was prepared and pedigree analysis was performed. After ENT examination, odyologic tests were performed. Results: The etiological features of deafness were found for genetic causes as 429 cases (51.1%), 127 children (15.1%) for acquired group and 284 children (33.8%) for unknown group. We confirmed 136 (15.5%) syndromic deaf children and 19 of them (13.9%) were autosomal recessive (AR), 105 of them (77.2%) were autosomal dominant (AD), six (4.4%) of them were X-linked. Two hundred and ninety-three deaf (33.4%) children were in the familial nonsyndromic group. In this group, the inheritance of 255 (87%) were AR, 23 (7.8%) were AD and 15 (5.2%) were X-linked recessive. Febrile convulsion was identified as the most common etiology in 36 (4.3%) cases in the acquired group. Three hundred and twenty-two (67.7%) children had profound HL (above 91 dB), 111 (23.3%) had severe HL and 43 (9%) had moderately severe HL. Sensorineural. HL was found in 439 (92.2%) and mixed type hearing loss was seen 37 (7.8%) of 476 cases. We found many major and minor abnormalities and ocular, ear and dental pathologies. The prevalence of ear diseases was found in 203 (24.2%) of children. Impacted wax was found in 80 (9.5%) of 840 children with otoscopic examination and was the most common pathology, retraction in 70 (8.3%) and perforation in 15 (1.8%) followed it. Conclusion: Preventable ear disease are important health problems among school children for the deaf because these diseases can affect the real level and type of deafness, so determining early diagnostic criteria, ear diseases and minor abnormalities is important for early rehabilitation. Syndromes can be prevented in pregnancy, infections can be prevented in prenatal or postnatal period but unknown group cannot be prevented although the unknown etiology can be reduced by multidiciplinary approach.Öğe Hemimacroglossia caused by isolated plexiform neurofibroma: a case report(Wiley, 2006) Güçlü, Ender; Tokmak, Abdurrahman; Oğhan, Fatih; Öztürk, Özcan; Egeli, ErolObjectives: The present case is a diffuse isolated plexiform neurofibroma of the tongue that was not associated with neurofibromatosis that we treated with intraoral surgery. Study Design: A case report. Methods. We present a 5-year-old girl with isolated plexiform neurofibroma of the tongue with infiltration of the tongue base and review treatment approaches for this very rare tumor. Results. An intraoral approach appears to be a good alternative method that allows both an acceptable exposure for total excision and limited postoperative sequelae. Conclusions: Isolated plexiform neurofibroma. of the tongue is very rare. It causes a massive macroglossia that is progressive with advance of years and disturbs the patient's speech, occlusion, and tongue movements. Involvement of the tongue may be associated with infiltration into the deep structures of the neck by the tumor, thereby presenting considerable operative difficulties.Öğe İlkokul çağındaki çocuklarda kulak burun boğaz hastalıkları tarama sonuçlarının sosyoekonomik seviyeye değerlendirilmesi(2003) Harputoğlu, Uğur; Egeli, Erol; Oğhan, Fatih; Mayda, Atilla; Öztürk, ÖzcanAmaç: Düzce’de ilkokul çağındaki çocuklarda kulak burun boğaz hastalıklarının yaygınlığını ve sosyoekonomik seviyeye göre dağılımını araştırmak.Gereç ve Yöntem: 1282 ilkokul çağındaki öğrenci tarandı. Detaylı bir anamnez alındıktan sonra tüm çocukların kulak burun boğaz muayeneleri ve timpanometrik ölçümleri yapıldı. İlkokullardan ikisi şehrin kırsalında bulunup sosyoekonomik seviyesi daha düşüktü. Diğer bir ilkokul ise şehrin merkezinde ve sosyoekonomik seviyesi daha yüksekti. Bu okullardaki öğrenciler kulak burun boğaz hastalıklarının yaygınlığı açısından ki-kare testi ile istatistiksel olarak karşılaştırıldı.Bulgular: Merkezde yer alan ve sosyoekonomik seviyesi daha yüksek olan ilkokul çocuklarına göre, kırsalda yer alan ilkokul çocuklarında kulak burun boğaz hastalıklarının yaygınlığı açısından anlamlı fark vardı (p<0.001).Sonuç: Kulak burun boğaz hastalıklarının yaygınlığında yaş, mevsim ve bulunulan ülke etkili olabileceği gibi, sosyoekonomik düzey de etkili olmaktadır. İlkokul çocuklarının anne-babaları ve öğretmenleri bu yaşlarda yüksek oranda görülen KBB hastalıkları konusunda eğitilmelidirler.