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dc.contributor.authorAyhan, Selim
dc.contributor.authorOzturk, Serkan
dc.contributor.authorDikbas, Oguz
dc.contributor.authorErdem, Alim
dc.contributor.authorOzlu, Mehmet Fatih
dc.contributor.authorBaltaci, Davut
dc.contributor.authorAlcelik, Aytekin
dc.date.accessioned2021-06-23T19:28:50Z
dc.date.available2021-06-23T19:28:50Z
dc.date.issued2012
dc.identifier.issn1875-2136
dc.identifier.urihttps://doi.org/10.1016/j.acvd.2012.07.003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7073
dc.descriptionWOS:000312513100003en_US
dc.descriptionPubMed: 23199618en_US
dc.description.abstractBackground. - Hyperthyroidism is an important cardiovascular risk factor in the development of atrial fibrillation and heart failure. Increased atrial electromechanical intervals are used to predict atrial fibrillation, measured by tissue Doppler imaging (TDI). Aims. - To evaluate atrial electromechanical delay (EMD) and left atrial (LA) mechanical function in patients with overt hyperthyroidism. Methods. - Thirty-four patients with overt hyperthyroidism and 34 controls were included. A diagnosis of overt hyperthyroidism was reached with decreased serum thyroid-stimulating hormone (TSH) and increased free T4 (fT4) concentrations. Using TDI, atrial electromechanical coupling (PA) was obtained from the lateral mitral annulus (PA lateral), septal mitral annulus (PA septum) and right ventricular tricuspid annulus (PA tricuspid). LA volumes (maximum, minimum and presystolic) were measured by the disks method in apical four-chamber view and indexed to body surface area. LA active and passive emptying volumes and fractions were calculated. Results. - LA diameter was significantly higher in hyperthyroid patients (P = 0.001). LA passive emptying volume and fraction were significantly decreased in hyperthyroid patients (P = 0.038 and P < 0.001). LA active emptying volume and fraction were significantly increased in hyperthyroid patients (P < 0.001 and P < 0.001). Left and right intra-atrial (PA lateral-PA septum and PA septum-PA tricuspid) and interatrial (PA lateral-PA tricuspid) EMDs were significantly higher in hyperthyroid patients (29.2 +/- 4.4 vs 18.1 +/- 2.6, P < 0.001; 18.7 +/- 4.3 vs 10.6 +/- 2.0, P < 0.001; and 10.5 +/- 2.9 vs 7.1 +/- 1.2, P < 0.001, respectively). Stepwise linear regression analysis demonstrated that fT4 and TSH concentrations were independent predictors of interatrial EMD (beta = 0.436, P < 0.001 and beta = -0.310, P = 0.005, respectively). Conclusion. - This study showed prolonged atrial electromechanical intervals and impaired LA mechanical function in patients with overt hyperthyroidism, which may be an early sign of subclinical cardiac involvement and dysrhythmias in overt hyperthyroidism. (c) 2012 Elsevier Masson SAS. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherElsevier Massonen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtrial functionen_US
dc.subjectAtrial conduction timeen_US
dc.subjectInteratrial delayen_US
dc.subjectHyperthyroidismen_US
dc.titleDetection of subclinical atrial dysfunction by two-dimensional echocardiography in patients with overt hyperthyroidismen_US
dc.typearticleen_US
dc.contributor.department[0-Belirlenecek]en_US
dc.contributor.authorID0000-0002-3156-1076en_US
dc.contributor.institutionauthor[0-Belirlenecek]
dc.identifier.doi10.1016/j.acvd.2012.07.003
dc.identifier.volume105en_US
dc.identifier.issue12en_US
dc.identifier.startpage631en_US
dc.identifier.endpage638en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.ispartofArchives Of Cardiovascular Diseasesen_US


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