The role of platelet indices in determining atopy in childhood asthma
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Asthma is the most common chronic airways disease of childhood. Allergic asthma is the most common phenotype in childhood. Definition of allergic asthma is typically based on presence or absence of atopy. In asthma, platelets have been found to actively participate in airway inflammation. The aim of this study is to evaluate levels of platelet indices in atopic and non-atopic asthmatic patients and to investigate the usefulness as a marker for the detection of atopy. Patients with asthma between January 2014 and January 2015 were retrospectively screened. 142 patients who fit for inclusion exclusion criteria enrolled into the study. Patients were grouped according to the skin prick test. The results of a complete blood count, serum total Ig E results were obtained from the laboratory information system. The percentage of eosinophils, total Ig E levels, platelet distribution width; was significantly higher in the group with atopic asthma (respectively p=<0.001, <0.001, 0.018). On the other hand platecrit atopic asthmatic group (n=72) was significantly lower than non-atopic (n=70). (p=0.016). The ROC curves analysis were constructed in order to test the ability of platelet distribution width and PCT levels to predict atopy. The area under ROC curve of PDW was 0.60 [95% confidence interval (CI) 0.52-0.68; p=0.031] and cut-off value was >15.9. The area under ROC curve of PCT was 0.58 [95% confidence interval (CI) 0.49-0.66; p=0.095] and cut-off value was <0.32. The results of this study shows that platelet distribution width may determine the phenotype of asthma. So, prospective, multicenter studies with larger cohort may obtain further data about platelet distribution width in asthma.