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dc.contributor.authorYildiz, Nebil
dc.contributor.authorDogan, Nazile
dc.contributor.authorYildiz, Serpil
dc.contributor.authorAltunrende, Burcu
dc.contributor.authorDikbas, Oguz
dc.description.abstractObjective: Quantitative sensory testing (QST) thermal threshold evaluation is used in order to determine small fiber neuropathy, and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) Pain Scale is used in diagnosing neuropathic pain. The aim of this study is to find out the normal QST thermal threshold values, and to compare the QST values of normal controls and patients with type II diabetes mellitus, who do not have large fiber neuropathy. With this comparison, the study also aims to determine whether QST abnormalities are present in patients without neuropathic pain. Methods: A total of one hundred normal subjects between the ages of 20 and 69, and 50 patients with type II diabetes mellitus aged 40 to 69 years with no sign of large fiber neuropathy were recruited. The normal subjects were divided into 5 subgroups according to their ages. The mean values of the QST thermal detection and thermal pain thresholds were determined. Sixty normal subjects between the ages of 40-69 were defined as a control group for comparison with the diabetic group. The patients were divided into subgroups according to their LANSS points and their data were compared with the data of age-matched controls. Results: The mean ages of total normal subjects and the control group were 44.8 +/- 14.4 and 57.4 +/- 8.4, respectively. In diabetic group, according to LANSS, 10 patients (mean age, 55.1 +/- 8.5 years) scored above 12 (14.6 +/- 3.5), and 40 patients (mean age, 55.5 +/- 8.4 years) scored under 12 points (6.8 +/- 3.4). In the LANSS>12 group, the least abnormality rate was 100%, and the most frequently detected abnormality was in the foot cold pain threshold (70%). In the LANSS<12 group, the least abnormality rate was 67.5%, and the most frequently detected abnormality was in the hand cold pain threshold (45%). Conclusion: It was demonstrated that QST was successful in determining thermal detection abnormalities in all patients with probable neuropathic pain according to LANSS Pain Scale. QST is a test, which gives reliable and reproducible results in the diagnosis of small fiber sensory neuropathy. Because of its subjectivity and inefficacy in differentiation of peripheral and central causes, QST findings should be evaluated together with findings of neurological examination and nerve conduction studies. (Archives of Neuropsychiatry 2010;47:223-9)en_US
dc.subjectQuantitative sensory testingen_US
dc.subjectNeuropathic painen_US
dc.subjectDiabetes Mellitus Type IIen_US
dc.subjectSmall fiber neuropathyen_US
dc.titleThe Evaluation of Small Nerve Fiber Dysfunction with Quantitative Sensory Testing in Patients with Type II Diabetes Mellitus without Large Fiber Neuropathy, and Normal Values for Thermal Thresholdsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.journalNoropsikiyatri Arsivi-Archives Of Neuropsychiatryen_US

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