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Öğe Age specific prevalence of hepatitis B and hepatitis C among pregnant women in the northwestern region of Turkey(Indian Society of Gastroenterology, 2014) Simavlı, Serap Aynur; Özlü, Tülay; Küçükbayrak, Beyhan[No abstract available]Öğe Alterations in placental pendrin expression in pre-eclampsia(Taylor & Francis Ltd, 2014) Karataş, Ahmet; Erdem, Havva; Albayrak, Mustafa; Oktay, Murat; Özlü, Tülay; Dönmez, Melahat EmineIntroduction: Pendrin is an integral membrane protein and plays a key role in extracellular fluid volume and blood pressure control. We aimed to investigate the relationship between pendrin immunostaining intensity in normal and pre-eclamptic placental tissue. Methods: Fifty-six placental tissues, of which 26 were in pre-eclamptic, and 30 were in control group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Results: There was more positive immunstaining in the pre-eclamptic placenta compared to the controls (p<0.001). A significant positive correlation was observed between immunostaining level and diastolic blood pressure (r = 0.533, p = 0.005) in the pre-eclamptic group. However, no significant correlation was observed between any condition and immunostaining level in the control group. Conclusions: Placentas in the pre-eclamptic group were significantly more immunostained with pendrin than were those in the control group. In addition, a positive correlation between immunostaining intensity with pendrin and both systolic and diastolic blood pressure were observed. Pendrin may play a role in the mechanism of severe hypertension in women with pre-eclampsia.Öğe Anal atresia, abnormal genitalia, and absent thumb : congenital malformations associated with mosaic ring chromosome 13(Medecine Et Hygiene, 2013) Ocak, Zeynep; Özlü, Tülay; Vural, MehmetAnal atresia, abnormal genitalia, and absent thumb: congenital malformations associated with mosaic ring chromosome 13: Because of the deletion of a segment of the chromosome during the formation of a ring, several clinical findings may be associated with ring chromosomes. Ring chromosome 13 is one of such disorders in which the genotype-phenotype correlation is stronger by virtue of the accumulating literature. It can be associated with multiple congenital abnormalities and severe mental retardation. We report a case with mosaic ring chromosome 13 whose prenatal ultrasound revealed bilateral ventriculomegaly. Anal atresia, unidentifiable external genitalia, and an absent thumb were observed in the postmortem examination.Öğe Antiemetic effects of dexamethasone and ondansetron combination during cesarean sections under spinal anaesthesia(Makerere Univ, Fac Med, 2013) Demirhan, Abdullah; Tekelioğlu, Yaşar Ümit; Akkaya, Akcan; Özlü, Tülay; Yıldız, İsa; Bayır, Hakan; Koçoğlu, Hasan; Duran, BülentBackground: Nausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of post-delivery intraoperative nausea and vomiting (IONV) during CS under spinal anesthesia. Objective: To compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the single use of each agent to decrease the incidence of postdelivery IONV during CS under spinal anesthesia. Methods: A randomized, prospective, double blind study was performed on 90 patients undergoing planned CS under spinal anesthesia. Patients received 4mg ondansetron in Group O, 8mg dexamethasone in GroupD, 4mg ondansetron+8mg dexamethasone in Group OD intravenously within 1-2 minutes after the umbilical cord was clamped. Frequency of postdelivery IONV episodes was recorded. Results: A total of 86 eligible patients were included in the study. There were 29 patients in Group O, 29 patients in Group D and 28 patients in Group OD. There were no statistically significant difference between the groups in terms of baseline characteristics and intraoperative managements. Frequency of intraoperative nausea, retching and vomiting experiences were similar between the groups(p>0.05). Conclusion: Single dose 4mg ondansetron, 8mg dexamethasone, or combined use of 8mg dexamethasone+4mg ondansetron, given intravenously is all effective agents for the control of postdelivery IONV. Combined use of dexamethasone and ondansetron for the same indication does not seem to increase the antiemetic efficacy.