Causes of hypouricemia among outpatients
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Background: The aim of this study was no examine the ratio and underlying causes of hypouricemia in patients visiting our outpatient clinics. The assoication between hypouricemia and uricosuria and other renal tubular defects was also studied. Methods: Serum uric acid levels were determined by uricase methods in 18,330 serum samples. Hypouricemia was defined as a serum uric acid level less than 2.0 mg/dL. Fractional excretion of uric acid (FEUA) higher than 10% was considered as pathological uricousuria. Results: The frequency of hypouricemia in our patient population was 0.51% (94/18,330). Moreover, using univariate analysis, hypouricemia was associated with age, gender, diet, drugs, and tea and coffee consumption. Multivariate analysis revealed that FEUA, drugs and tea consumption were associated with hypouricemia. Conclusion: Hypouricemia is a relatively uncommon finding among our patients and when it occurs it is frequently caused by inappropriate uricosuria.