Öğe İlkokul çağındaki çocuklarda kulak burun boğaz hastalıkları tarama sonuçlarının sosyoekonomik seviyeye göre değerlendirilmesi(2003) Öztürk, Özcan; Harputoğlu, Uğur; Egeli, Erol; Oğhan, Fatih; Mayda, AtillaAmaç: Düzce’de ilkokul çağındaki çocuklarda kulak burun boğaz hastalıklarının yaygınlığını ve sosyoekonomik seviyeye göre dağılımını araştırmak. Gereç ve Yöntem: 1282 ilkokul çağındaki öğrenci tarandı. Detaylı bir anamnez alındıktan sonra tüm çocukların kulak burun boğaz muayeneleri ve timpanometrik ölçümleri yapıldı. İlkokullardan ikisi şehrin kırsalında bulunup sosyoekonomik seviyesi daha düşüktü. Diğer bir ilkokul ise şehrin merkezinde ve sosyoekonomik seviyesi daha yüksekti. Bu okullardaki öğrenciler kulak burun boğaz hastalıklarının yaygınlığı açısından ki-kare testi ile istatistiksel olarak karşılaştırıldı. Bulgular: Merkezde yer alan ve sosyoekonomik seviyesi daha yüksek olan ilkokul çocuklarına göre, kırsalda yer alan ilkokul çocuklarında kulak burun boğaz hastalıklarının yaygınlığı açısından anlamlı fark vardı (p<0.001). Sonuç: Kulak burun boğaz hastalıklarının yaygınlığında yaş, mevsim ve bulunulan ülke etkili olabileceği gibi, sosyoekonomik düzey de etkili olmaktadır. İlkokul çocuklarının anne-babaları ve öğretmenleri bu yaşlarda yüksek oranda görülen KBB hastalıkları konusunda eğitilmelidirler.Öğe İnternal laringosel (Olgu sunumu)(2005) Erdoğmuş, Beşir; Yazici, Burhan; Öztürk, ÖzcanLaringosel, laringeal sakkülün kistik dilatasyonu ile seyreden nadir bir hastalıktır. Manyetik rezonans görüntüleme laringoselin tanı, tedavi, tiplendirme, anatomik uzanımının belirlenmesi, komplikasyon ve neoplazm varlığının araştırılmasında en faydalı radyolojik yöntemdir. Bu çalışmada ses kısıklığı ve solunum zorluğuna neden olan laringosel olgusunun manyetik rezonans görüntüleme bulguları sunulmuştur.Öğe Larinks Psödosarkoması: Olgu sunumu(2004) Öztürk, Özcan; Belli, Şeyda Bayyel; Alper, Murat; Egeli, Erol; Kaleli, ÇetinLarinksin psödosarkoması nadir görülen ve hala tartışmalı olan bir malign neoplazmdır. Psödosarkoma küçük bir karsinomatöz kısım ve daha büyük sarkomaya benzeyen kısımdan oluşur. Sarkomatoid doku fibrosarkoma veya bazı indiferansiye pleomorfik sarkomaya benzer. Larinks psödosarkoması sıklıkla glottik alanda, polipoid şekilli olarak görülür ve bu doku granülasyon dokusu ile karıştırılabilir. Biz vokal kord psödosarkoması ile ortaya çıkan bir olgu sunumu yaptık. Hasta 68 yaşında bir erkekti ve iki aydır süren bir ses kısıklığı tarifliyordu. Sağ vokal korddan kaynaklanan polipoid bir kitle tespit edildi. İlk biyopsi kronik inflamatuar infiltrasyon şeklinde tanı aldı. İkinci biyopside ise polipoid sarkomatoid karsinoma tanımlandı. Hastaya sağ kordektomi uygulandı. Hastanın 30 aylık takibi sonucunda herhangi bir nüks tespit edilmedi.Öğe Laryngocele in association with ankylosing spondylitis(Springer Wien, 2005) Erdoğmuş, Beşir; Yazıcı, Burhan; Öztürk, Özcan; Ataoğlu, Safinaz; Yazıcı, SelmaA laryngocele is a cystic dilatation of the laryngeal saccule. The etiology of laryngoceles is unclear, but congenital and acquired factors are considered to play a role in their development. An acquired laryngocele may develop when the laryngeal ventricle becomes functionally obstructed as a result of an increase in intraglottic pressure, such as that caused by excessive coughing, playing a wind instrument, glass blowing or obstruction of appendicular ostium. We present a case of laryngocele in a patient with ankylosing spondylitis. To the authors' knowledge, and from a review of the literature, this combination has not been previously described. The laryngocele was also infected in this case. We believe that development of the laryngocele might be a result of increased intra-abdominal pressure, caused by rheumatoid arthritis, with associated increased intralaryngeal pressure.