Öğe Are there any genotoxic effects of laser epilation applications on human? an observational study(Mrs Deepika Charan, 2014) Ocak, Zeynep; Özlü, Tülay; Taşdemir, Şener; Bilen, Handan; Kocaman, Ertuğrul MevlütBackground: Laser epilation is a method of removal of unwanted hair from the body and its use for this cosmetic purpose is gaining increasing popularity. Sister chromatid exchange (SCE) is a critical method for determining genotoxicity caused by several mutagens and carcinogens under in vivo and in vitro conditions. Aims & Objective: In this study, we aimed to determine whether removal of unwanted hair by laser epilation causes genotoxicity in women undergoing this procedure. Materials and Methods: 40 voluntary women who admitted to the dermatology clinics for the removal of unwanted hair by laser epilation were included. Skin types of all patients were classified according to Fitzpatrick Scale. Laser epilation was applied by Alexandrite (Light Age Epicare Duo) at a 755 nm wavelength laser. The possible genotoxic effects in women who had laser epilation to the whole leg (upper and lower leg) and face was investigated by the SCE method. Results: The blood samples that were drawn before and 24 hours after the laser application showed no significant differences between the SCE frequencies (p>0.05). Conclusion: We could not find any significant genotoxic effect of laser epilation in women undergoing this procedure. As far as we know, this is the first study that investigates the relationship between laser applications and genotoxic effects.Öğe Association between omentin levels and insulin resistance in pregnancy(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2014) Aktaş, Gülali; Alçelik, Aytekin; Özlü, Tülay; Tosun, Mehmet; Tekçe, Buket Kın; Savlı, Haluk; Tekçe, HikmetAims: Omentin is a new adipokine secreted mainly from visceral adipose tissue. Serum omentin is found to be reduced in patients with impaired glucose tolerance, type 2 diabetes mellitus, obesity and insulin resistant states. Despite the fact that pregnancy is also characterized with hyperinsulinemia, literature is lacking about data of omentin levels and its association with insulin resistance in pregnant women. We aimed to evaluate the association of omentin levels and insulin resistance in pregnant women and to compare these levels with those of non-pregnant, nondiabetic women. Methods: Uncomplicated pregnant women who admit to our outpatient clinics for routine follow-up were included in the study group. Non-pregnant women without diabetes mellitus were served as control group. Fasting glucose, insulin, omentin levels and HOMA IR were recorded. SPSS 15.0 for Windows was used for statistical analysis. Results: There were 36 pregnant women in the study group and 37 healthy, non-pregnant women in the control group. Serum omentin and fasting glucose levels were significantly decreased and fasting insulin was significantly increased in the study group compared to control group. Conclusion: Omentin might be an indicator of insulin resistance in pregnant women. Larger prospective studies are needed to claim whether omentin can have a clinical use for diagnosis of gestational diabetes mellitus.Öğe The Association of Omentin Levels in Non-Diabetic Postmenopausal Women with Bone Mineral Density and Total Body Composition(2015) Özlü, Tülay; Sarman, Hakan; Alçelik, Aytekin; Işık, Cengiz; Yazıcı, Selma; Tosun, Mehmet; Caglar, HilalObjectives: Positive relation between body mass and bone mineral density (BMD) is thought to be due to weight bearing effect. However, adipose tissue derived adipokines may have important effects on bone. Obese women have decreased levels of omentin in circulation which is related with adverse metabolic events. The hypothesis was that performed in this study, we aimed to study the association of omentin levels with body composition and BMD in non-diabetic postmenopausal women. Methods: Postmenopausal