PLATELET DISTRIBUTION WIDTH AND NEUTROPHIL-LYMPHOCYTE RATIO IN PROGRESSION TO PREECLAMPSIA AND SEVERE PREECLAMPSIA
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Background and aim: Preeclampsia is a multisystemic, hypertensive disorder without a well-known etiology, affecting 3-9% of pregnancies. The aim of this study is to demonstrate the roles of hematological markers at prediction of PE by a comparison between their levels prior and following the disorder and at determine the usefulness of them at deciding the severity of PE. Material and methods: This research is a retrospective and cross-sectional study performed between January 2012 and March 2018. SPSS (Statistical Package for Social Sciences) version 15.0 (SPSS Inc., USA) is used for statistical analysis.. Kolmogorov-Smirnov, Anova, Kruskal-Wallis, Paired Samples and Wilcoxon tests are used for interpreting data. Test results are assesed within 95% confidence interval and statistical significance is considered if p<0.05. Results: Two hundred and sixty nine pregnant women were recruited into our study. 115 women delivered with severe preeclampsia (SPE), 105 with mild preeclampsia (MPE) and 49 with gestational hypertension (GHT). After the progression to severe preeclampsia, MPV, RDW and PDW were found higher (p=0.005, p=0.0002, p=0.032). RDW is significantly elevated after diagnosis of MPE (p=0.006). After the diagnosis of SPE, MPE and GHT, MPV was higher in SPE subgroup with respect to MPE and GHT subgroups (respectively p=0.043, p=0.014). PDW and NLR were significantly lower in gestational hypertension patients which were evolving to preeclampsia (p=0.015, p=0.010). Conclusion: Lower PDW and NLR levels were found to be related with developing preeclampsia in GHT patients. As preeclamp-sia becomes severe, MPV levels increase and platelet counts decrease.