Öğe Local control of primary oropharyngeal malignant melanomas with limited tissue excision: a report of three cases(Springer, 2005) Öztürk, Özcan; Cansız, Harun; Güzel, M. Zeki; Karakullukçu, Barış; Özek, HüsnüMucosal malignant melanomas are rare lesions, and they have different characteristics from their cutaneous counterparts. Since extended excisions of mucosal malignant melanomas located in the oropharyngeal region cause significant morbidity, limited surgical excision comes into consideration. Three cases of extensive oropharyngeal malignant melanomas were resected with 0.5-1.5-cm healthy tissue margins. The cases were followed for local recurrences. Case 1 applied radiotherapy and chemotherapy in addition to immunotherapy, and the patient is still alive without any local recurrences 18 months after surgery. The patient in case 2 underwent radiotherapy and immunotherapy and died 6 months after surgery. The patient in case 3 received chemotherapy in addition to immunotherapy and died 12 months after surgery as a result of distant metastasis. All cases were without any local recurrences. Surgical excision with limited tumor-free tissue margins may be the surgery of choice to prevent morbidity associated with wide resection of oropharyngeal malignant melanomas if other authors also reconfirm these results with many more cases in the future.Öğe Measuring the correlation between adenoidal-nasopharyngeal ratio (AN ratio) and tympanogram in children(Elsevier Ireland Ltd, 2005) Egeli, Erol; Oğhan, Fatih; Öztürk, Özcan; Harputluoğlu, Uğur; Yazıcı, BurhanObjective: To evaluate the correlation between adenoidal-nasopharyngeal ratio (AN ratio) and tympanogram in children. Study design: A prospective clinical study from June 2002 to May 2003. Method: A total of 64 children, aged 6-9 years who presented with nasal obstruction, snoring, mouth breathing, and hyponasal speech were examined and AN ratio was calculated by using the lateral neck radiograms and compared with the tympano-metric values. The relationship between AN ratio and middle-ear pressure was evaluated, regarding the AN ratio of 0.71. The chi-square test was used to analyze the correlation between AN ratio and middle ear pressures and Wilcoxon test was used to compare the changes between the mean AN ratio values, and mean middle ear pressures (including A and C type tympanograms) before and after medical therapy. Results: Middle-ear effusions and C type tympanograms in impedance audiometry were both related to eustachian tube dysfunction resulting from enlargement of the adenoids with AN ratios higher than 0.71. Middle ear pressures were found tower in children with AN ratio greater than 0.71 than in children AN ratio less than 0.71 and the difference was highly significant (p < 0.001). Although medical treatment of large adenoids was rather effective to shrink the adenoid tissue (p < 0.001), it did not cause a statistically significant change in tympanometric values (p > 0.05). Conclusions: Antibiotherapy is effective in reducing adenoid size without signs and symptoms of infection. The reduction of the adenoids in size after 3 weeks of antibiotherapy has an positive effect on recovery of eustachian tube function but is not sufficient in patients with middle ear effusion. Early ventilation tube insertion may be an alternative therapy for the middle ear effusions not improving by 3 weeks medical therapy.Öğe Nasal carriage of pathogenic bacteria in medical students: effects of clinic exposure on prevalence and antibiotic susceptibility(Springer, 2007) Güçlü, Ender; Yavuz, Mehmet Tevfik; Tokmak, Abdurrahman; Behçet, Mustafa; Karalı, Elif; Öztürk, Özcan; Egeli, ErolStaphylococcus aureus is a major cause of community-acquired and nosocomial infections worldwide. One important source of this pathogen for nosocomial infections is the nasal carriage of S. aureus among hospital personnel. There are only a few studies investigating the carriage of S. aureus in a community of medical students. Oral and nasal flora of 179 medical students with varying clinical exposures were determined. Oral cultures revealed no nosocomial pathogen and nasal cultures showed an increasing rate of S. aureus carriage with increasing clinical exposure. Methicillin resistance also demonstrated a tendency toward increasing with increasing clinical exposure.