women aged 40 to 70 years, scheduled for BMD testing were prospectively evaluated. Patients with known diabetes, chronic renal failure, chronic liver disease, malabsorption, inflammatory bowel disease, <40 and >70 years of age were excluded. BMD and body composition were measured by DXA (GE-Lunar DPX pro). Fasting blood samples were obtained for analysis of complete blood count, glucose, creatinine, lipid profile and omentin. Statistical analyses were performed by using SPSS version 18 for windows. P<0.05 was considered statistically significant. Results: Mean age of the patients in the osteoporosis group was higher than that of the control group (59.1±7.6 vs 53.3±5.7, p<0.05). Mean omentin level was higher in osteoporosis group than in osteopenia and control groups (479.7±141.6 vs 342.3±173.6 and 346.8±127.2, p<0.05). Total body fat mass, muscle mass and the T score of lumbar spine had a negative correlation with omentin levels (r=-0.252, -0.276, -0.344, p<0.05). Conclusions: Body composition does not seem to effect omentin levels. Women with a lower BMI have increased omentin levels. Higher omentin levels are associated with lower T scores at the lumbar spine.Öğe Association of recurrent pregnancy loss with chromosomal abnormalities and hereditary thrombophilias(Makerere Univ, Fac Med, 2013) Ocak, Zeynep; Özlü, Tülay; Özyurt, OsmanBackground: Recurrent pregnancy loss (RPL) which is generally known as > 3 consecutive pregnancy losses before 20 weeks' gestation is seen in 0.5-2% of women Objective: To evaluate the association of parental and fetal chromosomal abnormalities with recurrent pregnancy loss in our area and to analyze the frequency of three types of hereditary thrombophilia's; (MTHFR C677T polymorphisms, FV Leiden G1691A mutation and Prothrombin (factor II) G20210A mutation) in these female patients. Methods: The present case-control retrospective study was performed between February 2007 and December 2011 on 495 couples, who had two or more consecutive pregnancy losses before 20 weeks' gestation. We used conventional cytogenetic analysis and polymerase chain reaction-restriction fragment length polymorphism. Results: Parental chromosomal abnormality was detected in 28 cases (2.8% of all cases, 5.7% of the couples) most of which (92.9%) were structural abnormalities. All of the structural abnormalities were balanced chromosomal translocations. Chromosomal analysis performed from the abortion materials detected a major chromosomal abnormality in 31.9% of the cases. The most frequently observed alteration in the hereditary thrombophilia genes was heterozygote mutation for the MTHFR C677T polymorphisms (n=55). Conclusion: Balanced translocations are the most commonly detected chromosomal abnormalities in couples being evaluated for recurrent pregnancy loss and these patients are the best candidates for offering prenatal genetic diagnosis by the help of which there is a possibility of obtaining a better reproductive outcome.Öğe Bicuspid aortic valve and severe aortic stenosis in a newborn exposed to carbamazapine during pregnancy(2014) Karataş, Zehra; Karataş, Ahmet; Özlü, Tülay; Göksügür, Sevil Bilir; Varan, BirgülThe use of antiepileptic drugs increases the risk of major congenital malformations during pregnancy. Here, we report an infant who had a history of in-utero carbamazepine exposure and who was born with a cardiac malformation. The infant was born at 39 weeks of gestation vagi- nally to an epileptic mother who had been treated with carbamazepine throughout her pregnancy. He was referred due to cardiac murmur in the second week of his life. The mother had not received folic acid supplementation. Transthoracic echocardiography revealed bicuspid aortic valve, mild aortic stenosis, patent ductus arteriosus, patent foramen ovale and the renal ultrasound revealed mild left hydronephrosis. Follow-up echocardiography performed 14 weeks later showed increased severity of aortic stenosis and percutaneous balloon aortic valvuloplasty was performed. To our knowledge, there is only one case report in the literature mentioning the association of a bicuspid aortic valve and aortic stenosis with oxcarbazepine exposure, which is a structural derivative of carbamazepine. However, there are no reports for association with carbamazepine itself. Bicuspid aorta and aortic stenosis may be among the cardiac malformations that result from the teratogenic effect of carbamazepine.Öğe Clinical and cytogenetic results of a large series of amniocentesis cases from Turkey: report of 6124 cases(Wiley, 2014) Ocak, Zeynep; Özlü, Tülay; Yazıcıoğlu, Hasan Fehmi; Özyurt, Osman; Aygün, MehmetAimThe aim of this study was to document the clinical and cytogenetic results of a large series of amniocentesis (AS) cases from Turkey. Material and MethodsSecond-trimester amniocentesis cases performed in Suleymaniye Maternity Hospital for Research and Training between January 2007 and December 2011 were included. ResultsDuring this period, 6124 AS were performed. Indications were increased risk in maternal serum screening (MSS) (56%), advanced maternal age (29%) and pathologic ultrasound finding (11.5%). Most frequent MSS abnormality was abnormal triple test result (58%). Overall culture success rate was 98.8%. Chromosomal abnormality was detected in 215 (3.6%) of the 6052 cytogenetic results (74.9% numerical, 25.1% structural). Most frequent numerical chromosomal abnormality was trisomy 21 (61.9%). Clinically insignificant polymorphisms were the most frequent structural changes (n=571). Most frequent polymorphism was increase in heterochromatin region in the 1st chromosome (n=158). Advanced maternal age had a positive predictive value of 5.2%. Among the MSS tests, the combined test had the highest positive predictive value (5.2%). ConclusionsIn our study, abnormal MSS (and among these, abnormal triple test result) was the most frequent indication for amniocentesis. Our overall culture success rate was 98.8%. Frequency of major chromosomal abnormality was 3.2% and trisomy 21 was the most frequent abnormality.Öğe Dexamethasone added to levobupivacaine in ultrasound-guided tranversus abdominis plain block increased the duration of postoperative analgesia after caesarean section : a randomized, double blind, controlled trial(Verduci Publisher, 2014) Akkaya, Akcan; Yıldız, İsa; Tekelioğlu, Ümit Yaşar; Demirhan, Abdullah; Bayır, Hakan; Özlü, Tülay; Bilgi, MuratOBJECTIVES: When added to local anaesthetics, dexamethasone can prolong the duration of peripheral blocks. Dexamethasone has a long and efficient glucocorticoid structure and presents anti-inflammatory properties. The aim of this study was to determine the effect of dexamethasone on the block duration added to levobupivacaine used for transversus abdominis block (TAP) applied to patients who underwent caesarean section. PATIENTS AND METHODS: Forty-two patients with spinal anaesthesia in an American Society of Anesthesiologists (ASA) I-II risk group were included in the study and divided into two groups. Bilateral 30 ml 0.25% levobupivacaine and 2 ml 0.9% NaCl for the levobupivacaine group and bilateral 30 ml 0.25% levobupivacaine and 2 ml dexamethasone (8 mg) for the dexamethasone group were administered in a TAP block performed with ultrasonography. The time need for the first analgesic in the postoperative period was recorded. The numeric evaluation scale, and the total additional analgesic amounts were recorded. RESULTS: The time before the administration of the first additional analgesic dose was prolonged significantly in the dexamethasone group compared to the levobupivacaine group (p = 0.004). The pain scores were lower in the dexamethasone group for superficial pain. A significant difference for the dexamethasone group was observed in the evaluation of deep pain. The total consumption of tramadol was significantly lower in the dexamethasone group (p = 0.001). CONCLUSIONS: The utilization of dexamethasone, which has a prolonging effect on the transversus abdominis plane block, may be an alternative to epidural opioid analgesia in caesarean section. We observed that dexamethasone added to levobupivacaine in a TAP block applied for analgesia following a caesarean section procedure prolonged the time required for analgesia.Öğe The effect of feto-maternal blood type incompatibility on development of gestational diabetes mellitus(Societa Editrice Universo, 2014) Kanat, Mustafa; Göksügür, Sevil Bilir; Özlü, Tülay; Tunçkale, Aydın; Öztürk, B.; Karagöz, YalçınObjective. To assess the relation between fetal and maternal blood type (ABO, Rh) incompatibility and development of gestational diabetes mellitus (GDM). Materials and Methods. A total of 500 pregnant women underwent diagnostic test for GDM by a 100-g oral glucose tolerance test (OGTT) after an 8 to 12-h overnight fast participated in this study. OGTT was performed between the 24-28 weeks of gestation, but participants who were at high risk for GDM were tested after the first prenatal visit. In the postpartum period, maternal and infant blood types were determined. Presence of GDM was evaluated in terms of matched and unmatched fetal and maternal ABO and Rh blood types separately. Results. GDM was detected in 235 participants. Unmatched ABO blood types between the mother-infant pairs were present in 44.7% (n=105) of GDM (+) and 35.8 % (n=95) of GDM (-) patients. Incompatible feto-maternal ABO blood type was positively correlated with development of GDM which was marginally significant. (p=0.045; R=1.2;95% CL; 1.004-1.48). However, Rh feto-maternal blood type incompatibility was not related with development of GDM. Conclusions. Feto-maternal ABO blood type incompatibility may be a weak risk factor for the development of GDM. © Società Editrice Universo (SEU).Öğe Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells(Verduci Publisher, 2013) Ocak, Zeynep; Acar, Muradiye; Gündüz, E.; Gündüz, Mehmet; Demircan, Kadir; Üyeturk, Ümmügül; Özlü, TülayAIM: To investigate the effects of hypericin which is obtained from the plant Hypericum perforatum on the expression and the regulation of ADAMTS8 and ADAMTS9 genes in MCF7 breast cancer cells and on the viability of these cells. MATERIALS AND METHODS: MCF7 cells were cultured and were separately exposed to 2, 10 and 50 mu l/mL of hypericin. After 24 hours, RNA was isolated from these cells and converted to cDNA. The expression levels of ADAMTS8 and ADAMTS9 genes were evaluated using the Reverse Transcription Polymerase Chain Reaction. XTT (2,3-bis-( 2-methoxy-4-nitro-5-sulfophenyl)-2Htetrazolium-5-carboxanilide, disodium salt) cell viability assay was used to determine cytotoxicity. RESULTS: ADAMTS9 expression in MCF7 cells were increased 1.8 and 3.6 fold with the use of 2 and 10 mu l/mL of hypericin, respectively; and decreased 0.7 fold with the use of 50 mu l/mL of hypericin. There was no significant change in the ADAMTS8 expression. Rapid cell death was observed in the cancer cells when hypericin was used at a dose of >= 50 mu l/mL. CONCLUSIONS: The increase in ADAMTS9 expression can be a useful factor in the prevention of possible metastasis in breast cancer and for the occurrence of a tumor suppressive effect. Hypericin increases the expression of ADAMTS9, therefore, it may show its antitumoral and anti-apoptotic effects by means of ADAMTS9.Öğe The effect of smoking on placental pendrin expression(Taylor & Francis Inc, 2017) Karataş, Ahmet; Erdem, Havva; Karataş, Zehra; Özlü, Tülay; Çakmak, BülentPendrin is important for transport of iodine across the placenta. Thiocyanate coming from cigarette is a competitive inhibitor of iodine transport. We aimed to evaluate the pendrin immunostaining intensity in placentas of smoker and non-smoker women. Placental tissues from 61 women, of which 28 were in smoking, and 33 were in non-smoking group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Birth weight was significantly lower in the smoker group (p=0.024). There was a negative correlation between birth weight and intensity of placental pendrin immunostaining in the smoker group (r=-0.44, p=0.02). Placentas of the smoking women showed significantly higher immunostaining with pendrin than the control group (p=0.006). Thiocyonate coming from cigarettes may competitively inhibit pendrin mediated iodine transport in the placenta and adversely affect foetal development by this mechanism.Öğe Endothelial nitric oxide synthase gene polymorphisms (Promoter-786T/C, Exon 894 G/T and intron G10T) in unexplained female infertility(Karger, 2014) Karataş, Ahmet; Eröz, Recep; Bahadır, Anzel; Keskin, Fatih; Özlü, TülayBackground/Aims: Recent investigations in both males and females show that there may also be some genetic risk factors associated with infertility, and endothelial nitric oxide synthase (eNOS) has important functions in implantation. We aimed to investigate the association of three different polymorphisms of eNOS (promoter -786T/C, exon 894 G/T and intron G10T) with unexplained female infertility. Materials and Methods: Two groups of patients were included in the study: (1) women with unexplained infertility and (2) healthy, fertile women with normal menstrual cycles. eNOS polymorphisms were studied in genomic DNA of each patient by polynnerase chain reaction-restriction fragment length polymorphism method. Results: Forty-one women with unexplained infertility and 40 fertile women were included. Baseline physical characteristics and hormonal parameters of the two groups were similar. For eNOS exon 894 G/T polymorphism, the GG honnozygotes were significantly lower and the heterozygotes GT were significantly higher in the infertile group than in the control group (p < 0.05). eNOS gene polymorphism both for promoter and intron were similar in the two groups (p > 0.05). Conclusion: Altered eNOS protein caused by eNOS exon 894 G/T polymorphism might cause implantation failure, which may be a possible cause of unexplained female infertility. (C) 2014 S. Karger AG, BaselÖğe Enterobius vermicularis : can it be a possible pathogen in Bartholin gland abscess formation?(Wiley-Blackwell, 2014) Dönmez, Melahat Emine; Özlü, Tülay; Yılmaz, Fahri; Ayaz, ErolThe most frequent disorders of the Bartholin glands are cysts or abscesses. Bartholin gland abscesses occur generally as a result of polymicrobial infections or agents that cause sexually transmitted diseases. But as far as we know, no parasite has been previously reported among the infectious agents that are detected from the abscesses of the Bartholin gland. Here, we report a 45-year-old woman, in the Bartholin abscess aspirate of whom Enterobius vermicularis eggs were detected in between the inflammatory infiltrate by cytological examination.Öğe Evaluation of chromosomal abnormalities and common trombophilic mutations in cases with recurrent miscarriage(Makerere Univ, Fac Med, 2014) Karataş, Ahmet; Eröz, Recep; Albayrak, Mustafa; Özlü, Tülay; Çakmak, BülentBackground: Recurrent miscarriage (RM) is a frequent obstetric problem. Its' pathophysiology is poorly understood. Infections, genetic, endocrine, anatomic and immunologic problems have been suggested as causes for RM. Objective: To evaluate the frequency of chromosomal abnormalities and 3 common thrombophilic mutations in couples with RM. Methods: A retrospective data collection was performed for the results of the cytogenetic analysis of the couples and Methylenetetrahydrofolate Reductase (MTHFR) C677T, Factor V Leiden (FVL) G1691A and Prothrombin (PTm) G20210A mutations of the mother in 142 couples suffering from RM. Results: Prevalence of FVL, MTHFR, and PTm gene mutations were similar between cases shaving 2 or >= 3 abortions (P=0.528; P=0.233; P=0.375). In patients with FVL, MTHFR and PTm gene mutations, the OR's of having >= 3 abortions when compared to having 2 abortions were 1.515 (95% CI: 0.414-5.552), 0.573 (95% CI: 0.228-1.441), and 2.848 (95% CI: 0.355-22.871). All cases with PTm mutation had >= 3 abortions and all abortions occurred between 6-8 gestational weeks. Conclusion: Chromosomal abnormalities and thrombophilic mutations (especially PTm) seem to have an important role in RM. Additional larger studies involving investigation of more genes that may have a role in pregnancy are needed to assess this association.Öğe Evaluation of treatment success in patients undergoing transobturator tape surgery(Turkish Society of Obstetrics and Gynecology, 2014) Karataş, Ahmet; Duran, Bülent; Özlü, Tülay; Koç, Önder; Dönmez, Melahat Emine; Güler, ArzuObjective: Transobturator tape (TOT), a minimal invasive surgical technique in the treatment of urinary incontinence, is also frequently applied in addition to other gynecologic surgeries. Previous studies report a cure rate of 80%-92% with TOT. In this study, we aimed to evaluate treatment success in patients in whom TOT was performed in our clinics. Material and Methods: Patients in whom TOT was performed in our clinics between January 2009 and April 2013 were retrospectively evaluated. Follow up records were investigated to evaluate the TOT success rate and other urogynecologic problems that developed during follow up. Presence of ongoing urinary incontinence was accepted as TOT failure. Results: One hundred seven cases in whom TOT was performed and had available data were included. Median age of the cases was 59 (26-84) years. 72% (n=77) of them were in menopause, 91.6% (n=98) were multiparous and 59.8% (n=64) had other simultaneous gynecologic surgeries. Most frequent simultaneous operation was vaginal hysterectomy (n=42, 39.3%). Median postoperative follow up duration was 2.4 years (0.5-4 years). 12.1% (n=14) of the cases had ongoing urinary incontinence during follow up. Our TOT success rate was 87.9%. This rate was 87.5% in cases with simultaneous surgery and 88.4% in cases without a simultaneous surgery (p>0.05); 85.7% in postmenopausal and 93.3% in premenopausal cases (p>0.05). During follow up, cystocele developed in 8.4% and cuff prolapsus developed in 11.2% of the cases. Conclusion: Cure rate of TOT cases in our clinics were in accordance with the numbers in the literature. TOT success rate is not affected by the menopausal status or the application of any other simultaneous gynecologic surgery.Öğe Fetal isolated short femur in the second trimester and adverse pregnancy outcomes(Wiley-Blackwell, 2013) Özlü, Tülay; Özcan, TülinObjectiveThis study aims to evaluate the association of isolated short femur (ISF) in the second trimester ultrasound with adverse pregnancy outcomes. MethodAll obstetric scans between 16 and 24weeks of gestation from 1 January 2006 to 1 June 2012 were retrospectively evaluated. Multiple pregnancies, major congenital or chromosomal anomalies and subjects with incomplete outcome data were excluded. Femur length (FL) measurement from the earliest scan of singleton pregnancies was selected. An ISF was defined as a FL less than the tenth percentile in a fetus with an abdominal circumference greater than or equal to the tenth percentile. The primary outcomes were small for gestational age (SGA), birth weight below the third and fifth percentiles, low birth weight (LBW), preterm birth (PTB) and preeclampsia (PE). A 5-min Apgar score of less than 7 and a neonatal intensive care unit admission were secondary outcomes. ResultsOf the 4992 eligible fetuses, 312 (6%) had an ISF. Mothers in the short femur group were shorter and had a lower prepregnancy and delivery weight than the group with normal FL (p<0.05). Multiple logistic regression revealed a significant increase in birth weight below fifth percentile, SGA, LBW infants and PTB (<32, <34 and <37weeks) in the ISF group (p<0.05). The incidence of PE was similar in both groups. ConclusionIsolated short femur in the second trimester increases the risk of LBW, SGA and PTB, but not of PE. (c) 2013 John Wiley & Sons, Ltd.Öğe Forearm compartment syndrome owing to being stuck in the birth canal: a case report(W B Saunders Co-Elsevier Inc, 2012) Işık, Cengiz; Demirhan, Abdullah; Karabekmez, Furkan Erol; Tekelioğlu, Ümit Yaşar; Altunhan, Hüseyin; Özlü, TülayNeonatal compartment syndrome is a rare condition mainly involving the upper extremity associated with necrotic lesions. It is often initially misdiagnosed because the skin lesions mimic several other conditions of the newborn. Early diagnosis and timely intervention are of paramount importance to achieve the best outcome. In the present case, we describe a newborn with forearm compartment syndrome owing to being stuck in the birth canal. (C) 2012 Elsevier Inc. All rights reserved.
